Troy Hackett
Last active: 3/3/2020


Dr. Hackett studies the organization of the auditory cortex combining anatomical and neurophysiological techniques. The major emphasis of the research is to assemble a model of auditory cortical processing from: 1) identification of the cortical areas involved in the processing of auditory information; 2) reconstruction of the circuitry that underlies the auditory cortical network; 3) recording of neurophysiological response profiles for neurons in individual areas; and 4) comparative analyses of these features between species. The long term goal of this research is to establish a comprehensive model of auditory processing in the human cerebral cortex. Research is supported by the National Institutes of Health (NIDCD).


The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. The use of nonhuman primates in studies of noise injury and treatment. Burton JA, Valero MD, Hackett TA, Ramachandran R (2019) J Acoust Soc Am 146(5): 3770
    › Primary publication · 31795680 (PubMed) · PMC6881191 (PubMed Central)
  2. GLP-1: Molecular mechanisms and outcomes of a complex signaling system. Smith NK, Hackett TA, Galli A, Flynn CR (2019) Neurochem Int : 94-105
    › Primary publication · 31002893 (PubMed) · PMC7081944 (PubMed Central)
  3. Beyond the H&E: Advanced Technologies for in situ Tissue Biomarker Imaging. Himmel LE, Hackett TA, Moore JL, Adams WR, Thomas G, Novitskaya T, Caprioli RM, Zijlstra A, Mahadevan-Jansen A, Boyd KL (2018) ILAR J 59(1): 51-65
    › Primary publication · 30462242 (PubMed) · PMC6645175 (PubMed Central)
  4. Adenosine A Receptor mRNA Expression by Neurons and Glia in the Auditory Forebrain. Hackett TA (2018) Anat Rec (Hoboken) 301(11): 1882-1905
    › Primary publication · 30315630 (PubMed) · PMC6282551 (PubMed Central)
  5. Synergistic Transcriptional Changes in AMPA and GABA Receptor Genes Support Compensatory Plasticity Following Unilateral Hearing Loss. Balaram P, Hackett TA, Polley DB (2019) Neuroscience : 108-119
    › Primary publication · 30176318 (PubMed) · PMC6395571 (PubMed Central)
  6. Bile diversion, a bariatric surgery, and bile acid signaling reduce central cocaine reward. Reddy IA, Smith NK, Erreger K, Ghose D, Saunders C, Foster DJ, Turner B, Poe A, Albaugh VL, McGuinness O, Hackett TA, Grueter BA, Abumrad NN, Flynn CR, Galli A (2018) PLoS Biol 16(7): e2006682
    › Primary publication · 30048457 (PubMed) · PMC6061973 (PubMed Central)
  7. Presynaptic Neuronal Nicotinic Receptors Differentially Shape Select Inputs to Auditory Thalamus and Are Negatively Impacted by Aging. Sottile SY, Hackett TA, Cai R, Ling L, Llano DA, Caspary DM (2017) J Neurosci 37(47): 11377-11389
    › Primary publication · 29061702 (PubMed) · PMC5700421 (PubMed Central)
  8. Noise-induced cochlear synaptopathy in rhesus monkeys (Macaca mulatta). Valero MD, Burton JA, Hauser SN, Hackett TA, Ramachandran R, Liberman MC (2017) Hear Res : 213-223
    › Primary publication · 28712672 (PubMed) · PMC5632522 (PubMed Central)
  9. Restoring auditory cortex plasticity in adult mice by restricting thalamic adenosine signaling. Blundon JA, Roy NC, Teubner BJW, Yu J, Eom TY, Sample KJ, Pani A, Smeyne RJ, Han SB, Kerekes RA, Rose DC, Hackett TA, Vuppala PK, Freeman BB, Zakharenko SS (2017) Science 356(6345): 1352-1356
