Sergey Dikalov, Ph.D.

Profile

Our lab studies the diverse pathophysiological role of reactive oxygen species (ROS) such as superoxide radical, hydrogen peroxide, nitric oxide (NO·) and peroxynitrite. We were one of the first groups reported on development of mitochondrial oxidative stress and mitochondrial impairment under conditions of endothelial dysfunction and hypertension.  Our lab has uncovered specific molecular mechanisms of mitochondrial ROS upregulation and their contribution in the development of hypertension by overexpression of mitochondrial superoxide dismutase (SOD2) and mitochondria targeted SOD mimetic antioxidants. Our team continues to develop a deeper understanding of the complex redox cell signaling pathways and oxidative stress in the pathogenesis of hypertension and other pathological conditions.

Publications

The following timeline graph is generated from all co-authored publications.

1. Gastroesophageal Reflux Induces Protein Adducts in the Esophagus. Caspa Gokulan R, Adcock JM, Zagol-Ikapitte I, Mernaugh R, Williams P, Washington KM, Boutaud O, Oates JA, Dikalov SI, Zaika AI (2019) Cell Mol Gastroenterol Hepatol 7(2): 480-482.e7
   › Primary publication · 30827415 (PubMed) · PMC6410348 (PubMed Central)
2. Use of Electron Paramagnetic Resonance in Biological Samples at Ambient Temperature and 77 K. Elajaili HB, Hernandez-Lagunas L, Ranguelova K, Dikalov S, Nozik-Grayck E (2019) J Vis Exp (143)
   › Primary publication · 30688300 (PubMed) · PMC8015406 (PubMed Central)
3. Crosstalk Between Mitochondrial Hyperacetylation and Oxidative Stress in Vascular Dysfunction and Hypertension. Dikalov SI, Dikalova AE (2019) Antioxid Redox Signal 31(10): 710-721
   › Primary publication · 30618267 (PubMed) · PMC6708267 (PubMed Central)
4. Tobacco smoking induces cardiovascular mitochondrial oxidative stress, promotes endothelial dysfunction, and enhances hypertension. Dikalov S, Itani H, Richmond B, Vergeade A, Rahman SMJ, Boutaud O, Blackwell T, Massion PP, Harrison DG, Dikalova A (2019) Am J Physiol Heart Circ Physiol 316(3): H639-H646
   › Primary publication · 30608177 (PubMed) · PMC6459311 (PubMed Central)
5. Hypertension and increased endothelial mechanical stretch promote monocyte differentiation and activation: roles of STAT3, interleukin 6 and hydrogen peroxide. Loperena R, Van Beusecum JP, Itani HA, Engel N, Laroumanie F, Xiao L, Elijovich F, Laffer CL, Gnecco JS, Noonan J, Maffia P, Jasiewicz-Honkisz B, Czesnikiewicz-Guzik M, Mikolajczyk T, Sliwa T, Dikalov S, Weyand CM, Guzik TJ, Harrison DG (2018) Cardiovasc Res 114(11): 1547-1563
   › Primary publication · 29800237 (PubMed) · PMC6106108 (PubMed Central)
6. Physiological Levels of Nitric Oxide Diminish Mitochondrial Superoxide. Potential Role of Mitochondrial Dinitrosyl Iron Complexes and Nitrosothiols. Dikalov SI, Mayorov VI, Panov AV (2017) Front Physiol : 907
   › Primary publication · 29163230 (PubMed) · PMC5681960 (PubMed Central)
7. Ascorbic acid attenuates endothelial permeability triggered by cell-free hemoglobin. Kuck JL, Bastarache JA, Shaver CM, Fessel JP, Dikalov SI, May JM, Ware LB (2018) Biochem Biophys Res Commun 495(1): 433-437
   › Primary publication · 29129689 (PubMed) · PMC5736437 (PubMed Central)
8. Cellular accumulation and antioxidant activity of acetoxymethoxycarbonyl pyrrolidine nitroxides. Dikalov SI, Dikalova AE, Morozov DA, Kirilyuk IA (2018) Free Radic Res 52(3): 339-350
   › Primary publication · 29098905 (PubMed) · PMC5915311 (PubMed Central)
9. Dendritic Cell Amiloride-Sensitive Channels Mediate Sodium-Induced Inflammation and Hypertension. Barbaro NR, Foss JD, Kryshtal DO, Tsyba N, Kumaresan S, Xiao L, Mernaugh RL, Itani HA, Loperena R, Chen W, Dikalov S, Titze JM, Knollmann BC, Harrison DG, Kirabo A (2017) Cell Rep 21(4): 1009-1020
   › Primary publication · 29069584 (PubMed) · PMC5674815 (PubMed Central)
10. Endothelial nitric oxide synthase modulates Toll-like receptor 4-mediated IL-6 production and permeability via nitric oxide-independent signaling. Stark RJ, Koch SR, Choi H, Mace EH, Dikalov SI, Sherwood ER, Lamb FS (2018) FASEB J 32(2): 945-956
    › Primary publication · 29061842 (PubMed) · PMC5888395 (PubMed Central)
