Eric Sebzda
Last active: 1/20/2015

Profile

A unique aspect of the immune system is its ability to transport cells great distances in a short period of time. These trafficking mechanisms dictate the efficiency of an immune response, both in terms of pathogen clearance and susceptibility to autoimmune diseases. The Sebzda laboratory studies B and T cell trafficking during immune responses. Specially, we are interested in determining how cell activation releases these lymphocytes from a homeostatic migration pattern and targets these cells to sites of inflammation. We are currently using a series of genetically modified animal models to analyze early regulatory events in cellular trafficking. The ultimate goal of this research is to identify potential therapeutic targets that enhance/inhibit lymphocyte trafficking to specific tissues and thus aid in pathogen clearance or limit autoimmune reactions, respectively.

Publications

The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. KLF2 is a rate-limiting transcription factor that can be targeted to enhance regulatory T-cell production. Pabbisetty SK, Rabacal W, Maseda D, Cendron D, Collins PL, Hoek KL, Parekh VV, Aune TM, Sebzda E (2014) Proc Natl Acad Sci U S A 111(26): 9579-84
    › Primary publication · 24979767 (PubMed) · PMC4084438 (PubMed Central)
  2. Follicular B cell trafficking within the spleen actively restricts humoral immune responses. Hoek KL, Gordy LE, Collins PL, Parekh VV, Aune TM, Joyce S, Thomas JW, Van Kaer L, Sebzda E (2010) Immunity 33(2): 254-65
    › Primary publication · 20691614 (PubMed) · PMC2929658 (PubMed Central)
  3. Transcription factor KLF2 regulates the migration of naive T cells by restricting chemokine receptor expression patterns. Sebzda E, Zou Z, Lee JS, Wang T, Kahn ML (2008) Nat Immunol 9(3): 292-300
    › Primary publication · 18246069 (PubMed)