NOTICE: Labnodes now supports vumc.org email addresses. If your email changed, please update your profile today.
Bernard Rousseau
Last active: 2/16/2015

Profile

Optimal function of the vocal fold lamina propria is essential to human voice production. The lamina propria is an area of connective tissue that is uniquely different from tissues found elsewhere in the body. Histological and physiological comparisons can be made with other tissues such as skin and joints that undergo frequent trauma, repeated cycles of inflammation, and decreased function secondary to injury. However, no other tissue in the body undergoes mechanical forces similar to the vibration that the vocal folds experience during phonation. Our research program investigates the role of phonation on organization and remodeling of the vocal fold and novel methods for vocal fold tissue regeneration. Our research efforts are funded by the National Institutes of Health, National Institute on Deafness and Other Communication Disorders. Current projects include the investigation of phonation on expression and deposition of the extracellular matrix, and the use of growth factors and novel therapeutic agents to improve the effects of aging on the vocal fold lamina propria. Our laboratory uses a combination of histology, neurophysiology, and molecular biology techniques to accomplish these aims. Ultimately, the goal of our programmatic research efforts are centered around improving the management of patients with voice disorders.

Publications

The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. Randomized controlled trial of supplemental augmentative and alternative communication versus voice rest alone after phonomicrosurgery. Rousseau B, Gutmann ML, Mau T, Francis DO, Johnson JP, Novaleski CK, Vinson KN, Garrett CG (2015) Otolaryngol Head Neck Surg 152(3): 494-500
    › Primary publication · 25605690 (PubMed) · PMC4617180 (PubMed Central)
  2. Effects of phonation time and magnitude dose on vocal fold epithelial genes, barrier integrity, and function. Kojima T, Valenzuela CV, Novaleski CK, Van Deusen M, Mitchell JR, Garrett CG, Sivasankar MP, Rousseau B (2014) Laryngoscope 124(12): 2770-8
    › Primary publication · 25073715 (PubMed) · PMC4241156 (PubMed Central)
  3. The ophthalmology microscalpel versus standard scalpels and wound healing in a rat model. Pearce EC, Hall JE, Boyd KL, Rousseau B, Ries WR (2014) Otolaryngol Head Neck Surg 151(3): 424-30
    › Primary publication · 24866476 (PubMed)
  4. Nonlinear analyses of elicited modal, raised, and pressed rabbit phonation. Awan SN, Novaleski CK, Rousseau B (2014) J Voice 28(5): 538-47
    › Primary publication · 24836360 (PubMed) · PMC4157117 (PubMed Central)
  5. Quantification of acute vocal fold epithelial surface damage with increasing time and magnitude doses of vibration exposure. Kojima T, Van Deusen M, Jerome WG, Garrett CG, Sivasankar MP, Novaleski CK, Rousseau B (2014) PLoS One 9(3): e91615
    › Primary publication · 24626217 (PubMed) · PMC3953437 (PubMed Central)
  6. Fluid-structure interaction involving large deformations: 3D simulations and applications to biological systems. Tian FB, Dai H, Luo H, Doyle JF, Rousseau B (2014) J Comput Phys
    › Primary publication · 24415796 (PubMed) · PMC3884079 (PubMed Central)
  7. Recovery of vibratory function after vocal fold microflap in a rabbit model. Kojima T, Mitchell JR, Garrett CG, Rousseau B (2014) Laryngoscope 124(2): 481-6
    › Primary publication · 23901003 (PubMed) · PMC4610918 (PubMed Central)
  8. Biochemical basis of vocal fold mobilization after microflap surgery in a rabbit model. Mitchell JR, Kojima T, Wu H, Garrett CG, Rousseau B (2014) Laryngoscope 124(2): 487-93
    › Primary publication · 23775575 (PubMed) · PMC4576344 (PubMed Central)
