Kevin Osteen
Last active: 2/19/2015

Profile

Among normal adult tissues, the endometrial lining of the human uterus undergoes perhaps the most dynamic cycle of steroid controlled growth, differentiation and tissue breakdown. The rate of estrogen-driven cell growth during the proliferative phase of the menstrual cycle rivals that of many tumors while progesterone inhibits endometrial growth and appears to provide protection from the development of both benign diseases and certain neoplasms. Ovarian steroids clearly control the endometrium and endometrial activity; however, steroids alone cannot account for the entire orchestration of such well-controlled and often focal patterns of cellular proliferation and differentiation which are observed. To better understand steroid sensitive tissue behavior, my research laboratory has focused on the endometrium as a model to identify interrelationships between steroid action and stromal-epithelial cell communication via specific paracrine factors. Of special interest to us are the cellular and molecular mechanisms which control steroid-dependent versus steroid-independent expressions of metalloproteinases. These enzymes are necessary for degradation of extracellular matrix proteins and play important roles in the extensive tissue remodeling which normally occurs during the menstrual cycle as well as during establishment of the hemochorial placenta. Metalloproteinases may also contribute to the pathophysiology of endometrial dysfunction including abnormal bleeding, defects of placentation and the extrauterine disease endometriosis. Recently, we have extended our studies to investigate altered metalloproteinase gene and protein expression relative to the reproductive toxicology of dioxin.

Publications

The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. Developmental exposure of mice to dioxin promotes transgenerational testicular inflammation and an increased risk of preterm birth in unexposed mating partners. Bruner-Tran KL, Ding T, Yeoman KB, Archibong A, Arosh JA, Osteen KG (2014) PLoS One 9(8): e105084
    › Primary publication · 25127480 (PubMed) · PMC4134254 (PubMed Central)
  2. The Role of Endocrine Disruptors in the Epigenetics of Reproductive Disease and Dysfunction: Potential Relevance to Humans. Bruner-Tran KL, Resuehr D, Ding T, Lucas JA, Osteen KG (2012) Curr Obstet Gynecol Rep 1(3): 116-123
    › Primary publication · 24932427 (PubMed) · PMC4056573 (PubMed Central)
  3. 1,25-dihydroxyvitamin d3 reduces extracellular matrix-associated protein expression in human uterine fibroid cells. Halder SK, Osteen KG, Al-Hendy A (2013) Biol Reprod 89(6): 150
    › Primary publication · 24174578 (PubMed) · PMC4076359 (PubMed Central)
  4. Vitamin D3 inhibits expression and activities of matrix metalloproteinase-2 and -9 in human uterine fibroid cells. Halder SK, Osteen KG, Al-Hendy A (2013) Hum Reprod 28(9): 2407-16
    › Primary publication · 23814095 (PubMed) · PMC3748859 (PubMed Central)
  5. Medical management of endometriosis: emerging evidence linking inflammation to disease pathophysiology. Bruner-Tran KL, Herington JL, Duleba AJ, Taylor HS, Osteen KG (2013) Minerva Ginecol 65(2): 199-213
    › Primary publication · 23598784 (PubMed) · PMC3718308 (PubMed Central)
  6. Resveratrol potentiates effect of simvastatin on inhibition of mevalonate pathway in human endometrial stromal cells. Villanueva JA, Sokalska A, Cress AB, Ortega I, Bruner-Tran KL, Osteen KG, Duleba AJ (2013) J Clin Endocrinol Metab 98(3): E455-62
    › Primary publication · 23386644 (PubMed) · PMC3590465 (PubMed Central)
  7. Effects of simvastatin on retinoic acid system in primary human endometrial stromal cells and in a chimeric model of human endometriosis. Sokalska A, Anderson M, Villanueva J, Ortega I, Bruner-Tran KL, Osteen KG, Duleba AJ (2013) J Clin Endocrinol Metab 98(3): E463-71
    › Primary publication · 23337719 (PubMed) · PMC3590479 (PubMed Central)
  8. Dietary fish oil supplementation inhibits formation of endometriosis-associated adhesions in a chimeric mouse model. Herington JL, Glore DR, Lucas JA, Osteen KG, Bruner-Tran KL (2013) Fertil Steril 99(2): 543-50
    › Primary publication · 23103017 (PubMed) · PMC3582352 (PubMed Central)