11. Electron Paramagnetic Resonance Measurements of Reactive Oxygen Species by Cyclic Hydroxylamine Spin Probes. Dikalov SI, Polienko YF, Kirilyuk I (2018) Antioxid Redox Signal 28(15): 1433-1443
    › Primary publication · 29037084 (PubMed) · PMC5910043 (PubMed Central)
12. Activation of NADPH oxidases leads to DNA damage in esophageal cells. Bhardwaj V, Gokulan RC, Horvat A, Yermalitskaya L, Korolkova O, Washington KM, El-Rifai W, Dikalov SI, Zaika AI (2017) Sci Rep 7(1): 9956
    › Primary publication · 28855537 (PubMed) · PMC5577233 (PubMed Central)
13. Sirt3 Impairment and SOD2 Hyperacetylation in Vascular Oxidative Stress and Hypertension. Dikalova AE, Itani HA, Nazarewicz RR, McMaster WG, Flynn CR, Uzhachenko R, Fessel JP, Gamboa JL, Harrison DG, Dikalov SI (2017) Circ Res 121(5): 564-574
    › Primary publication · 28684630 (PubMed) · PMC5562527 (PubMed Central)
14. High salt intake reprioritizes osmolyte and energy metabolism for body fluid conservation. Kitada K, Daub S, Zhang Y, Klein JD, Nakano D, Pedchenko T, Lantier L, LaRocque LM, Marton A, Neubert P, Schröder A, Rakova N, Jantsch J, Dikalova AE, Dikalov SI, Harrison DG, Müller DN, Nishiyama A, Rauh M, Harris RC, Luft FC, Wassermann DH, Sands JM, Titze J (2017) J Clin Invest 127(5): 1944-1959
    › Primary publication · 28414295 (PubMed) · PMC5409074 (PubMed Central)
15. Early Effects of Prolonged Cardiac Arrest and Ischemic Postconditioning during Cardiopulmonary Resuscitation on Cardiac and Brain Mitochondrial Function in Pigs. Matsuura TR, Bartos JA, Tsangaris A, Shekar KC, Olson MD, Riess ML, Bienengraeber M, Aufderheide TP, Neumar RW, Rees JN, McKnite SH, Dikalova AE, Dikalov SI, Douglas HF, Yannopoulos D (2017) Resuscitation : 8-15
    › Primary publication · 28408349 (PubMed) · PMC5552370 (PubMed Central)
16. Prevention of DNA damage in Barrett's esophageal cells exposed to acidic bile salts. Bhardwaj V, Horvat A, Korolkova O, Washington MK, El-Rifai W, Dikalov SI, Zaika AI (2016) Carcinogenesis 37(12): 1161-1169
    › Primary publication · 27655834 (PubMed) · PMC5137263 (PubMed Central)
17. Measurement of Reactive Oxygen Species, Reactive Nitrogen Species, and Redox-Dependent Signaling in the Cardiovascular System: A Scientific Statement From the American Heart Association. Griendling KK, Touyz RM, Zweier JL, Dikalov S, Chilian W, Chen YR, Harrison DG, Bhatnagar A, American Heart Association Council on Basic Cardiovascular Sciences (2016) Circ Res 119(5): e39-75
    › Primary publication · 27418630 (PubMed) · PMC5446086 (PubMed Central)
18. Cardiolipin fatty acid remodeling regulates mitochondrial function by modifying the electron entry point in the respiratory chain. Vergeade A, Bertram CC, Bikineyeva AT, Zackert WE, Zinkel SS, May JM, Dikalov SI, Roberts LJ, Boutaud O (2016) Mitochondrion : 88-95
    › Primary publication · 27085476 (PubMed) · PMC4860904 (PubMed Central)
19. Mitochondrial Cyclophilin D in Vascular Oxidative Stress and Hypertension. Itani HA, Dikalova AE, McMaster WG, Nazarewicz RR, Bikineyeva AT, Harrison DG, Dikalov SI (2016) Hypertension 67(6): 1218-27
    › Primary publication · 27067720 (PubMed) · PMC4865418 (PubMed Central)
20. Cell-free hemoglobin: a novel mediator of acute lung injury. Shaver CM, Upchurch CP, Janz DR, Grove BS, Putz ND, Wickersham NE, Dikalov SI, Ware LB, Bastarache JA (2016) Am J Physiol Lung Cell Mol Physiol 310(6): L532-41
    › Primary publication · 26773065 (PubMed) · PMC4796260 (PubMed Central)
21. Contribution of mitochondrial oxidative stress to hypertension. Dikalov SI, Dikalova AE (2016) Curr Opin Nephrol Hypertens 25(2): 73-80
    › Primary publication · 26717313 (PubMed) · PMC4766975 (PubMed Central)
22. Antihypertensive effect of mitochondria-targeted proxyl nitroxides. Dikalova AE, Kirilyuk IA, Dikalov SI (2015) Redox Biol : 355-62
    › Primary publication · 25677087 (PubMed) · PMC4326181 (PubMed Central)
23. DC isoketal-modified proteins activate T cells and promote hypertension. Kirabo A, Fontana V, de Faria AP, Loperena R, Galindo CL, Wu J, Bikineyeva AT, Dikalov S, Xiao L, Chen W, Saleh MA, Trott DW, Itani HA, Vinh A, Amarnath V, Amarnath K, Guzik TJ, Bernstein KE, Shen XZ, Shyr Y, Chen SC, Mernaugh RL, Laffer CL, Elijovich F, Davies SS, Moreno H, Madhur MS, Roberts J, Harrison DG (2014) J Clin Invest 124(10): 4642-56
    › Primary publication · 25244096 (PubMed) · PMC4220659 (PubMed Central)
