Charles Sanders
Faculty Member
Last active: 11/21/2018

Profile

Molecular Biophysical Basis of Diseases Related to Membrane Protein Dysfunction and Misfolding

A surprising number of diseases are caused or impacted by missense mutations in genes encoding membrane proteins that result in protein dysfunction and/or misfolding and mistrafficking early in the secretory pathway. We seek to elucidate the molecular biophysical mechanisms by which such mutations result in these defects. Our approach is to carry out studies of purified membrane proteins under well-controlled conditions and then correlating observations from these studies with what is known about the behavior of the corresponding mutant protein in vivo. We are pursuing several systems. We have discovered that the amyloid precursor protein (APP) that is closely associated with the development of Alzheimer's disease binds cholesterol in a way that may help to control production of the amyloid-beta polypeptide. We seek to understand exactly how and why cholesterol binds to APP and by what mechanisms this regulates amyloid-beta production. A second system involves Long QT Syndrome mutant forms of both the human KCNQ1 potassium channel and a modulatory partner, KCNE1. We are unraveling the mechanisms by which mutations in either of these proteins result in serious, even fatal cardiac arrhythmias. Another project involves a protein of the human peripheral nervous system known as peripheral myelin protein 22 (PMP22). PMP22 is known to undergo mutation-prompted misfolding which results in Charcot-Marie-Tooth Disease. We also study the integrin family or receptors that link the cell to the extracellular matrix, with a particular interest in integrins that are related to kidney function and fibrosis, as commonly occurs in type II diabetes. We also study the interactions of arrestins with G protein-coupled receptors (GPCRs). These studies employ a wide range of techniques spanning the range from molecular biophysics/spectroscopy/biochemistry to cellular/molecular biology. However, solution NMR spectroscopy is the central technique of the lab and the method for which this lab is best known. Additional information is found at the lab web site: http://structbio.vanderbilt.edu/sanders  

Training in the Sanders Lab Trainees in the Sanders lab are also broadly trained in membrane protein biochemistry and biophysics. This often involves learning practical NMR spectroscopy. Trainees are also encouraged to broaden their horizons even further by interacting closely with, or even carrying out experiments in the labs of our collaborators, who are generally more physiologically-oriented that the Sanders lab. Students are also constantly exhorted to master the literature related to their project and to develop a strong biomedical perspective for their work. Finally, the PI of this lab believes that is very important for trainees to be taught the ins and outs of the research culture, including funding strategies, peer review service, and how to be a good collaborator and colleague. See, for example the document "What is Expected of a Ph.D. Student or Postdoctoral Fellow in the Sanders Lab?" which can be view on-line at: http://structbio.vanderbilt.edu/sanders/Sanders_Lab_Guide_Comprehensive.pdf  

