Tricia Thornton-Wells
Last active: 2/12/2015

Profile

Research in my lab is focused on the genetic and neural bases of neuropsychiatric and neurodevelopmental disorders. We use magnetic resonance imaging (MRI) to derive functional and structural brain-based endophenotypes, and we conduct genetic studies to identify novel associations between genes, endophenotypes, and behavior. We develop and employ statistical and computational methods for the joint analysis of genetic and neuroimaging data (i.e., "imaging genetics").

Publications

The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. Impact of family structure and common environment on heritability estimation for neuroimaging genetics studies using Sequential Oligogenic Linkage Analysis Routines. Koran ME, Thornton-Wells TA, Jahanshad N, Glahn DC, Thompson PM, Blangero J, Nichols TE, Kochunov P, Landman BA (2014) J Med Imaging (Bellingham) 1(1): 014005
    › Primary publication · 25558465 (PubMed) · PMC4281883 (PubMed Central)
  2. Rarity of the Alzheimer disease-protective APP A673T variant in the United States. Wang LS, Naj AC, Graham RR, Crane PK, Kunkle BW, Cruchaga C, Murcia JD, Cannon-Albright L, Baldwin CT, Zetterberg H, Blennow K, Kukull WA, Faber KM, Schupf N, Norton MC, Tschanz JT, Munger RG, Corcoran CD, Rogaeva E, Alzheimer's Disease Genetics Consortium, Lin CF, Dombroski BA, Cantwell LB, Partch A, Valladares O, Hakonarson H, St George-Hyslop P, Green RC, Goate AM, Foroud TM, Carney RM, Larson EB, Behrens TW, Kauwe JS, Haines JL, Farrer LA, Pericak-Vance MA, Mayeux R, Schellenberg GD, National Institute on Aging-Late-Onset Alzheimer’s Disease (NIA-LOAD) Family Study, Albert MS, Albin RL, Apostolova LG, Arnold SE, Barber R, Barmada M, Barnes LL, Beach TG, Becker JT, Beecham GW, Beekly D, Bennett DA, Bigio EH, Bird TD, Blacker D, Boeve BF, Bowen JD, Boxer A, Burke JR, Buxbaum JD, Cairns NJ, Cao C, Carlson CS, Carroll SL, Chui HC, Clark DG, Cribbs DH, Crocco EA, DeCarli C, DeKosky ST, Demirci FY, Dick M, Dickson DW, Duara R, Ertekin-Taner N, Fallon KB, Farlow MR, Ferris S, Frosch MP, Galasko DR, Ganguli M, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Glass JD, Graff-Radford NR, Growdon JH, Hamilton RL, Hamilton-Nelson KL, Harrell LE, Head E, Honig LS, Hulette CM, Hyman BT, Jarvik GP, Jicha GA, Jin LW, Jun G, Jun G, Kamboh MI, Karydas A, Kaye JA, Kim R, Koo EH, Kowall NW, Kramer JH, LaFerla FM, Lah JJ, Leverenz JB, Levey AI, Li G, Lieberman AP, Lopez OL, Lunetta KL, Lyketsos CG, Mack WJ, Marson DC, Martin ER, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam WM, Miller BL, Miller CA, Miller JW, Montine TJ, Morris JC, Murrell JR, Olichney JM, Parisi JE, Perry W, Peskind E, Petersen RC, Pierce A, Poon WW, Potter H, Quinn JF, Raj A, Raskind M, Reiman EM, Reisberg B, Reitz C, Ringman JM, Roberson ED, Rosen HJ, Rosenberg RN, Sano M, Saykin AJ, Schneider JA, Schneider LS, Seeley WW, Smith AG, Sonnen JA, Spina S, Stern RA, Tanzi RE, Thornton-Wells TA, Trojanowski JQ, Troncoso JC, Tsuang DW, Van Deerlin VM, Van Eldik LJ, Vardarajan BN, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Williamson J, Wishnek S, Woltjer RL, Wright CB, Younkin SG, Yu CE, Yu L (2015) JAMA Neurol 72(2): 209-16
    › Primary publication · 25531812 (PubMed) · PMC4324097 (PubMed Central)
  3. Genetic variation modifies risk for neurodegeneration based on biomarker status. Hohman TJ, Koran ME, Thornton-Wells TA, Alzheimer's Neuroimaging Initiative (2014) Front Aging Neurosci : 183
    › Primary publication · 25140149 (PubMed) · PMC4121544 (PubMed Central)
  4. Differences in age-related effects on brain volume in Down syndrome as compared to Williams syndrome and typical development. Koran ME, Hohman TJ, Edwards CM, Vega JN, Pryweller JR, Slosky LE, Crockett G, Villa de Rey L, Meda SA, Dankner N, Avery SN, Blackford JU, Dykens EM, Thornton-Wells TA (2014) J Neurodev Disord 6(1): 8
    › Primary publication · 24713364 (PubMed) · PMC4022321 (PubMed Central)
  5. Genetic modification of the relationship between phosphorylated tau and neurodegeneration. Hohman TJ, Koran ME, Thornton-Wells TA, Alzheimer's Disease Neuroimaging Initiative (2014) Alzheimers Dement 10(6): 637-645.e1
