Ariel Deutch
Last active: 3/3/2020


Central dopamine (DA) systems are critically involved in a number of neuropsychiatric disorders, including schizophrenia and Parkinson's disease. Our lab focuses on the studies of the DA innervations of prefrontal cortex and striatal complex, using a number of anatomical, biochemical and molecular approaches. Studies on the prefrontal cortical DA innervation seek to delineate the anatomical organization of the projections and to define the mechanisms through which alterations in cortical DA systems transsynaptically regulate subcortical systems. The latter studies involve two broad experimental strategies: biochemical studies aimed at characterizing the regulation of GABAergic interneurons in the cortex by DA, and examination of the regulatory changes induced in subcortical DA systems by selective destruction of the cortical DA innervations. A major effort is devoted to understanding how antipsychotic drugs, particularly atypical antipsychotic drugs, elicit their therapeutic and side effects. Studies of the DA innervation of the striatum aim to understand the progressive nature of Parkinson's disease, particularly changes in dendritic spines of neurons that receive convergent dopaminergic and glutamatergic inputs. To this end we use both structural and biochemical measures to study the plasticity of dendritic spines following striatal dopamine depletion. A third set of studies explores the mechanisms of action of hallucinogens and their ability to alter thalamocortical and corticothalamic signaling. We are particularly interested in dissociating event initiating at the thalamus or cortex determining if ability of hallucinogens to activate the cortex.


Featured publications are shown below:

  1. (Micro)Glia as Effectors of Cortical Volume Loss in Schizophrenia. Mallya AP, Deutch AY (2018) Schizophr Bull 44(5): 948-957
    › Primary publication · 30124942 (PubMed) · PMC6101531 (PubMed Central)
  2. Microglial Pruning of Synapses in the Prefrontal Cortex During Adolescence. Mallya AP, Wang HD, Lee HNR, Deutch AY (2019) Cereb Cortex 29(4): 1634-1643
    › Primary publication · 29668872 (PubMed) · PMC6418387 (PubMed Central)
  3. [F]fallypride characterization of striatal and extrastriatal D receptors in Parkinson's disease. Stark AJ, Smith CT, Petersen KJ, Trujillo P, van Wouwe NC, Donahue MJ, Kessler RM, Deutch AY, Zald DH, Claassen DO (2018) Neuroimage Clin : 433-442
    › Primary publication · 29541577 (PubMed) · PMC5849871 (PubMed Central)
  4. Organization of afferents to the orbitofrontal cortex in the rat. Murphy MJM, Deutch AY (2018) J Comp Neurol 526(9): 1498-1526
    › Primary publication · 29524205 (PubMed) · PMC5899655 (PubMed Central)
  5. Liraglutide for the Treatment of Antipsychotic Drug-Induced Weight Gain. Deutch AY (2017) JAMA Psychiatry 74(11): 1172-1173
    › Primary publication · 28973118 (PubMed)
  6. Connecting imaging mass spectrometry and magnetic resonance imaging-based anatomical atlases for automated anatomical interpretation and differential analysis. Verbeeck N, Spraggins JM, Murphy MJM, Wang HD, Deutch AY, Caprioli RM, Van de Plas R (2017) Biochim Biophys Acta Proteins Proteom 1865(7): 967-977
    › Primary publication · 28254588 (PubMed)
  7. Extending Corticostriatal Systems. Deutch AY (2016) JAMA Psychiatry 73(8): 871-2
    › Primary publication · 27367649 (PubMed)
  8. Cortical hierarchy governs rat claustrocortical circuit organization. White MG, Cody PA, Bubser M, Wang HD, Deutch AY, Mathur BN (2017) J Comp Neurol 525(6): 1347-1362
    › Primary publication · 26801010 (PubMed) · PMC4958609 (PubMed Central)
  9. Functional Connectome Analysis of Dopamine Neuron Glutamatergic Connections in Forebrain Regions. Mingote S, Chuhma N, Kusnoor SV, Field B, Deutch AY, Rayport S (2015) J Neurosci 35(49): 16259-71
    › Primary publication · 26658874 (PubMed) · PMC4682788 (PubMed Central)
  10. Editorial: The Claustrum: charting a way forward for the brain's most mysterious nucleus. Deutch AY, Mathur BN (2015) Front Syst Neurosci : 103
    › Primary publication · 26236204 (PubMed) · PMC4502348 (PubMed Central)
  11. A role for the p75 neurotrophin receptor in axonal degeneration and apoptosis induced by oxidative stress. Kraemer BR, Snow JP, Vollbrecht P, Pathak A, Valentine WM, Deutch AY, Carter BD (2014) J Biol Chem 289(31): 21205-16
    › Primary publication · 24939843 (PubMed) · PMC4118083 (PubMed Central)
  12. The thorny problem of dyskinesias: dendritic spines, synaptic plasticity, and striatal dysfunction. Deutch AY (2014) Biol Psychiatry 75(9): 676-7
    › Primary publication · 24731696 (PubMed) · PMC4120525 (PubMed Central)
  13. Dopamine denervation of the prefrontal cortex increases expression of the astrocytic glutamate transporter GLT-1. Vollbrecht PJ, Simmler LD, Blakely RD, Deutch AY (2014) J Neurochem 130(1): 109-14
