Igor Feoktistov
Last active: 5/29/2014


The focus of the Feoktistov laboratory is to study the role of adenosine in physiological processes and disease states. Research interests center on two general areas: the protective role of adenosine in ischemic tissues and its potential for cardiac revascularization and regeneration using progenitor cells; and the role of adenosine in chronic lung diseases such as asthma. Adenosine is generated in response to tissue hypoxia, cell stress or damage and exerts effects in essentially every organ system by interacting with four G protein-coupled receptors designated A1, A2A, A2B, and A3. A central hypothesis of our laboratory is that in pathophysiological situations associated with tissue hypoxia, when local levels of extracellular adenosine are considerably increased, A2B receptors become an integral part of a feedback mechanism aimed to restore oxygen supply to the affected tissues. Once activated, these receptors contribute to hypoxia-induced neovascularization by inducing synthesis of angiogenic factors molecules. Although adenosine acts in most cases as a protective metabolite in various tissues, it serves as amplifier of lung inflammation and damage. Adenosine triggers asthma in asthmatic patients but not in normals, and blockade of adenosine receptors appears to be the mechanisms of action of theophylline and other xanthines. Our research is also aimed at identifying the specific receptor type that mediates adenosine actions in asthmatics. It is hoped that this research will lead to the development of more potent and specific anti-asthmatic drugs with lesser side effects than theophylline.


The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. Role of adenosine A2B receptor signaling in contribution of cardiac mesenchymal stem-like cells to myocardial scar formation. Ryzhov S, Sung BH, Zhang Q, Weaver A, Gumina RJ, Biaggioni I, Feoktistov I (2014) Purinergic Signal 10(3): 477-86
    › Primary publication · 24584483 (PubMed) · PMC4152448 (PubMed Central)
  2. Role of JunB in adenosine A2B receptor-mediated vascular endothelial growth factor production. Ryzhov S, Biktasova A, Goldstein AE, Zhang Q, Biaggioni I, Dikov MM, Feoktistov I (2014) Mol Pharmacol 85(1): 62-73
    › Primary publication · 24136993 (PubMed) · PMC3868903 (PubMed Central)
  3. Adenosine A2B receptors on cardiac stem cell antigen (Sca)-1-positive stromal cells play a protective role in myocardial infarction. Ryzhov S, Zhang Q, Biaggioni I, Feoktistov I (2013) Am J Pathol 183(3): 665-72
    › Primary publication · 23827818 (PubMed) · PMC3763763 (PubMed Central)
  4. Role of A2B adenosine receptors in regulation of paracrine functions of stem cell antigen 1-positive cardiac stromal cells. Ryzhov S, Goldstein AE, Novitskiy SV, Blackburn MR, Biaggioni I, Feoktistov I (2012) J Pharmacol Exp Ther 341(3): 764-74
    › Primary publication · 22431204 (PubMed) · PMC3362889 (PubMed Central)
  5. Adenosinergic regulation of the expansion and immunosuppressive activity of CD11b+Gr1+ cells. Ryzhov S, Novitskiy SV, Goldstein AE, Biktasova A, Blackburn MR, Biaggioni I, Dikov MM, Feoktistov I (2011) J Immunol 187(11): 6120-9
    › Primary publication · 22039302 (PubMed) · PMC3221925 (PubMed Central)
