James West
Last active: 4/2/2019

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Publications

The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. Low-grade albuminuria in pulmonary arterial hypertension. Nickel NP, de Jesus Perez VA, Zamanian RT, Fessel JP, Cogan JD, Hamid R, West JD, de Caestecker MP, Yang H, Austin ED (2019) Pulm Circ 9(2): 2045894018824564
    › Primary publication · 30632900 (PubMed) · PMC6557031 (PubMed Central)
  2. Human PAH is characterized by a pattern of lipid-related insulin resistance. Hemnes AR, Luther JM, Rhodes CJ, Burgess JP, Carlson J, Fan R, Fessel JP, Fortune N, Gerszten RE, Halliday SJ, Hekmat R, Howard L, Newman JH, Niswender KD, Pugh ME, Robbins IM, Sheng Q, Shibao CA, Shyr Y, Sumner S, Talati M, Wharton J, Wilkins MR, Ye F, Yu C, West J, Brittain EL (2019) JCI Insight 4(1)
    › Primary publication · 30626738 (PubMed) · PMC6485674 (PubMed Central)
  3. Bone Marrow-Derived Proangiogenic Cells Mediate Pulmonary Arteriole Stiffening via Serotonin 2B Receptor Dependent Mechanism. Bloodworth NC, Clark CR, West JD, Snider JC, Gaskill C, Shay S, Scott C, Bastarache J, Gladson S, Moore C, D'Amico R, Brittain EL, Tanjore H, Blackwell TS, Majka SM, Merryman WD (2018) Circ Res 123(12): e51-e64
    › Primary publication · 30566041 (PubMed) · PMC6309812 (PubMed Central)
  4. A checkpoint on innate myeloid cells in pulmonary arterial hypertension. Bryant AJ, Fu C, Lu Y, Brantly ML, Mehrad B, Moldawer LL, Brusko TM, Brittain EL, West JD, Austin ED, Hamid R (2019) Pulm Circ 9(1): 2045894018823528
    › Primary publication · 30562157 (PubMed) · PMC6329033 (PubMed Central)
  5. Adverse physiologic effects of Western diet on right ventricular structure and function: role of lipid accumulation and metabolic therapy. Brittain EL, Talati M, Fortune N, Agrawal V, Meoli DF, West J, Hemnes AR (2019) Pulm Circ 9(1): 2045894018817741
    › Primary publication · 30451070 (PubMed) · PMC6295706 (PubMed Central)
  6. Pulmonary Vascular Platform Models the Effects of Flow and Pressure on Endothelial Dysfunction in Associated Pulmonary Arterial Hypertension. D'Amico RW, Faley S, Shim HN, Prosser JR, Agrawal V, Bellan LM, West JD (2018) Int J Mol Sci 19(9)
    › Primary publication · 30158434 (PubMed) · PMC6164056 (PubMed Central)
  7. Clinical and genetic associations with prostacyclin response in pulmonary arterial hypertension. Halliday SJ, Xu M, Thayer TE, Mosley JD, Sheng Q, Ye F, Farber-Eger EH, Pugh ME, Robbins IR, Assad TR, West JD, Brittain EL, Hemnes AR (2018) Pulm Circ 8(4): 2045894018800544
    › Primary publication · 30142026 (PubMed) · PMC6134494 (PubMed Central)
  8. Ubiquitin chains: a new way of screening for regulatory differences in pulmonary hypertension. Rathinasabapathy A, West JD (2018) Pulm Circ 8(3): 2045894018796782
    › Primary publication · 30124137 (PubMed) · PMC6109854 (PubMed Central)
  9. Myeloid-Derived Suppressor Cells and Pulmonary Hypertension. Bryant AJ, Mehrad B, Brusko TM, West JD, Moldawer LL (2018) Int J Mol Sci 19(8)
    › Primary publication · 30081463 (PubMed) · PMC6121540 (PubMed Central)
  10. A potential therapeutic role for angiotensin-converting enzyme 2 in human pulmonary arterial hypertension. Hemnes AR, Rathinasabapathy A, Austin EA, Brittain EL, Carrier EJ, Chen X, Fessel JP, Fike CD, Fong P, Fortune N, Gerszten RE, Johnson JA, Kaplowitz M, Newman JH, Piana R, Pugh ME, Rice TW, Robbins IM, Wheeler L, Yu C, Loyd JE, West J (2018) Eur Respir J 51(6)