24. Nox2-induced production of mitochondrial superoxide in angiotensin II-mediated endothelial oxidative stress and hypertension. Dikalov SI, Nazarewicz RR, Bikineyeva A, Hilenski L, Lassègue B, Griendling KK, Harrison DG, Dikalova AE (2014) Antioxid Redox Signal 20(2): 281-94
    › Primary publication · 24053613 (PubMed) · PMC3887459 (PubMed Central)
25. Role of mitochondrial oxidative stress in hypertension. Dikalov SI, Ungvari Z (2013) Am J Physiol Heart Circ Physiol 305(10): H1417-27
    › Primary publication · 24043248 (PubMed) · PMC3840266 (PubMed Central)
26. Nox2 as a potential target of mitochondrial superoxide and its role in endothelial oxidative stress. Nazarewicz RR, Dikalova AE, Bikineyeva A, Dikalov SI (2013) Am J Physiol Heart Circ Physiol 305(8): H1131-40
    › Primary publication · 23955717 (PubMed) · PMC3798790 (PubMed Central)
27. Mitochondrial ROS in the prohypertensive immune response. Nazarewicz RR, Dikalov SI (2013) Am J Physiol Regul Integr Comp Physiol 305(2): R98-100
    › Primary publication · 23657641 (PubMed) · PMC3726999 (PubMed Central)
28. Does scavenging of mitochondrial superoxide attenuate cancer prosurvival signaling pathways? Nazarewicz RR, Dikalova A, Bikineyeva A, Ivanov S, Kirilyuk IA, Grigor'ev IA, Dikalov SI (2013) Antioxid Redox Signal 19(4): 344-9
    › Primary publication · 23373855 (PubMed) · PMC3700017 (PubMed Central)
29. Rapid and specific measurements of superoxide using fluorescence spectroscopy. Nazarewicz RR, Bikineyeva A, Dikalov SI (2013) J Biomol Screen 18(4): 498-503
    › Primary publication · 23190737 (PubMed) · PMC4210376 (PubMed Central)
30. Methods for detection of mitochondrial and cellular reactive oxygen species. Dikalov SI, Harrison DG (2014) Antioxid Redox Signal 20(2): 372-82
    › Primary publication · 22978713 (PubMed) · PMC3887411 (PubMed Central)
31. Angiotensin II-induced production of mitochondrial reactive oxygen species: potential mechanisms and relevance for cardiovascular disease. Dikalov SI, Nazarewicz RR (2013) Antioxid Redox Signal 19(10): 1085-94
    › Primary publication · 22443458 (PubMed) · PMC3771548 (PubMed Central)
32. Mitochondrial reactive oxygen species and calcium uptake regulate activation of phagocytic NADPH oxidase. Dikalov SI, Li W, Doughan AK, Blanco RR, Zafari AM (2012) Am J Physiol Regul Integr Comp Physiol 302(10): R1134-42
    › Primary publication · 22442197 (PubMed) · PMC3362147 (PubMed Central)
33. Cross talk between mitochondria and NADPH oxidases. Dikalov S (2011) Free Radic Biol Med 51(7): 1289-301
    › Primary publication · 21777669 (PubMed) · PMC3163726 (PubMed Central)
34. Respiration and ROS production in brain and spinal cord mitochondria of transgenic rats with mutant G93a Cu/Zn-superoxide dismutase gene. Panov A, Kubalik N, Zinchenko N, Hemendinger R, Dikalov S, Bonkovsky HL (2011) Neurobiol Dis 44(1): 53-62
    › Primary publication · 21745570 (PubMed)
35. Anti-inflammatory activity of Chios mastic gum is associated with inhibition of TNF-alpha induced oxidative stress. Triantafyllou A, Bikineyeva A, Dikalova A, Nazarewicz R, Lerakis S, Dikalov S (2011) Nutr J : 64
    › Primary publication · 21645369 (PubMed) · PMC3127998 (PubMed Central)
36. Role of increased guanosine triphosphate cyclohydrolase-1 expression and tetrahydrobiopterin levels upon T cell activation. Chen W, Li L, Brod T, Saeed O, Thabet S, Jansen T, Dikalov S, Weyand C, Goronzy J, Harrison DG (2011) J Biol Chem 286(16): 13846-51
    › Primary publication · 21343293 (PubMed) · PMC3077585 (PubMed Central)
37. EPR detection of cellular and mitochondrial superoxide using cyclic hydroxylamines. Dikalov SI, Kirilyuk IA, Voinov M, Grigor'ev IA (2011) Free Radic Res 45(4): 417-30
    › Primary publication · 21128732 (PubMed) · PMC4210377 (PubMed Central)
38. Regulation of endothelial cell tetrahydrobiopterin pathophysiological and therapeutic implications. Harrison DG, Chen W, Dikalov S, Li L (2010) Adv Pharmacol : 107-32
    › Primary publication · 21081217 (PubMed)
39. Therapeutic targeting of mitochondrial superoxide in hypertension. Dikalova AE, Bikineyeva AT, Budzyn K, Nazarewicz RR, McCann L, Lewis W, Harrison DG, Dikalov SI (2010) Circ Res 107(1): 106-16
    › Primary publication · 20448215 (PubMed) · PMC2901409 (PubMed Central)