    › Primary publication · 24611756 (PubMed) · PMC4065617 (PubMed Central)
  14. Antipsychotic drug-like effects of the selective M4 muscarinic acetylcholine receptor positive allosteric modulator VU0152100. Byun NE, Grannan M, Bubser M, Barry RL, Thompson A, Rosanelli J, Gowrishankar R, Kelm ND, Damon S, Bridges TM, Melancon BJ, Tarr JC, Brogan JT, Avison MJ, Deutch AY, Wess J, Wood MR, Lindsley CW, Gore JC, Conn PJ, Jones CK (2014) Neuropsychopharmacology 39(7): 1578-93
    › Primary publication · 24442096 (PubMed) · PMC4023154 (PubMed Central)
  15. REEPing the benefits of an animal model of hereditary spastic paraplegia. Deutch AY, Hedera P, Colbran RJ (2013) J Clin Invest 123(10): 4134-6
    › Primary publication · 24051371 (PubMed) · PMC3784552 (PubMed Central)
  16. Parkinson's disease redefined. Deutch AY (2013) Lancet Neurol 12(5): 422-3
    › Primary publication · 23582176 (PubMed)
  17. Genetic inhibition of CaMKII in dorsal striatal medium spiny neurons reduces functional excitatory synapses and enhances intrinsic excitability. Klug JR, Mathur BN, Kash TL, Wang HD, Matthews RT, Robison AJ, Anderson ME, Deutch AY, Lovinger DM, Colbran RJ, Winder DG (2012) PLoS One 7(9): e45323
    › Primary publication · 23028932 (PubMed) · PMC3448631 (PubMed Central)
  18. The effects of nigrostriatal dopamine depletion on the thalamic parafascicular nucleus. Kusnoor SV, Bubser M, Deutch AY (2012) Brain Res : 46-55
    › Primary publication · 22353754 (PubMed) · PMC3772731 (PubMed Central)
  19. The Cbln family of proteins interact with multiple signaling pathways. Wei P, Pattarini R, Rong Y, Guo H, Bansal PK, Kusnoor SV, Deutch AY, Parris J, Morgan JI (2012) J Neurochem 121(5): 717-29
    › Primary publication · 22220752 (PubMed) · PMC3342465 (PubMed Central)
  20. Comparison of Cbln1 and Cbln2 functions using transgenic and knockout mice. Rong Y, Wei P, Parris J, Guo H, Pattarini R, Correia K, Li L, Kusnoor SV, Deutch AY, Morgan JI (2012) J Neurochem 120(4): 528-40
    › Primary publication · 22117778 (PubMed) · PMC3259274 (PubMed Central)
  21. Age- and duration-dependent effects of MPTP on cortical serotonin systems. Ansah TA, Ferguson MC, Nayyar T, Deutch AY (2011) Neurosci Lett 504(2): 160-164
    › Primary publication · 21964387 (PubMed) · PMC3210582 (PubMed Central)
  22. Extracerebellar role for Cerebellin1: modulation of dendritic spine density and synapses in striatal medium spiny neurons. Kusnoor SV, Parris J, Muly EC, Morgan JI, Deutch AY (2010) J Comp Neurol 518(13): 2525-37
    › Primary publication · 20503425 (PubMed) · PMC2919330 (PubMed Central)
  23. Tissue-specific variation of Ube3a protein expression in rodents and in a mouse model of Angelman syndrome. Gustin RM, Bichell TJ, Bubser M, Daily J, Filonova I, Mrelashvili D, Deutch AY, Colbran RJ, Weeber EJ, Haas KF (2010) Neurobiol Dis 39(3): 283-91
    › Primary publication · 20423730 (PubMed) · PMC2922926 (PubMed Central)
  24. 5-HT2A receptor antagonists improve motor impairments in the MPTP mouse model of Parkinson's disease. Ferguson MC, Nayyar T, Deutch AY, Ansah TA (2010) Neuropharmacology 59(1-2): 31-6
    › Primary publication · 20361986 (PubMed) · PMC2878885 (PubMed Central)
  25. Cortical regulation of striatal medium spiny neuron dendritic remodeling in parkinsonism: modulation of glutamate release reverses dopamine depletion-induced dendritic spine loss. Garcia BG, Neely MD, Deutch AY (2010) Cereb Cortex 20(10): 2423-32
    › Primary publication · 20118184 (PubMed) · PMC2936803 (PubMed Central)
  26. Is the loss of thalamostriatal neurons protective in parkinsonism? Kusnoor SV, Muly EC, Morgan JI, Deutch AY (2009) Parkinsonism Relat Disord : S162-6
    › Primary publication · 20082981 (PubMed) · PMC2900831 (PubMed Central)
  27. Regionally specific effects of atypical antipsychotic drugs on striatal Fos expression: The nucleus accumbens shell as a locus of antipsychotic action. Deutch AY, Lee MC, Iadarola MJ (1992) Mol Cell Neurosci 3(4): 332-41
    › Primary publication · 19912876 (PubMed)
  28. Dystrophic dendrites in prefrontal cortical pyramidal cells of dopamine D1 and D2 but not D4 receptor knockout mice. Wang HD, Stanwood GD, Grandy DK, Deutch AY (2009) Brain Res : 58-64
    › Primary publication · 19747903 (PubMed) · PMC2783753 (PubMed Central)
  29. Combination of diOlistic labeling with retrograde tract tracing and immunohistochemistry. Neely MD, Stanwood GD, Deutch AY (2009) J Neurosci Methods 184(2): 332-6
    › Primary publication · 19712695 (PubMed) · PMC2796483 (PubMed Central)
  30. Mechanisms of action of clozapine in the treatment of neuroleptic-resistant and neuroleptic-intolerant schizophrenia. Deutch A (1995) Eur Psychiatry : 39s-46s
    › Primary publication · 19698391 (PubMed)
