Bjorn Knollmann
Last active: 4/25/2016

Profile

My laboratory is interested in the biology of cardiac arrhythmias. Using genetically-altered mice as model systems, ongoing research examines several key pathways of arrhythmias and sudden death in humans: 1) Impaired cardiac calcium cycling and mutations in cardiac Ca2+ handling proteins, 2) Troponin T mutations associated with hypertrophic cardiomyopathy and 3) Mutations associated with the congenital long QT syndrome. In neither case the mechanisms that lead to sudden cardiac death are fully understood. The laboratory performs comprehensive studies from the molecular level to the whole animal in each mouse model in order to better understand the mechanisms of arrhythmogenesis. For example, single cell patch-clamp, intracellular calcium and cell shortening measurements, whole-heart electro-physiology and contractility measurements, and in vivo electrocardiogram and hemodynamic studies are performed. This research may identify therapeutic strategies, which then can be tested in the same model system prior to human studies.

Publications

The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. Channel Activity of Cardiac Ryanodine Receptors (RyR2) Determines Potency and Efficacy of Flecainide and R-Propafenone against Arrhythmogenic Calcium Waves in Ventricular Cardiomyocytes. Savio-Galimberti E, Knollmann BC (2015) PLoS One 10(6): e0131179
    › Primary publication · 26121139 (PubMed) · PMC4488248 (PubMed Central)
  2. Comparable calcium handling of human iPSC-derived cardiomyocytes generated by multiple laboratories. Hwang HS, Kryshtal DO, Feaster TK, Sánchez-Freire V, Zhang J, Kamp TJ, Hong CC, Wu JC, Knollmann BC (2015) J Mol Cell Cardiol : 79-88
    › Primary publication · 25982839 (PubMed) · PMC4530041 (PubMed Central)
  3. Research priorities in sarcomeric cardiomyopathies. van der Velden J, Ho CY, Tardiff JC, Olivotto I, Knollmann BC, Carrier L (2015) Cardiovasc Res 105(4): 449-56
    › Primary publication · 25631582 (PubMed) · PMC4375392 (PubMed Central)
  4. Modelling sarcomeric cardiomyopathies in the dish: from human heart samples to iPSC cardiomyocytes. Eschenhagen T, Mummery C, Knollmann BC (2015) Cardiovasc Res 105(4): 424-38
    › Primary publication · 25618410 (PubMed) · PMC4349163 (PubMed Central)
  5. Alternating membrane potential/calcium interplay underlies repetitive focal activity in a genetic model of calcium-dependent atrial arrhythmias. Lou Q, Belevych AE, Radwański PB, Liu B, Kalyanasundaram A, Knollmann BC, Fedorov VV, Györke S (2015) J Physiol 593(6): 1443-58
    › Primary publication · 25384790 (PubMed) · PMC4376423 (PubMed Central)
  6. Calcium in atrial fibrillation - pulling the trigger or not? Gomez-Hurtado N, Knollmann BC (2014) J Clin Invest 124(11): 4684-6
    › Primary publication · 25329688 (PubMed) · PMC4347245 (PubMed Central)
  7. Multiple modes of ryanodine receptor 2 inhibition by flecainide. Mehra D, Imtiaz MS, van Helden DF, Knollmann BC, Laver DR (2014) Mol Pharmacol 86(6): 696-706
    › Primary publication · 25274603 (PubMed) · PMC4244595 (PubMed Central)
  8. Divergent regulation of ryanodine receptor 2 calcium release channels by arrhythmogenic human calmodulin missense mutants. Hwang HS, Nitu FR, Yang Y, Walweel K, Pereira L, Johnson CN, Faggioni M, Chazin WJ, Laver D, George AL, Cornea RL, Bers DM, Knollmann BC (2014) Circ Res 114(7): 1114-24
    › Primary publication · 24563457 (PubMed) · PMC3990285 (PubMed Central)
