Ana Carneiro
Last active: 2/15/2016


My laboratory studies the molecular mechanisms by which integrins protein complexes influence cell function and behavior. Integrins coordinate cell surface receptors, neurotransmitter transporters and intracellular signaling proteins in a tissue-dependent manner. Therefore, first we need to figure out which signaling networks and proteins are modulated by integrins. We focus on the discovery and characterization of protein-protein interactions through biochemical and proteomic approaches. These findings are then taken to the whole animal, where we generate genetically modified mice or disrupt the protein complexes by pharmacological manipulation and measure the outcome in behavioral studies.


The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. Mice lacking integrin β3 expression exhibit altered response to chronic stress. Varney S, Polston KF, Jessen T, Carneiro AM (2015) Neurobiol Stress : 51-58
    › Primary publication · 26634222 (PubMed) · PMC4664197 (PubMed Central)
  2. Integrin β3 Haploinsufficiency Modulates Serotonin Transport and Antidepressant-Sensitive Behavior in Mice. Mazalouskas M, Jessen T, Varney S, Sutcliffe JS, Veenstra-VanderWeele J, Cook EH, Carneiro AM (2015) Neuropsychopharmacology 40(8): 2015-24
    › Primary publication · 25684064 (PubMed) · PMC4839525 (PubMed Central)
  3. Pro32Pro33 mutations in the integrin β3 PSI domain result in αIIbβ3 priming and enhanced adhesion: reversal of the hypercoagulability phenotype by the Src inhibitor SKI-606. Oliver KH, Jessen T, Crawford EL, Chung CY, Sutcliffe JS, Carneiro AM (2014) Mol Pharmacol 85(6): 921-31
    › Primary publication · 24695082 (PubMed) · PMC4014669 (PubMed Central)
  4. Quantitative trait loci mapping and gene network analysis implicate protocadherin-15 as a determinant of brain serotonin transporter expression. Ye R, Carneiro AM, Han Q, Airey D, Sanders-Bush E, Zhang B, Lu L, Williams R, Blakely RD (2014) Genes Brain Behav 13(3): 261-75
    › Primary publication · 24405699 (PubMed) · PMC4436591 (PubMed Central)
  5. Evaluation of heritable determinants of blood and brain serotonin homeostasis using recombinant inbred mice. Ye R, Carneiro AM, Airey D, Sanders-Bush E, Williams RW, Lu L, Wang J, Zhang B, Blakely RD (2014) Genes Brain Behav 13(3): 247-60
    › Primary publication · 24102824 (PubMed) · PMC3979832 (PubMed Central)
  6. Serotonin transporter and integrin beta 3 genes interact to modulate serotonin uptake in mouse brain. Whyte A, Jessen T, Varney S, Carneiro AM (2014) Neurochem Int : 122-6
    › Primary publication · 24083985 (PubMed) · PMC3969782 (PubMed Central)
  7. Single molecule analysis of serotonin transporter regulation using antagonist-conjugated quantum dots reveals restricted, p38 MAPK-dependent mobilization underlying uptake activation. Chang JC, Tomlinson ID, Warnement MR, Ustione A, Carneiro AM, Piston DW, Blakely RD, Rosenthal SJ (2012) J Neurosci 32(26): 8919-29
    › Primary publication · 22745492 (PubMed) · PMC3426861 (PubMed Central)
  8. Autism gene variant causes hyperserotonemia, serotonin receptor hypersensitivity, social impairment and repetitive behavior. Veenstra-VanderWeele J, Muller CL, Iwamoto H, Sauer JE, Owens WA, Shah CR, Cohen J, Mannangatti P, Jessen T, Thompson BJ, Ye R, Kerr TM, Carneiro AM, Crawley JN, Sanders-Bush E, McMahon DG, Ramamoorthy S, Daws LC, Sutcliffe JS, Blakely RD (2012) Proc Natl Acad Sci U S A 109(14): 5469-74
    › Primary publication · 22431635 (PubMed) · PMC3325657 (PubMed Central)
  9. Transgenic elimination of high-affinity antidepressant and cocaine sensitivity in the presynaptic serotonin transporter. Thompson BJ, Jessen T, Henry LK, Field JR, Gamble KL, Gresch PJ, Carneiro AM, Horton RE, Chisnell PJ, Belova Y, McMahon DG, Daws LC, Blakely RD (2011) Proc Natl Acad Sci U S A 108(9): 3785-90
    › Primary publication · 21282638 (PubMed) · PMC3048100 (PubMed Central)
  10. Absence of preference for social novelty and increased grooming in integrin β3 knockout mice: initial studies and future directions. Carter MD, Shah CR, Muller CL, Crawley JN, Carneiro AM, Veenstra-VanderWeele J (2011) Autism Res 4(1): 57-67
    › Primary publication · 21254450 (PubMed) · PMC3073711 (PubMed Central)
  11. cGMP-dependent protein kinase Ialpha associates with the antidepressant-sensitive serotonin transporter and dictates rapid modulation of serotonin uptake. Steiner JA, Carneiro AM, Wright J, Matthies HJ, Prasad HC, Nicki CK, Dostmann WR, Buchanan CC, Corbin JD, Francis SH, Blakely RD (2009) Mol Brain : 26
    › Primary publication · 19656393 (PubMed) · PMC2731736 (PubMed Central)
  12. Functional coding variation in recombinant inbred mouse lines reveals multiple serotonin transporter-associated phenotypes. Carneiro AM, Airey DC, Thompson B, Zhu CB, Lu L, Chesler EJ, Erikson KM, Blakely RD (2009) Proc Natl Acad Sci U S A 106(6): 2047-52
    › Primary publication · 19179283 (PubMed) · PMC2632716 (PubMed Central)
  13. Going with the flow: trafficking-dependent and -independent regulation of serotonin transport. Steiner JA, Carneiro AM, Blakely RD (2008) Traffic 9(9): 1393-402
    › Primary publication · 18445122 (PubMed) · PMC2773847 (PubMed Central)
  14. Interactions between integrin alphaIIbbeta3 and the serotonin transporter regulate serotonin transport and platelet aggregation in mice and humans. Carneiro AM, Cook EH, Murphy DL, Blakely RD (2008) J Clin Invest 118(4): 1544-52
    › Primary publication · 18317590 (PubMed) · PMC2260909 (PubMed Central)
  15. Serotonin-, protein kinase C-, and Hic-5-associated redistribution of the platelet serotonin transporter. Carneiro AM, Blakely RD (2006) J Biol Chem 281(34): 24769-80
    › Primary publication · 16803896 (PubMed) · PMC3875312 (PubMed Central)
  16. p38 MAPK activation elevates serotonin transport activity via a trafficking-independent, protein phosphatase 2A-dependent process. Zhu CB, Carneiro AM, Dostmann WR, Hewlett WA, Blakely RD (2005) J Biol Chem 280(16): 15649-58
    › Primary publication · 15728187 (PubMed)