  6. Role of adenosine A(2B) receptors in inflammation. Feoktistov I, Biaggioni I (2011) Adv Pharmacol : 115-44
    › Primary publication · 21586358 (PubMed) · PMC3748596 (PubMed Central)
  7. Experimental myocardial infarction triggers canonical Wnt signaling and endothelial-to-mesenchymal transition. Aisagbonhi O, Rai M, Ryzhov S, Atria N, Feoktistov I, Hatzopoulos AK (2011) Dis Model Mech 4(4): 469-83
    › Primary publication · 21324930 (PubMed) · PMC3124051 (PubMed Central)
  8. Adenosine receptors in wound healing, fibrosis and angiogenesis. Feoktistov I, Biaggioni I, Cronstein BN (2009) Handb Exp Pharmacol (193): 383-97
    › Primary publication · 19639289 (PubMed) · PMC3729032 (PubMed Central)
  9. Attenuation of chronic pulmonary inflammation in A2B adenosine receptor knockout mice. Zaynagetdinov R, Ryzhov S, Goldstein AE, Yin H, Novitskiy SV, Goleniewska K, Polosukhin VV, Newcomb DC, Mitchell D, Morschl E, Zhou Y, Blackburn MR, Peebles RS, Biaggioni I, Feoktistov I (2010) Am J Respir Cell Mol Biol 42(5): 564-71
    › Primary publication · 19556606 (PubMed) · PMC2874442 (PubMed Central)
  10. Differential role of the carboxy-terminus of the A(2B) adenosine receptor in stimulation of adenylate cyclase, phospholipase Cbeta, and interleukin-8. Ryzhov S, Zaynagetdinov R, Goldstein AE, Matafonov A, Biaggioni I, Feoktistov I (2009) Purinergic Signal 5(3): 289-98
    › Primary publication · 19125355 (PubMed) · PMC2717310 (PubMed Central)
  11. Host A(2B) adenosine receptors promote carcinoma growth. Ryzhov S, Novitskiy SV, Zaynagetdinov R, Goldstein AE, Carbone DP, Biaggioni I, Dikov MM, Feoktistov I (2008) Neoplasia 10(9): 987-95
    › Primary publication · 18714400 (PubMed) · PMC2517644 (PubMed Central)
  12. Adenosine receptors in regulation of dendritic cell differentiation and function. Novitskiy SV, Ryzhov S, Zaynagetdinov R, Goldstein AE, Huang Y, Tikhomirov OY, Blackburn MR, Biaggioni I, Carbone DP, Feoktistov I, Dikov MM (2008) Blood 112(5): 1822-31
    › Primary publication · 18559975 (PubMed) · PMC2518889 (PubMed Central)
  13. Effect of A2B adenosine receptor gene ablation on proinflammatory adenosine signaling in mast cells. Ryzhov S, Zaynagetdinov R, Goldstein AE, Novitskiy SV, Dikov MM, Blackburn MR, Biaggioni I, Feoktistov I (2008) J Immunol 180(11): 7212-20
    › Primary publication · 18490720 (PubMed) · PMC3628765 (PubMed Central)
  14. Adenosine receptor-mediated adhesion of endothelial progenitors to cardiac microvascular endothelial cells. Ryzhov S, Solenkova NV, Goldstein AE, Lamparter M, Fleenor T, Young PP, Greelish JP, Byrne JG, Vaughan DE, Biaggioni I, Hatzopoulos AK, Feoktistov I (2008) Circ Res 102(3): 356-63
    › Primary publication · 18032734 (PubMed) · PMC2803108 (PubMed Central)
  15. Effect of A2B adenosine receptor gene ablation on adenosine-dependent regulation of proinflammatory cytokines. Ryzhov S, Zaynagetdinov R, Goldstein AE, Novitskiy SV, Blackburn MR, Biaggioni I, Feoktistov I (2008) J Pharmacol Exp Ther 324(2): 694-700
    › Primary publication · 17965229 (PubMed)
  16. Role of adenosine receptors in the regulation of angiogenic factors and neovascularization in hypoxia. Ryzhov S, McCaleb JL, Goldstein AE, Biaggioni I, Feoktistov I (2007) J Pharmacol Exp Ther 320(2): 565-72
    › Primary publication · 17132813 (PubMed)