Publications

The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow. Tseng HY, Samarelli AV, Kammerer P, Scholze S, Ziegler T, Immler R, Zent R, Sperandio M, Sanders CR, Fässler R, Böttcher RT (2018) J Cell Sci 131(22)
    › Primary publication · 30333137 (PubMed) · PMC6262777 (PubMed Central)
  2. De novo designed transmembrane peptides activating the α5β1 integrin. Mravic M, Hu H, Lu Z, Bennett JS, Sanders CR, Orr AW, DeGrado WF (2018) Protein Eng Des Sel 31(5): 181-190
    › Primary publication · 29992271 (PubMed) · PMC6151875 (PubMed Central)
  3. Bexarotene Binds to the Amyloid Precursor Protein Transmembrane Domain, Alters Its α-Helical Conformation, and Inhibits γ-Secretase Nonselectively in Liposomes. Kamp F, Scheidt HA, Winkler E, Basset G, Heinel H, Hutchison JM, LaPointe LM, Sanders CR, Steiner H, Huster D (2018) ACS Chem Neurosci 9(7): 1702-1713
    › Primary publication · 29717863 (PubMed) · PMC6051911 (PubMed Central)
  4. Mechanisms of KCNQ1 channel dysfunction in long QT syndrome involving voltage sensor domain mutations. Huang H, Kuenze G, Smith JA, Taylor KC, Duran AM, Hadziselimovic A, Meiler J, Vanoye CG, George AL, Sanders CR (2018) Sci Adv 4(3): eaar2631
    › Primary publication · 29532034 (PubMed) · PMC5842040 (PubMed Central)
  5. Predicting the Functional Impact of KCNQ1 Variants of Unknown Significance. Li B, Mendenhall JL, Kroncke BM, Taylor KC, Huang H, Smith DK, Vanoye CG, Blume JD, George AL, Sanders CR, Meiler J (2017) Circ Cardiovasc Genet 10(5)
    › Primary publication · 29021305 (PubMed) · PMC5679743 (PubMed Central)
  6. Talin regulates integrin β1-dependent and -independent cell functions in ureteric bud development. Mathew S, Palamuttam RJ, Mernaugh G, Ramalingam H, Lu Z, Zhang MZ, Ishibe S, Critchley DR, Fässler R, Pozzi A, Sanders CR, Carroll TJ, Zent R (2017) Development 144(22): 4148-4158
    › Primary publication · 28993400 (PubMed) · PMC5719244 (PubMed Central)
  7. Dodecyl-β-melibioside Detergent Micelles as a Medium for Membrane Proteins. Hutchison JM, Lu Z, Li GC, Travis B, Mittal R, Deatherage CL, Sanders CR (2017) Biochemistry 56(41): 5481-5484
    › Primary publication · 28980804 (PubMed) · PMC5685800 (PubMed Central)
  8. Peripheral myelin protein 22 alters membrane architecture. Mittendorf KF, Marinko JT, Hampton CM, Ke Z, Hadziselimovic A, Schlebach JP, Law CL, Li J, Wright ER, Sanders CR, Ohi MD (2017) Sci Adv 3(7): e1700220
    › Primary publication · 28695207 (PubMed) · PMC5498104 (PubMed Central)
  9. Structural and biochemical differences between the Notch and the amyloid precursor protein transmembrane domains. Deatherage CL, Lu Z, Kroncke BM, Ma S, Smith JA, Voehler MW, McFeeters RL, Sanders CR (2017) Sci Adv 3(4): e1602794
    › Primary publication · 28439555 (PubMed) · PMC5389784 (PubMed Central)
  10. Implications of the differing roles of the β1 and β3 transmembrane and cytoplasmic domains for integrin function. Lu Z, Mathew S, Chen J, Hadziselimovic A, Palamuttam R, Hudson BG, Fässler R, Pozzi A, Sanders CR, Zent R (2016) Elife
    › Primary publication · 27929375 (PubMed) · PMC5207772 (PubMed Central)