  9. Comparison of ventilation and voice outcomes between unilateral laryngeal pacing and unilateral cordotomy for the treatment of bilateral vocal fold paralysis. Li Y, Pearce EC, Mainthia R, Athavale SM, Dang J, Ashmead DH, Garrett CG, Rousseau B, Billante CR, Zealear DL (2013) ORL J Otorhinolaryngol Relat Spec 75(2): 68-73
    › Primary publication · 23736349 (PubMed) · PMC3798066 (PubMed Central)
  10. Modulation of inflammatory and profibrotic signaling in a rabbit model of acute phonotrauma using triamcinolone. Hall JE, Suehiro A, Branski RC, Garrett CG, Rousseau B (2012) Otolaryngol Head Neck Surg 147(2): 302-7
    › Primary publication · 22399283 (PubMed) · PMC4583202 (PubMed Central)
  11. Feasibility and acute healing of vocal fold microflap incisions in a rabbit model. Suehiro A, Bock JM, Hall JE, Garrett CG, Rousseau B (2012) Laryngoscope 122(3): 600-5
    › Primary publication · 22253007 (PubMed) · PMC3387431 (PubMed Central)
  12. Optimal concentration of hepatocyte growth factor for treatment of the aged rat vocal fold. Suehiro A, Wright H, Rousseau B (2011) Laryngoscope 121(8): 1726-34
    › Primary publication · 21792961 (PubMed) · PMC3146029 (PubMed Central)
  13. Compliance and quality of life in patients on prescribed voice rest. Rousseau B, Cohen SM, Zeller AS, Scearce L, Tritter AG, Garrett CG (2011) Otolaryngol Head Neck Surg 144(1): 104-7
    › Primary publication · 21493397 (PubMed)
  14. Raised intensity phonation compromises vocal fold epithelial barrier integrity. Rousseau B, Suehiro A, Echemendia N, Sivasankar M (2011) Laryngoscope 121(2): 346-51
    › Primary publication · 21271586 (PubMed) · PMC3042495 (PubMed Central)
  15. Effects of basic fibroblast growth factor on rat vocal fold fibroblasts. Suehiro A, Hirano S, Kishimoto Y, Tateya I, Rousseau B, Ito J (2010) Ann Otol Rhinol Laryngol 119(10): 690-6
    › Primary publication · 21049855 (PubMed)
  16. Effects of raised-intensity phonation on inflammatory mediator gene expression in normal rabbit vocal fold. Swanson ER, Ohno T, Abdollahian D, Garrett CG, Rousseau B (2010) Otolaryngol Head Neck Surg 143(4): 567-72
    › Primary publication · 20879195 (PubMed) · PMC2923810 (PubMed Central)
  17. Acute dysphonia secondary to vocal fold hemorrhage after vardenafil use. Singh V, Cohen SM, Rousseau B, Noordzij JP, Garrett CG, Ossoff RH (2010) Ear Nose Throat J 89(6): E21-2
    › Primary publication · 20556726 (PubMed)
  18. Qualitative characterization of elastic fiber distribution in the mouse vocal fold: further development of an animal model. Watts CR, Marler JA, Rousseau B (2011) J Voice 25(1): e1-6
    › Primary publication · 20137895 (PubMed)
  19. Treatment of acute vocal fold scar with local injection of basic fibroblast growth factor: a canine study. Suehiro A, Hirano S, Kishimoto Y, Rousseau B, Nakamura T, Ito J (2010) Acta Otolaryngol 130(7): 844-50
    › Primary publication · 20082571 (PubMed)
  20. Age-associated changes in the expression and deposition of vocal fold collagen and hyaluronan. Ohno T, Hirano S, Rousseau B (2009) Ann Otol Rhinol Laryngol 118(10): 735-41
    › Primary publication · 19894402 (PubMed) · PMC2782757 (PubMed Central)
  21. Regenerative effects of basic fibroblast growth factor on extracellular matrix production in aged rat vocal folds. Ohno T, Yoo MJ, Swanson ER, Hirano S, Ossoff RH, Rousseau B (2009) Ann Otol Rhinol Laryngol 118(8): 559-64
    › Primary publication · 19746753 (PubMed) · PMC2782572 (PubMed Central)
  22. Regeneration of aged rat vocal folds using hepatocyte growth factor therapy. Ohno T, Yoo MJ, Swanson ER, Hirano S, Ossoff RH, Rousseau B (2009) Laryngoscope 119(7): 1424-30
    › Primary publication · 19507223 (PubMed) · PMC3056162 (PubMed Central)