  31. Cortical serotonin and norepinephrine denervation in parkinsonism: preferential loss of the beaded serotonin innervation. Nayyar T, Bubser M, Ferguson MC, Neely MD, Shawn Goodwin J, Montine TJ, Deutch AY, Ansah TA (2009) Eur J Neurosci 30(2): 207-16
    › Primary publication · 19659923 (PubMed) · PMC2765981 (PubMed Central)
  32. Localization of myocyte enhancer factor 2 in the rodent forebrain: regionally-specific cytoplasmic expression of MEF2A. Neely MD, Robert EM, Baucum AJ, Colbran RJ, Muly EC, Deutch AY (2009) Brain Res : 55-65
    › Primary publication · 19362076 (PubMed) · PMC2723059 (PubMed Central)
  33. Proteomic analysis illuminates a novel structural definition of the claustrum and insula. Mathur BN, Caprioli RM, Deutch AY (2009) Cereb Cortex 19(10): 2372-9
    › Primary publication · 19168664 (PubMed) · PMC2742595 (PubMed Central)
  34. Antipsychotic drugs: comparison in animal models of efficacy, neurotransmitter regulation, and neuroprotection. Lieberman JA, Bymaster FP, Meltzer HY, Deutch AY, Duncan GE, Marx CE, Aprille JR, Dwyer DS, Li XM, Mahadik SP, Duman RS, Porter JH, Modica-Napolitano JS, Newton SS, Csernansky JG (2008) Pharmacol Rev 60(3): 358-403
    › Primary publication · 18922967 (PubMed) · PMC4821196 (PubMed Central)
  35. Novel selective allosteric activator of the M1 muscarinic acetylcholine receptor regulates amyloid processing and produces antipsychotic-like activity in rats. Jones CK, Brady AE, Davis AA, Xiang Z, Bubser M, Tantawy MN, Kane AS, Bridges TM, Kennedy JP, Bradley SR, Peterson TE, Ansari MS, Baldwin RM, Kessler RM, Deutch AY, Lah JJ, Levey AI, Lindsley CW, Conn PJ (2008) J Neurosci 28(41): 10422-33
    › Primary publication · 18842902 (PubMed) · PMC2577155 (PubMed Central)
  36. Rat meningeal and brain microvasculature pericytes co-express the vesicular glutamate transporters 2 and 3. Mathur BN, Deutch AY (2008) Neurosci Lett 435(2): 90-4
    › Primary publication · 18358609 (PubMed) · PMC3679921 (PubMed Central)
  37. Striatal plasticity and medium spiny neuron dendritic remodeling in parkinsonism. Deutch AY, Colbran RJ, Winder DJ (2007) Parkinsonism Relat Disord : S251-8
    › Primary publication · 18267246 (PubMed) · PMC4820336 (PubMed Central)
  38. Imaging mass spectrometry of proteins and peptides: 3D volume reconstruction. Andersson M, Groseclose MR, Deutch AY, Caprioli RM (2008) Nat Methods 5(1): 101-8
    › Primary publication · 18165806 (PubMed)
  39. Cortical regulation of dopamine depletion-induced dendritic spine loss in striatal medium spiny neurons. Neely MD, Schmidt DE, Deutch AY (2007) Neuroscience 149(2): 457-64
    › Primary publication · 17888581 (PubMed) · PMC2094700 (PubMed Central)
  40. The orexins/hypocretins and schizophrenia. Deutch AY, Bubser M (2007) Schizophr Bull 33(6): 1277-83
    › Primary publication · 17728265 (PubMed) · PMC2779882 (PubMed Central)
  41. Systemic administration of a proteasome inhibitor does not cause nigrostriatal dopamine degeneration. Mathur BN, Neely MD, Dyllick-Brenzinger M, Tandon A, Deutch AY (2007) Brain Res : 83-9
    › Primary publication · 17706185 (PubMed) · PMC2040265 (PubMed Central)
  42. Dopamine depletion of the prefrontal cortex induces dendritic spine loss: reversal by atypical antipsychotic drug treatment. Wang HD, Deutch AY (2008) Neuropsychopharmacology 33(6): 1276-86
    › Primary publication · 17687264 (PubMed) · PMC4753804 (PubMed Central)
  43. Glucocorticoid modulation of tryptophan hydroxylase-2 protein in raphe nuclei and 5-hydroxytryptophan concentrations in frontal cortex of C57/Bl6 mice. Clark JA, Flick RB, Pai LY, Szalayova I, Key S, Conley RK, Deutch AY, Hutson PH, Mezey E (2008) Mol Psychiatry 13(5): 498-506
    › Primary publication · 17622221 (PubMed) · PMC3392182 (PubMed Central)
  44. 5-Hydroxytryptamine2C receptor contribution to m-chlorophenylpiperazine and N-methyl-beta-carboline-3-carboxamide-induced anxiety-like behavior and limbic brain activation. Hackler EA, Turner GH, Gresch PJ, Sengupta S, Deutch AY, Avison MJ, Gore JC, Sanders-Bush E (2007) J Pharmacol Exp Ther 320(3): 1023-9
    › Primary publication · 17138863 (PubMed)
  45. Striatal plasticity in parkinsonism: dystrophic changes in medium spiny neurons and progression in Parkinson's disease. Deutch AY (2006) J Neural Transm Suppl (70): 67-70
    › Primary publication · 17017511 (PubMed)
  46. Amphetamine-elicited striatal Fos expression is attenuated in neurotensin null mutant mice. Fadel J, Dobner PR, Deutch AY (2006) Neurosci Lett 402(1-2): 97-101
    › Primary publication · 16632196 (PubMed)
  47. p90 ribosomal S6 kinase 2 exerts a tonic brake on G protein-coupled receptor signaling. Sheffler DJ, Kroeze WK, Garcia BG, Deutch AY, Hufeisen SJ, Leahy P, Brüning JC, Roth BL (2006) Proc Natl Acad Sci U S A 103(12): 4717-22
    › Primary publication · 16537434 (PubMed) · PMC1450237 (PubMed Central)
