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Our lab uses neuroimaging and complementary methods to explore the neurobiology of addiction and its consequences in humans. Studies include those of drug use and reward function, the role of mood and monoamines in drug use and reward dysfunction, drug-induced toxicity, and neural mechanisms of overeating and obesity.Specific research topics include: 1. MDMA (Ecstasy) Toxicity These projects attempt to characterize the long-term consequences of recreational MDMA use in humans. We used multimodal MRI and MRS approaches to examine MDMA effects on brain structure, function, and chemical composition. We use PET to characterize persistent MDMA effects on brain serotonergic receptors. We also examine the relationship between brain activation and behavioral performance, personality, psychiatric symptoms, and genetic effects. 2. Neurobiology of Obesity These projects explore the neurobiology of obesity from an addiction perspective examining food salience in obesity. fMRI studies examine the neural bases of brain responding to food cues of varying palatability and caloric density. Effects of satiety and hunger are assayed. Eye-tracking studies examine for altered attentional or incentive salience for food cues in obesity. Because altered food salience may be a major mechanism for relapse in obesity when attempting to regulate food intake, exploring the effects of caloric content, palatability, hunger and satiety on attentional salience is an essential step toward documenting the role of these mechanisms in obesity. 3. Serotonin genetics Our studies of serotonin genetics and brain function examine the relationship between common functional allelic variations in genes encoding serotonin receptors and the serotonin reuptake transporter and brain structure, function, receptor expression, and personality. 4. Neurobiology of Euphoria Our studies of the neurobiology of euphoria employ functional MRI during drug administration with continous mood assessment to probe the neural correlates of drug effects and to identify neural substrates mediating self-report of the euphoric mood change.

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    (615) 322-2303 (p)
    615-322-3764 (f)
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    Keywords

    Depression Drug Abuse Neuroimaging Obesity Serotonin