    › Primary publication · 29903860 (PubMed) · PMC6613216 (PubMed Central)
  11. rhACE2 Therapy Modifies Bleomycin-Induced Pulmonary Hypertension via Rescue of Vascular Remodeling. Rathinasabapathy A, Bryant AJ, Suzuki T, Moore C, Shay S, Gladson S, West JD, Carrier EJ (2018) Front Physiol : 271
    › Primary publication · 29731719 (PubMed) · PMC5922219 (PubMed Central)
  12. JNK2 regulates vascular remodeling in pulmonary hypertension. Das M, Zawada WM, West J, Stenmark KR (2018) Pulm Circ 8(3): 2045894018778156
    › Primary publication · 29718758 (PubMed) · PMC6055330 (PubMed Central)
  13. The Selective Angiotensin II Type 2 Receptor Agonist, Compound 21, Attenuates the Progression of Lung Fibrosis and Pulmonary Hypertension in an Experimental Model of Bleomycin-Induced Lung Injury. Rathinasabapathy A, Horowitz A, Horton K, Kumar A, Gladson S, Unger T, Martinez D, Bedse G, West J, Raizada MK, Steckelings UM, Sumners C, Katovich MJ, Shenoy V (2018) Front Physiol : 180
    › Primary publication · 29636695 (PubMed) · PMC5881224 (PubMed Central)
  14. Precision Modeling of Pulmonary Hypertension Pathology with Induced Pluripotent Stem Cell-derived Cells. West JD, Carrier EJ (2018) Am J Respir Crit Care Med 198(2): 154-155
    › Primary publication · 29596760 (PubMed) · PMC6058992 (PubMed Central)
  15. Upregulation of SERT and ADORA1 in broilers with acute right ventricular failure. Kamely M, Karimi Torshizi MA, Wideman RF, West J (2017) Res Vet Sci
    › Primary publication · 29174607 (PubMed)
  16. Vildagliptin ameliorates pulmonary fibrosis in lipopolysaccharide-induced lung injury by inhibiting endothelial-to-mesenchymal transition. Suzuki T, Tada Y, Gladson S, Nishimura R, Shimomura I, Karasawa S, Tatsumi K, West J (2017) Respir Res 18(1): 177
    › Primary publication · 29037205 (PubMed) · PMC5644255 (PubMed Central)
  17. Isolation and characterization of endothelial-to-mesenchymal transition cells in pulmonary arterial hypertension. Suzuki T, Carrier EJ, Talati MH, Rathinasabapathy A, Chen X, Nishimura R, Tada Y, Tatsumi K, West J (2018) Am J Physiol Lung Cell Mol Physiol 314(1): L118-L126
    › Primary publication · 28935639 (PubMed) · PMC5866427 (PubMed Central)
  18. A disease-associated frameshift mutation in caveolin-1 disrupts caveolae formation and function through introduction of a de novo ER retention signal. Copeland CA, Han B, Tiwari A, Austin ED, Loyd JE, West JD, Kenworthy AK (2017) Mol Biol Cell 28(22): 3095-3111
    › Primary publication · 28904206 (PubMed) · PMC5662265 (PubMed Central)
  19. Oestrogen inhibition reverses pulmonary arterial hypertension and associated metabolic defects. Chen X, Austin ED, Talati M, Fessel JP, Farber-Eger EH, Brittain EL, Hemnes AR, Loyd JE, West J (2017) Eur Respir J 50(2)
    › Primary publication · 28775043 (PubMed) · PMC6532788 (PubMed Central)
  20. The Relationship of Bone Mineral Density in Men with Chronic Obstructive Pulmonary Disease Classified According to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) Combined Chronic Obstructive Pulmonary Disease (COPD) Assessment System. Sakurai-Iesato Y, Kawata N, Tada Y, Iesato K, Matsuura Y, Yahaba M, Suzuki T, Ikari J, Yanagawa N, Kasahara Y, West J, Tatsumi K (2017) Intern Med 56(14): 1781-1790
    › Primary publication · 28717072 (PubMed) · PMC5548669 (PubMed Central)
  21. Pulmonary vascular effect of insulin in a rodent model of pulmonary arterial hypertension. Trammell AW, Talati M, Blackwell TR, Fortune NL, Niswender KD, Fessel JP, Newman JH, West JD, Hemnes AR (2017) Pulm Circ 7(3): 624-634