  48. Selective elimination of glutamatergic synapses on striatopallidal neurons in Parkinson disease models. Day M, Wang Z, Ding J, An X, Ingham CA, Shering AF, Wokosin D, Ilijic E, Sun Z, Sampson AR, Mugnaini E, Deutch AY, Sesack SR, Arbuthnott GW, Surmeier DJ (2006) Nat Neurosci 9(2): 251-9
    › Primary publication · 16415865 (PubMed)
  49. A channel to neurodegeneration. Deutch AY, Winder DG (2006) Nat Med 12(1): 17-8
    › Primary publication · 16397545 (PubMed)
  50. Dopamine depletion alters phosphorylation of striatal proteins in a model of Parkinsonism. Brown AM, Deutch AY, Colbran RJ (2005) Eur J Neurosci 22(1): 247-56
    › Primary publication · 16029214 (PubMed) · PMC4819997 (PubMed Central)
  51. Dopaminergic regulation of orexin neurons. Bubser M, Fadel JR, Jackson LL, Meador-Woodruff JH, Jing D, Deutch AY (2005) Eur J Neurosci 21(11): 2993-3001
    › Primary publication · 15978010 (PubMed)
  52. Neurotensin activates GABAergic interneurons in the prefrontal cortex. Petrie KA, Schmidt D, Bubser M, Fadel J, Carraway RE, Deutch AY (2005) J Neurosci 25(7): 1629-36
    › Primary publication · 15716398 (PubMed) · PMC6725935 (PubMed Central)
  53. Dendritic degeneration in neostriatal medium spiny neurons in Parkinson disease. Zaja-Milatovic S, Milatovic D, Schantz AM, Zhang J, Montine KS, Samii A, Deutch AY, Montine TJ (2005) Neurology 64(3): 545-7
    › Primary publication · 15699393 (PubMed)
  54. The neurotensin agonist PD149163 increases Fos expression in the prefrontal cortex of the rat. Petrie KA, Bubser M, Casey CD, Davis MD, Roth BL, Deutch AY (2004) Neuropsychopharmacology 29(10): 1878-88
    › Primary publication · 15150532 (PubMed)
  55. Effects of antipsychotic drugs on neurogenesis in the forebrain of the adult rat. Wang HD, Dunnavant FD, Jarman T, Deutch AY (2004) Neuropsychopharmacology 29(7): 1230-8
    › Primary publication · 15085089 (PubMed)
  56. Distribution of dopamine D2-like receptors in the human thalamus: autoradiographic and PET studies. Rieck RW, Ansari MS, Whetsell WO, Deutch AY, Kessler RM (2004) Neuropsychopharmacology 29(2): 362-72
    › Primary publication · 14627996 (PubMed)
  57. Profiling genes related to mitochondrial function in mice treated with N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Gu G, Deutch AY, Franklin J, Levy S, Wallace DC, Zhang J (2003) Biochem Biophys Res Commun 308(1): 197-205
    › Primary publication · 12890501 (PubMed)
  58. The hallucinogen 1-[2,5-dimethoxy-4-iodophenyl]-2-aminopropane (DOI) increases cortical extracellular glutamate levels in rats. Scruggs JL, Schmidt D, Deutch AY (2003) Neurosci Lett 346(3): 137-40
    › Primary publication · 12853103 (PubMed)
  59. Neurotensin: dual roles in psychostimulant and antipsychotic drug responses. Dobner PR, Deutch AY, Fadel J (2003) Life Sci 73(6): 801-11
    › Primary publication · 12801600 (PubMed)
  60. Differential activation of orexin neurons by antipsychotic drugs associated with weight gain. Fadel J, Bubser M, Deutch AY (2002) J Neurosci 22(15): 6742-6
    › Primary publication · 12151553 (PubMed) · PMC6758179 (PubMed Central)
  61. Hyperexcitability and epilepsy associated with disruption of the mouse neuronal-specific K-Cl cotransporter gene. Woo NS, Lu J, England R, McClellan R, Dufour S, Mount DB, Deutch AY, Lovinger DM, Delpire E (2002) Hippocampus 12(2): 258-68
    › Primary publication · 12000122 (PubMed)
  62. Anatomical substrates of orexin-dopamine interactions: lateral hypothalamic projections to the ventral tegmental area. Fadel J, Deutch AY (2002) Neuroscience 111(2): 379-87
    › Primary publication · 11983323 (PubMed)
  63. Differential effects of typical and atypical antipsychotic drugs on striosome and matrix compartments of the striatum. Bubser M, Deutch AY (2002) Eur J Neurosci 15(4): 713-20
    › Primary publication · 11886451 (PubMed)
  64. Neurotensin-deficient mice show altered responses to antipsychotic drugs. Dobner PR, Fadel J, Deitemeyer N, Carraway RE, Deutch AY (2001) Proc Natl Acad Sci U S A 98(14): 8048-53
    › Primary publication · 11427716 (PubMed) · PMC35465 (PubMed Central)
  65. Introduction. Deutch AY (2001) Parkinsonism Relat Disord 7(3): 163
    › Primary publication · 11331181 (PubMed)
  66. The neurotensin antagonist SR 48692 attenuates haloperidol-induced striatal Fos expression in the rat. Fadel J, Dobner PR, Deutch AY (2001) Neurosci Lett 303(1): 17-20
    › Primary publication · 11297813 (PubMed)
  67. Distribution of serotonin 5-HT(2A) receptors in afferents of the rat striatum. Bubser M, Backstrom JR, Sanders-Bush E, Roth BL, Deutch AY (2001) Synapse 39(4): 297-304
    › Primary publication · 11169779 (PubMed)
  68. DOI-Induced activation of the cortex: dependence on 5-HT2A heteroceptors on thalamocortical glutamatergic neurons. Scruggs JL, Patel S, Bubser M, Deutch AY (2000) J Neurosci 20(23): 8846-52
    › Primary publication · 11102493 (PubMed) · PMC6773058 (PubMed Central)
