Katherine Murray
Last active: 4/4/2019

Profile

Ion channels are critical for normal electrical activity in cardiac and vascular smooth muscle, while even mild dysfunction can cause life-threatening cardiac arrhythmias in humans. The principal goal of our research is to investigate the signaling processes and proteins that modulate the activity of cardiovascular ion channels. Circulating hormones that activate intracellular signaling cascades, and ultimately protein kinases, can rapidly regulate ion channel function. Our recent work demonstrates that protein kinases can also modify intracellular trafficking of cardiac sodium channels to alter expression at the cell surface. Given the critical role of these channels in electrical impulse conduction, we are actively investigating the molecular features of this process. We have also chosen to study a potassium channel signaling complex that underlies an important repolarizing current, IKur. Because IKur is atrial-specific in humans, it represents an attractive target for pharmacologic therapy of cardiac arrhythmias, and improved understanding of its molecular components would permit optimal drug design. Another area of interest is the electrical remodeling that occurs with atrial fibrillation, a common cardiac arrhythmia that is a major cause of stroke and death in the US. The remodeling process causes the arrhythmia to perpetuate itself, rendering it refractory to treatment. An in vitro model of atrial fibrillation has been created to investigate basic mechanisms of development and associated changes in gene expression. These studies should improve our understanding of the molecular basis of ionic currents in the cardiovascular system and contribute to the development of new therapeutic approaches in treating cardiac arrhythmias.

Publications

The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. Development of an algorithm to identify serious opioid toxicity in children. Chung CP, Callahan ST, Cooper WO, Murray KT, Hall K, Dudley JA, Stein CM, Ray WA (2015) BMC Res Notes : 293
    › Primary publication · 26141980 (PubMed) · PMC4491206 (PubMed Central)
  2. Out-of-hospital mortality among patients receiving methadone for noncancer pain. Ray WA, Chung CP, Murray KT, Cooper WO, Hall K, Stein CM (2015) JAMA Intern Med 175(3): 420-7
    › Primary publication · 25599329 (PubMed) · PMC4346542 (PubMed Central)
  3. Genetic and clinical risk prediction model for postoperative atrial fibrillation. Kolek MJ, Muehlschlegel JD, Bush WS, Parvez B, Murray KT, Stein CM, Shoemaker MB, Blair MA, Kor KC, Roden DM, Donahue BS, Fox AA, Shernan SK, Collard CD, Body SC, Darbar D (2015) Circ Arrhythm Electrophysiol 8(1): 25-31
    › Primary publication · 25567478 (PubMed) · PMC4334678 (PubMed Central)
  4. Hypertension is associated with preamyloid oligomers in human atrium: a missing link in atrial pathophysiology? Sidorova TN, Mace LC, Wells KS, Yermalitskaya LV, Su PF, Shyr Y, Atkinson JB, Fogo AB, Prinsen JK, Byrne JG, Petracek MR, Greelish JP, Hoff SJ, Ball SK, Glabe CG, Brown NJ, Barnett JV, Murray KT (2014) J Am Heart Assoc 3(6): e001384
    › Primary publication · 25468655 (PubMed) · PMC4338732 (PubMed Central)
  5. Effect of omega-three polyunsaturated fatty acids on inflammation, oxidative stress, and recurrence of atrial fibrillation. Darghosian L, Free M, Li J, Gebretsadik T, Bian A, Shintani A, McBride BF, Solus J, Milne G, Crossley GH, Thompson D, Vidaillet H, Okafor H, Darbar D, Murray KT, Stein CM (2015) Am J Cardiol 115(2): 196-201
    › Primary publication · 25465932 (PubMed) · PMC4276435 (PubMed Central)
  6. Reactive γ-ketoaldehydes promote protein misfolding and preamyloid oligomer formation in rapidly-activated atrial cells. Sidorova TN, Yermalitskaya LV, Mace LC, Wells KS, Boutaud O, Prinsen JK, Davies SS, Roberts LJ, Dikalov SI, Glabe CG, Amarnath V, Barnett JV, Murray KT (2015) J Mol Cell Cardiol : 295-302