  17. Cross-talk between G(s)- and G(q)-coupled pathways in regulation of interleukin-4 by A(2B) adenosine receptors in human mast cells. Ryzhov S, Goldstein AE, Biaggioni I, Feoktistov I (2006) Mol Pharmacol 70(2): 727-35
    › Primary publication · 16707627 (PubMed)
  18. Hypoxia modulates adenosine receptors in human endothelial and smooth muscle cells toward an A2B angiogenic phenotype. Feoktistov I, Ryzhov S, Zhong H, Goldstein AE, Matafonov A, Zeng D, Biaggioni I (2004) Hypertension 44(5): 649-54
    › Primary publication · 15452028 (PubMed)
  19. Adenosine-activated mast cells induce IgE synthesis by B lymphocytes: an A2B-mediated process involving Th2 cytokines IL-4 and IL-13 with implications for asthma. Ryzhov S, Goldstein AE, Matafonov A, Zeng D, Biaggioni I, Feoktistov I (2004) J Immunol 172(12): 7726-33
    › Primary publication · 15187156 (PubMed)
  20. Adenosine receptor, protein kinase G, and p38 mitogen-activated protein kinase-dependent up-regulation of serotonin transporters involves both transporter trafficking and activation. Zhu CB, Hewlett WA, Feoktistov I, Biaggioni I, Blakely RD (2004) Mol Pharmacol 65(6): 1462-74
    › Primary publication · 15155839 (PubMed)
  21. A(2B) adenosine receptors increase cytokine release by bronchial smooth muscle cells. Zhong H, Belardinelli L, Maa T, Feoktistov I, Biaggioni I, Zeng D (2004) Am J Respir Cell Mol Biol 30(1): 118-25
    › Primary publication · 12855406 (PubMed)
  22. Mast cell-mediated stimulation of angiogenesis: cooperative interaction between A2B and A3 adenosine receptors. Feoktistov I, Ryzhov S, Goldstein AE, Biaggioni I (2003) Circ Res 92(5): 485-92
    › Primary publication · 12600879 (PubMed)
  23. Differential expression of adenosine receptors in human endothelial cells: role of A2B receptors in angiogenic factor regulation. Feoktistov I, Goldstein AE, Ryzhov S, Zeng D, Belardinelli L, Voyno-Yasenetskaya T, Biaggioni I (2002) Circ Res 90(5): 531-8
    › Primary publication · 11909816 (PubMed)
  24. Inhibition of human mast cell activation with the novel selective adenosine A(2B) receptor antagonist 3-isobutyl-8-pyrrolidinoxanthine (IPDX)(2). Feoktistov I, Garland EM, Goldstein AE, Zeng D, Belardinelli L, Wells JN, Biaggioni I (2001) Biochem Pharmacol 62(9): 1163-73
    › Primary publication · 11705449 (PubMed)
  25. Role of adenosine in asthma. Feoktistov I, Biaggioni I (1996) Drug Dev Res : 333-6
    › Primary publication · 11542498 (PubMed)
  26. Proliferation, migration, and ERK activation in human retinal endothelial cells through A(2B) adenosine receptor stimulation. Grant MB, Davis MI, Caballero S, Feoktistov I, Biaggioni I, Belardinelli L (2001) Invest Ophthalmol Vis Sci 42(9): 2068-73
    › Primary publication · 11481274 (PubMed)
  27. Cyclic AMP and protein kinase A stimulate Cdc42: role of A(2) adenosine receptors in human mast cells. Feoktistov I, Goldstein AE, Biaggioni I (2000) Mol Pharmacol 58(5): 903-10
    › Primary publication · 11040036 (PubMed)
  28. Adenosine A(2A) and A(2B) receptors in cultured human and porcine coronary artery endothelial cells. Olanrewaju HA, Qin W, Feoktistov I, Scemama JL, Mustafa SJ (2000) Am J Physiol Heart Circ Physiol 279(2): H650-6
    › Primary publication · 10924064 (PubMed)