  11. Regulation of KCNQ/Kv7 family voltage-gated K channels by lipids. Taylor KC, Sanders CR (2017) Biochim Biophys Acta Biomembr 1859(4): 586-597
    › Primary publication · 27818172 (PubMed) · PMC5305565 (PubMed Central)
  12. Structural basis for KCNE3 modulation of potassium recycling in epithelia. Kroncke BM, Van Horn WD, Smith J, Kang C, Welch RC, Song Y, Nannemann DP, Taylor KC, Sisco NJ, George AL, Meiler J, Vanoye CG, Sanders CR (2016) Sci Adv 2(9): e1501228
    › Primary publication · 27626070 (PubMed) · PMC5017827 (PubMed Central)
  13. How γ-secretase hits a moving target. Sanders CR (2016) Elife
    › Primary publication · 27580373 (PubMed) · PMC5007112 (PubMed Central)
  14. Documentation of an Imperative To Improve Methods for Predicting Membrane Protein Stability. Kroncke BM, Duran AM, Mendenhall JL, Meiler J, Blume JD, Sanders CR (2016) Biochemistry 55(36): 5002-9
    › Primary publication · 27564391 (PubMed) · PMC5024705 (PubMed Central)
  15. A pH-Mediated Topological Switch within the N-Terminal Domain of Human Caveolin-3. Kim JH, Schlebach JP, Lu Z, Peng D, Reasoner KC, Sanders CR (2016) Biophys J 110(11): 2475-2485
    › Primary publication · 27276265 (PubMed) · PMC4906379 (PubMed Central)
  16. Transthyretin Suppresses Amyloid-β Secretion by Interfering with Processing of the Amyloid-β Protein Precursor. Li X, Song Y, Sanders CR, Buxbaum JN (2016) J Alzheimers Dis 52(4): 1263-75
    › Primary publication · 27079720 (PubMed) · PMC4980917 (PubMed Central)
  17. Structural and Molecular Determinants of Membrane Binding by the HIV-1 Matrix Protein. Mercredi PY, Bucca N, Loeliger B, Gaines CR, Mehta M, Bhargava P, Tedbury PR, Charlier L, Floquet N, Muriaux D, Favard C, Sanders CR, Freed EO, Marchant J, Summers MF (2016) J Mol Biol 428(8): 1637-55
    › Primary publication · 26992353 (PubMed) · PMC4836608 (PubMed Central)
  18. Topologically Diverse Human Membrane Proteins Partition to Liquid-Disordered Domains in Phase-Separated Lipid Vesicles. Schlebach JP, Barrett PJ, Day CA, Kim JH, Kenworthy AK, Sanders CR (2016) Biochemistry 55(7): 985-8
    › Primary publication · 26859249 (PubMed) · PMC4766968 (PubMed Central)
  19. Probing Structural Dynamics and Topology of the KCNE1 Membrane Protein in Lipid Bilayers via Site-Directed Spin Labeling and Electron Paramagnetic Resonance Spectroscopy. Sahu ID, Craig AF, Dunagan MM, Troxel KR, Zhang R, Meiberg AG, Harmon CN, McCarrick RM, Kroncke BM, Sanders CR, Lorigan GA (2015) Biochemistry 54(41): 6402-12
    › Primary publication · 26418890 (PubMed) · PMC4812432 (PubMed Central)
  20. Influence of Arrestin on the Photodecay of Bovine Rhodopsin. Chatterjee D, Eckert CE, Slavov C, Saxena K, Fürtig B, Sanders CR, Gurevich VV, Wachtveitl J, Schwalbe H (2015) Angew Chem Int Ed Engl 54(46): 13555-60
    › Primary publication · 26383645 (PubMed) · PMC4685475 (PubMed Central)
  21. Development of electron spin echo envelope modulation spectroscopy to probe the secondary structure of recombinant membrane proteins in a lipid bilayer. Zhang R, Sahu ID, Gibson KR, Muhammad NB, Bali AP, Comer RG, Liu L, Craig AF, Mccarrick RM, Dabney-Smith C, Sanders CR, Lorigan GA (2015) Protein Sci 24(11): 1707-13
    › Primary publication · 26355804 (PubMed) · PMC4622204 (PubMed Central)