  69. Stoichiometry of tyrosine hydroxylase phosphorylation in the nigrostriatal and mesolimbic systems in vivo: effects of acute haloperidol and related compounds. Salvatore MF, Garcia-Espana A, Goldstein M, Deutch AY, Haycock JW (2000) J Neurochem 75(1): 225-32
    › Primary publication · 10854265 (PubMed)
  70. The distribution and origin of the calretinin-containing innervation of the nucleus accumbens of the rat. Bubser M, Scruggs JL, Young CD, Deutch AY (2000) Eur J Neurosci 12(5): 1591-8
    › Primary publication · 10792437 (PubMed)
  71. Clozapine pretreatment modifies haloperidol-elicited forebrain Fos induction: a regionally-specific double dissociation. Young CD, Bubser M, Meltzer HY, Deutch AY (1999) Psychopharmacology (Berl) 144(3): 255-63
    › Primary publication · 10435392 (PubMed)
  72. Stress induces Fos expression in neurons of the thalamic paraventricular nucleus that innervate limbic forebrain sites. Bubser M, Deutch AY (1999) Synapse 32(1): 13-22
    › Primary publication · 10188633 (PubMed)
  73. 5-HT2 receptor regulation of extracellular GABA levels in the prefrontal cortex. Abi-Saab WM, Bubser M, Roth RH, Deutch AY (1999) Neuropsychopharmacology 20(1): 92-6
    › Primary publication · 9885788 (PubMed)
  74. Psychostimulant-induced Fos protein expression in the thalamic paraventricular nucleus. Deutch AY, Bubser M, Young CD (1998) J Neurosci 18(24): 10680-7
    › Primary publication · 9852603 (PubMed) · PMC6793371 (PubMed Central)
  75. The effects of thalamic paraventricular nucleus lesions on cocaine-induced locomotor activity and sensitization. Young CD, Deutch AY (1998) Pharmacol Biochem Behav 60(3): 753-8
    › Primary publication · 9678661 (PubMed)
  76. Effects of desmethylclozapine on Fos protein expression in the forebrain: in vivo biological activity of the clozapine metabolite. Young CD, Meltzer HY, Deutch AY (1998) Neuropsychopharmacology 19(1): 99-103
    › Primary publication · 9608582 (PubMed)
  77. Dopaminergic regulation of extracellular gamma-aminobutyric acid levels in the prefrontal cortex of the rat. Grobin AC, Deutch AY (1998) J Pharmacol Exp Ther 285(1): 350-7
    › Primary publication · 9536031 (PubMed)
  78. Thalamic paraventricular nucleus neurons collateralize to innervate the prefrontal cortex and nucleus accumbens. Bubser M, Deutch AY (1998) Brain Res 787(2): 304-10
    › Primary publication · 9518661 (PubMed)
  79. Immunohistochemical studies on phosphorylation of tyrosine hydroxylase in central catecholamine neurons using site- and phosphorylation state-specific antibodies. Xu ZQ, Lew JY, Harada K, Aman K, Goldstein M, Deutch A, Haycock JW, Hökfelt T (1998) Neuroscience 82(3): 727-38
    › Primary publication · 9483531 (PubMed)
  80. Serotonin 5-HT2A receptors are expressed on pyramidal cells and interneurons in the rat cortex. Willins DL, Deutch AY, Roth BL (1997) Synapse 27(1): 79-82
    › Primary publication · 9268067 (PubMed)
  81. A functional neuroanatomy of anxiety and fear: implications for the pathophysiology and treatment of anxiety disorders. Charney DS, Deutch A (1996) Crit Rev Neurobiol 10(3-4): 419-46
    › Primary publication · 8978989 (PubMed)
  82. The effects of antipsychotic drugs on Fos protein expression in the prefrontal cortex: cellular localization and pharmacological characterization. Deutch AY, Duman RS (1996) Neuroscience 70(2): 377-89
    › Primary publication · 8848147 (PubMed)
  83. Effects of D2 dopamine receptor antagonists on Fos protein expression in the striatal complex and entorhinal cortex of the nonhuman primate. Deutch AY, Lewis DA, Whitehead RE, Elsworth JD, Iadarola MJ, Redmond DE, Roth RH (1996) Synapse 23(3): 182-91
    › Primary publication · 8807746 (PubMed)
  84. Psychobiologic mechanisms of posttraumatic stress disorder. Charney DS, Deutch AY, Krystal JH, Southwick SM, Davis M (1993) Arch Gen Psychiatry 50(4): 295-305
    › Primary publication · 8466391 (PubMed)
  85. The patterns of afferent innervation of the core and shell in the "accumbens" part of the rat ventral striatum: immunohistochemical detection of retrogradely transported fluoro-gold. Brog JS, Salyapongse A, Deutch AY, Zahm DS (1993) J Comp Neurol 338(2): 255-78
    › Primary publication · 8308171 (PubMed)
  86. The effects of haloperidol and clozapine on extracellular GABA levels in the prefrontal cortex of the rat: an in vivo microdialysis study. Bourdelais AJ, Deutch AY (1994) Cereb Cortex 4(1): 69-77
    › Primary publication · 8180492 (PubMed)
  87. Prefrontal cortical dopamine systems and the elaboration of functional corticostriatal circuits: implications for schizophrenia and Parkinson's disease. Deutch AY (1993) J Neural Transm Gen Sect 91(2-3): 197-221
    › Primary publication · 8099797 (PubMed)