    › Primary publication · 25463275 (PubMed) · PMC4302000 (PubMed Central)
  7. Quantitative Imaging of Preamyloid Oligomers, a Novel Structural Abnormality, in Human Atrial Samples. Sidorova TN, Mace LC, Wells KS, Yermalitskaya LV, Su PF, Shyr Y, Byrne JG, Petracek MR, Greelish JP, Hoff SJ, Ball SK, Glabe CG, Brown NJ, Barnett JV, Murray KT (2014) J Histochem Cytochem 62(7): 479-87
    › Primary publication · 24789805 (PubMed) · PMC4072180 (PubMed Central)
  8. 2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the Heart Rhythm Society. January CT, Wann LS, Alpert JS, Calkins H, Cigarroa JE, Cleveland JC, Conti JB, Ellinor PT, Ezekowitz MD, Field ME, Murray KT, Sacco RL, Stevenson WG, Tchou PJ, Tracy CM, Yancy CW, American College of Cardiology/American Heart Association Task Force on Practice Guidelines (2014) J Am Coll Cardiol 64(21): e1-76
    › Primary publication · 24685669 (PubMed)
  9. 2014 AHA/ACC/HRS Guideline for the Management of Patients With Atrial Fibrillation: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the Heart Rhythm Society. January CT, Wann LS, Alpert JS, Calkins H, Cleveland JC, Cigarroa JE, Conti JB, Ellinor PT, Ezekowitz MD, Field ME, Murray KT, Sacco RL, Stevenson WG, Tchou PJ, Tracy CM, Yancy CW (2014) J Am Coll Cardiol
    › Primary publication · 24685668 (PubMed)
  10. 2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: executive summary: a report of the American College of Cardiology/American Heart Association Task Force on practice guidelines and the Heart Rhythm Society. January CT, Wann LS, Alpert JS, Calkins H, Cigarroa JE, Cleveland JC, Conti JB, Ellinor PT, Ezekowitz MD, Field ME, Murray KT, Sacco RL, Stevenson WG, Tchou PJ, Tracy CM, Yancy CW, ACC/AHA Task Force Members (2014) Circulation 130(23): 2071-104
    › Primary publication · 24682348 (PubMed)
  11. 2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: a report of the American College of Cardiology/American Heart Association Task Force on practice guidelines and the Heart Rhythm Society. January CT, Wann LS, Alpert JS, Calkins H, Cigarroa JE, Cleveland JC, Conti JB, Ellinor PT, Ezekowitz MD, Field ME, Murray KT, Sacco RL, Stevenson WG, Tchou PJ, Tracy CM, Yancy CW, ACC/AHA Task Force Members (2014) Circulation 130(23): e199-267
    › Primary publication · 24682347 (PubMed) · PMC4676081 (PubMed Central)
  12. It's a funny thing…. Murray KT (2013) J Cardiovasc Electrophysiol 24(12): 1401-2
    › Primary publication · 24033556 (PubMed)
  13. Propoxyphene and the risk of out-of-hospital death. Ray WA, Murray KT, Kawai V, Graham DJ, Cooper WO, Hall K, Stein CM (2013) Pharmacoepidemiol Drug Saf 22(4): 403-12
    › Primary publication · 23408551 (PubMed) · PMC3694329 (PubMed Central)
  14. Validation of a computer case definition for sudden cardiac death in opioid users. Kawai VK, Murray KT, Stein CM, Cooper WO, Graham DJ, Hall K, Ray WA (2012) BMC Res Notes : 473
    › Primary publication · 22938531 (PubMed) · PMC3512474 (PubMed Central)
  15. Angiotensin-converting enzyme inhibition or mineralocorticoid receptor blockade do not affect prevalence of atrial fibrillation in patients undergoing cardiac surgery. Pretorius M, Murray KT, Yu C, Byrne JG, Billings FT, Petracek MR, Greelish JP, Hoff SJ, Ball SK, Mishra V, Body SC, Brown NJ (2012) Crit Care Med 40(10): 2805-12
    › Primary publication · 22824930 (PubMed) · PMC3588582 (PubMed Central)
  16. Azithromycin and the risk of cardiovascular death. Ray WA, Murray KT, Hall K, Arbogast PG, Stein CM (2012) N Engl J Med 366(20): 1881-90
    › Primary publication · 22591294 (PubMed) · PMC3374857 (PubMed Central)