  22. Promotion of BRCA2-Dependent Homologous Recombination by DSS1 via RPA Targeting and DNA Mimicry. Zhao W, Vaithiyalingam S, San Filippo J, Maranon DG, Jimenez-Sainz J, Fontenay GV, Kwon Y, Leung SG, Lu L, Jensen RB, Chazin WJ, Wiese C, Sung P (2015) Mol Cell 59(2): 176-87
    › Primary publication · 26145171 (PubMed) · PMC4506714 (PubMed Central)
  23. Conformational Stability and Pathogenic Misfolding of the Integral Membrane Protein PMP22. Schlebach JP, Narayan M, Alford C, Mittendorf KF, Carter BD, Li J, Sanders CR (2015) J Am Chem Soc 137(27): 8758-68
    › Primary publication · 26102530 (PubMed) · PMC4507940 (PubMed Central)
  24. Notch Transmembrane Domain: Secondary Structure and Topology. Deatherage CL, Lu Z, Kim JH, Sanders CR (2015) Biochemistry 54(23): 3565-8
    › Primary publication · 26023825 (PubMed) · PMC4472088 (PubMed Central)
  25. Discovery of tricyclic indoles that potently inhibit Mcl-1 using fragment-based methods and structure-based design. Burke JP, Bian Z, Shaw S, Zhao B, Goodwin CM, Belmar J, Browning CF, Vigil D, Friberg A, Camper DV, Rossanese OW, Lee T, Olejniczak ET, Fesik SW (2015) J Med Chem 58(9): 3794-805
    › Primary publication · 25844895 (PubMed) · PMC5565203 (PubMed Central)
  26. Biophysical characterization of interactions between the C-termini of peripheral nerve claudins and the PDZ₁ domain of zonula occludens. Wu J, Peng D, Zhang Y, Lu Z, Voehler M, Sanders CR, Li J (2015) Biochem Biophys Res Commun 459(1): 87-93
    › Primary publication · 25712527 (PubMed) · PMC4363178 (PubMed Central)
  27. Simian virus Large T antigen interacts with the N-terminal domain of the 70 kD subunit of Replication Protein A in the same mode as multiple DNA damage response factors. Ning B, Feldkamp MD, Cortez D, Chazin WJ, Friedman KL, Fanning E (2015) PLoS One 10(2): e0116093
    › Primary publication · 25706313 (PubMed) · PMC4337903 (PubMed Central)
  28. Diphenylpyrazoles as replication protein a inhibitors. Waterson AG, Kennedy JP, Patrone JD, Pelz NF, Feldkamp MD, Frank AO, Vangamudi B, Souza-Fagundes EM, Rossanese OW, Chazin WJ, Fesik SW (2015) ACS Med Chem Lett 6(2): 140-5
    › Primary publication · 25699140 (PubMed) · PMC4329576 (PubMed Central)
  29. Human PrimPol is a highly error-prone polymerase regulated by single-stranded DNA binding proteins. Guilliam TA, Jozwiakowski SK, Ehlinger A, Barnes RP, Rudd SG, Bailey LJ, Skehel JM, Eckert KA, Chazin WJ, Doherty AJ (2015) Nucleic Acids Res 43(2): 1056-68
    › Primary publication · 25550423 (PubMed) · PMC4333378 (PubMed Central)
  30. The homology model of PMP22 suggests mutations resulting in peripheral neuropathy disrupt transmembrane helix packing. Mittendorf KF, Kroncke BM, Meiler J, Sanders CR (2014) Biochemistry 53(39): 6139-41
    › Primary publication · 25243937 (PubMed) · PMC4188248 (PubMed Central)
  31. Structural investigation of the transmembrane domain of KCNE1 in proteoliposomes. Sahu ID, Kroncke BM, Zhang R, Dunagan MM, Smith HJ, Craig A, McCarrick RM, Sanders CR, Lorigan GA (2014) Biochemistry 53(40): 6392-401
    › Primary publication · 25234231 (PubMed) · PMC4196734 (PubMed Central)
