Jorge Gamboa
Last active: 4/15/2019

Profile

My research is focused on the role of oxidative stress and inflammation in chronic kidney disease and their impact on muscle mitochondria in humans. Patients with chronic kidney disease suffer from frailty and sarcopenia, conditions that are associated with increased mortality in this population. Mitochondrial abnormalities in skeletal muscle may explain the frailty phenotype in patients with chronic kidney disease. We have been studying ultrastructure changes and mitochondrial function in skeletal muscle biopsies from patients with chronic kidney disease and healthy controls. We have been evaluated mitochondrial function in vivo using 31P magnetic resonance spectroscopy.  We have also used in vitro and in vivo techniques to measure markers of mitochondrial function and mitochondrial content.

Publications

The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. Exercise and CKD: Skeletal Muscle Dysfunction and Practical Application of Exercise to Prevent and Treat Physical Impairments in CKD. Roshanravan B, Gamboa J, Wilund K (2017) Am J Kidney Dis 69(6): 837-852
    › Primary publication · 28427790 (PubMed) · PMC5441955 (PubMed Central)
  2. Cytochrome P450 epoxygenase-derived epoxyeicosatrienoic acids contribute to insulin sensitivity in mice and in humans. Gangadhariah MH, Dieckmann BW, Lantier L, Kang L, Wasserman DH, Chiusa M, Caskey CF, Dickerson J, Luo P, Gamboa JL, Capdevila JH, Imig JD, Yu C, Pozzi A, Luther JM (2017) Diabetologia 60(6): 1066-1075
    › Primary publication · 28352940 (PubMed) · PMC5921930 (PubMed Central)
  3. CKD and Muscle Mitochondrial Energetics. Roshanravan B, Kestenbaum B, Gamboa J, Jubrias SA, Ayers E, Curtin L, Himmelfarb J, de Boer IH, Conley KE (2016) Am J Kidney Dis 68(4): 658-659
    › Primary publication · 27312460 (PubMed) · PMC5063821 (PubMed Central)
  4. Mitochondrial dysfunction and oxidative stress in patients with chronic kidney disease. Gamboa JL, Billings FT, Bojanowski MT, Gilliam LA, Yu C, Roshanravan B, Roberts LJ, Himmelfarb J, Ikizler TA, Brown NJ (2016) Physiol Rep 4(9)
    › Primary publication · 27162261 (PubMed) · PMC4873632 (PubMed Central)
  5. Comparative effects of immediate-release and extended-release aspirin on basal and bradykinin-stimulated excretion of thromboxane and prostacyclin metabolites. Gamboa JL, Devin JK, Ramirez CE, Yu C, Nian H, Lee RH, Brown NJ (2016) Pharmacol Res Perspect 4(2): e00221
    › Primary publication · 27069632 (PubMed) · PMC4804312 (PubMed Central)
  6. Treatment with Sildenafil Improves Insulin Sensitivity in Prediabetes: A Randomized, Controlled Trial. Ramirez CE, Nian H, Yu C, Gamboa JL, Luther JM, Brown NJ, Shibao CA (2015) J Clin Endocrinol Metab 100(12): 4533-40
    › Primary publication · 26580240 (PubMed) · PMC4667163 (PubMed Central)
  7. Angiotensin converting enzyme inhibition increases ADMA concentration in patients on maintenance hemodialysis--a randomized cross-over study. Gamboa JL, Pretorius M, Sprinkel KC, Brown NJ, Ikizler TA (2015) BMC Nephrol : 167
    › Primary publication · 26494370 (PubMed) · PMC4618919 (PubMed Central)
  8. Gender-specific effects of depression and suicidal ideation in prosocial behaviors. Cáceda R, Moskovciak T, Prendes-Alvarez S, Wojas J, Engel A, Wilker SH, Gamboa JL, Stowe ZN (2014) PLoS One 9(9): e108733
    › Primary publication · 25259712 (PubMed) · PMC4178187 (PubMed Central)
  9. Whole genome sequencing of Ethiopian highlanders reveals conserved hypoxia tolerance genes. Udpa N, Ronen R, Zhou D, Liang J, Stobdan T, Appenzeller O, Yin Y, Du Y, Guo L, Cao R, Wang Y, Jin X, Huang C, Jia W, Cao D, Guo G, Claydon VE, Hainsworth R, Gamboa JL, Zibenigus M, Zenebe G, Xue J, Liu S, Frazer KA, Li Y, Bafna V, Haddad GG (2014) Genome Biol 15(2): R36
    › Primary publication · 24555826 (PubMed) · PMC4054780 (PubMed Central)
  10. Whole-genome sequencing uncovers the genetic basis of chronic mountain sickness in Andean highlanders. Zhou D, Udpa N, Ronen R, Stobdan T, Liang J, Appenzeller O, Zhao HW, Yin Y, Du Y, Guo L, Cao R, Wang Y, Jin X, Huang C, Jia W, Cao D, Guo G, Gamboa JL, Villafuerte F, Callacondo D, Xue J, Liu S, Frazer KA, Li Y, Bafna V, Haddad GG (2013) Am J Hum Genet 93(3): 452-62