  9. Suppression of spontaneous ca elevations prevents atrial fibrillation in calsequestrin 2-null hearts. Faggioni M, Savio-Galimberti E, Venkataraman R, Hwang HS, Kannankeril PJ, Darbar D, Knollmann BC (2014) Circ Arrhythm Electrophysiol 7(2): 313-20
    › Primary publication · 24493699 (PubMed) · PMC3989424 (PubMed Central)
  10. Genetic ablation of ryanodine receptor 2 phosphorylation at Ser-2808 aggravates Ca(2+)-dependent cardiomyopathy by exacerbating diastolic Ca2+ release. Liu B, Ho HT, Velez-Cortes F, Lou Q, Valdivia CR, Knollmann BC, Valdivia HH, Gyorke S (2014) J Physiol 592(9): 1957-73
    › Primary publication · 24445321 (PubMed) · PMC4230772 (PubMed Central)
  11. Dantrolene: from better bacon to a treatment for ventricular fibrillation. Roden DM, Knollmann BC (2014) Circulation 129(8): 834-6
    › Primary publication · 24403562 (PubMed) · PMC3959791 (PubMed Central)
  12. Calsequestrin 2 deletion causes sinoatrial node dysfunction and atrial arrhythmias associated with altered sarcoplasmic reticulum calcium cycling and degenerative fibrosis within the mouse atrial pacemaker complex1. Glukhov AV, Kalyanasundaram A, Lou Q, Hage LT, Hansen BJ, Belevych AE, Mohler PJ, Knollmann BC, Periasamy M, Györke S, Fedorov VV (2015) Eur Heart J 36(11): 686-97
    › Primary publication · 24216388 (PubMed) · PMC4359358 (PubMed Central)
  13. Inositol 1,4,5-trisphosphate receptors: "exciting" players in cardiac excitation-contraction coupling? Roderick HL, Knollmann BC (2013) Circulation 128(12): 1273-5
    › Primary publication · 23983251 (PubMed) · PMC3885819 (PubMed Central)
  14. Familial hypertrophic cardiomyopathy: is the Frank-Starling law kaput? Huke S, Knollmann BC (2013) Circ Res 112(11): 1409-11
    › Primary publication · 23704214 (PubMed) · PMC3767756 (PubMed Central)
  15. Myofilament calcium de-sensitization and contractile uncoupling prevent pause-triggered ventricular tachycardia in mouse hearts with chronic myocardial infarction. Venkataraman R, Baldo MP, Hwang HS, Veltri T, Pinto JR, Baudenbacher FJ, Knollmann BC (2013) J Mol Cell Cardiol : 8-15
    › Primary publication · 23570978 (PubMed) · PMC3683590 (PubMed Central)
  16. Induced pluripotent stem cell-derived cardiomyocytes: boutique science or valuable arrhythmia model? Knollmann BC (2013) Circ Res 112(6): 969-76; discussion 976
    › Primary publication · 23569106 (PubMed) · PMC3667201 (PubMed Central)
  17. Focal energy deprivation underlies arrhythmia susceptibility in mice with calcium-sensitized myofilaments. Huke S, Venkataraman R, Faggioni M, Bennuri S, Hwang HS, Baudenbacher F, Knollmann BC (2013) Circ Res 112(10): 1334-44
    › Primary publication · 23532597 (PubMed) · PMC3850761 (PubMed Central)
  18. Triple mode of action of flecainide in catecholaminergic polymorphic ventricular tachycardia. Steele DS, Hwang HS, Knollmann BC (2013) Cardiovasc Res 98(2): 326-7
    › Primary publication · 23512981 (PubMed) · PMC3657388 (PubMed Central)
  19. Parameter sensitivity analysis of stochastic models provides insights into cardiac calcium sparks. Lee YS, Liu OZ, Hwang HS, Knollmann BC, Sobie EA (2013) Biophys J 104(5): 1142-50
    › Primary publication · 23473497 (PubMed) · PMC3870797 (PubMed Central)
  20. Triadin regulates cardiac muscle couplon structure and microdomain Ca(2+) signalling: a path towards ventricular arrhythmias. Chopra N, Knollmann BC (2013) Cardiovasc Res 98(2): 187-91
    › Primary publication · 23396608 (PubMed) · PMC3633157 (PubMed Central)