  88. Identification of the neural systems subserving the actions of clozapine: clues from immediate-early gene expression. Deutch AY (1994) J Clin Psychiatry : 37-42
    › Primary publication · 7961570 (PubMed)
  89. Regulation of cortical and subcortical glutamate receptor subunit expression by antipsychotic drugs. Fitzgerald LW, Deutch AY, Gasic G, Heinemann SF, Nestler EJ (1995) J Neurosci 15(3 Pt 2): 2453-61
    › Primary publication · 7891180 (PubMed) · PMC6578121 (PubMed Central)
  90. 5-HT1a agonist +/-8-OH-DPAT modulates basal and stress-induced changes in medial prefrontal cortical dopamine. Rasmusson AM, Goldstein LE, Deutch AY, Bunney BS, Roth RH (1994) Synapse 18(3): 218-24
    › Primary publication · 7855734 (PubMed)
  91. Antibodies to a segment of tyrosine hydroxylase phosphorylated at serine 40. Goldstein M, Lee KY, Lew JY, Harada K, Wu J, Haycock JW, Hokfelt T, Deutch AY (1995) J Neurochem 64(5): 2281-7
    › Primary publication · 7722513 (PubMed)
  92. Antipsychotic drugs induce Fos protein in the thalamic paraventricular nucleus: a novel locus of antipsychotic drug action. Deutch AY, Ongür D, Duman RS (1995) Neuroscience 66(2): 337-46
    › Primary publication · 7477876 (PubMed)
  93. Mesencephalic dopamine modulation of pituitary and central beta-endorphin: relation to food intake regulation. Deutch AY, Martin RJ (1983) Life Sci 33(3): 281-7
    › Primary publication · 6865661 (PubMed)
  94. Kainic acid stimulation of the lateral septum elicits tachycardia. Deutch AY, Clark LS, Peacock LJ (1984) Brain Res Bull 12(3): 209-14
    › Primary publication · 6144375 (PubMed)
  95. Footshock and conditioned stress increase 3,4-dihydroxyphenylacetic acid (DOPAC) in the ventral tegmental area but not substantia nigra. Deutch AY, Tam SY, Roth RH (1985) Brain Res 333(1): 143-6
    › Primary publication · 3995282 (PubMed)
  96. Activation of the locus coeruleus induced by selective stimulation of the ventral tegmental area. Deutch AY, Goldstein M, Roth RH (1986) Brain Res 363(2): 307-14
    › Primary publication · 3942901 (PubMed)
  97. Uptake and utilization of metabolites in specific brain sites relative to feeding status. Kasser TR, Deutch A, Martin RJ (1986) Physiol Behav 36(6): 1161-5
    › Primary publication · 3725921 (PubMed)
  98. Mesolimbic and mesocortical dopamine activation induced by phencyclidine: contrasting pattern to striatal response. Deutch AY, Tam SY, Freeman AS, Bowers MB, Roth RH (1987) Eur J Pharmacol 134(3): 257-64
    › Primary publication · 3569414 (PubMed)
  99. Calcitonin gene-related peptide in the ventral tegmental area: selective modulation of prefrontal cortical dopamine metabolism. Deutch AY, Roth RH (1987) Neurosci Lett 74(2): 169-74
    › Primary publication · 3554009 (PubMed)
  100. Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on catecholamines and metabolites in primate brain and CSF. Elsworth JD, Deutch AY, Redmond DE, Sladek JR, Roth RH (1987) Brain Res 415(2): 293-9
    › Primary publication · 3496938 (PubMed)
  101. Transplantation of fetal dopamine neurons in primate brain reverses MPTP induced parkinsonism. Sladek JR, Redmond DE, Collier TJ, Haber SN, Elsworth JD, Deutch AY, Roth RH (1987) Prog Brain Res : 309-23
    › Primary publication · 3495818 (PubMed)
  102. Differential responsiveness to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity in sub-regions of the primate substantia nigra and striatum. Elsworth JD, Deutch AY, Redmond DE, Sladek JR, Roth RH (1987) Life Sci 40(2): 193-202
    › Primary publication · 3491946 (PubMed)
  103. Preferential vulnerability of A8 dopamine neurons in the primate to the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Deutch AY, Elsworth JD, Goldstein M, Fuxe K, Redmond DE, Sladek JR, Roth RH (1986) Neurosci Lett 68(1): 51-6
    › Primary publication · 3487756 (PubMed)
  104. Immunohistochemical localization of a neuronal nicotinic acetylcholine receptor in mammalian brain. Deutch AY, Holliday J, Roth RH, Chun LL, Hawrot E (1987) Proc Natl Acad Sci U S A 84(23): 8697-701
    › Primary publication · 3317419 (PubMed) · PMC299613 (PubMed Central)
  105. Stress and the mesocorticolimbic dopamine systems. Roth RH, Tam SY, Ida Y, Yang JX, Deutch AY (1988) Ann N Y Acad Sci : 138-47
    › Primary publication · 3059920 (PubMed)
  106. Biochemical analysis of caudate nucleus biopsy samples from parkinsonian patients. Goldstein M, Lieberman AN, Helmer E, Koslow M, Ransohoff J, Elsworth JD, Roth RH, Deutch AY (1988) Ann Neurol 24(5): 685-8
    › Primary publication · 2904793 (PubMed)
  107. Regulation of A8 dopamine neurons by somatostatin. Deutch AY, Bean AJ, Roth RH (1988) Eur J Pharmacol 147(2): 317-20
    › Primary publication · 2896598 (PubMed)
  108. Stress-induced alterations in neurotensin, somatostatin and corticotropin-releasing factor in mesotelencephalic dopamine system regions. Deutch AY, Bean AJ, Bissette G, Nemeroff CB, Robbins RJ, Roth RH (1987) Brain Res 417(2): 350-4