    › Primary publication · 23954164 (PubMed) · PMC3769925 (PubMed Central)
  11. Is depression the link between suicide and high altitude? Gamboa JL, Caceda R, Arregui A (2011) High Alt Med Biol 12(4): 403-4; author reply 405
    › Primary publication · 22206568 (PubMed) · PMC6463990 (PubMed Central)
  12. Comparative effects of angiotensin-converting enzyme inhibition and angiotensin-receptor blockade on inflammation during hemodialysis. Gamboa JL, Pretorius M, Todd-Tzanetos DR, Luther JM, Yu C, Ikizler TA, Brown NJ (2012) J Am Soc Nephrol 23(2): 334-42
    › Primary publication · 22158433 (PubMed) · PMC3269170 (PubMed Central)
  13. Muscle endurance and mitochondrial function after chronic normobaric hypoxia: contrast of respiratory and limb muscles. Gamboa JL, Andrade FH (2012) Pflugers Arch 463(2): 327-38
    › Primary publication · 22113781 (PubMed) · PMC3274731 (PubMed Central)
  14. Combined angiotensin-converting enzyme inhibition and receptor blockade associate with increased risk of cardiovascular death in hemodialysis patients. Chan KE, Ikizler TA, Gamboa JL, Yu C, Hakim RM, Brown NJ (2011) Kidney Int 80(9): 978-985
    › Primary publication · 21775975 (PubMed) · PMC3656595 (PubMed Central)
  15. Rat diaphragm mitochondria have lower intrinsic respiratory rates than mitochondria in limb muscles. Garcia-Cazarin ML, Gamboa JL, Andrade FH (2011) Am J Physiol Regul Integr Comp Physiol 300(6): R1311-5
    › Primary publication · 21389333 (PubMed) · PMC3119153 (PubMed Central)
  16. Chronic hypoxia increases insulin-stimulated glucose uptake in mouse soleus muscle. Gamboa JL, Garcia-Cazarin ML, Andrade FH (2011) Am J Physiol Regul Integr Comp Physiol 300(1): R85-91
    › Primary publication · 20962202 (PubMed) · PMC3023279 (PubMed Central)
  17. Extension of the neuroprotective time window for thiazolidinediones in ischemic stroke is dependent on time of reperfusion. Gamboa J, Blankenship DA, Niemi JP, Landreth GE, Karl M, Hilow E, Sundararajan S (2010) Neuroscience 170(3): 846-57
    › Primary publication · 20691766 (PubMed) · PMC2939146 (PubMed Central)
  18. Mitochondrial content and distribution changes specific to mouse diaphragm after chronic normobaric hypoxia. Gamboa JL, Andrade FH (2010) Am J Physiol Regul Integr Comp Physiol 298(3): R575-83
    › Primary publication · 20007520 (PubMed) · PMC2838662 (PubMed Central)
  19. Age-related changes of cell death pathways in rat extraocular muscle. McMullen CA, Ferry AL, Gamboa JL, Andrade FH, Dupont-Versteegden EE (2009) Exp Gerontol 44(6-7): 420-5
    › Primary publication · 19341788 (PubMed) · PMC2720059 (PubMed Central)
  20. Abnormal energy regulation in early life: childhood gene expression may predict subsequent chronic mountain sickness. Huicho L, Xing G, Qualls C, Rivera-Ch M, Gamboa JL, Verma A, Appenzeller O (2008) BMC Pediatr : 47
    › Primary publication · 18954447 (PubMed) · PMC2582028 (PubMed Central)
  21. Lower respiratory capacity in extraocular muscle mitochondria: evidence for intrinsic differences in mitochondrial composition and function. Patel SP, Gamboa JL, McMullen CA, Rabchevsky A, Andrade FH (2009) Invest Ophthalmol Vis Sci 50(1): 180-6
    › Primary publication · 18791171 (PubMed) · PMC2615070 (PubMed Central)
  22. Adaptation and mal-adaptation to ambient hypoxia; Andean, Ethiopian and Himalayan patterns. Xing G, Qualls C, Huicho L, Rivera-Ch M, River-Ch M, Stobdan T, Slessarev M, Prisman E, Ito S, Ito S, Wu H, Norboo A, Dolma D, Kunzang M, Norboo T, Gamboa JL, Claydon VE, Fisher J, Zenebe G, Gebremedhin A, Hainsworth R, Verma A, Appenzeller O (2008) PLoS One 3(6): e2342
    › Primary publication · 18523639 (PubMed) · PMC2396283 (PubMed Central)
  23. Altered PPARgamma expression and activation after transient focal ischemia in rats. Victor NA, Wanderi EW, Gamboa J, Zhao X, Aronowski J, Deininger K, Lust WD, Landreth GE, Sundararajan S (2006) Eur J Neurosci 24(6): 1653-63
    › Primary publication · 17004929 (PubMed)