    › Primary publication · 28663494 (PubMed) · PMC5523828 (PubMed Central)
  10. lncRNA expression in the auditory forebrain during postnatal development. Guo Y, Zhang P, Sheng Q, Zhao S, Hackett TA (2016) Gene 593(1): 201-216
    › Primary publication · 27544636 (PubMed) · PMC5034298 (PubMed Central)
  11. Glucagon-like peptide 1 receptor activation regulates cocaine actions and dopamine homeostasis in the lateral septum by decreasing arachidonic acid levels. Reddy IA, Pino JA, Weikop P, Osses N, Sørensen G, Bering T, Valle C, Bluett RJ, Erreger K, Wortwein G, Reyes JG, Graham D, Stanwood GD, Hackett TA, Patel S, Fink-Jensen A, Torres GE, Galli A (2016) Transl Psychiatry : e809
    › Primary publication · 27187231 (PubMed) · PMC5070047 (PubMed Central)
  12. A Distributed Network for Social Cognition Enriched for Oxytocin Receptors. Mitre M, Marlin BJ, Schiavo JK, Morina E, Norden SE, Hackett TA, Aoki CJ, Chao MV, Froemke RC (2016) J Neurosci 36(8): 2517-35
    › Primary publication · 26911697 (PubMed) · PMC4764667 (PubMed Central)
  13. Reduced GABA neuron density in auditory cerebral cortex of subjects with major depressive disorder. Smiley JF, Hackett TA, Bleiwas C, Petkova E, Stankov A, Mann JJ, Rosoklija G, Dwork AJ (2016) J Chem Neuroanat 76(Pt B): 108-121
    › Primary publication · 26686292 (PubMed) · PMC4903945 (PubMed Central)
  14. Transcriptional maturation of the mouse auditory forebrain. Hackett TA, Guo Y, Clause A, Hackett NJ, Garbett K, Zhang P, Polley DB, Mirnics K (2015) BMC Genomics : 606
    › Primary publication · 26271746 (PubMed) · PMC4536593 (PubMed Central)
  15. Differential maturation of vesicular glutamate and GABA transporter expression in the mouse auditory forebrain during the first weeks of hearing. Hackett TA, Clause AR, Takahata T, Hackett NJ, Polley DB (2016) Brain Struct Funct 221(5): 2619-73
    › Primary publication · 26159773 (PubMed) · PMC4707137 (PubMed Central)
  16. Auditory properties in the parabelt regions of the superior temporal gyrus in the awake macaque monkey: an initial survey. Kajikawa Y, Frey S, Ross D, Falchier A, Hackett TA, Schroeder CE (2015) J Neurosci 35(10): 4140-50
    › Primary publication · 25762661 (PubMed) · PMC4355194 (PubMed Central)
  17. Anatomic organization of the auditory cortex. Hackett TA (2015) Handb Clin Neurol : 27-53
    › Primary publication · 25726261 (PubMed)
  18. Predictive motor control of sensory dynamics in auditory active sensing. Morillon B, Hackett TA, Kajikawa Y, Schroeder CE (2015) Curr Opin Neurobiol : 230-8
    › Primary publication · 25594376 (PubMed) · PMC4898262 (PubMed Central)
  19. Feedforward and feedback projections of caudal belt and parabelt areas of auditory cortex: refining the hierarchical model. Hackett TA, de la Mothe LA, Camalier CR, Falchier A, Lakatos P, Kajikawa Y, Schroeder CE (2014) Front Neurosci : 72
    › Primary publication · 24795550 (PubMed) · PMC4001064 (PubMed Central)
  20. Hemispheric asymmetry of primary auditory cortex and Heschl's gyrus in schizophrenia and nonpsychiatric brains. Smiley JF, Hackett TA, Preuss TM, Bleiwas C, Figarsky K, Mann JJ, Rosoklija G, Javitt DC, Dwork AJ (2013) Psychiatry Res 214(3): 435-43