    › Primary publication · 2888514 (PubMed)
  109. Reversal of parkinsonism by fetal nerve cell transplants in primate brain. Sladek JR, Collier TJ, Haber SN, Deutch AY, Elsworth JD, Roth RH, Redmond DE (1987) Ann N Y Acad Sci : 641-57
    › Primary publication · 2886092 (PubMed)
  110. The ascending projections of the dopaminergic neurons of the substantia nigra, zona reticulata: a combined retrograde tracer-immunohistochemical study. Deutch AY, Goldstein M, Roth RH (1986) Neurosci Lett 71(3): 257-63
    › Primary publication · 2879262 (PubMed)
  111. Transplants of primate neurons. Redmond DE, Sladek JR, Roth RH, Collier TJ, Elsworth JD, Deutch AY, Haber S (1986) Lancet 2(8514): 1046
    › Primary publication · 2877218 (PubMed)
  112. Fetal neuronal grafts in monkeys given methylphenyltetrahydropyridine. Redmond DE, Sladek JR, Roth RH, Collier TJ, Elsworth JD, Deutch AY, Haber S (1986) Lancet 1(8490): 1125-7
    › Primary publication · 2871381 (PubMed)
  113. The anxiogenic beta-carboline FG-7142 increases in vivo and in vitro tyrosine hydroxylation in the prefrontal cortex. Knorr AM, Deutch AY, Roth RH (1989) Brain Res 495(2): 355-61
    › Primary publication · 2765936 (PubMed)
  114. The effects of perinatal diazepam exposure on stress-induced activation of the mesotelencephalic dopamine system. Deutch AY, Gruen RJ, Roth RH (1989) Neuropsychopharmacology 2(2): 105-14
    › Primary publication · 2742725 (PubMed)
  115. Controlled release of dopamine from a polymeric brain implant: in vivo characterization. During MJ, Freese A, Sabel BA, Saltzman WM, Deutch A, Roth RH, Langer R (1989) Ann Neurol 25(4): 351-6
    › Primary publication · 2634975 (PubMed)
  116. Symptomatic and asymptomatic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated primates: biochemical changes in striatal regions. Elsworth JD, Deutch AY, Redmond DE, Taylor JR, Sladek JR, Roth RH (1989) Neuroscience 33(2): 323-31
    › Primary publication · 2622529 (PubMed)
  117. Effects of dopamine depletion on striatal neurotensin: biochemical and immunohistochemical studies. Bean AJ, During MJ, Deutch AY, Roth RH (1989) J Neurosci 9(12): 4430-8
    › Primary publication · 2593006 (PubMed) · PMC6569647 (PubMed Central)
  118. Topographical organization of the efferent projections of the medial prefrontal cortex in the rat: an anterograde tract-tracing study with Phaseolus vulgaris leucoagglutinin. Sesack SR, Deutch AY, Roth RH, Bunney BS (1989) J Comp Neurol 290(2): 213-42
    › Primary publication · 2592611 (PubMed)
  119. Morphological, neurochemical, and behavioral characterizations associated with the combined treatment of diethyldithiocarbamate and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice. Yurek DM, Deutch AY, Roth RH, Sladek JR (1989) Brain Res 497(2): 250-9
    › Primary publication · 2573405 (PubMed)
  120. Antibodies to a synthetic peptide corresponding to a Ser-40-containing segment of tyrosine hydroxylase: activation and immunohistochemical localization of tyrosine hydroxylase. Lee KY, Lew JY, Tang D, Schlesinger DH, Deutch AY, Goldstein M (1989) J Neurochem 53(4): 1238-44
    › Primary publication · 2570128 (PubMed)
  121. 3-Acetylpyridine-induced degeneration of the nigrostriatal dopamine system: an animal model of olivopontocerebellar atrophy-associated parkinsonism. Deutch AY, Rosin DL, Goldstein M, Roth RH (1989) Exp Neurol 105(1): 1-9
    › Primary publication · 2568269 (PubMed)
  122. Regionally-specific alterations in mesotelencephalic dopamine synthesis in diabetic rats: association with precursor tyrosine. Bradberry CW, Karasic DH, Deutch AY, Roth RH (1989) J Neural Transm Gen Sect 78(3): 221-9
    › Primary publication · 2529883 (PubMed)
  123. Telencephalic projections of the A8 dopamine cell group. Deutch AY, Goldstein M, Baldino F, Roth RH (1988) Ann N Y Acad Sci : 27-50
    › Primary publication · 2462395 (PubMed)
  124. Mild footshock stress dissociates substance P from substance K and dynorphin from Met- and Leu-enkephalin. Bannon MJ, Deutch AY, Tam SY, Zamir N, Eskay RL, Lee JM, Maggio JE, Roth RH (1986) Brain Res 381(2): 393-6
    › Primary publication · 2428438 (PubMed)
  125. Substance K and substance P differentially modulate mesolimbic and mesocortical systems. Deutch AY, Maggio JE, Bannon MJ, Kalivas PW, Tam SY, Goldstein M, Roth RH (1985) Peptides : 113-22
    › Primary publication · 2417207 (PubMed)
  126. Substance K and substance P in the ventral tegmental area. Kalivas PW, Deutch AY, Maggio JE, Mantyh PW, Roth RH (1985) Neurosci Lett 57(3): 241-6
    › Primary publication · 2412193 (PubMed)
  127. MPTP reduces dopamine and norepinephrine concentrations in the supplementary motor area and cingulate cortex of the primate. Elsworth JD, Deutch AY, Redmond DE, Sladek JR, Roth RH (1990) Neurosci Lett 114(3): 316-22