    › Primary publication · 28704134 (PubMed) · PMC5841889 (PubMed Central)
  22. Dysfunctional BMPR2 signaling drives an abnormal endothelial requirement for glutamine in pulmonary arterial hypertension. Egnatchik RA, Brittain EL, Shah AT, Fares WH, Ford HJ, Monahan K, Kang CJ, Kocurek EG, Zhu S, Luong T, Nguyen TT, Hysinger E, Austin ED, Skala MC, Young JD, Roberts LJ, Hemnes AR, West J, Fessel JP (2017) Pulm Circ 7(1): 186-199
    › Primary publication · 28680578 (PubMed) · PMC5448547 (PubMed Central)
  23. Kidney dysfunction in patients with pulmonary arterial hypertension. Nickel NP, O'Leary JM, Brittain EL, Fessel JP, Zamanian RT, West JD, Austin ED (2017) Pulm Circ 7(1): 38-54
    › Primary publication · 28680564 (PubMed) · PMC5448543 (PubMed Central)
  24. Disruption of lineage specification in adult pulmonary mesenchymal progenitor cells promotes microvascular dysfunction. Gaskill CF, Carrier EJ, Kropski JA, Bloodworth NC, Menon S, Foronjy RF, Taketo MM, Hong CC, Austin ED, West JD, Means AL, Loyd JE, Merryman WD, Hemnes AR, De Langhe S, Blackwell TS, Klemm DJ, Majka SM (2017) J Clin Invest 127(6): 2262-2276
    › Primary publication · 28463231 (PubMed) · PMC5451236 (PubMed Central)
  25. Genotype-phenotype effects of mutations on disease severity in mouse models of pulmonary hypertension. Frump AL, Datta A, Ghose S, West J, de Caestecker MP (2016) Pulm Circ 6(4): 597-607
    › Primary publication · 28090303 (PubMed) · PMC5210048 (PubMed Central)
  26. Genome Editing in Large Animals. West J, Gill WW (2016) J Equine Vet Sci : 1-6
    › Primary publication · 27766006 (PubMed) · PMC5067081 (PubMed Central)
  27. Novel signaling pathways in pulmonary arterial hypertension (2015 Grover Conference Series). Awad KS, West JD, de Jesus Perez V, MacLean M (2016) Pulm Circ 6(3): 285-94
    › Primary publication · 27683605 (PubMed) · PMC5019081 (PubMed Central)
  28. Scavengers of reactive γ-ketoaldehydes extend Caenorhabditis elegans lifespan and healthspan through protein-level interactions with SIR-2.1 and ETS-7. Nguyen TT, Caito SW, Zackert WE, West JD, Zhu S, Aschner M, Fessel JP, Roberts LJ (2016) Aging (Albany NY) 8(8): 1759-80
    › Primary publication · 27514077 (PubMed) · PMC5032694 (PubMed Central)
  29. Reply: Expanded Role for Bone Marrow-derived Hematopoietic Stem and Progenitor Cells in Pulmonary Arterial Hypertension. Yan L, West J, Hamid R (2016) Am J Respir Crit Care Med 194(3): 384-5
    › Primary publication · 27479065 (PubMed) · PMC4970599 (PubMed Central)
  30. Translational Advances in the Field of Pulmonary Hypertension Molecular Medicine of Pulmonary Arterial Hypertension. From Population Genetics to Precision Medicine and Gene Editing. Austin ED, West J, Loyd JE, Hemnes AR (2017) Am J Respir Crit Care Med 195(1): 23-31
    › Primary publication · 27398627 (PubMed) · PMC5214922 (PubMed Central)
  31. Antagonism of the thromboxane-prostanoid receptor is cardioprotective against right ventricular pressure overload. West JD, Voss BM, Pavliv L, de Caestecker M, Hemnes AR, Carrier EJ (2016) Pulm Circ 6(2): 211-23
    › Primary publication · 27252848 (PubMed) · PMC4869926 (PubMed Central)
  32. Endothelial-to-mesenchymal transition in lipopolysaccharide-induced acute lung injury drives a progenitor cell-like phenotype. Suzuki T, Tada Y, Nishimura R, Kawasaki T, Sekine A, Urushibara T, Kato F, Kinoshita T, Ikari J, West J, Tatsumi K (2016) Am J Physiol Lung Cell Mol Physiol 310(11): L1185-98
