Brian Christman
Last active: 2/19/2015

Profile

Our research efforts are currently funded via two NIH grants: (1) PO1HL066196 (Program Project Grant-- Liver-lung interaction in the pathogenesis of lung inflammation, and (2) R01CA092313-- Chemotherapy Toxicity Reduction via Urea Cycle Support. By way of background, the hepatic urea cycle is the primary end pathway of nitrogen catabolism. This cycle fixes ammonia and generates urea. A key intermediate in the cycle is arginine, the substrate for NO generation via the actions of nitric oxide synthase. NOS, when provided with sufficient cofactors (NADPH, tetrahydrobiopterin, oxygen) and substrate, exists in a homodimeric form and produces mainly NO. During periods of substrate limitation or cofactor oxidation, "uncoupled NOS" generates large quantities of superoxide anion. In work supported by our PPG, we have found that mice with partial deficiency of proximal urea cycle enzymes experience increased post-endotoxin in vivo lipid peroxidation, as assessed by GC/MS measurement of isoprostanes and isofurans. This can be ameliorated by manipulation of NOS cofactors and substrate provision. In parallel studies supported by the NCI, we are engaged in a Phase II clinical trial of providing urea cycle intermediates to patients receiving escalated dose chemotherapy and stem cell transplant. This is aimed at reducing regimen related toxicity. . . . .