40. The delivery of superoxide dismutase encapsulated in polyketal microparticles to rat myocardium and protection from myocardial ischemia-reperfusion injury. Seshadri G, Sy JC, Brown M, Dikalov S, Yang SC, Murthy N, Davis ME (2010) Biomaterials 31(6): 1372-9
    › Primary publication · 19889454 (PubMed) · PMC2813932 (PubMed Central)
41. Targeted detoxification of selected reactive oxygen species in the vascular endothelium. Shuvaev VV, Christofidou-Solomidou M, Bhora F, Laude K, Cai H, Dikalov S, Arguiri E, Solomides CC, Albelda SM, Harrison DG, Muzykantov VR (2009) J Pharmacol Exp Ther 331(2): 404-11
    › Primary publication · 19692634 (PubMed) · PMC2775262 (PubMed Central)
42. The C242T CYBA polymorphism as a major determinant of NADPH oxidase activity in patients with cardiovascular disease. Mehranpour P, Wang SS, Blanco RR, Li W, Song Q, Lassègue B, Dikalov SI, Austin H, Zafari AM (2009) Cardiovasc Hematol Agents Med Chem 7(3): 251-9
    › Primary publication · 19689263 (PubMed)
43. The neuromediator glutamate, through specific substrate interactions, enhances mitochondrial ATP production and reactive oxygen species generation in nonsynaptic brain mitochondria. Panov A, Schonfeld P, Dikalov S, Hemendinger R, Bonkovsky HL, Brooks BR (2009) J Biol Chem 284(21): 14448-56
    › Primary publication · 19304986 (PubMed) · PMC2682893 (PubMed Central)
44. Long-term exposure to AZT, but not d4T, increases endothelial cell oxidative stress and mitochondrial dysfunction. Kline ER, Bassit L, Hernandez-Santiago BI, Detorio MA, Liang B, Kleinhenz DJ, Walp ER, Dikalov S, Jones DP, Schinazi RF, Sutliff RL (2009) Cardiovasc Toxicol 9(1): 1-12
    › Primary publication · 19067249 (PubMed) · PMC2714048 (PubMed Central)
45. Calcium-dependent NOX5 nicotinamide adenine dinucleotide phosphate oxidase contributes to vascular oxidative stress in human coronary artery disease. Guzik TJ, Chen W, Gongora MC, Guzik B, Lob HE, Mangalat D, Hoch N, Dikalov S, Rudzinski P, Kapelak B, Sadowski J, Harrison DG (2008) J Am Coll Cardiol 52(22): 1803-9
    › Primary publication · 19022160 (PubMed) · PMC2593790 (PubMed Central)
46. Sustained release of a p38 inhibitor from non-inflammatory microspheres inhibits cardiac dysfunction. Sy JC, Seshadri G, Yang SC, Brown M, Oh T, Dikalov S, Murthy N, Davis ME (2008) Nat Mater 7(11): 863-8
    › Primary publication · 18931671 (PubMed) · PMC2705946 (PubMed Central)
47. Distinct roles of Nox1 and Nox4 in basal and angiotensin II-stimulated superoxide and hydrogen peroxide production. Dikalov SI, Dikalova AE, Bikineyeva AT, Schmidt HH, Harrison DG, Griendling KK (2008) Free Radic Biol Med 45(9): 1340-51
    › Primary publication · 18760347 (PubMed) · PMC2630771 (PubMed Central)
48. Honokiol is a potent scavenger of superoxide and peroxyl radicals. Dikalov S, Losik T, Arbiser JL (2008) Biochem Pharmacol 76(5): 589-96
    › Primary publication · 18640101 (PubMed) · PMC2575413 (PubMed Central)
49. Vascular oxidative stress and nitric oxide depletion in HIV-1 transgenic rats are reversed by glutathione restoration. Kline ER, Kleinhenz DJ, Liang B, Dikalov S, Guidot DM, Hart CM, Jones DP, Sutliff RL (2008) Am J Physiol Heart Circ Physiol 294(6): H2792-804
    › Primary publication · 18456725 (PubMed) · PMC2586125 (PubMed Central)
50. Detection of reactive oxygen species and nitric oxide in vascular cells and tissues: comparison of sensitivity and specificity. Cai H, Dikalov S, Griendling KK, Harrison DG (2007) Methods Mol Med : 293-311
    › Primary publication · 18287681 (PubMed)
51. Molecular mechanisms of angiotensin II-mediated mitochondrial dysfunction: linking mitochondrial oxidative damage and vascular endothelial dysfunction. Doughan AK, Harrison DG, Dikalov SI (2008) Circ Res 102(4): 488-96
    › Primary publication · 18096818 (PubMed)
52. Role of the T cell in the genesis of angiotensin II induced hypertension and vascular dysfunction. Guzik TJ, Hoch NE, Brown KA, McCann LA, Rahman A, Dikalov S, Goronzy J, Weyand C, Harrison DG (2007) J Exp Med 204(10): 2449-60
    › Primary publication · 17875676 (PubMed) · PMC2118469 (PubMed Central)
53. Mitochondrial redox cycling of mitoquinone leads to superoxide production and cellular apoptosis. Doughan AK, Dikalov SI (2007) Antioxid Redox Signal 9(11): 1825-36