  24. Chronic hypoxia in Andeans; are there lessons for neurology at sea level? Appenzeller O, Minko T, Qualls C, Pozharov V, Gamboa J, Gamboa A, Pakunlu RI (2006) J Neurol Sci 247(1): 93-9
    › Primary publication · 16733057 (PubMed)
  25. Gene expression, autonomic function and chronic hypoxia:lessons from the Andes. Appenzeller O, Minko T, Qualls C, Pozharov V, Gamboa J, Gamboa A, Wang Y (2006) Clin Auton Res 16(3): 217-22
    › Primary publication · 16583294 (PubMed)
  26. Plasma catecholamines and blood volume in native Andeans during hypoxia and normoxia. Gamboa A, Gamboa JL, Holmes C, Sharabi Y, Leon-Velarde F, Fischman GJ, Appenzeller O, Goldstein DS (2006) Clin Auton Res 16(1): 40-5
    › Primary publication · 16477494 (PubMed)
  27. Comments on Point-Counterpoint "Positive effects of intermittent hypoxia (live high:train low) on exercise performance are/are not mediated primarily by augmented red cell volume". Gamboa A, Gamboa JL (2006) J Appl Physiol (1985) 100(1): 366-7
    › Primary publication · 16402429 (PubMed)
  28. Migraine in the Andes and headache at sea level. Appenzeller O, Minko T, Qualls C, Pozharov V, Gamboa J, Gamboa A, Wang Y (2005) Cephalalgia 25(12): 1117-21
    › Primary publication · 16305600 (PubMed)
  29. Neuronal migration is transiently delayed by prenatal exposure to intermittent hypoxia. Zechel JL, Gamboa JL, Peterson AG, Puchowicz MA, Selman WR, Lust WD (2005) Birth Defects Res B Dev Reprod Toxicol 74(4): 287-99
    › Primary publication · 16094620 (PubMed)
  30. Carbonic anhydrase activity in the red blood cells of sea level and high altitude natives. Gamboa J, Caceda R, Gamboa A, Monge-C C (2000) Biol Res 33(3-4): 207-8
    › Primary publication · 15696680 (PubMed)
  31. Peroxisome proliferator-activated receptor-gamma ligands reduce inflammation and infarction size in transient focal ischemia. Sundararajan S, Gamboa JL, Victor NA, Wanderi EW, Lust WD, Landreth GE (2005) Neuroscience 130(3): 685-96
    › Primary publication · 15590152 (PubMed)
  32. Cerebral vasoreactivity in Andeans and headache at sea level. Appenzeller O, Passino C, Roach R, Gamboa J, Gamboa A, Bernardi L, Bonfichi M, Malcovati L (2004) J Neurol Sci 219(1-2): 101-6
    › Primary publication · 15050445 (PubMed)
  33. Ventilation, autonomic function, sleep and erythropoietin. Chronic mountain sickness of Andean natives. Bernardi L, Roach RC, Keyl C, Spicuzza L, Passino C, Bonfichi M, Gamboa A, Gamboa J, Malcovati L, Schneider A, Casiraghi N, Mori A, Leon-Velarde F (2003) Adv Exp Med Biol : 161-75
    › Primary publication · 14713121 (PubMed)
  34. Effect of domperidone on ventilation and polycythemia after 5 weeks of chronic hypoxia in rats. Gamboa J, Macarlupú JL, Rivera-Chira M, Monge-C C, León-Velarde F (2003) Respir Physiol Neurobiol 135(1): 1-8
    › Primary publication · 12706060 (PubMed)
  35. Gene expression in the Andes; relevance to neurology at sea level. Appenzeller O, Minko T, Pozharov V, Bonfichi M, Malcovati L, Gamboa J, Bernardi L (2003) J Neurol Sci 207(1-2): 37-41
    › Primary publication · 12614929 (PubMed)
  36. Activation of caspase-12, an endoplasmic reticulum resident caspase, after permanent focal ischemia in rat. Mouw G, Zechel JL, Gamboa J, Lust WD, Selman WR, Ratcheson RA (2003) Neuroreport 14(2): 183-6
    › Primary publication · 12598725 (PubMed)
  37. Acral paresthesias in the Andes and neurology at sea level. Appenzeller O, Thomas PK, Ponsford S, Gamboa JL, Cáceda R, Milner P (2002) Neurology 59(10): 1532-5
    › Primary publication · 12451192 (PubMed)
  38. Energetic metabolism in mouse cerebral cortex during chronic hypoxia. Cáceda R, Gamboa JL, Boero JA, Monge-C C, Arregui A (2001) Neurosci Lett 301(3): 171-4
    › Primary publication · 11257425 (PubMed)
  39. Neurological manifestations in chronic mountain sickness: the burning feet-burning hands syndrome. Thomas PK, King RH, Feng SF, Muddle JR, Workman JM, Gamboa J, Tapia R, Vargas M, Appenzeller O (2000) J Neurol Neurosurg Psychiatry 69(4): 447-52
    › Primary publication · 10990502 (PubMed) · PMC1737143 (PubMed Central)