  9. Progesterone-dependent regulation of endometrial cannabinoid receptor type 1 (CB1-R) expression is disrupted in women with endometriosis and in isolated stromal cells exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Resuehr D, Glore DR, Taylor HS, Bruner-Tran KL, Osteen KG (2012) Fertil Steril 98(4): 948-56.e1
    › Primary publication · 22789143 (PubMed) · PMC3462249 (PubMed Central)
  10. Simvastatin decreases invasiveness of human endometrial stromal cells. Sokalska A, Cress A, Bruner-Tran KL, Osteen KG, Taylor HS, Ortega I, Duleba AJ (2012) Biol Reprod 87(1): 2, 1-6
    › Primary publication · 22492974 (PubMed) · PMC3406552 (PubMed Central)
  11. An orthotopic model of platinum-sensitive high grade serous fallopian tube carcinoma. Khabele D, Fadare O, Liu AY, Wilson AJ, Wass E, Osteen K, Crispens MA (2012) Int J Clin Exp Pathol 5(1): 37-45
    › Primary publication · 22295145 (PubMed) · PMC3267484 (PubMed Central)
  12. Statins inhibit monocyte chemotactic protein 1 expression in endometriosis. Cakmak H, Basar M, Seval-Celik Y, Osteen KG, Duleba AJ, Taylor HS, Lockwood CJ, Arici A (2012) Reprod Sci 19(6): 572-9
    › Primary publication · 22267540 (PubMed) · PMC3439122 (PubMed Central)
  13. Immune interactions in endometriosis. Herington JL, Bruner-Tran KL, Lucas JA, Osteen KG (2011) Expert Rev Clin Immunol 7(5): 611-26
    › Primary publication · 21895474 (PubMed) · PMC3204940 (PubMed Central)
  14. Novel therapies targeting endometriosis. Taylor HS, Osteen KG, Bruner-Tran KL, Lockwood CJ, Krikun G, Sokalska A, Duleba AJ (2011) Reprod Sci 18(9): 814-23
    › Primary publication · 21693775 (PubMed) · PMC4046304 (PubMed Central)
  15. Preconception omega-3 fatty acid supplementation of adult male mice with a history of developmental 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure prevents preterm birth in unexposed female partners. McConaha ME, Ding T, Lucas JA, Arosh JA, Osteen KG, Bruner-Tran KL (2011) Reproduction 142(2): 235-41
    › Primary publication · 21653731 (PubMed) · PMC3730265 (PubMed Central)
  16. Developmental dioxin exposure of either parent is associated with an increased risk of preterm birth in adult mice. Ding T, McConaha M, Boyd KL, Osteen KG, Bruner-Tran KL (2011) Reprod Toxicol 31(3): 351-8
    › Primary publication · 21093581 (PubMed) · PMC3075349 (PubMed Central)
  17. Developmental exposure to TCDD reduces fertility and negatively affects pregnancy outcomes across multiple generations. Bruner-Tran KL, Osteen KG (2011) Reprod Toxicol 31(3): 344-50
    › Primary publication · 20955784 (PubMed) · PMC3044210 (PubMed Central)
  18. Development and prevention of postsurgical adhesions in a chimeric mouse model of experimental endometriosis. Herington JL, Crispens MA, Carvalho-Macedo AC, Camargos AF, Lebovic DI, Bruner-Tran KL, Osteen KG (2011) Fertil Steril 95(4): 1295-301.e1
    › Primary publication · 20934690 (PubMed) · PMC3038191 (PubMed Central)
  19. Resveratrol inhibits development of experimental endometriosis in vivo and reduces endometrial stromal cell invasiveness in vitro. Bruner-Tran KL, Osteen KG, Taylor HS, Sokalska A, Haines K, Duleba AJ (2011) Biol Reprod 84(1): 106-12
    › Primary publication · 20844278 (PubMed) · PMC3012565 (PubMed Central)
  20. Dioxin-like PCBs and endometriosis. Bruner-Tran KL, Osteen KG (2010) Syst Biol Reprod Med 56(2): 132-46
    › Primary publication · 20377312 (PubMed) · PMC2867352 (PubMed Central)
  21. Dioxin and endometrial progesterone resistance. Bruner-Tran KL, Ding T, Osteen KG (2010) Semin Reprod Med 28(1): 59-68
    › Primary publication · 20104429 (PubMed) · PMC2875884 (PubMed Central)
  22. The immunoconjugate "icon" targets aberrantly expressed endothelial tissue factor causing regression of endometriosis. Krikun G, Hu Z, Osteen K, Bruner-Tran KL, Schatz F, Taylor HS, Toti P, Arcuri F, Konigsberg W, Garen A, Booth CJ, Lockwood CJ (2010) Am J Pathol 176(2): 1050-6
    › Primary publication · 20042667 (PubMed) · PMC2808107 (PubMed Central)
  23. Experimental endometriosis in immunocompromised mice after adoptive transfer of human leukocytes. Bruner-Tran KL, Carvalho-Macedo AC, Duleba AJ, Crispens MA, Osteen KG (2010) Fertil Steril 93(8): 2519-24
    › Primary publication · 19608172 (PubMed) · PMC2873129 (PubMed Central)