    › Primary publication · 17854275 (PubMed)
54. Regulation of tetrahydrobiopterin biosynthesis by shear stress. Widder JD, Chen W, Li L, Dikalov S, Thöny B, Hatakeyama K, Harrison DG (2007) Circ Res 101(8): 830-8
    › Primary publication · 17704208 (PubMed)
55. ESR techniques for the detection of nitric oxide in vivo as an index of endothelial function. Fink B, Dikalov S, Fink N (2006) Pharmacol Rep : 8-15
    › Primary publication · 17332666 (PubMed)
56. Measurement of reactive oxygen species in cardiovascular studies. Dikalov S, Griendling KK, Harrison DG (2007) Hypertension 49(4): 717-27
    › Primary publication · 17296874 (PubMed) · PMC1993891 (PubMed Central)
57. Production of extracellular superoxide by human lymphoblast cell lines: comparison of electron spin resonance techniques and cytochrome C reduction assay. Dikalov SI, Li W, Mehranpour P, Wang SS, Zafari AM (2007) Biochem Pharmacol 73(7): 972-80
    › Primary publication · 17222393 (PubMed) · PMC1868485 (PubMed Central)
58. Species- and tissue-specific relationships between mitochondrial permeability transition and generation of ROS in brain and liver mitochondria of rats and mice. Panov A, Dikalov S, Shalbuyeva N, Hemendinger R, Greenamyre JT, Rosenfeld J (2007) Am J Physiol Cell Physiol 292(2): C708-18
    › Primary publication · 17050617 (PubMed)
59. Early determinants of H2O2-induced endothelial dysfunction. Boulden BM, Widder JD, Allen JC, Smith DA, Al-Baldawi RN, Harrison DG, Dikalov SI, Jo H, Dudley SC (2006) Free Radic Biol Med 41(5): 810-7
    › Primary publication · 16895801 (PubMed) · PMC1592456 (PubMed Central)
60. ESR techniques for the detection of nitric oxide in vivo and in tissues. Dikalov S, Fink B (2005) Methods Enzymol : 597-610
    › Primary publication · 16291267 (PubMed)
61. The measurement of nitric oxide production by cultured endothelial cells. Hart CM, Kleinhenz DJ, Dikalov SI, Boulden BM, Dudley SC (2005) Methods Enzymol : 502-14
    › Primary publication · 16291257 (PubMed)
62. Rotenone model of Parkinson disease: multiple brain mitochondria dysfunctions after short term systemic rotenone intoxication. Panov A, Dikalov S, Shalbuyeva N, Taylor G, Sherer T, Greenamyre JT (2005) J Biol Chem 280(51): 42026-35
    › Primary publication · 16243845 (PubMed)
63. Nox1 overexpression potentiates angiotensin II-induced hypertension and vascular smooth muscle hypertrophy in transgenic mice. Dikalova A, Clempus R, Lassègue B, Cheng G, McCoy J, Dikalov S, San Martin A, Lyle A, Weber DS, Weiss D, Taylor WR, Schmidt HH, Owens GK, Lambeth JD, Griendling KK (2005) Circulation 112(17): 2668-76
    › Primary publication · 16230485 (PubMed)
64. Atrial fibrillation increases production of superoxide by the left atrium and left atrial appendage: role of the NADPH and xanthine oxidases. Dudley SC, Hoch NE, McCann LA, Honeycutt C, Diamandopoulos L, Fukai T, Harrison DG, Dikalov SI, Langberg J (2005) Circulation 112(9): 1266-73
    › Primary publication · 16129811 (PubMed)
65. Characterization of the high-resolution ESR spectra of superoxide radical adducts of 5-(diethoxyphosphoryl)-5-methyl-1-pyrroline N-oxide (DEPMPO) and 5,5-dimethyl-1-pyrroline N-oxide (DMPO). Analysis of conformational exchange. Dikalov S, Jiang J, Mason RP (2005) Free Radic Res 39(8): 825-36
    › Primary publication · 16036362 (PubMed)
66. Interactions of peroxynitrite with uric acid in the presence of ascorbate and thiols: implications for uncoupling endothelial nitric oxide synthase. Kuzkaya N, Weissmann N, Harrison DG, Dikalov S (2005) Biochem Pharmacol 70(3): 343-54
    › Primary publication · 15963955 (PubMed)
67. Regulation of xanthine oxidoreductase protein expression by hydrogen peroxide and calcium. McNally JS, Saxena A, Cai H, Dikalov S, Harrison DG (2005) Arterioscler Thromb Vasc Biol 25(8): 1623-8
    › Primary publication · 15905466 (PubMed)
68. Functional association of nox1 with p22phox in vascular smooth muscle cells. Hanna IR, Hilenski LL, Dikalova A, Taniyama Y, Dikalov S, Lyle A, Quinn MT, Lassègue B, Griendling KK (2004) Free Radic Biol Med 37(10): 1542-9
    › Primary publication · 15477006 (PubMed)
69. Bone morphogenic protein 4 produced in endothelial cells by oscillatory shear stress induces monocyte adhesion by stimulating reactive oxygen species production from a nox1-based NADPH oxidase. Sorescu GP, Song H, Tressel SL, Hwang J, Dikalov S, Smith DA, Boyd NL, Platt MO, Lassègue B, Griendling KK, Jo H (2004) Circ Res 95(8): 773-9