  17. Activation of protein kinase C alters the intracellular distribution and mobility of cardiac Na+ channels. Hallaq H, Wang DW, Kunic JD, George AL, Wells KS, Murray KT (2012) Am J Physiol Heart Circ Physiol 302(3): H782-9
    › Primary publication · 22101522 (PubMed) · PMC3353784 (PubMed Central)
  18. ADHD drugs and serious cardiovascular events in children and young adults. Cooper WO, Habel LA, Sox CM, Chan KA, Arbogast PG, Cheetham TC, Murray KT, Quinn VP, Stein CM, Callahan ST, Fireman BH, Fish FA, Kirshner HS, O'Duffy A, Connell FA, Ray WA (2011) N Engl J Med 365(20): 1896-904
    › Primary publication · 22043968 (PubMed) · PMC4943074 (PubMed Central)
  19. Left atrial hypertension after repeated catheter ablations for atrial fibrillation. Shoemaker MB, Hemnes AR, Robbins IM, Langberg JJ, Ellis CR, Aznaurov SG, Fredi JL, Slosky DA, Roden DM, Murray KT, Piana RN, Mendes LA, Whalen SP (2011) J Am Coll Cardiol 57(19): 1918-9
    › Primary publication · 21545950 (PubMed)
  20. Ionic mechanisms of pacemaker activity in spontaneously contracting atrial HL-1 cells. Yang Z, Murray KT (2011) J Cardiovasc Pharmacol 57(1): 28-36
    › Primary publication · 20881602 (PubMed) · PMC3023001 (PubMed Central)
  21. Preventing atrial fibrillation: more evidence to turn up the heat. Murray KT, Mace LC (2011) J Cardiovasc Electrophysiol 22(2): 191-2
    › Primary publication · 20807273 (PubMed)
  22. Outcomes with concurrent use of clopidogrel and proton-pump inhibitors: a cohort study. Ray WA, Murray KT, Griffin MR, Chung CP, Smalley WE, Hall K, Daugherty JR, Kaltenbach LA, Stein CM (2010) Ann Intern Med 152(6): 337-45
    › Primary publication · 20231564 (PubMed) · PMC3176584 (PubMed Central)
  23. Cardiovascular risks of nonsteroidal antiinflammatory drugs in patients after hospitalization for serious coronary heart disease. Ray WA, Varas-Lorenzo C, Chung CP, Castellsague J, Murray KT, Stein CM, Daugherty JR, Arbogast PG, García-Rodríguez LA (2009) Circ Cardiovasc Qual Outcomes 2(3): 155-63
    › Primary publication · 20031832 (PubMed)
  24. A computer case definition for sudden cardiac death. Chung CP, Murray KT, Stein CM, Hall K, Ray WA (2010) Pharmacoepidemiol Drug Saf 19(6): 563-72
    › Primary publication · 20029823 (PubMed) · PMC3181496 (PubMed Central)
  25. Treatment of elderly hypertensive patients with epithelial sodium channel inhibitors combined with a thiazide diuretic reduces coronary mortality and sudden cardiac death. Hebert PR, Coffey CS, Byrne DW, Scott TA, Fagard RH, Rottman JN, Murray KT, Oates JA (2008) J Am Soc Hypertens 2(5): 355-65
    › Primary publication · 19727429 (PubMed) · PMC2633478 (PubMed Central)
  26. Transcriptional remodeling of rapidly stimulated HL-1 atrial myocytes exhibits concordance with human atrial fibrillation. Mace LC, Yermalitskaya LV, Yi Y, Yang Z, Morgan AM, Murray KT (2009) J Mol Cell Cardiol 47(4): 485-92
    › Primary publication · 19615375 (PubMed) · PMC2754068 (PubMed Central)
  27. Why amiodarone is better: another piece of the puzzle. Murray KT (2009) J Cardiovasc Electrophysiol 20(7): 811-2
    › Primary publication · 19460071 (PubMed)
  28. Atypical antipsychotic drugs and the risk of sudden cardiac death. Ray WA, Chung CP, Murray KT, Hall K, Stein CM (2009) N Engl J Med 360(3): 225-35
    › Primary publication · 19144938 (PubMed) · PMC2713724 (PubMed Central)
  29. Milrinone use is associated with postoperative atrial fibrillation after cardiac surgery. Fleming GA, Murray KT, Yu C, Byrne JG, Greelish JP, Petracek MR, Hoff SJ, Ball SK, Brown NJ, Pretorius M (2008) Circulation 118(16): 1619-25
    › Primary publication · 18824641 (PubMed) · PMC2770257 (PubMed Central)
  30. When an ICD is not the answer... hypothyroidism-induced cardiomyopathy and torsades de pointes. Ellis CR, Murray KT (2008) J Cardiovasc Electrophysiol 19(10): 1105-7