    › Primary publication · 27106288 (PubMed)
  33. Mechanisms of Lipid Accumulation in the Bone Morphogenetic Protein Receptor Type 2 Mutant Right Ventricle. Talati MH, Brittain EL, Fessel JP, Penner N, Atkinson J, Funke M, Grueter C, Jerome WG, Freeman M, Newman JH, West J, Hemnes AR (2016) Am J Respir Crit Care Med 194(6): 719-28
    › Primary publication · 27077479 (PubMed) · PMC5027228 (PubMed Central)
  34. Fatty Acid Metabolic Defects and Right Ventricular Lipotoxicity in Human Pulmonary Arterial Hypertension. Brittain EL, Talati M, Fessel JP, Zhu H, Penner N, Calcutt MW, West JD, Funke M, Lewis GD, Gerszten RE, Hamid R, Pugh ME, Austin ED, Newman JH, Hemnes AR (2016) Circulation 133(20): 1936-44
    › Primary publication · 27006481 (PubMed) · PMC4870107 (PubMed Central)
  35. The Endothelial Prolyl-4-Hydroxylase Domain 2/Hypoxia-Inducible Factor 2 Axis Regulates Pulmonary Artery Pressure in Mice. Kapitsinou PP, Rajendran G, Astleford L, Michael M, Schonfeld MP, Fields T, Shay S, French JL, West J, Haase VH (2016) Mol Cell Biol 36(10): 1584-94
    › Primary publication · 26976644 (PubMed) · PMC4859687 (PubMed Central)
  36. Critical Genomic Networks and Vasoreactive Variants in Idiopathic Pulmonary Arterial Hypertension. Hemnes AR, Zhao M, West J, Newman JH, Rich S, Archer SL, Robbins IM, Blackwell TS, Cogan J, Loyd JE, Zhao Z, Gaskill C, Jetter C, Kropski JA, Majka SM, Austin ED (2016) Am J Respir Crit Care Med 194(4): 464-75
    › Primary publication · 26926454 (PubMed) · PMC5003329 (PubMed Central)
  37. Serotonin 2B Receptor Antagonism Prevents Heritable Pulmonary Arterial Hypertension. West JD, Carrier EJ, Bloodworth NC, Schroer AK, Chen P, Ryzhova LM, Gladson S, Shay S, Hutcheson JD, Merryman WD (2016) PLoS One 11(2): e0148657
    › Primary publication · 26863209 (PubMed) · PMC4749293 (PubMed Central)
  38. Expression of mutant bone morphogenetic protein receptor II worsens pulmonary hypertension secondary to pulmonary fibrosis. Bryant AJ, Robinson LJ, Moore CS, Blackwell TR, Gladson S, Penner NL, Burman A, McClellan LJ, Polosukhin VV, Tanjore H, McConaha ME, Gleaves LA, Talati MA, Hemnes AR, Fessel JP, Lawson WE, Blackwell TS, West JD (2015) Pulm Circ 5(4): 681-90
    › Primary publication · 26697175 (PubMed) · PMC4671742 (PubMed Central)
  39. Redox biology in pulmonary arterial hypertension (2013 Grover Conference Series). Fessel JP, West JD (2015) Pulm Circ 5(4): 599-609
    › Primary publication · 26697167 (PubMed) · PMC4671734 (PubMed Central)
  40. Bone Marrow-derived Cells Contribute to the Pathogenesis of Pulmonary Arterial Hypertension. Yan L, Chen X, Talati M, Nunley BW, Gladson S, Blackwell T, Cogan J, Austin E, Wheeler F, Loyd J, West J, Hamid R (2016) Am J Respir Crit Care Med 193(8): 898-909
    › Primary publication · 26651104 (PubMed) · PMC4849178 (PubMed Central)
  41. Endothelial HIF signaling regulates pulmonary fibrosis-associated pulmonary hypertension. Bryant AJ, Carrick RP, McConaha ME, Jones BR, Shay SD, Moore CS, Blackwell TR, Gladson S, Penner NL, Burman A, Tanjore H, Hemnes AR, Karwandyar AK, Polosukhin VV, Talati MA, Dong HJ, Gleaves LA, Carrier EJ, Gaskill C, Scott EW, Majka SM, Fessel JP, Haase VH, West JD, Blackwell TS, Lawson WE (2016) Am J Physiol Lung Cell Mol Physiol 310(3): L249-62
    › Primary publication · 26637636 (PubMed) · PMC4838140 (PubMed Central)