    › Primary publication · 15388638 (PubMed)
70. Interference of 7,8-dihydroneopterin with peroxynitrite-mediated reactions. Oettl K, Greilberger J, Dikalov S, Reibnegger G (2004) Biochem Biophys Res Commun 321(2): 379-85
    › Primary publication · 15358187 (PubMed)
71. Detection of intracellular superoxide formation in endothelial cells and intact tissues using dihydroethidium and an HPLC-based assay. Fink B, Laude K, McCann L, Doughan A, Harrison DG, Dikalov S (2004) Am J Physiol Cell Physiol 287(4): C895-902
    › Primary publication · 15306539 (PubMed)
72. IQGAP1, a novel vascular endothelial growth factor receptor binding protein, is involved in reactive oxygen species--dependent endothelial migration and proliferation. Yamaoka-Tojo M, Ushio-Fukai M, Hilenski L, Dikalov SI, Chen YE, Tojo T, Fukai T, Fujimoto M, Patrushev NA, Wang N, Kontos CD, Bloom GS, Alexander RW (2004) Circ Res 95(3): 276-83
    › Primary publication · 15217908 (PubMed)
73. C242T CYBA polymorphism of the NADPH oxidase is associated with reduced respiratory burst in human neutrophils. Wyche KE, Wang SS, Griendling KK, Dikalov SI, Austin H, Rao S, Fink B, Harrison DG, Zafari AM (2004) Hypertension 43(6): 1246-51
    › Primary publication · 15078863 (PubMed)
74. Cupric-amyloid beta peptide complex stimulates oxidation of ascorbate and generation of hydroxyl radical. Dikalov SI, Vitek MP, Mason RP (2004) Free Radic Biol Med 36(3): 340-7
    › Primary publication · 15036353 (PubMed)
75. Vascular oxidant stress enhances progression and angiogenesis of experimental atheroma. Khatri JJ, Johnson C, Magid R, Lessner SM, Laude KM, Dikalov SI, Harrison DG, Sung HJ, Rong Y, Galis ZS (2004) Circulation 109(4): 520-5
    › Primary publication · 14744973 (PubMed)
76. Oscillatory shear stress stimulates endothelial production of O2- from p47phox-dependent NAD(P)H oxidases, leading to monocyte adhesion. Hwang J, Saha A, Boo YC, Sorescu GP, McNally JS, Holland SM, Dikalov S, Giddens DP, Griendling KK, Harrison DG, Jo H (2003) J Biol Chem 278(47): 47291-8
    › Primary publication · 12958309 (PubMed)
77. Role of xanthine oxidoreductase and NAD(P)H oxidase in endothelial superoxide production in response to oscillatory shear stress. McNally JS, Davis ME, Giddens DP, Saha A, Hwang J, Dikalov S, Jo H, Harrison DG (2003) Am J Physiol Heart Circ Physiol 285(6): H2290-7
    › Primary publication · 12958034 (PubMed)
78. Characterization of the high resolution ESR spectra of the methoxyl radical adducts of 5-(diethoxyphosphoryl)-5-methyl-1-pyrroline N-oxide (DEPMPO). Dikalov S, Tordo P, Motten A, Mason RP (2003) Free Radic Res 37(7): 705-12
    › Primary publication · 12911266 (PubMed)
79. Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension. Landmesser U, Dikalov S, Price SR, McCann L, Fukai T, Holland SM, Mitch WE, Harrison DG (2003) J Clin Invest 111(8): 1201-9
    › Primary publication · 12697739 (PubMed) · PMC152929 (PubMed Central)
80. Interactions of peroxynitrite, tetrahydrobiopterin, ascorbic acid, and thiols: implications for uncoupling endothelial nitric-oxide synthase. Kuzkaya N, Weissmann N, Harrison DG, Dikalov S (2003) J Biol Chem 278(25): 22546-54
    › Primary publication · 12692136 (PubMed)
81. Electron spin resonance characterization of vascular xanthine and NAD(P)H oxidase activity in patients with coronary artery disease: relation to endothelium-dependent vasodilation. Spiekermann S, Landmesser U, Dikalov S, Bredt M, Gamez G, Tatge H, Reepschläger N, Hornig B, Drexler H, Harrison DG (2003) Circulation 107(10): 1383-9
    › Primary publication · 12642358 (PubMed)
82. Novel role of gp91(phox)-containing NAD(P)H oxidase in vascular endothelial growth factor-induced signaling and angiogenesis. Ushio-Fukai M, Tang Y, Fukai T, Dikalov SI, Ma Y, Fujimoto M, Quinn MT, Pagano PJ, Johnson C, Alexander RW (2002) Circ Res 91(12): 1160-7
    › Primary publication · 12480817 (PubMed)
83. Vascular oxidative stress and endothelial dysfunction in patients with chronic heart failure: role of xanthine-oxidase and extracellular superoxide dismutase. Landmesser U, Spiekermann S, Dikalov S, Tatge H, Wilke R, Kohler C, Harrison DG, Hornig B, Drexler H (2002) Circulation 106(24): 3073-8
