Profile

The overarching goal of the Aronoff lab is to improve human health through discovery, with a primary interest on maternal-child wellness. The Aronoff lab primarily studies bacterial infections that complicate pregnancy. These infections include perinatal streptococcal infections and postpartum clostridial infections. Our major interest is revealing root molecular mechanisms whereby bacterial pathogens evade innate immunity within the female reproductive tract. In this context we have a special interest in the role that host-derived lipid mediators (eicosanoids) play in modulating immune responses to microbial invaders. Our work with toxigenic clostridia has extended to non-reproductive tract infections, such as colitis caused by Clostridium diffficile. Members of our lab engage in a range of research approaches, from purely bench science to translational science to purely clinical research. We value interdisciplinary team science.

Publications

The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. Accelerating Precision Drug Development and Drug Repurposing by Leveraging Human Genetics. Pulley JM, Shirey-Rice JK, Lavieri RR, Jerome RN, Zaleski NM, Aronoff DM, Bastarache L, Niu X, Holroyd KJ, Roden DM, Skaar EP, Niswender CM, Marnett LJ, Lindsley CW, Ekstrom LB, Bentley AR, Bernard GR, Hong CC, Denny JC (2017) Assay Drug Dev Technol
    › Primary publication · 28379727 (PubMed)
  2. Incidence and prevalence of type 2 diabetes mellitus with HIV infection in Africa: a systematic review and meta-analysis. Prioreschi A, Munthali RJ, Soepnel L, Goldstein JA, Micklesfield LK, Aronoff DM, Norris SA (2017) BMJ Open 7(3): e013953
    › Primary publication · 28360243 (PubMed) · PMC5372101 (PubMed Central)
  3. Group B Streptococcus Induces Neutrophil Recruitment to Gestational Tissues and Elaboration of Extracellular Traps and Nutritional Immunity. Kothary V, Doster RS, Rogers LM, Kirk LA, Boyd KL, Romano-Keeler J, Haley KP, Manning SD, Aronoff DM, Gaddy JA (2017) Front Cell Infect Microbiol : 19
    › Primary publication · 28217556 (PubMed) · PMC5289994 (PubMed Central)
  4. DOHaD at the intersection of maternal immune activation and maternal metabolic stress: a scoping review. Goldstein JA, Norris SA, Aronoff DM (2017) J Dev Orig Health Dis 8(3): 273-283
    › Primary publication · 28196555 (PubMed)
  5. Current concepts in maternal-fetal immunology: Recognition and response to microbial pathogens by decidual stromal cells. Anders AP, Gaddy JA, Doster RS, Aronoff DM (2017) Am J Reprod Immunol 77(3)
    › Primary publication · 28044385 (PubMed) · PMC5321847 (PubMed Central)
  6. Lipid profiling of polarized human monocyte-derived macrophages. Montenegro-Burke JR, Sutton JA, Rogers LM, Milne GL, McLean JA, Aronoff DM (2016) Prostaglandins Other Lipid Mediat : 1-8
    › Primary publication · 27871801 (PubMed)
  7. Differing mechanisms of surviving phagosomal stress among group B Streptococcus strains of varying genotypes. Korir ML, Laut C, Rogers LM, Plemmons JA, Aronoff DM, Manning SD (2016) Virulence : 1-14
    › Primary publication · 27791478 (PubMed)
  8. Neither vaginal nor buccal administration of 800 μg misoprostol alters mucosal and systemic immune activation or the cervicovaginal microbiome: a pilot study. Kalams SA, Rogers LM, Smith RM, Barnett L, Crumbo K, Sumner S, Prashad N, Rybczyk K, Milne G, Dowd SE, Chong E, Winikoff B, Aronoff DM (2016) Eur J Contracept Reprod Health Care 21(6): 436-442