  29. Adenosine receptor activation induces vascular endothelial growth factor in human retinal endothelial cells. Grant MB, Tarnuzzer RW, Caballero S, Ozeck MJ, Davis MI, Spoerri PE, Feoktistov I, Biaggioni I, Shryock JC, Belardinelli L (1999) Circ Res 85(8): 699-706
    › Primary publication · 10521243 (PubMed)
  30. Role of p38 mitogen-activated protein kinase and extracellular signal-regulated protein kinase kinase in adenosine A2B receptor-mediated interleukin-8 production in human mast cells. Feoktistov I, Goldstein AE, Biaggioni I (1999) Mol Pharmacol 55(4): 726-34
    › Primary publication · 10101031 (PubMed)
  31. Prostaglandin E-prostanoid-3 receptor activation of cyclic AMP response element-mediated gene transcription. Audoly LP, Ma L, Feoktistov I, de Foe SK, Breyer MD, Breyer RM (1999) J Pharmacol Exp Ther 289(1): 140-8
    › Primary publication · 10086997 (PubMed)
  32. Adenosine A2B receptors: a novel therapeutic target in asthma? Feoktistov I, Polosa R, Holgate ST, Biaggioni I (1998) Trends Pharmacol Sci 19(4): 148-53
    › Primary publication · 9612090 (PubMed)
  33. Pharmacological characterization of adenosine A2B receptors: studies in human mast cells co-expressing A2A and A2B adenosine receptor subtypes. Feoktistov I, Biaggioni I (1998) Biochem Pharmacol 55(5): 627-33
    › Primary publication · 9515573 (PubMed)
  34. Adenosine A2B receptors. Feoktistov I, Biaggioni I (1997) Pharmacol Rev 49(4): 381-402
    › Primary publication · 9443164 (PubMed)
  35. Prostanoid receptor with a novel pharmacological profile in human erythroleukemia cells. Feoktistov I, Breyer RM, Biaggioni I (1997) Biochem Pharmacol 54(8): 917-26
    › Primary publication · 9354592 (PubMed)
  36. Characterization of adenosine receptors in human erythroleukemia cells and platelets: further evidence for heterogeneity of adenosine A2 receptor subtypes. Feoktistov I, Biaggioni I (1993) Mol Pharmacol 43(6): 909-14
    › Primary publication · 8391117 (PubMed)
  37. Positive modulation of intracellular Ca2+ levels by adenosine A2b receptors, prostacyclin, and prostaglandin E1 via a cholera toxin-sensitive mechanism in human erythroleukemia cells. Feoktistov I, Murray JJ, Biaggioni I (1994) Mol Pharmacol 45(6): 1160-7
    › Primary publication · 8022409 (PubMed)
  38. Adenosine A2b receptors evoke interleukin-8 secretion in human mast cells. An enprofylline-sensitive mechanism with implications for asthma. Feoktistov I, Biaggioni I (1995) J Clin Invest 96(4): 1979-86
    › Primary publication · 7560091 (PubMed) · PMC185836 (PubMed Central)
  39. [Effect of calmodulin inhibitor trifluoperazine on calcium activation of phosphorylase in glycosomes of rabbit skeletal muscles]. Larionov NP, Feoktistov IA (1982) Biull Eksp Biol Med 94(9): 35-6
    › Primary publication · 7171821 (PubMed)
  40. [Somatogenic reactive psychosis]. Pervomaiskiĭ BIa, Ialdygina AS, Feoktistov IuA (1973) Klin Med (Mosk) 51(9): 103-7
    › Primary publication · 4791323 (PubMed)
  41. [Effect of frenolone on the contractile function of papillary muscles]. Larionov NP, Laptev BI, Afanasiev SA, Malyshev IIu, Feoktistov IA (1986) Kardiologiia 26(10): 101-3
    › Primary publication · 3795689 (PubMed)