    › Primary publication · 18399973 (PubMed)
  31. Four and a half LIM protein 1: a partner for KCNA5 in human atrium. Yang Z, Browning CF, Hallaq H, Yermalitskaya L, Esker J, Hall MR, Link AJ, Ham AJ, McGrath MJ, Mitchell CA, Murray KT (2008) Cardiovasc Res 78(3): 449-57
    › Primary publication · 18281375 (PubMed)
  32. Nonantiarrhythmic drug therapy for atrial fibrillation. Murray KT, Mace LC, Yang Z (2007) Heart Rhythm 4(3 Suppl): S88-90
    › Primary publication · 17336893 (PubMed)
  33. Quantitation of protein kinase A-mediated trafficking of cardiac sodium channels in living cells. Hallaq H, Yang Z, Viswanathan PC, Fukuda K, Shen W, Wang DW, Wells KS, Zhou J, Yi J, Murray KT (2006) Cardiovasc Res 72(2): 250-61
    › Primary publication · 16973141 (PubMed)
  34. Genetic susceptibility to acquired long QT syndrome: pharmacologic challenge in first-degree relatives. Kannankeril PJ, Roden DM, Norris KJ, Whalen SP, George AL, Murray KT (2005) Heart Rhythm 2(2): 134-40
    › Primary publication · 15851285 (PubMed)
  35. Inhibition of angiotensin II signaling and recurrence of atrial fibrillation in AFFIRM. Murray KT, Rottman JN, Arbogast PG, Shemanski L, Primm RK, Campbell WB, Solomon AJ, Olgin JE, Wilson MJ, Dimarco JP, Beckman KJ, Dennish G, Naccarelli GV, Ray WA, AFFIRM Investigators (2004) Heart Rhythm 1(6): 669-75
    › Primary publication · 15851238 (PubMed)
  36. Rapid stimulation causes electrical remodeling in cultured atrial myocytes. Yang Z, Shen W, Rottman JN, Wikswo JP, Murray KT (2005) J Mol Cell Cardiol 38(2): 299-308
    › Primary publication · 15698836 (PubMed)
  37. Expression of multiple KCNE genes in human heart may enable variable modulation of I(Ks). Lundquist AL, Manderfield LJ, Vanoye CG, Rogers CS, Donahue BS, Chang PA, Drinkwater DC, Murray KT, George AL (2005) J Mol Cell Cardiol 38(2): 277-87
    › Primary publication · 15698834 (PubMed)
  38. Oral erythromycin and the risk of sudden death from cardiac causes. Ray WA, Murray KT, Meredith S, Narasimhulu SS, Hall K, Stein CM (2004) N Engl J Med 351(11): 1089-96
    › Primary publication · 15356306 (PubMed)
  39. Cyclic antidepressants and the risk of sudden cardiac death. Ray WA, Meredith S, Thapa PB, Hall K, Murray KT (2004) Clin Pharmacol Ther 75(3): 234-41
    › Primary publication · 15001975 (PubMed)
  40. Phosphorylation and putative ER retention signals are required for protein kinase A-mediated potentiation of cardiac sodium current. Zhou J, Shin HG, Yi J, Shen W, Williams CP, Murray KT (2002) Circ Res 91(6): 540-6
    › Primary publication · 12242273 (PubMed)
  41. Modulation of the human Kv1.5 channel by protein kinase C activation: role of the Kvbeta1.2 subunit. Williams CP, Hu N, Shen W, Mashburn AB, Murray KT (2002) J Pharmacol Exp Ther 302(2): 545-50
    › Primary publication · 12130714 (PubMed)
  42. Allelic variants in long-QT disease genes in patients with drug-associated torsades de pointes. Yang P, Kanki H, Drolet B, Yang T, Wei J, Viswanathan PC, Hohnloser SH, Shimizu W, Schwartz PJ, Stanton M, Murray KT, Norris K, George AL, Roden DM (2002) Circulation 105(16): 1943-8
    › Primary publication · 11997281 (PubMed)
  43. Aspirin: redundant in users of nonaspirin, nonsteroidal antiinflammatory agents? Ray WA, Murray KT (2002) Am Heart J 143(3): 381-2
    › Primary publication · 11868040 (PubMed)
  44. Antipsychotics and the risk of sudden cardiac death. Ray WA, Meredith S, Thapa PB, Meador KG, Hall K, Murray KT (2001) Arch Gen Psychiatry 58(12): 1161-7
    › Primary publication · 11735845 (PubMed)
  45. Conventional protein kinase C isoforms and cross-activation of protein kinase A regulate cardiac Na+ current. Shin HG, Murray KT (2001) FEBS Lett 495(3): 154-8
    › Primary publication · 11334883 (PubMed)