    › Primary publication · 24148910 (PubMed) · PMC3851973 (PubMed Central)
  21. Development of myelination and cholinergic innervation in the central auditory system of a prosimian primate (Otolemur garnetti). Miller DJ, Lackey EP, Hackett TA, Kaas JH (2013) J Comp Neurol 521(16): 3804-16
    › Primary publication · 23749337 (PubMed) · PMC4120266 (PubMed Central)
  22. Differential expression of vesicular glutamate transporters 1 and 2 may identify distinct modes of glutamatergic transmission in the macaque visual system. Balaram P, Hackett TA, Kaas JH (2013) J Chem Neuroanat : 21-38
    › Primary publication · 23524295 (PubMed) · PMC3695749 (PubMed Central)
  23. Neural latencies across auditory cortex of macaque support a dorsal stream supramodal timing advantage in primates. Camalier CR, D'Angelo WR, Sterbing-D'Angelo SJ, de la Mothe LA, Hackett TA (2012) Proc Natl Acad Sci U S A 109(44): 18168-73
    › Primary publication · 23074251 (PubMed) · PMC3497796 (PubMed Central)
  24. VGLUT1 mRNA and protein expression in the visual system of prosimian galagos (Otolemur garnetti). Balaram P, Hackett TA, Kaas JH (2011) Eye Brain 2011(3): 81-98
    › Primary publication · 22912561 (PubMed) · PMC3422692 (PubMed Central)
  25. Evidence for ape and human specializations in geniculostriate projections from VGLUT2 immunohistochemistry. Bryant KL, Suwyn C, Reding KM, Smiley JF, Hackett TA, Preuss TM (2012) Brain Behav Evol 80(3): 210-21
    › Primary publication · 22889767 (PubMed) · PMC3503454 (PubMed Central)
  26. EphA signaling impacts development of topographic connectivity in auditory corticofugal systems. Torii M, Hackett TA, Rakic P, Levitt P, Polley DB (2013) Cereb Cortex 23(4): 775-85
    › Primary publication · 22490549 (PubMed) · PMC3593572 (PubMed Central)
  27. Thalamic connections of auditory cortex in marmoset monkeys: lateral belt and parabelt regions. de la Mothe LA, Blumell S, Kajikawa Y, Hackett TA (2012) Anat Rec (Hoboken) 295(5): 822-36
    › Primary publication · 22467603 (PubMed)
  28. Cortical connections of auditory cortex in marmoset monkeys: lateral belt and parabelt regions. de la Mothe LA, Blumell S, Kajikawa Y, Hackett TA (2012) Anat Rec (Hoboken) 295(5): 800-21
    › Primary publication · 22461313 (PubMed) · PMC3379817 (PubMed Central)
  29. Auditory cortical tuning to band-pass noise in primate A1 and CM: a comparison to pure tones. Kajikawa Y, Camalier CR, de la Mothe LA, D'Angelo WR, Sterbing-D'Angelo SJ, Hackett TA (2011) Neurosci Res 70(4): 401-7
    › Primary publication · 21540062 (PubMed) · PMC3130097 (PubMed Central)
  30. Linking topography to tonotopy in the mouse auditory thalamocortical circuit. Hackett TA, Barkat TR, O'Brien BM, Hensch TK, Polley DB (2011) J Neurosci 31(8): 2983-95
    › Primary publication · 21414920 (PubMed) · PMC3073837 (PubMed Central)
  31. VGLUT1 and VGLUT2 mRNA expression in the primate auditory pathway. Hackett TA, Takahata T, Balaram P (2011) Hear Res 274(1-2): 129-41
    › Primary publication · 21111036 (PubMed) · PMC3073021 (PubMed Central)
  32. Information flow in the auditory cortical network. Hackett TA (2011) Hear Res 271(1-2): 133-46
    › Primary publication · 20116421 (PubMed) · PMC3022347 (PubMed Central)
  33. Multisensory integration in auditory and auditory-related areas of cortex. Hackett TA, Schroeder CE (2009) Hear Res 258(1-2): 1-3