Publications

The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. When nature meets nurture: persistent Yersinia infection. Watson GT, Huaman MA, Semler MW, Manners J, Woron AM, Carpenter LR, Christman BW (2013) Am J Med 126(7): 578-80
    › Primary publication · 23664165 (PubMed)
  2. Low plasma citrulline levels are associated with acute respiratory distress syndrome in patients with severe sepsis. Ware LB, Magarik JA, Wickersham N, Cunningham G, Rice TW, Christman BW, Wheeler AP, Bernard GR, Summar ML (2013) Crit Care 17(1): R10
    › Primary publication · 23327349 (PubMed) · PMC4056746 (PubMed Central)
  3. Flash mob research: a single-day, multicenter, resident-directed study of respiratory rate. Semler MW, Stover DG, Copland AP, Hong G, Johnson MJ, Kriss MS, Otepka H, Wang L, Christman BW, Rice TW (2013) Chest 143(6): 1740-1744
    › Primary publication · 23197319 (PubMed) · PMC3747725 (PubMed Central)
  4. Safety of sapropterin dihydrochloride (6r-bh4) in patients with pulmonary hypertension. Robbins IM, Hemnes AR, Gibbs JS, Christman BW, Howard L, Meehan S, Cabrita I, Gonzalez R, Oyler T, Zhao L, Du RH, Mendes LA, Wilkins MR (2011) Exp Lung Res 37(1): 26-34
    › Primary publication · 21077779 (PubMed)
  5. Peptidylarginine deiminase 2 suppresses inhibitory {kappa}B kinase activity in lipopolysaccharide-stimulated RAW 264.7 macrophages. Lee HJ, Joo M, Abdolrasulnia R, Young DG, Choi I, Ware LB, Blackwell TS, Christman BW (2010) J Biol Chem 285(51): 39655-62
    › Primary publication · 20937835 (PubMed) · PMC3000946 (PubMed Central)
  6. Discovery of an operon that participates in agmatine metabolism and regulates biofilm formation in Pseudomonas aeruginosa. Williams BJ, Du RH, Calcutt MW, Abdolrasulnia R, Christman BW, Blackwell TS (2010) Mol Microbiol 76(1): 104-19
    › Primary publication · 20149107 (PubMed) · PMC4227303 (PubMed Central)
  7. Excessive nitric oxide function and blood pressure regulation in patients with autonomic failure. Gamboa A, Shibao C, Diedrich A, Paranjape SY, Farley G, Christman B, Raj SR, Robertson D, Biaggioni I (2008) Hypertension 51(6): 1531-6
    › Primary publication · 18426998 (PubMed) · PMC2497433 (PubMed Central)
  8. Hospital-acquired Bordetella bronchiseptica infection following hematopoietic stem cell transplantation. Huebner ES, Christman B, Dummer S, Tang YW, Goodman S (2006) J Clin Microbiol 44(7): 2581-3
    › Primary publication · 16825386 (PubMed) · PMC1489478 (PubMed Central)
  9. Nitric oxide precursors and congenital heart surgery: a randomized controlled trial of oral citrulline. Smith HA, Canter JA, Christian KG, Drinkwater DC, Scholl FG, Christman BW, Rice GD, Barr FE, Summar ML (2006) J Thorac Cardiovasc Surg 132(1): 58-65
    › Primary publication · 16798303 (PubMed)
  10. A study of aspirin and clopidogrel in idiopathic pulmonary arterial hypertension. Robbins IM, Kawut SM, Yung D, Reilly MP, Lloyd W, Cunningham G, Loscalzo J, Kimmel SE, Christman BW, Barst RJ (2006) Eur Respir J 27(3): 578-84
    › Primary publication · 16507859 (PubMed)
  11. Unmasked adult-onset urea cycle disorders in the critical care setting. Summar ML, Barr F, Dawling S, Smith W, Lee B, Singh RH, Rhead WJ, Sniderman King L, Christman BW (2005) Crit Care Clin 21(4 Suppl): S1-8
    › Primary publication · 16227111 (PubMed)
  12. Endotoxin-induced acute lung injury requires interaction with the liver. Siore AM, Parker RE, Stecenko AA, Cuppels C, McKean M, Christman BW, Cruz-Gervis R, Brigham KL (2005) Am J Physiol Lung Cell Mol Physiol 289(5): L769-76
    › Primary publication · 16006484 (PubMed)
  13. The hemochromatosis C282Y allele: a risk factor for hepatic veno-occlusive disease after hematopoietic stem cell transplantation. Kallianpur AR, Hall LD, Yadav M, Byrne DW, Speroff T, Dittus RS, Haines JL, Christman BW, Summar ML (2005) Bone Marrow Transplant 35(12): 1155-64
    › Primary publication · 15834437 (PubMed)
  14. Sepsis in cirrhosis: report on the 7th meeting of the International Ascites Club. Wong F, Bernardi M, Balk R, Christman B, Moreau R, Garcia-Tsao G, Patch D, Soriano G, Hoefs J, Navasa M, International Ascites Club (2005) Gut 54(5): 718-25
    › Primary publication · 15831923 (PubMed) · PMC1774473 (PubMed Central)
  15. Oxidant stress but not thromboxane decreases with epoprostenol therapy. Robbins IM, Morrow JD, Christman BW (2005) Free Radic Biol Med 38(5): 568-74
    › Primary publication · 15683712 (PubMed)
  16. Cellular and molecular pathobiology of pulmonary arterial hypertension. Humbert M, Morrell NW, Archer SL, Stenmark KR, MacLean MR, Lang IM, Christman BW, Weir EK, Eickelberg O, Voelkel NF, Rabinovitch M (2004) J Am Coll Cardiol 43(12 Suppl S): 13S-24S
    › Primary publication · 15194174 (PubMed)
  17. Patency of the preterm fetal ductus arteriosus is regulated by endothelial nitric oxide synthase and is independent of vasa vasorum in the mouse. Richard C, Gao J, LaFleur B, Christman BW, Anderson J, Brown N, Reese J (2004) Am J Physiol Regul Integr Comp Physiol 287(3): R652-60
    › Primary publication · 15142832 (PubMed)
  18. Environmentally determined genetic expression: clinical correlates with molecular variants of carbamyl phosphate synthetase I. Summar ML, Hall L, Christman B, Barr F, Smith H, Kallianpur A, Brown N, Yadav M, Willis A, Eeds A, Cermak E, Summar S, Wilson A, Arvin M, Putnam A, Wills M, Cunningham G (2004) Mol Genet Metab : S12-9
    › Primary publication · 15050969 (PubMed)
  19. Increased prevalence of the HFE C282Y hemochromatosis allele in women with breast cancer. Kallianpur AR, Hall LD, Yadav M, Christman BW, Dittus RS, Haines JL, Parl FF, Summar ML (2004) Cancer Epidemiol Biomarkers Prev 13(2): 205-12
    › Primary publication · 14973098 (PubMed)