  32. Influence of Pathogenic Mutations on the Energetics of Translocon-Mediated Bilayer Integration of Transmembrane Helices. Schlebach JP, Sanders CR (2015) J Membr Biol 248(3): 371-81
    › Primary publication · 25192979 (PubMed) · PMC4362857 (PubMed Central)
  33. Purification and structural study of the voltage-sensor domain of the human KCNQ1 potassium ion channel. Peng D, Kim JH, Kroncke BM, Law CL, Xia Y, Droege KD, Van Horn WD, Vanoye CG, Sanders CR (2014) Biochemistry 53(12): 2032-42
    › Primary publication · 24606221 (PubMed) · PMC3977583 (PubMed Central)
  34. Impact of bilayer lipid composition on the structure and topology of the transmembrane amyloid precursor C99 protein. Song Y, Mittendorf KF, Lu Z, Sanders CR (2014) J Am Chem Soc 136(11): 4093-6
    › Primary publication · 24564538 (PubMed) · PMC3985881 (PubMed Central)
  35. The integrin β1 subunit regulates paracellular permeability of kidney proximal tubule cells. Elias BC, Mathew S, Srichai MB, Palamuttam R, Bulus N, Mernaugh G, Singh AB, Sanders CR, Harris RC, Pozzi A, Zent R (2014) J Biol Chem 289(12): 8532-44
    › Primary publication · 24509849 (PubMed) · PMC3961677 (PubMed Central)
  36. Cholesterol as a co-solvent and a ligand for membrane proteins. Song Y, Kenworthy AK, Sanders CR (2014) Protein Sci 23(1): 1-22
    › Primary publication · 24155031 (PubMed) · PMC3892294 (PubMed Central)
  37. Structure and expression of a novel compact myelin protein - small VCP-interacting protein (SVIP). Wu J, Peng D, Voehler M, Sanders CR, Li J (2013) Biochem Biophys Res Commun 440(1): 173-8
    › Primary publication · 24055875 (PubMed) · PMC3828079 (PubMed Central)
  38. DEER EPR measurements for membrane protein structures via bifunctional spin labels and lipodisq nanoparticles. Sahu ID, McCarrick RM, Troxel KR, Zhang R, Smith HJ, Dunagan MM, Swartz MS, Rajan PV, Kroncke BM, Sanders CR, Lorigan GA (2013) Biochemistry 52(38): 6627-32
    › Primary publication · 23984855 (PubMed) · PMC3826088 (PubMed Central)
  39. Reversible folding of human peripheral myelin protein 22, a tetraspan membrane protein. Schlebach JP, Peng D, Kroncke BM, Mittendorf KF, Narayan M, Carter BD, Sanders CR (2013) Biochemistry 52(19): 3229-41
    › Primary publication · 23639031 (PubMed) · PMC3762913 (PubMed Central)
  40. The quiet renaissance of protein nuclear magnetic resonance. Barrett PJ, Chen J, Cho MK, Kim JH, Lu Z, Mathew S, Peng D, Song Y, Van Horn WD, Zhuang T, Sönnichsen FD, Sanders CR (2013) Biochemistry 52(8): 1303-20
    › Primary publication · 23368985 (PubMed) · PMC3592982 (PubMed Central)
  41. Involvement of distinct arrestin-1 elements in binding to different functional forms of rhodopsin. Zhuang T, Chen Q, Cho MK, Vishnivetskiy SA, Iverson TM, Gurevich VV, Sanders CR (2013) Proc Natl Acad Sci U S A 110(3): 942-7
    › Primary publication · 23277586 (PubMed) · PMC3549108 (PubMed Central)
  42. The backbone dynamics of the amyloid precursor protein transmembrane helix provides a rationale for the sequential cleavage mechanism of γ-secretase. Pester O, Barrett PJ, Hornburg D, Hornburg P, Pröbstle R, Widmaier S, Kutzner C, Dürrbaum M, Kapurniotu A, Sanders CR, Scharnagl C, Langosch D (2013) J Am Chem Soc 135(4): 1317-29
    › Primary publication · 23265086 (PubMed) · PMC3560327 (PubMed Central)