    › Primary publication · 19932881 (PubMed)
  34. Projection from visual areas V2 and prostriata to caudal auditory cortex in the monkey. Falchier A, Schroeder CE, Hackett TA, Lakatos P, Nascimento-Silva S, Ulbert I, Karmos G, Smiley JF (2010) Cereb Cortex 20(7): 1529-38
    › Primary publication · 19875677 (PubMed) · PMC2882821 (PubMed Central)
  35. Regional and laminar distribution of the vesicular glutamate transporter, VGluT2, in the macaque monkey auditory cortex. Hackett TA, de la Mothe LA (2009) J Chem Neuroanat 38(2): 106-16
    › Primary publication · 19446630 (PubMed) · PMC2774764 (PubMed Central)
  36. Anatomical organization of the auditory cortex. Hackett TA (2008) J Am Acad Audiol 19(10): 774-9
    › Primary publication · 19358457 (PubMed)
  37. Coding of FM sweep trains and twitter calls in area CM of marmoset auditory cortex. Kajikawa Y, de la Mothe LA, Blumell S, Sterbing-D'Angelo SJ, D'Angelo W, Camalier CR, Hackett TA (2008) Hear Res 239(1-2): 107-25
    › Primary publication · 18342463 (PubMed) · PMC2581800 (PubMed Central)
  38. Sources of somatosensory input to the caudal belt areas of auditory cortex. Hackett TA, Smiley JF, Ulbert I, Karmos G, Lakatos P, de la Mothe LA, Schroeder CE (2007) Perception 36(10): 1419-30
    › Primary publication · 18265825 (PubMed)
  39. Multisensory convergence in auditory cortex, I. Cortical connections of the caudal superior temporal plane in macaque monkeys. Smiley JF, Hackett TA, Ulbert I, Karmas G, Lakatos P, Javitt DC, Schroeder CE (2007) J Comp Neurol 502(6): 894-923
    › Primary publication · 17447261 (PubMed)
  40. Multisensory convergence in auditory cortex, II. Thalamocortical connections of the caudal superior temporal plane. Hackett TA, De La Mothe LA, Ulbert I, Karmos G, Smiley J, Schroeder CE (2007) J Comp Neurol 502(6): 924-52
    › Primary publication · 17444488 (PubMed)
  41. Fluorescent retrograde axonal tracing of the facial nerve. O'Malley MR, Wittkopf JE, Cutler JL, Labadie RF, Hackett TA, Haynes DS (2006) Laryngoscope 116(10): 1792-7
    › Primary publication · 17003730 (PubMed)
  42. Thalamic connections of the auditory cortex in marmoset monkeys: core and medial belt regions. de la Mothe LA, Blumell S, Kajikawa Y, Hackett TA (2006) J Comp Neurol 496(1): 72-96
    › Primary publication · 16528728 (PubMed) · PMC4419740 (PubMed Central)
  43. Cortical connections of the auditory cortex in marmoset monkeys: core and medial belt regions. de la Mothe LA, Blumell S, Kajikawa Y, Hackett TA (2006) J Comp Neurol 496(1): 27-71
    › Primary publication · 16528722 (PubMed)
  44. Entropy analysis of neuronal spike train synchrony. Kajikawa Y, Hackett TA (2005) J Neurosci Methods 149(1): 90-3
    › Primary publication · 16026849 (PubMed)
  45. Neurosurgical access to cortical areas in the lateral fissure of primates. Hackett TA, Karmos G, Schroeder CE, Ulbert I, Sterbing-D'Angelo SJ, D'Angelo WR, Kajikawa Y, Blumell S, de la Mothe L (2005) J Neurosci Methods 141(1): 103-13
    › Primary publication · 15585294 (PubMed)
  46. A comparison of neuron response properties in areas A1 and CM of the marmoset monkey auditory cortex: tones and broadband noise. Kajikawa Y, de La Mothe L, Blumell S, Hackett TA (2005) J Neurophysiol 93(1): 22-34