    › Primary publication · 12473554 (PubMed)
84. Nucleoside reverse transcriptase inhibitors impair endothelium-dependent relaxation by increasing superoxide. Sutliff RL, Dikalov S, Weiss D, Parker J, Raidel S, Racine AK, Russ R, Haase CP, Taylor WR, Lewis W (2002) Am J Physiol Heart Circ Physiol 283(6): H2363-70
    › Primary publication · 12388299 (PubMed)
85. NAD(P)H oxidase-derived hydrogen peroxide mediates endothelial nitric oxide production in response to angiotensin II. Cai H, Li Z, Dikalov S, Holland SM, Hwang J, Jo H, Dudley SC, Harrison DG (2002) J Biol Chem 277(50): 48311-7
    › Primary publication · 12377764 (PubMed)
86. Role of p47(phox) in vascular oxidative stress and hypertension caused by angiotensin II. Landmesser U, Cai H, Dikalov S, McCann L, Hwang J, Jo H, Holland SM, Harrison DG (2002) Hypertension 40(4): 511-5
    › Primary publication · 12364355 (PubMed) · PMC4734745 (PubMed Central)
87. Peroxidase properties of extracellular superoxide dismutase: role of uric acid in modulating in vivo activity. Hink HU, Santanam N, Dikalov S, McCann L, Nguyen AD, Parthasarathy S, Harrison DG, Fukai T (2002) Arterioscler Thromb Vasc Biol 22(9): 1402-8
    › Primary publication · 12231557 (PubMed)
88. Noninvasive diagnostic tool for inflammation-induced oxidative stress using electron spin resonance spectroscopy and an extracellular cyclic hydroxylamine. Dikalov SI, Dikalova AE, Mason RP (2002) Arch Biochem Biophys 402(2): 218-26
    › Primary publication · 12051666 (PubMed)
89. Geldanamycin leads to superoxide formation by enzymatic and non-enzymatic redox cycling. Implications for studies of Hsp90 and endothelial cell nitric-oxide synthase. Dikalov S, Landmesser U, Harrison DG (2002) J Biol Chem 277(28): 25480-5
    › Primary publication · 11983711 (PubMed)
90. Overexpression of cytochrome P450 CYP2J2 protects against hypoxia-reoxygenation injury in cultured bovine aortic endothelial cells. Yang B, Graham L, Dikalov S, Mason RP, Falck JR, Liao JK, Zeldin DC (2001) Mol Pharmacol 60(2): 310-20
    › Primary publication · 11455018 (PubMed)
91. Spin trapping of polyunsaturated fatty acid-derived peroxyl radicals: reassignment to alkoxyl radical adducts. Dikalov SI, Mason RP (2001) Free Radic Biol Med 30(2): 187-97
    › Primary publication · 11163536 (PubMed)
92. Formation of Reactive Oxygen Species in Various Vascular Cells During Glyceryltrinitrate Metabolism. Dikalov S, Fink B, Skatchkov M, Sommer O, Bassenge E (1998) J Cardiovasc Pharmacol Ther 3(1): 51-62
    › Primary publication · 10684481 (PubMed)
93. A new approach for extracellular spin trapping of nitroglycerin-induced superoxide radicals both in vitro and in vivo. Fink B, Dikalov S, Bassenge E (2000) Free Radic Biol Med 28(1): 121-8
    › Primary publication · 10656298 (PubMed)
94. Reassignment of organic peroxyl radical adducts. Dikalov SI, Mason RP (1999) Free Radic Biol Med 27(7-8): 864-72
    › Primary publication · 10515591 (PubMed)
95. Comparison of glyceryl trinitrate-induced with pentaerythrityl tetranitrate-induced in vivo formation of superoxide radicals: effect of vitamin C. Dikalov S, Fink B, Skatchkov M, Bassenge E (1999) Free Radic Biol Med 27(1-2): 170-6
    › Primary publication · 10443933 (PubMed)
96. Amyloid beta peptides do not form peptide-derived free radicals spontaneously, but can enhance metal-catalyzed oxidation of hydroxylamines to nitroxides. Dikalov SI, Vitek MP, Maples KR, Mason RP (1999) J Biol Chem 274(14): 9392-9
    › Primary publication · 10092619 (PubMed)
97. Superoxide radical scavenging by phenolic bronchodilators under aprotic and aqueous conditions. Zwicker K, Damerau W, Dikalov S, Scholtyssek H, Schimke I, Zimmer G (1998) Biochem Pharmacol 56(3): 301-5
    › Primary publication · 9744566 (PubMed)
98. Formation of reactive oxygen species by pentaerithrityltetranitrate and glyceryl trinitrate in vitro and development of nitrate tolerance. Dikalov S, Fink B, Skatchkov M, Stalleicken D, Bassenge E (1998) J Pharmacol Exp Ther 286(2): 938-44
    › Primary publication · 9694953 (PubMed)
99. Oxygen radical generation and enzymatic properties of mitochondria in hypoxia/reoxygenation. Zwicker K, Dikalov S, Matuschka S, Mainka L, Hofmann M, Khramtsov V, Zimmer G (1998) Arzneimittelforschung 48(6): 629-36