    › Primary publication · 27636701 (PubMed)
  9. Staphylococcus aureus Infection of Human Gestational Membranes Induces Bacterial Biofilm Formation and Host Production of Cytokines. Doster RS, Kirk LA, Tetz LM, Rogers LM, Aronoff DM, Gaddy JA (2017) J Infect Dis 215(4): 653-657
    › Primary publication · 27436434 (PubMed)
  10. Increased lethality and defective pulmonary clearance of Streptococcus pneumoniae in microsomal prostaglandin E synthase-1-knockout mice. Dolan JM, Weinberg JB, O'Brien E, Abashian A, Procario MC, Aronoff DM, Crofford LJ, Peters-Golden M, Ward L, Mancuso P (2016) Am J Physiol Lung Cell Mol Physiol 310(11): L1111-20
    › Primary publication · 27059285 (PubMed) · PMC4935474 (PubMed Central)
  11. Draft Genome Sequence of an Invasive Streptococcus agalactiae Isolate Lacking Pigmentation. Singh P, Aronoff DM, Davies HD, Manning SD (2016) Genome Announc 4(1)
    › Primary publication · 26950320 (PubMed) · PMC4767910 (PubMed Central)
  12. Prostaglandin E2 Regulation of Macrophage Innate Immunity. Kimmel DW, Rogers LM, Aronoff DM, Cliffel DE (2016) Chem Res Toxicol 29(1): 19-25
    › Primary publication · 26656203 (PubMed)
  13. The influence of non-steroidal anti-inflammatory drugs on the gut microbiome. Rogers MA, Aronoff DM (2016) Clin Microbiol Infect 22(2): 178.e1-9
    › Primary publication · 26482265 (PubMed) · PMC4754147 (PubMed Central)
  14. Reply to Planche et al. Rao K, Young VB, Aronoff DM (2015) Clin Infect Dis 61(7): 1211-2
    › Primary publication · 26092487 (PubMed) · PMC4560910 (PubMed Central)
  15. Mono-ethylhexyl phthalate stimulates prostaglandin secretion in human placental macrophages and THP-1 cells. Tetz LM, Aronoff DM, Loch-Caruso R (2015) Reprod Biol Endocrinol : 56
    › Primary publication · 26036283 (PubMed) · PMC4462084 (PubMed Central)
  16. Identification of toxemia in patients with Clostridium difficile infection. Yu H, Chen K, Wu J, Yang Z, Shi L, Barlow LL, Aronoff DM, Garey KW, Savidge TC, von Rosenvinge EC, Kelly CP, Feng H (2015) PLoS One 10(4): e0124235
    › Primary publication · 25885671 (PubMed) · PMC4401762 (PubMed Central)
  17. Clostridium difficile ribotype 027: relationship to age, detectability of toxins A or B in stool with rapid testing, severe infection, and mortality. Rao K, Micic D, Natarajan M, Winters S, Kiel MJ, Walk ST, Santhosh K, Mogle JA, Galecki AT, LeBar W, Higgins PD, Young VB, Aronoff DM (2015) Clin Infect Dis 61(2): 233-41
    › Primary publication · 25828993 (PubMed) · PMC4565993 (PubMed Central)
  18. Variation in germination of Clostridium difficile clinical isolates correlates to disease severity. Carlson PE, Kaiser AM, McColm SA, Bauer JM, Young VB, Aronoff DM, Hanna PC (2015) Anaerobe : 64-70
    › Primary publication · 25681667 (PubMed) · PMC4467518 (PubMed Central)
  19. Postoperative burden of hospital-acquired Clostridium difficile infection. Abdelsattar ZM, Krapohl G, Alrahmani L, Banerjee M, Krell RW, Wong SL, Campbell DA, Aronoff DM, Hendren S (2015) Infect Control Hosp Epidemiol 36(1): 40-6
    › Primary publication · 25627760 (PubMed) · PMC4597881 (PubMed Central)
  20. Low prevalence of Clostridium septicum fecal carriage in an adult population. Kopliku FA, Schubert AM, Mogle J, Schloss PD, Young VB, Aronoff DM (2015) Anaerobe : 34-6
    › Primary publication · 25481351 (PubMed) · PMC4385462 (PubMed Central)