    › Primary publication · 24656848 (PubMed) · PMC4169762 (PubMed Central)
  6. Epistatic genetic effects among Alzheimer's candidate genes. Hohman TJ, Koran ME, Thornton-Wells T, Alzheimer's Neuroimaging Initiative (2013) PLoS One 8(11): e80839
    › Primary publication · 24260488 (PubMed) · PMC3832488 (PubMed Central)
  7. Recurrent tissue-specific mtDNA mutations are common in humans. Samuels DC, Li C, Li B, Song Z, Torstenson E, Boyd Clay H, Rokas A, Thornton-Wells TA, Moore JH, Hughes TM, Hoffman RD, Haines JL, Murdock DG, Mortlock DP, Williams SM (2013) PLoS Genet 9(11): e1003929
    › Primary publication · 24244193 (PubMed) · PMC3820769 (PubMed Central)
  8. Interactions between GSK3β and amyloid genes explain variance in amyloid burden. Hohman TJ, Koran ME, Thornton-Wells TA, Alzheimer's Neuroimaging Initiative (2014) Neurobiol Aging 35(3): 460-5
    › Primary publication · 24112793 (PubMed) · PMC3864626 (PubMed Central)
  9. Genetic interactions within inositol-related pathways are associated with longitudinal changes in ventricle size. Koran ME, Hohman TJ, Meda SA, Thornton-Wells TA (2014) J Alzheimers Dis 38(1): 145-54
    › Primary publication · 24077433 (PubMed) · PMC3815519 (PubMed Central)
  10. Genetic interactions found between calcium channel genes modulate amyloid load measured by positron emission tomography. Koran ME, Hohman TJ, Thornton-Wells TA (2014) Hum Genet 133(1): 85-93
    › Primary publication · 24026422 (PubMed) · PMC4045094 (PubMed Central)
  11. Associations between KCNJ6 (GIRK2) gene polymorphisms and pain-related phenotypes. Bruehl S, Denton JS, Lonergan D, Koran ME, Chont M, Sobey C, Fernando S, Bush WS, Mishra P, Thornton-Wells TA (2013) Pain 154(12): 2853-9
    › Primary publication · 23994450 (PubMed) · PMC3845348 (PubMed Central)
  12. Regional brain differences in cortical thickness, surface area and subcortical volume in individuals with Williams syndrome. Meda SA, Pryweller JR, Thornton-Wells TA (2012) PLoS One 7(2): e31913
    › Primary publication · 22355403 (PubMed) · PMC3280212 (PubMed Central)
  13. White matter integrity deficits in prefrontal-amygdala pathways in Williams syndrome. Avery SN, Thornton-Wells TA, Anderson AW, Blackford JU (2012) Neuroimage 59(2): 887-94
    › Primary publication · 22008369 (PubMed) · PMC3254058 (PubMed Central)
  14. Alterations in diffusion properties of white matter in Williams syndrome. Arlinghaus LR, Thornton-Wells TA, Dykens EM, Anderson AW (2011) Magn Reson Imaging 29(9): 1165-74
    › Primary publication · 21907520 (PubMed) · PMC3199335 (PubMed Central)
  15. Using novel control groups to dissect the amygdala's role in Williams syndrome. Thornton-Wells TA, Avery SN, Blackford JU (2011) Dev Cogn Neurosci 1(3): 295-304
    › Primary publication · 21731599 (PubMed) · PMC3124852 (PubMed Central)
  16. Comparative linkage meta-analysis reveals regionally-distinct, disparate genetic architectures: application to bipolar disorder and schizophrenia. Tang B, Thornton-Wells T, Askland KD (2011) PLoS One 6(4): e19073
    › Primary publication · 21559500 (PubMed) · PMC3084739 (PubMed Central)
  17. Auditory attraction: activation of visual cortex by music and sound in Williams syndrome. Thornton-Wells TA, Cannistraci CJ, Anderson AW, Kim CY, Eapen M, Gore JC, Blake R, Dykens EM (2010) Am J Intellect Dev Disabil 115(2): 172-89
    › Primary publication · 20440382 (PubMed) · PMC2862007 (PubMed Central)
  18. Confronting complexity in late-onset Alzheimer disease: application of two-stage analysis approach addressing heterogeneity and epistasis. Thornton-Wells TA, Moore JH, Martin ER, Pericak-Vance MA, Haines JL (2008) Genet Epidemiol 32(3): 187-203
    › Primary publication · 18076107 (PubMed) · PMC2804868 (PubMed Central)
  19. Dissecting trait heterogeneity: a comparison of three clustering methods applied to genotypic data. Thornton-Wells TA, Moore JH, Haines JL (2006) BMC Bioinformatics : 204
    › Primary publication · 16611359 (PubMed) · PMC1525209 (PubMed Central)
  20. Genetics, statistics and human disease: analytical retooling for complexity. Thornton-Wells TA, Moore JH, Haines JL (2004) Trends Genet 20(12): 640-7
    › Primary publication · 15522460 (PubMed)