  42. Estrogen Metabolite 16α-Hydroxyestrone Exacerbates Bone Morphogenetic Protein Receptor Type II-Associated Pulmonary Arterial Hypertension Through MicroRNA-29-Mediated Modulation of Cellular Metabolism. Chen X, Talati M, Fessel JP, Hemnes AR, Gladson S, French J, Shay S, Trammell A, Phillips JA, Hamid R, Cogan JD, Dawson EP, Womble KE, Hedges LK, Martinez EG, Wheeler LA, Loyd JE, Majka SJ, West J, Austin ED (2016) Circulation 133(1): 82-97
    › Primary publication · 26487756 (PubMed) · PMC4698046 (PubMed Central)
  43. Influence of pulmonary emphysema on COPD assessment test-oriented categorization in GOLD document. Suzuki T, Tada Y, Kawata N, Ikari J, Kasahara Y, Sakurai Y, Iesato K, Nishimura R, West J, Tatsumi K (2015) Int J Chron Obstruct Pulmon Dis : 1199-205
    › Primary publication · 26150711 (PubMed) · PMC4480590 (PubMed Central)
  44. Increased prevalence of EPAS1 variant in cattle with high-altitude pulmonary hypertension. Newman JH, Holt TN, Cogan JD, Womack B, Phillips JA, Li C, Kendall Z, Stenmark KR, Thomas MG, Brown RD, Riddle SR, West JD, Hamid R (2015) Nat Commun : 6863
    › Primary publication · 25873470 (PubMed) · PMC4399003 (PubMed Central)
  45. Microvessel mechanobiology in pulmonary arterial hypertension: cause and effect. Bloodworth NC, West JD, Merryman WD (2015) Hypertension 65(3): 483-9
    › Primary publication · 25534705 (PubMed) · PMC4326545 (PubMed Central)
  46. Peripheral blood signature of vasodilator-responsive pulmonary arterial hypertension. Hemnes AR, Trammell AW, Archer SL, Rich S, Yu C, Nian H, Penner N, Funke M, Wheeler L, Robbins IM, Austin ED, Newman JH, West J (2015) Circulation 131(4): 401-9; discussion 409
    › Primary publication · 25361553 (PubMed) · PMC4308423 (PubMed Central)
  47. ABCG2pos lung mesenchymal stem cells are a novel pericyte subpopulation that contributes to fibrotic remodeling. Marriott S, Baskir RS, Gaskill C, Menon S, Carrier EJ, Williams J, Talati M, Helm K, Alford CE, Kropski JA, Loyd J, Wheeler L, Johnson J, Austin E, Nozik-Grayck E, Meyrick B, West JD, Klemm DJ, Majka SM (2014) Am J Physiol Cell Physiol 307(8): C684-98
    › Primary publication · 25122876 (PubMed) · PMC4200000 (PubMed Central)
  48. Identification of a common Wnt-associated genetic signature across multiple cell types in pulmonary arterial hypertension. West JD, Austin ED, Gaskill C, Marriott S, Baskir R, Bilousova G, Jean JC, Hemnes AR, Menon S, Bloodworth NC, Fessel JP, Kropski JA, Irwin D, Ware LB, Wheeler L, Hong CC, Meyrick B, Loyd JE, Bowman AB, Ess KC, Klemm DJ, Young PP, Merryman WD, Kotton D, Majka SM (2014) Am J Physiol Cell Physiol 307(5): C415-30
    › Primary publication · 24871858 (PubMed) · PMC4154073 (PubMed Central)
  49. Rescuing the BMPR2 signaling axis in pulmonary arterial hypertension. West J, Austin E, Fessel JP, Loyd J, Hamid R (2014) Drug Discov Today 19(8): 1241-5
    › Primary publication · 24794464 (PubMed) · PMC4396626 (PubMed Central)
  50. BMP pathway regulation of and by macrophages. Talati M, West J, Zaynagetdinov R, Hong CC, Han W, Blackwell T, Robinson L, Blackwell TS, Lane K (2014) PLoS One 9(4): e94119
    › Primary publication · 24713633 (PubMed) · PMC3979749 (PubMed Central)
  51. Interaction between bone morphogenetic protein receptor type 2 and estrogenic compounds in pulmonary arterial hypertension. Fessel JP, Chen X, Frump A, Gladson S, Blackwell T, Kang C, Johnson J, Loyd JE, Hemnes A, Austin E, West J (2013) Pulm Circ 3(3): 564-77
    › Primary publication · 24618541 (PubMed) · PMC4070799 (PubMed Central)