  43. An allosteric mechanism for drug block of the human cardiac potassium channel KCNQ1. Yang T, Smith JA, Leake BF, Sanders CR, Meiler J, Roden DM (2013) Mol Pharmacol 83(2): 481-9
    › Primary publication · 23193163 (PubMed) · PMC3558809 (PubMed Central)
  44. Enhancing integrin α1 inserted (I) domain affinity to ligand potentiates integrin α1β1-mediated down-regulation of collagen synthesis. Shi M, Pedchenko V, Greer BH, Van Horn WD, Santoro SA, Sanders CR, Hudson BG, Eichman BF, Zent R, Pozzi A (2012) J Biol Chem 287(42): 35139-52
    › Primary publication · 22888006 (PubMed) · PMC3471707 (PubMed Central)
  45. β1 integrin NPXY motifs regulate kidney collecting-duct development and maintenance by induced-fit interactions with cytosolic proteins. Mathew S, Lu Z, Palamuttam RJ, Mernaugh G, Hadziselimovic A, Chen J, Bulus N, Gewin LS, Voehler M, Meves A, Ballestrem C, Fässler R, Pozzi A, Sanders CR, Zent R (2012) Mol Cell Biol 32(20): 4080-91
    › Primary publication · 22869523 (PubMed) · PMC3457338 (PubMed Central)
  46. Purification and characterization of the human γ-secretase activating protein. Deatherage CL, Hadziselimovic A, Sanders CR (2012) Biochemistry 51(25): 5153-9
    › Primary publication · 22681044 (PubMed) · PMC3386298 (PubMed Central)
  47. The amyloid precursor protein has a flexible transmembrane domain and binds cholesterol. Barrett PJ, Song Y, Van Horn WD, Hustedt EJ, Schafer JM, Hadziselimovic A, Beel AJ, Sanders CR (2012) Science 336(6085): 1168-71
    › Primary publication · 22654059 (PubMed) · PMC3528355 (PubMed Central)
  48. Bicelles at low concentrations. Lu Z, Van Horn WD, Chen J, Mathew S, Zent R, Sanders CR (2012) Mol Pharm 9(4): 752-61
    › Primary publication · 22221179 (PubMed) · PMC3319193 (PubMed Central)
  49. Reconstitution of KCNE1 into lipid bilayers: comparing the structural, dynamic, and activity differences in micelle and vesicle environments. Coey AT, Sahu ID, Gunasekera TS, Troxel KR, Hawn JM, Swartz MS, Wickenheiser MR, Reid RJ, Welch RC, Vanoye CG, Kang C, Sanders CR, Lorigan GA (2011) Biochemistry 50(50): 10851-9
    › Primary publication · 22085289 (PubMed) · PMC3259855 (PubMed Central)
  50. Solution NMR approaches for establishing specificity of weak heterodimerization of membrane proteins. Zhuang T, Jap BK, Sanders CR (2011) J Am Chem Soc 133(50): 20571-80
    › Primary publication · 22084929 (PubMed) · PMC3241871 (PubMed Central)
  51. NSAID-based γ-secretase modulators do not bind to the amyloid-β polypeptide. Barrett PJ, Sanders CR, Kaufman SA, Michelsen K, Jordan JB (2011) Biochemistry 50(47): 10328-42
    › Primary publication · 21995415 (PubMed) · PMC3272834 (PubMed Central)
  52. Structural basis for the Trembler-J phenotype of Charcot-Marie-Tooth disease. Sakakura M, Hadziselimovic A, Wang Z, Schey KL, Sanders CR (2011) Structure 19(8): 1160-9
    › Primary publication · 21827951 (PubMed) · PMC3154623 (PubMed Central)
  53. Working model for the structural basis for KCNE1 modulation of the KCNQ1 potassium channel. Van Horn WD, Vanoye CG, Sanders CR (2011) Curr Opin Struct Biol 21(2): 283-91
    › Primary publication · 21296569 (PubMed) · PMC3070781 (PubMed Central)
