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Dr. Emmitte leads drug discovery teams and directs medicinal chemistry within the Vanderbilt Center for Neuroscience Drug Discovery. Current research efforts are focused on the discovery and optimization of novel small molecule therapeutics for the treatment of central nervous system (CNS) disorders, more specifically on allosteric modulators of G protein-coupled receptors (GPCRs), such as the metabotropic glutamate receptors (mGlu5). Dr. Emmitte recently led a project directed toward the discovery of novel negative allosteric modulators (NAMs) of mGlu5 for the treatment of fragile X disorder that culminated in the discovery of a novel preclinical candidate molecule and additional backup compounds. Additional areas of interest include the discovery and optimization of novel NAMs of mGlu1 and mGlu3. Finally, Dr. Emmitte serves as Co-director of the Vanderbilt Specialized Chemistry Center for Accelerated Probe Development, which is a member of the Molecular Libraries Probe Production Centers Network (MLPCN) initiated and supported by the National Institutes of Health (NIH) Molecular Libraries Roadmap.

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    615-936-8401 (p)
    615-343-9332 (f)
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    Keywords

    CNS Disorders Drug Discovery Medicinal Chemistr Medicinal Chemistry Metabotropic Glutamate Receptors Neuroscience Reaction Discovery Structure-based Ligand/Inhibitor Design Synthetic Chemistry