Daniel Lark
Wasserman Lab
Last active: 9/26/2018


My research focuses on understanding the pathogenesis and progression of insulin resistance and diabetes in skeletal muscle.  More specifically, I have recently discovered a link between integrin signaling and fatty acid metabolism that appears to contribute to metabolic disease. To elucidate the mechanisms involved, I apply comprehensive in vivo metabolic phenotyping coupled with in situ mitochondrial bioenergetics approaches to understand gene interactions in novel mouse models.  I aspire to direct an academic research laboratory.


The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. Direct real-time quantification of mitochondrial oxidative phosphorylation efficiency in permeabilized skeletal muscle myofibers. Lark DS, Torres MJ, Lin CT, Ryan TE, Anderson EJ, Neufer PD (2016) Am J Physiol Cell Physiol 311(2): C239-45
    › Primary publication · 27335172 (PubMed) · PMC5129772 (PubMed Central)
  2. Targeted overexpression of mitochondrial catalase protects against cancer chemotherapy-induced skeletal muscle dysfunction. Gilliam LA, Lark DS, Reese LR, Torres MJ, Ryan TE, Lin CT, Cathey BL, Neufer PD (2016) Am J Physiol Endocrinol Metab 311(2): E293-301
    › Primary publication · 27329802 (PubMed) · PMC5005971 (PubMed Central)
  3. Integrin-Linked Kinase in Muscle Is Necessary for the Development of Insulin Resistance in Diet-Induced Obese Mice. Kang L, Mokshagundam S, Reuter B, Lark DS, Sneddon CC, Hennayake C, Williams AS, Bracy DP, James FD, Pozzi A, Zent R, Wasserman DH (2016) Diabetes 65(6): 1590-600
    › Primary publication · 27207548 (PubMed) · PMC4878430 (PubMed Central)
  4. Protein Kinase A Governs Oxidative Phosphorylation Kinetics and Oxidant Emitting Potential at Complex I. Lark DS, Reese LR, Ryan TE, Torres MJ, Smith CD, Lin CT, Neufer PD (2015) Front Physiol : 332
    › Primary publication · 26635618 (PubMed) · PMC4646981 (PubMed Central)
  5. High-fat load: mechanism(s) of insulin resistance in skeletal muscle. Lark DS, Fisher-Wellman KH, Neufer PD (2012) Int J Obes Suppl 2(Suppl 2): S31-S36
    › Primary publication · 26052434 (PubMed) · PMC4457392 (PubMed Central)
  6. Enhanced mitochondrial superoxide scavenging does not improve muscle insulin action in the high fat-fed mouse. Lark DS, Kang L, Lustig ME, Bonner JS, James FD, Neufer PD, Wasserman DH (2015) PLoS One 10(5): e0126732
    › Primary publication · 25992608 (PubMed) · PMC4437982 (PubMed Central)
  7. Pyruvate dehydrogenase complex and nicotinamide nucleotide transhydrogenase constitute an energy-consuming redox circuit. Fisher-Wellman KH, Lin CT, Ryan TE, Reese LR, Gilliam LA, Cathey BL, Lark DS, Smith CD, Muoio DM, Neufer PD (2015) Biochem J 467(2): 271-80
    › Primary publication · 25643703 (PubMed) · PMC4442697 (PubMed Central)
  8. Do fish oil omega-3 fatty acids enhance antioxidant capacity and mitochondrial fatty acid oxidation in human atrial myocardium via PPARĪ³ activation? Anderson EJ, Thayne KA, Harris M, Shaikh SR, Darden TM, Lark DS, Williams JM, Chitwood WR, Kypson AP, Rodriguez E (2014) Antioxid Redox Signal 21(8): 1156-63
    › Primary publication · 24597798 (PubMed) · PMC4142835 (PubMed Central)
  9. Targeted metabolomics connects thioredoxin-interacting protein (TXNIP) to mitochondrial fuel selection and regulation of specific oxidoreductase enzymes in skeletal muscle. DeBalsi KL, Wong KE, Koves TR, Slentz DH, Seiler SE, Wittmann AH, Ilkayeva OR, Stevens RD, Perry CG, Lark DS, Hui ST, Szweda L, Neufer PD, Muoio DM (2014) J Biol Chem 289(12): 8106-20
    › Primary publication · 24482226 (PubMed) · PMC3961642 (PubMed Central)
  10. Mitochondrial glutathione depletion reveals a novel role for the pyruvate dehydrogenase complex as a key H2O2-emitting source under conditions of nutrient overload. Fisher-Wellman KH, Gilliam LAA, Lin CT, Cathey BL, Lark DS, Darrell Neufer P (2013) Free Radic Biol Med : 1201-1208
    › Primary publication · 24056031 (PubMed) · PMC3965186 (PubMed Central)
  11. Mitochondrial creatine kinase activity and phosphate shuttling are acutely regulated by exercise in human skeletal muscle. Perry CG, Kane DA, Herbst EA, Mukai K, Lark DS, Wright DC, Heigenhauser GJ, Neufer PD, Spriet LL, Holloway GP (2012) J Physiol 590(21): 5475-86
    › Primary publication · 22907058 (PubMed) · PMC3515832 (PubMed Central)
  12. Inhibiting myosin-ATPase reveals a dynamic range of mitochondrial respiratory control in skeletal muscle. Perry CG, Kane DA, Lin CT, Kozy R, Cathey BL, Lark DS, Kane CL, Brophy PM, Gavin TP, Anderson EJ, Neufer PD (2011) Biochem J 437(2): 215-22
    › Primary publication · 21554250 (PubMed) · PMC3863643 (PubMed Central)