Amy Palubinsky
Last active: 8/18/2014

Profile

My work is concentrated on understanding mitochondrial dysfunction and altered mitochondrial dynamics as they have been demonstrated in an increasing number of neurodegenerative disorders including stroke. My project is primarily focused on identifying key molecules involved in stress-sensing at the level of the mitochondria. 

Publications

The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. Alteration of isocitrate dehydrogenase following acute ischemic injury as a means to improve cellular energetic status in neuroadaptation. Grelli KN, Palubinsky AM, Kale AC, Lizama-Manibusan BN, Stankowski JN, Milne GL, Singer R, McLaughlin B (2013) CNS Neurol Disord Drug Targets 12(6): 849-60
    › Primary publication · 23469839 (PubMed) · PMC3770751 (PubMed Central)
  2. Metabolic multianalyte microphysiometry reveals extracellular acidosis is an essential mediator of neuronal preconditioning. McKenzie JR, Palubinsky AM, Brown JE, McLaughlin B, Cliffel DE (2012) ACS Chem Neurosci 3(7): 510-8
    › Primary publication · 22860220 (PubMed) · PMC3399578 (PubMed Central)
  3. Haploinsufficiency of the E3 ubiquitin ligase C-terminus of heat shock cognate 70 interacting protein (CHIP) produces specific behavioral impairments. McLaughlin B, Buendia MA, Saborido TP, Palubinsky AM, Stankowski JN, Stanwood GD (2012) PLoS One 7(5): e36340
    › Primary publication · 22606257 (PubMed) · PMC3350526 (PubMed Central)
  4. The role of central nervous system development in late-onset neurodegenerative disorders. Palubinsky AM, Martin JA, McLaughlin B (2012) Dev Neurosci 34(2-3): 129-39
    › Primary publication · 22572535 (PubMed) · PMC6065248 (PubMed Central)
  5. p66(shc)'s role as an essential mitophagic molecule in controlling neuronal redox and energetic tone. Kleman AM, Brown JE, Zeiger SL, Hettinger JC, Brooks JD, Holt B, Morrow JD, Musiek ES, Milne GL, McLaughlin B (2010) Autophagy 6(7): 948-9
    › Primary publication · 20724835 (PubMed) · PMC3679093 (PubMed Central)
  6. AMPK in the brain: its roles in energy balance and neuroprotection. Ronnett GV, Ramamurthy S, Kleman AM, Landree LE, Aja S (2009) J Neurochem : 17-23
    › Primary publication · 19393004 (PubMed) · PMC2925428 (PubMed Central)
  7. Pharmacological stimulation of brain carnitine palmitoyl-transferase-1 decreases food intake and body weight. Aja S, Landree LE, Kleman AM, Medghalchi SM, Vadlamudi A, McFadden JM, Aplasca A, Hyun J, Plummer E, Daniels K, Kemm M, Townsend CA, Thupari JN, Kuhajda FP, Moran TH, Ronnett GV (2008) Am J Physiol Regul Integr Comp Physiol 294(2): R352-61
    › Primary publication · 18056987 (PubMed)
  8. Physiological glucose is critical for optimized neuronal viability and AMPK responsiveness in vitro. Kleman AM, Yuan JY, Aja S, Ronnett GV, Landree LE (2008) J Neurosci Methods 167(2): 292-301
    › Primary publication · 17936912 (PubMed) · PMC2257477 (PubMed Central)
  9. Fatty acid synthase gene regulation in primary hypothalamic neurons. Kim EK, Kleman AM, Ronnett GV (2007) Neurosci Lett 423(3): 200-4
    › Primary publication · 17709201 (PubMed) · PMC4286184 (PubMed Central)
  10. Progressive and inhibitory cell cycle proteins act simultaneously to regulate neurotrophin-mediated proliferation and maturation of neuronal precursors. Simpson PJ, Moon C, Kleman AM, Connolly E, Ronnett GV (2007) Cell Cycle 6(9): 1077-89
    › Primary publication · 17404514 (PubMed)
  11. Fatty acid metabolism, the central nervous system, and feeding. Ronnett GV, Kleman AM, Kim EK, Landree LE, Tu Y (2006) Obesity (Silver Spring) : 201S-207S
    › Primary publication · 17021367 (PubMed)