    › Primary publication · 2402341 (PubMed)
  128. A cautionary note on the potential benefits of striatal dopamine implants. Deutch AY, During MJ (1990) Ann Neurol 28(1): 111
    › Primary publication · 2375628 (PubMed)
  129. MPTP-induced parkinsonism: relative changes in dopamine concentration in subregions of substantia nigra, ventral tegmental area and retrorubral field of symptomatic and asymptomatic vervet monkeys. Elsworth JD, Deutch AY, Redmond DE, Sladek JR, Roth RH (1990) Brain Res 513(2): 320-4
    › Primary publication · 2350702 (PubMed)
  130. Perinatal diazepam exposure: alterations in exploratory behavior and mesolimbic dopamine turnover. Gruen RJ, Deutch AY, Roth RH (1990) Pharmacol Biochem Behav 36(1): 169-75
    › Primary publication · 2349259 (PubMed)
  131. 3-Acetylpyridine results in degeneration of the extrapyramidal and cerebellar motor systems: loss of the dorsolateral striatal dopamine innervation. Deutch AY, Elsworth JD, Roth RH, Goldstein M, Deutsch AY (1990) Brain Res 527(1): 96-102
    › Primary publication · 2126479 (PubMed)
  132. Prefrontal cortical dopamine depletion enhances the responsiveness of mesolimbic dopamine neurons to stress. Deutch AY, Clark WA, Roth RH (1990) Brain Res 521(1-2): 311-5
    › Primary publication · 2119850 (PubMed)
  133. The determinants of stress-induced activation of the prefrontal cortical dopamine system. Deutch AY, Roth RH (1990) Prog Brain Res : 367-402; discussion 402-3
    › Primary publication · 2094906 (PubMed)
  134. Cryopreservation of human brain tissue. Robbins RJ, Torres-Aleman I, Lebranth C, Bradberry CW, Deutch AY, Welsh S, Roth RH, Spencer D, Redmond DE, Naftolin F (1990) Exp Neurol 107(3): 208-13
    › Primary publication · 1968397 (PubMed)
  135. Hypertrophy of dopamine neurons in the primate following ventromedial mesencephalic tegmentum lesion. Janson AM, Fuxe K, Goldstein M, Deutch AY (1991) Exp Brain Res 87(1): 232-8
    › Primary publication · 1756831 (PubMed)
  136. Biochemical and behavioral recovery in a rodent model of Parkinson's disease following stereotactic implantation of dopamine-containing liposomes. During MJ, Freese A, Deutch AY, Kibat PG, Sabel BA, Langer R, Roth RH (1992) Exp Neurol 115(2): 193-9
    › Primary publication · 1735466 (PubMed)
  137. Mechanisms of action of atypical antipsychotic drugs. Implications for novel therapeutic strategies for schizophrenia. Deutch AY, Moghaddam B, Innis RB, Krystal JH, Aghajanian GK, Bunney BS, Charney DS (1991) Schizophr Res 4(2): 121-56
    › Primary publication · 1674882 (PubMed)
  138. Stress selectively increases fos protein in dopamine neurons innervating the prefrontal cortex. Deutch AY, Lee MC, Gillham MH, Cameron DA, Goldstein M, Iadarola MJ (1991) Cereb Cortex 1(4): 273-92
    › Primary publication · 1668366 (PubMed)
  139. The regulation of subcortical dopamine systems by the prefrontal cortex: interactions of central dopamine systems and the pathogenesis of schizophrenia. Deutch AY (1992) J Neural Transm Suppl : 61-89
    › Primary publication · 1527521 (PubMed)
  140. Regulation of the prefrontal cortical dopamine system by the neuroactive steroid 3a,21-dihydroxy-5a-pregnane-20-one. Grobin AC, Roth RH, Deutch AY (1992) Brain Res 578(1-2): 351-6
    › Primary publication · 1511287 (PubMed)
  141. Functional expression and CNS distribution of a beta-alanine-sensitive neuronal GABA transporter. Clark JA, Deutch AY, Gallipoli PZ, Amara SG (1992) Neuron 9(2): 337-48
    › Primary publication · 1497897 (PubMed)
  142. Amygdala kindling potentiates seizure-stimulated immediate-early gene expression in rat cerebral cortex. Duman RS, Craig JS, Winston SM, Deutch AY, Hernandez TD (1992) J Neurochem 59(5): 1753-60
    › Primary publication · 1402920 (PubMed)
  143. The current status of neurotensin-dopamine interactions. Issues and speculations. Deutch AY, Zahm DS (1992) Ann N Y Acad Sci : 232-52
    › Primary publication · 1361115 (PubMed)
  144. Effects of 6-hydroxydopamine lesions of the prefrontal cortex on tyrosine hydroxylase activity in mesolimbic and nigrostriatal dopamine systems. Rosin DL, Clark WA, Goldstein M, Roth RH, Deutch AY (1992) Neuroscience 48(4): 831-9
    › Primary publication · 1352864 (PubMed)
  145. Pharmacological characterization of dopamine systems in the nucleus accumbens core and shell. Deutch AY, Cameron DS (1992) Neuroscience 46(1): 49-56
    › Primary publication · 1350665 (PubMed)
  146. Dopaminergic mechanisms in the pathogenesis of schizophrenia. Goldstein M, Deutch AY (1992) FASEB J 6(7): 2413-21
    › Primary publication · 1348713 (PubMed)
  147. Topography and functional role of dopaminergic projections from the ventral mesencephalic tegmentum to the ventral pallidum. Klitenick MA, Deutch AY, Churchill L, Kalivas PW (1992) Neuroscience 50(2): 371-86
    › Primary publication · 1279461 (PubMed)