  23. Characterization of raised phonation in an evoked rabbit phonation model. Swanson ER, Abdollahian D, Ohno T, Ge P, Zealear DL, Rousseau B (2009) Laryngoscope 119(7): 1439-43
    › Primary publication · 19422027 (PubMed) · PMC4684257 (PubMed Central)
  24. Extracellular matrix gene expression during wound healing of the injured rat vocal fold. Ohno T, Hirano S, Rousseau B (2009) Otolaryngol Head Neck Surg 140(5): 757-61
    › Primary publication · 19393425 (PubMed)
  25. Model of evoked rabbit phonation. Ge PJ, French LC, Ohno T, Zealear DL, Rousseau B (2009) Ann Otol Rhinol Laryngol 118(1): 51-5
    › Primary publication · 19244964 (PubMed) · PMC4684265 (PubMed Central)
  26. Gene expression of transforming growth factor-beta1 and hepatocyte growth factor during wound healing of injured rat vocal fold. Ohno T, Hirano S, Rousseau B (2009) Laryngoscope 119(4): 806-10
    › Primary publication · 19213039 (PubMed)
  27. Effect of hepatocyte growth factor on gene expression of extracellular matrix during wound healing of the injured rat vocal fold. Ohno T, French LC, Hirano S, Ossoff RH, Rousseau B (2008) Ann Otol Rhinol Laryngol 117(9): 696-702
    › Primary publication · 18834074 (PubMed)
  28. Extracellular matrix gene expression after vocal fold injury in a rabbit model. Rousseau B, Ge PJ, Ohno T, French LC, Thibeault SL (2008) Ann Otol Rhinol Laryngol 117(8): 598-603
    › Primary publication · 18771077 (PubMed) · PMC4684253 (PubMed Central)
  29. Experimentally induced phonation increases matrix metalloproteinase-1 gene expression in normal rabbit vocal fold. Rousseau B, Ge P, French LC, Zealear DL, Thibeault SL, Ossoff RH (2008) Otolaryngol Head Neck Surg 138(1): 62-8
    › Primary publication · 18164995 (PubMed) · PMC2912225 (PubMed Central)
  30. Investigation of anti-hyaluronidase treatment on vocal fold wound healing. Rousseau B, Tateya I, Lim X, Munoz-del-Rio A, Bless DM (2006) J Voice 20(3): 443-51
    › Primary publication · 16243482 (PubMed)
  31. Growth factor therapy for vocal fold scarring in a canine model. Hirano S, Bless DM, Nagai H, Rousseau B, Welham NV, Montequin DW, Ford CN (2004) Ann Otol Rhinol Laryngol 113(10): 777-85
    › Primary publication · 15535139 (PubMed)
  32. Functional outcomes of reduced hyaluronan in acute vocal fold scar. Rousseau B, Sohn J, Montequin DW, Tateya I, Bless DM (2004) Ann Otol Rhinol Laryngol 113(10): 767-76
    › Primary publication · 15535138 (PubMed)
  33. Prevention of vocal fold scarring by topical injection of hepatocyte growth factor in a rabbit model. Hirano S, Bless DM, Rousseau B, Welham N, Montequin D, Chan RW, Ford CN (2004) Laryngoscope 114(3): 548-56
    › Primary publication · 15091233 (PubMed)
  34. Characterization of chronic vocal fold scarring in a rabbit model. Rousseau B, Hirano S, Chan RW, Welham NV, Thibeault SL, Ford CN, Bless DM (2004) J Voice 18(1): 116-24
    › Primary publication · 15070231 (PubMed)
  35. Hyaluronan levels in acute vocal fold scar. Thibeault SL, Rousseau B, Welham NV, Hirano S, Bless DM (2004) Laryngoscope 114(4): 760-4
    › Primary publication · 15064637 (PubMed)
  36. Tracking outcomes after phonosurgery for sulcus vocalis: a case report. Welham NV, Rousseau B, Ford CN, Bless DM (2003) J Voice 17(4): 571-8
    › Primary publication · 14740937 (PubMed)
  37. Fibronectin and adhesion molecules on canine scarred vocal folds. Hirano S, Bless DM, Rousseau B, Welham N, Scheidt T, Ford CN (2003) Laryngoscope 113(6): 966-72
    › Primary publication · 12782806 (PubMed)
  38. Characterization of vocal fold scarring in a canine model. Rousseau B, Hirano S, Scheidt TD, Welham NV, Thibeault SL, Chan RW, Bless DM (2003) Laryngoscope 113(4): 620-7
    › Primary publication · 12671417 (PubMed)