Swati Rane, Ph.D.

Profile

I am currently a post-doctoral research fellow at Vanderbilt University Institute of Imaging Science (VUIIS). The primary focus of my research is the technical development of functional magnetic resonance imaging (fMRI) approaches to understand mechanisms of neurological disorders. Specifically, I am interested in investigating the relation of hemodynamic factors such as cerebral blood flow (CBF) and  cerebral blood volume (CBV) as well as metabolic demands or oxygen metabolism (CMRO₂) to neural activity. To this effect, my postdoctoral work broadly covers three directions as follows:
 
Technical development:  I program, develop, validate and improve MR sequences for CBV quantification with and without contrast. I have also developed protocols for multi-echo fMRI for R2* measurement for better microvascular sensitivity. Currently I work on a novel fMRI contrast mechanism using spin locking at very low B1 fields to improve sensitivity to microvasculature.

Neuroenergetic mechanisms: I perform single voxel spectroscopy measurement of γ aminobutyric acid (GABA) and glutamate (Glu) and investigate its relation to CBF, CBV, CMRO₂, and blood oxygen level-dependent (BOLD) signals. Recent work has focused on investigating the effect of GABA and Glu concentrations on CBF and resting state BOLD synchrony and BOLD amplitude.

Application to neurological disorders: I apply fMRI methods to Alzheimer's disease and aging related alterations in cognition. I study functional (CBF, CBV, and BOLD) changes and tissue atrophy in context of memory and cognitive performance in older adults, and adults at risk of Alzheimer's disease.

Other avenues: My work on contrast enhanced CBV mapping is used for measuring hippocampal dysfunction in first episode and chronic patients of Schizophrenia. Here at VUIIS, we have extended the arterial spin labeling approach to measure lymphatic flow in the axillary nodes. We are in the process of applying this methodology to determine risk of lymphedema in breast cancer surgery patients. New initiatives include cortical and sub-cortical atrophy assessment in motor sub-types of Parkinson's disease and differentiation of dementia in Parkinson's and Alzheimer's disease.

Publications

The following timeline graph is generated from all co-authored publications.

1. Functional MRI using spin lock editing preparation pulses. Rane S, Spear JT, Zu Z, Donahue MJ, Gore JC (2014) Magn Reson Imaging 32(7): 813-8
   › Primary publication · 24848291 (PubMed) · PMC4520216 (PubMed Central)
2. Bolus arrival time and cerebral blood flow responses to hypercarbia. Donahue MJ, Faraco CC, Strother MK, Chappell MA, Rane S, Dethrage LM, Hendrikse J, Siero JC (2014) J Cereb Blood Flow Metab 34(7): 1243-52
   › Primary publication · 24780904 (PubMed) · PMC4083394 (PubMed Central)
3. Anterior-posterior cerebral blood volume gradient in human subiculum. Talati P, Rane S, Kose S, Gore J, Heckers S (2014) Hippocampus 24(5): 503-9
   › Primary publication · 24677295 (PubMed) · PMC4039089 (PubMed Central)
4. The effect of echo time and post-processing procedure on blood oxygenation level-dependent (BOLD) functional connectivity analysis. Rane S, Mason E, Hussey E, Gore J, Ally BA, Donahue MJ (2014) Neuroimage : 39-47
   › Primary publication · 24675648 (PubMed) · PMC4066393 (PubMed Central)
5. γ-Aminobutyric acid (GABA) concentration inversely correlates with basal perfusion in human occipital lobe. Donahue MJ, Rane S, Hussey E, Mason E, Pradhan S, Waddell KW, Ally BA (2014) J Cereb Blood Flow Metab 34(3): 532-41
   › Primary publication · 24398941 (PubMed) · PMC3948135 (PubMed Central)
6. Clinical feasibility of noninvasive visualization of lymphatic flow with principles of spin labeling MR imaging: implications for lymphedema assessment. Rane S, Donahue PM, Towse T, Ridner S, Chappell M, Jordi J, Gore J, Donahue MJ (2013) Radiology 269(3): 893-902
   › Primary publication · 23864103 (PubMed) · PMC4485559 (PubMed Central)
7. Vessel-encoded arterial spin labeling (VE-ASL) reveals elevated flow territory asymmetry in older adults with substandard verbal memory performance. Donahue MJ, Hussey E, Rane S, Wilson T, van Osch M, Hartkamp N, Hendrikse J, Ally BA (2014) J Magn Reson Imaging 39(2): 377-86
   › Primary publication · 23633160 (PubMed) · PMC3735670 (PubMed Central)
8. Altered functional and structural connectivity in a schizophrenia patient with complete agenesis of the corpus callosum. Rane S, Kose S, Gore JC, Heckers S (2013) Am J Psychiatry 170(1): 122-3
   › Primary publication · 23288389 (PubMed)
9. Inverse correspondence between hippocampal perfusion and verbal memory performance in older adults. Rane S, Ally BA, Hussey E, Wilson T, Thornton-Wells T, Gore JC, Donahue MJ (2013) Hippocampus 23(3): 213-20
   › Primary publication · 23109214 (PubMed) · PMC3878078 (PubMed Central)
10. Measurement of T1 of human arterial and venous blood at 7T. Rane SD, Gore JC (2013) Magn Reson Imaging 31(3): 477-9
    › Primary publication · 23102945 (PubMed) · PMC3561475 (PubMed Central)
11. Comparison of in vivo and ex vivo diffusion tensor imaging in rhesus macaques at short and long diffusion times. Rane S, Duong TQ (2011) Open Neuroimag J : 172-8
    › Primary publication · 22253659 (PubMed) · PMC3258009 (PubMed Central)
12. DTI at long diffusion time improves fiber tracking. Rane S, Nair G, Duong TQ (2010) NMR Biomed 23(5): 459-65
    › Primary publication · 20175137 (PubMed) · PMC2949954 (PubMed Central)

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