  52. Echocardiographic assessment of the right heart in mice. Brittain E, Penner NL, West J, Hemnes A (2013) J Vis Exp (81)
    › Primary publication · 24326586 (PubMed) · PMC3992116 (PubMed Central)
  53. Gender, sex hormones and pulmonary hypertension. Austin ED, Lahm T, West J, Tofovic SP, Johansen AK, Maclean MR, Alzoubi A, Oka M (2013) Pulm Circ 3(2): 294-314
    › Primary publication · 24015330 (PubMed) · PMC3757824 (PubMed Central)
  54. Experimental and transgenic models of pulmonary hypertension. West J, Hemnes A (2011) Compr Physiol 1(2): 769-82
    › Primary publication · 23737202 (PubMed)
  55. Testosterone negatively regulates right ventricular load stress responses in mice. Hemnes AR, Maynard KB, Champion HC, Gleaves L, Penner N, West J, Newman JH (2012) Pulm Circ 2(3): 352-8
    › Primary publication · 23130103 (PubMed) · PMC3487303 (PubMed Central)
  56. A potential role for insulin resistance in experimental pulmonary hypertension. West J, Niswender KD, Johnson JA, Pugh ME, Gleaves L, Fessel JP, Hemnes AR (2013) Eur Respir J 41(4): 861-71
    › Primary publication · 22936709 (PubMed) · PMC3746982 (PubMed Central)
  57. Longitudinal analysis casts doubt on the presence of genetic anticipation in heritable pulmonary arterial hypertension. Larkin EK, Newman JH, Austin ED, Hemnes AR, Wheeler L, Robbins IM, West JD, Phillips JA, Hamid R, Loyd JE (2012) Am J Respir Crit Care Med 186(9): 892-6
    › Primary publication · 22923661 (PubMed) · PMC3530218 (PubMed Central)
  58. Role of BMPR2 alternative splicing in heritable pulmonary arterial hypertension penetrance. Cogan J, Austin E, Hedges L, Womack B, West J, Loyd J, Hamid R (2012) Circulation 126(15): 1907-16
    › Primary publication · 22923426 (PubMed) · PMC4113011 (PubMed Central)
  59. Metabolomic analysis of bone morphogenetic protein receptor type 2 mutations in human pulmonary endothelium reveals widespread metabolic reprogramming. Fessel JP, Hamid R, Wittmann BM, Robinson LJ, Blackwell T, Tada Y, Tanabe N, Tatsumi K, Hemnes AR, West JD (2012) Pulm Circ 2(2): 201-13
    › Primary publication · 22837861 (PubMed) · PMC3401874 (PubMed Central)
  60. Whole exome sequencing to identify a novel gene (caveolin-1) associated with human pulmonary arterial hypertension. Austin ED, Ma L, LeDuc C, Berman Rosenzweig E, Borczuk A, Phillips JA, Palomero T, Sumazin P, Kim HR, Talati MH, West J, Loyd JE, Chung WK (2012) Circ Cardiovasc Genet 5(3): 336-43
    › Primary publication · 22474227 (PubMed) · PMC3380156 (PubMed Central)
  61. BMPR2 expression is suppressed by signaling through the estrogen receptor. Austin ED, Hamid R, Hemnes AR, Loyd JE, Blackwell T, Yu C, Phillips Iii JA, Gaddipati R, Gladson S, Gu E, West J, Lane KB (2012) Biol Sex Differ 3(1): 6
    › Primary publication · 22348410 (PubMed) · PMC3310853 (PubMed Central)
  62. Connectivity map analysis of nonsense-mediated decay-positive BMPR2-related hereditary pulmonary arterial hypertension provides insights into disease penetrance. Flynn C, Zheng S, Yan L, Hedges L, Womack B, Fessel J, Cogan J, Austin E, Loyd J, West J, Zhao Z, Hamid R (2012) Am J Respir Cell Mol Biol 47(1): 20-7
    › Primary publication · 22312021 (PubMed) · PMC3402799 (PubMed Central)
  63. Cytoskeletal defects in Bmpr2-associated pulmonary arterial hypertension. Johnson JA, Hemnes AR, Perrien DS, Schuster M, Robinson LJ, Gladson S, Loibner H, Bai S, Blackwell TR, Tada Y, Harral JW, Talati M, Lane KB, Fagan KA, West J (2012) Am J Physiol Lung Cell Mol Physiol 302(5): L474-84