  46. Molecular heterogeneity of protein kinase C expression in human ventricle. Shin HG, Barnett JV, Chang P, Reddy S, Drinkwater DC, Pierson RN, Wiley RG, Murray KT (2000) Cardiovasc Res 48(2): 285-99
    › Primary publication · 11054475 (PubMed)
  47. A common polymorphism associated with antibiotic-induced cardiac arrhythmia. Sesti F, Abbott GW, Wei J, Murray KT, Saksena S, Schwartz PJ, Priori SG, Roden DM, George AL, Goldstein SA (2000) Proc Natl Acad Sci U S A 97(19): 10613-8
    › Primary publication · 10984545 (PubMed) · PMC27073 (PubMed Central)
  48. Stereoselective interactions of the enantiomers of chromanol 293B with human voltage-gated potassium channels. Yang IC, Scherz MW, Bahinski A, Bennett PB, Murray KT (2000) J Pharmacol Exp Ther 294(3): 955-62
    › Primary publication · 10945846 (PubMed)
  49. Activation of protein kinase A modulates trafficking of the human cardiac sodium channel in Xenopus oocytes. Zhou J, Yi J, Hu N, George AL, Murray KT (2000) Circ Res 87(1): 33-8
    › Primary publication · 10884369 (PubMed)
  50. Protein kinase A phosphorylation alters Kvbeta1.3 subunit-mediated inactivation of the Kv1.5 potassium channel. Kwak YG, Hu N, Wei J, George AL, Grobaski TD, Tamkun MM, Murray KT (1999) J Biol Chem 274(20): 13928-32
    › Primary publication · 10318802 (PubMed)
  51. Ibutilide. Murray KT (1998) Circulation 97(5): 493-7
    › Primary publication · 9490245 (PubMed)
  52. Functional effects of protein kinase C activation on the human cardiac Na+ channel. Murray KT, Hu NN, Daw JR, Shin HG, Watson MT, Mashburn AB, George AL (1997) Circ Res 80(3): 370-6
    › Primary publication · 9048657 (PubMed)
  53. A randomized, double-blind, placebo-controlled, dose-ranging study of dofetilide in patients with inducible sustained ventricular tachyarrhythmias. Echt DS, Lee JT, Murray KT, Vorperian V, Borganelli SM, Crawford DM, Friedrich T, Roden DM (1995) J Cardiovasc Electrophysiol 6(9): 687-99
    › Primary publication · 8556189 (PubMed)
  54. Modulation of an inactivating human cardiac K+ channel by protein kinase C. Murray KT, Fahrig SA, Deal KK, Po SS, Hu NN, Snyders DJ, Tamkun MM, Bennett PB (1994) Circ Res 75(6): 999-1005
    › Primary publication · 7955154 (PubMed)
  55. Effects of procainamide and lidocaine on defibrillation energy requirements in patients receiving implantable cardioverter defibrillator devices. Echt DS, Gremillion ST, Lee JT, Roden DM, Murray KT, Borganelli M, Crawford DM, Stewart JR, Hammon JW (1994) J Cardiovasc Electrophysiol 5(9): 752-60
    › Primary publication · 7827714 (PubMed)
  56. Mexiletine and tocainide: a comparison of antiarrhythmic efficacy, adverse effects, and predictive value of lidocaine testing. Murray KT, Barbey JT, Kopelman HA, Siddoway LA, Echt DS, Woosley RL, Roden DM (1989) Clin Pharmacol Ther 45(5): 553-61
    › Primary publication · 2498025 (PubMed)
  57. Suppression of ventricular arrhythmias in man by d-propranolol independent of beta-adrenergic receptor blockade. Murray KT, Reilly C, Koshakji RP, Roden DM, Lineberry MD, Wood AJ, Siddoway LA, Barbey JT, Woosley RL (1990) J Clin Invest 85(3): 836-42
    › Primary publication · 2155929 (PubMed) · PMC296501 (PubMed Central)
  58. Voltage clamp of the cardiac sodium current at 37 degrees C in physiologic solutions. Murray KT, Anno T, Bennett PB, Hondeghem LM (1990) Biophys J 57(3): 607-13
    › Primary publication · 2155034 (PubMed) · PMC1280754 (PubMed Central)
  59. Intravenous 3-methoxy-O-desmethyl-encainide in reentrant supraventricular tachycardia: a randomized double-blind placebo-controlled trial in patients undergoing EP study. Ware DL, Lee JT, Murray KT, Hanyok JJ, Roden DM, Echt DS (1991) Pacing Clin Electrophysiol 14(9): 1343-50
    › Primary publication · 1720527 (PubMed)