    › Primary publication · 9689418 (PubMed)
100. Detection of superoxide radicals and peroxynitrite by 1-hydroxy-4-phosphonooxy-2,2,6,6-tetramethylpiperidine: quantification of extracellular superoxide radicals formation. Dikalov S, Grigor'ev IA, Voinov M, Bassenge E (1998) Biochem Biophys Res Commun 248(2): 211-5
     › Primary publication · 9675114 (PubMed)
101. Quantification of superoxide radicals and peroxynitrite in vascular cells using oxidation of sterically hindered hydroxylamines and electron spin resonance. Dikalov S, Skatchkov M, Fink B, Bassenge E (1997) Nitric Oxide 1(5): 423-31
     › Primary publication · 9441913 (PubMed)
102. Synthesis and spin trapping applications of 2,2-dimethyl-d6-4-methyl-2H-imidazole-1-oxide-1-15N. Haseloff RF, Kirilyuk IA, Dikalov SI, Khramtsov VV, Utepbergenov DI, Blasig IE, Grigor'ev IA (1997) Free Radic Res 26(2): 159-68
     › Primary publication · 9257127 (PubMed)
103. Spin trapping of superoxide radicals and peroxynitrite by 1-hydroxy-3-carboxy-pyrrolidine and 1-hydroxy-2,2,6, 6-tetramethyl-4-oxo-piperidine and the stability of corresponding nitroxyl radicals towards biological reductants. Dikalov S, Skatchkov M, Bassenge E (1997) Biochem Biophys Res Commun 231(3): 701-4
     › Primary publication · 9070876 (PubMed)
104. Quantification of peroxynitrite, superoxide, and peroxyl radicals by a new spin trap hydroxylamine 1-hydroxy-2,2,6,6-tetramethyl-4-oxo-piperidine. Dikalov S, Skatchkov M, Bassenge E (1997) Biochem Biophys Res Commun 230(1): 54-7
     › Primary publication · 9020059 (PubMed)
105. Endothelium and platelet activity in heart failure. Bassenge E, Fink B, Skatchkov M, Dikalov S (1996) J Card Fail 2(4 Suppl): S203-8
     › Primary publication · 8951580 (PubMed)
106. Determination of rate constants of the reactions of thiols with superoxide radical by electron paramagnetic resonance: critical remarks on spectrophotometric approaches. Dikalov S, Khramtsov V, Zimmer G (1996) Arch Biochem Biophys 326(2): 207-18
     › Primary publication · 8611025 (PubMed)
107. Spin trapping of O-, C-, and S-centered radicals and peroxynitrite by 2H-imidazole-1-oxides. Dikalov S, Kirilyuk I, Grigor'ev I (1996) Biochem Biophys Res Commun 218(2): 616-22
     › Primary publication · 8561805 (PubMed)
108. Role of iron ion chelation by quinones in their reduction, OH-radical generation and lipid peroxidation. Dikalov S, Alov P, Rangelova D (1993) Biochem Biophys Res Commun 195(1): 113-9
     › Primary publication · 8395821 (PubMed)
109. Inherited enhancement of hydroxyl radical generation and lipid peroxidation in the S strain rats results in DNA rearrangements, degenerative diseases, and premature aging. Salganik RI, Solovyova NA, Dikalov SI, Grishaeva ON, Semenova LA, Popovsky AV (1994) Biochem Biophys Res Commun 199(2): 726-33
     › Primary publication · 8135816 (PubMed)
110. [Inherited hyperproduction of free radicals. The pathology of aging]. Salganik RI, Solov'eva NA, Grishaeva ON, Dikalov SI, Semenova LA, Popovskiĭ AV (1994) Dokl Akad Nauk 336(2): 257-60
     › Primary publication · 7951010 (PubMed)
111. [Increase in sensitivity of tumor cells to cyclophosphamide as a result of exposure to shock waves]. Mastikhin IV, Nikolin VP, Teslenko BS, Zelentsov EL, Maĭer VA, Salganik RI, Dikalov SI (1995) Dokl Akad Nauk 342(2): 262-4
     › Primary publication · 7633353 (PubMed)
112. [Biochemical mechanisms of hereditary cardiomyopathy development in W/SSM rats]. Solov'eva NA, Salganik RI, Grishaeva ON, Dikalov SI, Semenov DE (1995) Biull Eksp Biol Med 120(8): 151-4
     › Primary publication · 7579271 (PubMed)
113. Hydroxyl radical generation by oligonucleotide derivatives of anthracycline antibiotic and synthetic quinone. Dikalov SI, Rumyantseva GV, Weiner LM, Sergejev DS, Frolova EI, Godovikova TS, Zarytova VF (1991) Chem Biol Interact 77(3): 325-39
     › Primary publication · 1849049 (PubMed)
114. Role of quinone-iron(III) interaction in NADPH-dependent enzymatic generation of hydroxyl radicals. Dikalov SI, Rumyantseva GV, Piskunov AV, Weiner LM (1992) Biochemistry 31(37): 8947-53
     › Primary publication · 1390681 (PubMed)

Keywords & MeSH Terms

MeSH terms are retrieved from PubMed records. Learn more.

Key: MeSH Term Keyword