    › Primary publication · 22180660 (PubMed) · PMC3311512 (PubMed Central)
  64. Idiopathic and heritable PAH perturb common molecular pathways, correlated with increased MSX1 expression. Austin ED, Menon S, Hemnes AR, Robinson LR, Talati M, Fox KL, Cogan JD, Hamid R, Hedges LK, Robbins I, Lane K, Newman JH, Loyd JE, West J (2011) Pulm Circ 1(3): 389-98
    › Primary publication · 22140629 (PubMed) · PMC3224431 (PubMed Central)
  65. Oxidative injury is a common consequence of BMPR2 mutations. Lane KL, Talati M, Austin E, Hemnes AR, Johnson JA, Fessel JP, Blackwell T, Mernaugh RL, Robinson L, Fike C, Roberts LJ, West J (2011) Pulm Circ 1(1): 72-83
    › Primary publication · 21904662 (PubMed) · PMC3167174 (PubMed Central)
  66. Physiologic and molecular consequences of endothelial Bmpr2 mutation. Majka S, Hagen M, Blackwell T, Harral J, Johnson JA, Gendron R, Paradis H, Crona D, Loyd JE, Nozik-Grayck E, Stenmark KR, West J (2011) Respir Res : 84
    › Primary publication · 21696628 (PubMed) · PMC3141420 (PubMed Central)
  67. ACE2 improves right ventricular function in a pressure overload model. Johnson JA, West J, Maynard KB, Hemnes AR (2011) PLoS One 6(6): e20828
    › Primary publication · 21695173 (PubMed) · PMC3112229 (PubMed Central)
  68. Unrecognized glucose intolerance is common in pulmonary arterial hypertension. Pugh ME, Robbins IM, Rice TW, West J, Newman JH, Hemnes AR (2011) J Heart Lung Transplant 30(8): 904-11
    › Primary publication · 21493097 (PubMed) · PMC3129440 (PubMed Central)
  69. Effective treatments for PAH will require detailed knowledge of molecular aetiology. Johnson J, Loyd J, West J (2010) Int J Clin Pract Suppl (168): 3-4
    › Primary publication · 20939840 (PubMed)
  70. BMPR2 mutation alters the lung macrophage endothelin-1 cascade in a mouse model and patients with heritable pulmonary artery hypertension. Talati M, West J, Blackwell TR, Loyd JE, Meyrick B (2010) Am J Physiol Lung Cell Mol Physiol 299(3): L363-73
    › Primary publication · 20562228 (PubMed) · PMC2951074 (PubMed Central)
  71. Cross talk between Smad, MAPK, and actin in the etiology of pulmonary arterial hypertension. West J (2010) Adv Exp Med Biol : 265-78
    › Primary publication · 20204736 (PubMed)
  72. Copy-number variation in BMPR2 is not associated with the pathogenesis of pulmonary arterial hypertension. Johnson JA, Vnencak-Jones CL, Cogan JD, Loyd JE, West J (2009) BMC Med Genet : 58
    › Primary publication · 19531247 (PubMed) · PMC2706815 (PubMed Central)
  73. Alterations in oestrogen metabolism: implications for higher penetrance of familial pulmonary arterial hypertension in females. Austin ED, Cogan JD, West JD, Hedges LK, Hamid R, Dawson EP, Wheeler LA, Parl FF, Loyd JE, Phillips JA (2009) Eur Respir J 34(5): 1093-9
    › Primary publication · 19357154 (PubMed) · PMC3742124 (PubMed Central)
  74. Gene expression in BMPR2 mutation carriers with and without evidence of pulmonary arterial hypertension suggests pathways relevant to disease penetrance. West J, Cogan J, Geraci M, Robinson L, Newman J, Phillips JA, Lane K, Meyrick B, Loyd J (2008) BMC Med Genomics : 45
    › Primary publication · 18823550 (PubMed) · PMC2561034 (PubMed Central)
  75. Mice expressing BMPR2R899X transgene in smooth muscle develop pulmonary vascular lesions. West J, Harral J, Lane K, Deng Y, Ickes B, Crona D, Albu S, Stewart D, Fagan K (2008) Am J Physiol Lung Cell Mol Physiol 295(5): L744-55
    › Primary publication · 18723761 (PubMed) · PMC2584890 (PubMed Central)