  42. [The use of pharmacological preparations for the study of calmodulin interaction with enzymes]. Feoktistov IA, Baldenkov GN, Men'shikov MIu, Larionov NP (1987) Vopr Med Khim 33(2): 27-31
    › Primary publication · 3037792 (PubMed)
  43. [Effect of neurotropic drugs on calmodulin and troponin C-dependent processes]. Baldenkov GN, Men'shikov MIu, Feoktistov IA, Tkachuk VA (1985) Biokhimiia 50(7): 1141-50
    › Primary publication · 2864085 (PubMed)
  44. [Effect of calcium ions on the interaction of troponin C with rabbit skeletal muscle troponin I and troponin T immobilized on polyvinyl chloride]. Feoktistov IA, Krylatov AV, Zabeĭvorota SI, Cherviakov EB, Larionov NP (1989) Biokhimiia 54(2): 265-72
    › Primary publication · 2742925 (PubMed)
  45. [Phorbol ester blocks the coupling of GTP-binding protein with receptor-controlled calcium channels]. Bochkov VN, Feoktistov IA, Avdonin PV, Tkachuk VA (1989) Biokhimiia 54(9): 1533-42
    › Primary publication · 2556188 (PubMed)
  46. Metofenazate as a more selective calmodulin inhibitor than trifluoperazine. Tkachuk VA, Baldenkov GN, Feoktistov IA, Men'shikov MY, Quast U, Herzig JW (1987) Arzneimittelforschung 37(9): 1013-7
    › Primary publication · 2449225 (PubMed)
  47. Calmodulin and troponin C as targets for drug action. Herzig JW, Tkachuk VA, Baldenkov GN, Feoktistov IA, Men'shikov MYu , Quast U (1987) Biomed Biochim Acta 46(8-9): S440-3
    › Primary publication · 2449186 (PubMed)
  48. Adenosine inhibits the rise in intracellular calcium and platelet aggregation produced by thrombin: evidence that both effects are coupled to adenylate cyclase. Paul S, Feoktistov I, Hollister AS, Robertson D, Biaggioni I (1990) Mol Pharmacol 37(6): 870-5
    › Primary publication · 2359405 (PubMed)
  49. [The effect of calmodulin inhibitors and the new cardiotonic drug DPI 201-106 on the formation of interprotein bonds in the cardiac troponin complex]. Feoktistov IA, Krylatov AV, Larionov NP (1990) Biokhimiia 55(7): 1251-6
    › Primary publication · 2223899 (PubMed)
  50. [Interaction of calcium agonists and antagonists with Ca-binding proteins and their effect on cyclic nucleotide phosphodiesterase]. Feoktistov IA, Baldenkov GN, Barannik IV, Cherviakov EB, Larionov NP (1990) Biokhimiia 55(4): 754-9
    › Primary publication · 2165822 (PubMed)
  51. [The effect of media pH and autocatalytic phosphorylation on the interaction of kinase phosphorylase with calmodulin]. Goldshteĭn AE, Shur SA, Feoktistov IA (1990) Biokhimiia 55(12): 2255-60
    › Primary publication · 2096954 (PubMed)
  52. [Effects of high-density lipoproteins on thrombin-induced platelet aggregation]. Feoktistov IA, Vologushev SA, Karpov RS (1991) Biull Eksp Biol Med 111(5): 485-6
    › Primary publication · 1878561 (PubMed)
  53. [Mechanism of action of adenosine on intracellular calcium and platelet aggregation]. Feoktistov IA, Pol S, Khollister AS, Robertson D, Biadzhoni I (1991) Kardiologiia 31(11): 76-9
    › Primary publication · 1666665 (PubMed)
  54. Role of cyclic AMP in adenosine inhibition of intracellular calcium rise in human platelets. Comparison of adenosine effects on thrombin- and epinephrine-induced platelet stimulation. Feoktistov IA, Paul S, Hollister AS, Robertson D, Biaggioni I (1992) Am J Hypertens 5(6 Pt 2): 147S-153S
    › Primary publication · 1321639 (PubMed)