  54. Elucidation of inositol hexaphosphate and heparin interaction sites and conformational changes in arrestin-1 by solution nuclear magnetic resonance. Zhuang T, Vishnivetskiy SA, Gurevich VV, Sanders CR (2010) Biochemistry 49(49): 10473-85
    › Primary publication · 21050017 (PubMed) · PMC3074303 (PubMed Central)
  55. Integrin {alpha}1{beta}1 promotes caveolin-1 dephosphorylation by activating T cell protein-tyrosine phosphatase. Borza CM, Chen X, Mathew S, Mont S, Sanders CR, Zent R, Pozzi A (2010) J Biol Chem 285(51): 40114-24
    › Primary publication · 20940300 (PubMed) · PMC3000994 (PubMed Central)
  56. CHOBIMALT: a cholesterol-based detergent. Howell SC, Mittal R, Huang L, Travis B, Breyer RM, Sanders CR (2010) Biochemistry 49(44): 9572-83
    › Primary publication · 20919740 (PubMed) · PMC3030671 (PubMed Central)
  57. Lysophospholipid micelles sustain the stability and catalytic activity of diacylglycerol kinase in the absence of lipids. Koehler J, Sulistijo ES, Sakakura M, Kim HJ, Ellis CD, Sanders CR (2010) Biochemistry 49(33): 7089-99
    › Primary publication · 20666483 (PubMed) · PMC2923640 (PubMed Central)
  58. Direct binding of cholesterol to the amyloid precursor protein: An important interaction in lipid-Alzheimer's disease relationships? Beel AJ, Sakakura M, Barrett PJ, Sanders CR (2010) Biochim Biophys Acta 1801(8): 975-82
    › Primary publication · 20304095 (PubMed) · PMC2886191 (PubMed Central)
  59. Recent Advances in the Application of Solution NMR Spectroscopy to Multi-Span Integral Membrane Proteins. Kim HJ, Howell SC, Van Horn WD, Jeon YH, Sanders CR (2009) Prog Nucl Magn Reson Spectrosc 55(4): 335-360
    › Primary publication · 20161395 (PubMed) · PMC2782866 (PubMed Central)
  60. KCNQ1/KCNE1 assembly, co-translation not required. Vanoye CG, Welch RC, Tian C, Sanders CR, George AL (2010) Channels (Austin) 4(2): 108-14
    › Primary publication · 20139709 (PubMed) · PMC3045044 (PubMed Central)
  61. Functional delivery of a membrane protein into oocyte membranes using bicelles. Kang C, Vanoye CG, Welch RC, Van Horn WD, Sanders CR (2010) Biochemistry 49(4): 653-5
    › Primary publication · 20044833 (PubMed) · PMC2811756 (PubMed Central)
  62. Nonspecificity of binding of gamma-secretase modulators to the amyloid precursor protein. Beel AJ, Barrett P, Schnier PD, Hitchcock SA, Bagal D, Sanders CR, Jordan JB (2009) Biochemistry 48(50): 11837-9
    › Primary publication · 19928774 (PubMed) · PMC2794937 (PubMed Central)
  63. Bolaamphiphile-class surfactants can stabilize and support the function of solubilized integral membrane proteins. Li Q, Mittal R, Huang L, Travis B, Sanders CR (2009) Biochemistry 48(49): 11606-8
    › Primary publication · 19908902 (PubMed) · PMC2790596 (PubMed Central)
  64. The impact of window functions on NMR-based paramagnetic relaxation enhancement measurements in membrane proteins. Van Horn WD, Beel AJ, Kang C, Sanders CR (2010) Biochim Biophys Acta 1798(2): 140-9
    › Primary publication · 19751702 (PubMed) · PMC2812639 (PubMed Central)
  65. A sulfilimine bond identified in collagen IV. Vanacore R, Ham AJ, Voehler M, Sanders CR, Conrads TP, Veenstra TD, Sharpless KB, Dawson PE, Hudson BG (2009) Science 325(5945): 1230-4