  24. Simvastatin protects against the development of endometriosis in a nude mouse model. Bruner-Tran KL, Osteen KG, Duleba AJ (2009) J Clin Endocrinol Metab 94(7): 2489-94
    › Primary publication · 19366846 (PubMed) · PMC2708947 (PubMed Central)
  25. Dioxin may promote inflammation-related development of endometriosis. Bruner-Tran KL, Yeaman GR, Crispens MA, Igarashi TM, Osteen KG (2008) Fertil Steril 89(5 Suppl): 1287-98
    › Primary publication · 18394613 (PubMed) · PMC2430157 (PubMed Central)
  26. Developmental exposure of mice to TCDD elicits a similar uterine phenotype in adult animals as observed in women with endometriosis. Nayyar T, Bruner-Tran KL, Piestrzeniewicz-Ulanska D, Osteen KG (2007) Reprod Toxicol 23(3): 326-36
    › Primary publication · 17056225 (PubMed) · PMC1885235 (PubMed Central)
  27. Down-regulation of endometrial matrix metalloproteinase-3 and -7 expression in vitro and therapeutic regression of experimental endometriosis in vivo by a novel nonsteroidal progesterone receptor agonist, tanaproget. Bruner-Tran KL, Zhang Z, Eisenberg E, Winneker RC, Osteen KG (2006) J Clin Endocrinol Metab 91(4): 1554-60
    › Primary publication · 16418212 (PubMed)
  28. The activation function-1 domain of estrogen receptor alpha in uterine stromal cells is required for mouse but not human uterine epithelial response to estrogen. Kurita T, Medina R, Schabel AB, Young P, Gama P, Parekh TV, Brody J, Cunha GR, Osteen KG, Bruner-Tran KL, Gold LI (2005) Differentiation 73(6): 313-22
    › Primary publication · 16138832 (PubMed)
  29. Reduced expression of progesterone receptor-B in the endometrium of women with endometriosis and in cocultures of endometrial cells exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Igarashi TM, Bruner-Tran KL, Yeaman GR, Lessey BA, Edwards DP, Eisenberg E, Osteen KG (2005) Fertil Steril 84(1): 67-74
    › Primary publication · 16009159 (PubMed)
  30. Endometrial biology and the etiology of endometriosis. Osteen KG, Bruner-Tran KL, Eisenberg E (2005) Fertil Steril 84(1): 33-4; discussion 38-9
    › Primary publication · 16009151 (PubMed)
  31. Reduced progesterone action during endometrial maturation: a potential risk factor for the development of endometriosis. Osteen KG, Bruner-Tran KL, Eisenberg E (2005) Fertil Steril 83(3): 529-37
    › Primary publication · 15749474 (PubMed)
  32. A selective estrogen receptor-beta agonist causes lesion regression in an experimentally induced model of endometriosis. Harris HA, Bruner-Tran KL, Zhang X, Osteen KG, Lyttle CR (2005) Hum Reprod 20(4): 936-41
    › Primary publication · 15618247 (PubMed)
  33. Steroid and cytokine regulation of matrix metalloproteinases and the pathophysiology of endometriosis. Osteen KG, Igarashi TM, Yeaman GR, Bruner-Tran KL (2004) Gynecol Obstet Invest 57(1): 53-4
    › Primary publication · 14974460 (PubMed)
  34. An improved mouse model for endometriosis allows noninvasive assessment of lesion implantation and development. Fortin M, Lépine M, Pagé M, Osteen K, Massie B, Hugo P, Steff AM (2003) Fertil Steril : 832-8
    › Primary publication · 14505761 (PubMed)
  35. The matrix metalloproteinase system: changes, regulation, and impact throughout the ovarian and uterine reproductive cycle. Curry TE, Osteen KG (2003) Endocr Rev 24(4): 428-65
    › Primary publication · 12920150 (PubMed)
  36. Matrix metalloproteinases and endometriosis. Osteen KG, Yeaman GR, Bruner-Tran KL (2003) Semin Reprod Med 21(2): 155-64
    › Primary publication · 12917785 (PubMed)
  37. Expression profiling of endometrium from women with endometriosis reveals candidate genes for disease-based implantation failure and infertility. Kao LC, Germeyer A, Tulac S, Lobo S, Yang JP, Taylor RN, Osteen K, Lessey BA, Giudice LC (2003) Endocrinology 144(7): 2870-81
    › Primary publication · 12810542 (PubMed)
  38. Antiangiogenic agents are effective inhibitors of endometriosis. Hull ML, Charnock-Jones DS, Chan CL, Bruner-Tran KL, Osteen KG, Tom BD, Fan TP, Smith SK (2003) J Clin Endocrinol Metab 88(6): 2889-99
    › Primary publication · 12788903 (PubMed)
  39. Regulated expression of osteopontin in the peri-implantation rabbit uterus. Apparao KB, Illera MJ, Beyler SA, Olson GE, Osteen KG, Corjay MH, Boggess K, Lessey BA (2003) Biol Reprod 68(5): 1484-90
    › Primary publication · 12606431 (PubMed)