    › Primary publication · 15342713 (PubMed)
  47. Multivariate receptive field mapping in marmoset auditory cortex. Luczak A, Hackett TA, Kajikawa Y, Laubach M (2004) J Neurosci Methods 136(1): 77-85
    › Primary publication · 15126048 (PubMed)
  48. Anatomical mechanisms and functional implications of multisensory convergence in early cortical processing. Schroeder CE, Smiley J, Fu KG, McGinnis T, O'Connell MN, Hackett TA (2003) Int J Psychophysiol 50(1-2): 5-17
    › Primary publication · 14511832 (PubMed)
  49. Auditory cortical neurons respond to somatosensory stimulation. Fu KM, Johnston TA, Shah AS, Arnold L, Smiley J, Hackett TA, Garraghty PE, Schroeder CE (2003) J Neurosci 23(20): 7510-5
    › Primary publication · 12930789 (PubMed) · PMC6740753 (PubMed Central)
  50. Architectonic identification of the core region in auditory cortex of macaques, chimpanzees, and humans. Hackett TA, Preuss TM, Kaas JH (2001) J Comp Neurol 441(3): 197-222
    › Primary publication · 11745645 (PubMed)
  51. Sensory enrichment after peripheral nerve injury restores cortical, not thalamic, receptive field organization. Florence SL, Boydston LA, Hackett TA, Lachoff HT, Strata F, Niblock MM (2001) Eur J Neurosci 13(9): 1755-66
    › Primary publication · 11359527 (PubMed)
  52. Subdivisions of auditory cortex and processing streams in primates. Kaas JH, Hackett TA (2000) Proc Natl Acad Sci U S A 97(22): 11793-9
    › Primary publication · 11050211 (PubMed) · PMC34351 (PubMed Central)
  53. How the visual projection map instructs the auditory computational map. Kaas JH, Hackett TA (2000) J Comp Neurol 421(2): 143-5
    › Primary publication · 10813777 (PubMed)
  54. Thalamic and cortical contributions to neural plasticity after limb amputation. Florence SL, Hackett TA, Strata F (2000) J Neurophysiol 83(5): 3154-9
    › Primary publication · 10805710 (PubMed)
  55. 'What' and 'where' processing in auditory cortex. Kaas JH, Hackett TA (1999) Nat Neurosci 2(12): 1045-7
    › Primary publication · 10570476 (PubMed)
  56. Auditory processing in primate cerebral cortex. Kaas JH, Hackett TA, Tramo MJ (1999) Curr Opin Neurobiol 9(2): 164-70
    › Primary publication · 10322185 (PubMed)
  57. Callosal connections of the parabelt auditory cortex in macaque monkeys. Hackett TA, Stepniewska I, Kaas JH (1999) Eur J Neurosci 11(3): 856-66
    › Primary publication · 10103079 (PubMed)
  58. Prefrontal connections of the parabelt auditory cortex in macaque monkeys. Hackett TA, Stepniewska I, Kaas JH (1999) Brain Res 817(1-2): 45-58
    › Primary publication · 9889315 (PubMed)
  59. Thalamocortical connections of the parabelt auditory cortex in macaque monkeys. Hackett TA, Stepniewska I, Kaas JH (1998) J Comp Neurol 400(2): 271-86
    › Primary publication · 9766404 (PubMed)
  60. Subdivisions of auditory cortex and ipsilateral cortical connections of the parabelt auditory cortex in macaque monkeys. Hackett TA, Stepniewska I, Kaas JH (1998) J Comp Neurol 394(4): 475-95
    › Primary publication · 9590556 (PubMed)
  61. Subdivisions of auditory cortex and levels of processing in primates. Kaas JH, Hackett TA (1998) Audiol Neurootol 3(2-3): 73-85
    › Primary publication · 9575378 (PubMed)