    › Primary publication · 19729652 (PubMed) · PMC2876822 (PubMed Central)
  66. Distinct subdomains of the KCNQ1 S6 segment determine channel modulation by different KCNE subunits. Vanoye CG, Welch RC, Daniels MA, Manderfield LJ, Tapper AR, Sanders CR, George AL (2009) J Gen Physiol 134(3): 207-17
    › Primary publication · 19687231 (PubMed) · PMC2737226 (PubMed Central)
  67. Solution nuclear magnetic resonance structure of membrane-integral diacylglycerol kinase. Van Horn WD, Kim HJ, Ellis CD, Hadziselimovic A, Sulistijo ES, Karra MD, Tian C, Sönnichsen FD, Sanders CR (2009) Science 324(5935): 1726-9
    › Primary publication · 19556511 (PubMed) · PMC2764269 (PubMed Central)
  68. A unified hydrophobicity scale for multispan membrane proteins. Koehler J, Woetzel N, Staritzbichler R, Sanders CR, Meiler J (2009) Proteins 76(1): 13-29
    › Primary publication · 19089980 (PubMed) · PMC2761718 (PubMed Central)
  69. Cross-talk between integrins alpha1beta1 and alpha2beta1 in renal epithelial cells. Abair TD, Sundaramoorthy M, Chen D, Heino J, Ivaska J, Hudson BG, Sanders CR, Pozzi A, Zent R (2008) Exp Cell Res 314(19): 3593-604
    › Primary publication · 18809396 (PubMed) · PMC2729514 (PubMed Central)
  70. The peripheral neuropathy-linked Trembler and Trembler-J mutant forms of peripheral myelin protein 22 are folding-destabilized. Myers JK, Mobley CK, Sanders CR (2008) Biochemistry 47(40): 10620-9
    › Primary publication · 18795802 (PubMed) · PMC2566783 (PubMed Central)
  71. Structural studies of the transmembrane C-terminal domain of the amyloid precursor protein (APP): does APP function as a cholesterol sensor? Beel AJ, Mobley CK, Kim HJ, Tian F, Hadziselimovic A, Jap B, Prestegard JH, Sanders CR (2008) Biochemistry 47(36): 9428-46
    › Primary publication · 18702528 (PubMed) · PMC2572687 (PubMed Central)
  72. Structure of KCNE1 and implications for how it modulates the KCNQ1 potassium channel. Kang C, Tian C, Sönnichsen FD, Smith JA, Meiler J, George AL, Vanoye CG, Kim HJ, Sanders CR (2008) Biochemistry 47(31): 7999-8006
    › Primary publication · 18611041 (PubMed) · PMC2580054 (PubMed Central)
  73. Structural models for the KCNQ1 voltage-gated potassium channel. Smith JA, Vanoye CG, George AL, Meiler J, Sanders CR (2007) Biochemistry 46(49): 14141-52
    › Primary publication · 17999538 (PubMed) · PMC2565492 (PubMed Central)
  74. Preparation, functional characterization, and NMR studies of human KCNE1, a voltage-gated potassium channel accessory subunit associated with deafness and long QT syndrome. Tian C, Vanoye CG, Kang C, Welch RC, Kim HJ, George AL, Sanders CR (2007) Biochemistry 46(41): 11459-72
    › Primary publication · 17892302 (PubMed) · PMC2565491 (PubMed Central)
  75. Purification and initiation of structural characterization of human peripheral myelin protein 22, an integral membrane protein linked to peripheral neuropathies. Mobley CK, Myers JK, Hadziselimovic A, Ellis CD, Sanders CR (2007) Biochemistry 46(39): 11185-95
    › Primary publication · 17824619 (PubMed)
  76. Visiting order on membrane proteins by using nanotechnology. Sanders CR (2007) Proc Natl Acad Sci U S A 104(16): 6502-3
    › Primary publication · 17420448 (PubMed) · PMC1871815 (PubMed Central)