Eicosanoid is an umbrella term used to describe any oxidized derivative of arachidonic acid, a ubiquitous polyunsaturated fatty acid (PUFA) in humans.  Arachidonic acid can be oxidized in vivo via both enzymatic and non-enzymatic mechanisms to yield bioactive lipid mediators that are of central importance to human physiology and pathophysiology.  

The Eicosanoid Core Laboratory at Vanderbilt University was established in 1988 in order to provide investigators at the university with a central location for analysis of prostaglandins, leukotrienes, and isoprostanes.  Today the Eicosanoid Core Laboratory serves investigators not only at Vanderbilt but indeed around the world.


The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. Cruciferous vegetable intake is inversely correlated with circulating levels of proinflammatory markers in women. Jiang Y, Wu SH, Shu XO, Xiang YB, Ji BT, Milne GL, Cai Q, Zhang X, Gao YT, Zheng W, Yang G (2014) J Acad Nutr Diet 114(5): 700-8.e2
    › Primary publication · 24630682 (PubMed) · PMC4063312 (PubMed Central)
  2. A metabolomic analysis of omega-3 fatty acid-mediated attenuation of western diet-induced nonalcoholic steatohepatitis in LDLR-/- mice. Depner CM, Traber MG, Bobe G, Kensicki E, Bohren KM, Milne G, Jump DB (2013) PLoS One 8(12): e83756
    › Primary publication · 24358308 (PubMed) · PMC3866250 (PubMed Central)
  3. Preventive effects of NSAIDs, NO-NSAIDs, and NSAIDs plus difluoromethylornithine in a chemically induced urinary bladder cancer model. Nicastro HL, Grubbs CJ, Margaret Juliana M, Bode AM, Kim MS, Lu Y, You M, Milne GL, Boring D, Steele VE, Lubet RA (2014) Cancer Prev Res (Phila) 7(2): 246-54
    › Primary publication · 24346344 (PubMed)
  4. Isoprostane and isofuran lipid mediators accumulate in stored red blood cells and influence platelet function in vitro. Spinelli SL, Lannan KL, Casey AE, Croasdell A, Curran TM, Henrichs KF, Pollock SJ, Milne GA, Refaai MA, Francis CW, Phipps RP, Blumberg N (2014) Transfusion 54(6): 1569-79
    › Primary publication · 24192515 (PubMed) · PMC4010581 (PubMed Central)
  5. Prostaglandins are essential for cervical ripening in LPS-mediated preterm birth but not term or antiprogestin-driven preterm ripening. Timmons BC, Reese J, Socrate S, Ehinger N, Paria BC, Milne GL, Akins ML, Auchus RJ, McIntire D, House M, Mahendroo M (2014) Endocrinology 155(1): 287-98
    › Primary publication · 24189143 (PubMed) · PMC3868800 (PubMed Central)
  6. Higher serum iron is associated with increased oxidant stress in HIV-infected men. Crist MB, Melekhin VV, Bian A, Shintani A, Milne GL, Kallianpur AR, Dageforde LA, Haas DW, Hulgan T (2013) J Acquir Immune Defic Syndr 64(4): 367-73
    › Primary publication · 24169121 (PubMed) · PMC3816092 (PubMed Central)
  7. Nonexercise physical activity and inflammatory and oxidative stress markers in women. Wu SH, Shu XO, Chow WH, Xiang YB, Zhang X, Li HL, Cai Q, Milne G, Ji BT, Cai H, Rothman N, Gao YT, Zheng W, Yang G (2014) J Womens Health (Larchmt) 23(2): 159-67
    › Primary publication · 24168102 (PubMed) · PMC3922397 (PubMed Central)
  8. Tolerability and pharmacokinetics of delayed-release dimethyl fumarate administered with and without aspirin in healthy volunteers. Sheikh SI, Nestorov I, Russell H, O'Gorman J, Huang R, Milne GL, Scannevin RH, Novas M, Dawson KT (2013) Clin Ther 35(10): 1582-1594.e9
    › Primary publication · 24139424 (PubMed)
  9. Suboptimal inhibition of platelet cyclooxygenase 1 by aspirin in systemic lupus erythematosus: association with metabolic syndrome. Kawai VK, Avalos I, Oeser A, Oates JA, Milne GL, Solus JF, Chung CP, Stein CM (2014) Arthritis Care Res (Hoboken) 66(2): 285-92
    › Primary publication · 24022862 (PubMed) · PMC3946810 (PubMed Central)
  10. Impact of hematopoietic cyclooxygenase-1 deficiency on obesity-linked adipose tissue inflammation and metabolic disorders in mice. Saraswathi V, Ramnanan CJ, Wilks AW, Desouza CV, Eller AA, Murali G, Ramalingam R, Milne GL, Coate KC, Edgerton DS (2013) Metabolism 62(11): 1673-85
    › Primary publication · 23987235 (PubMed) · PMC4845736 (PubMed Central)
  11. Quantification of major urinary metabolites of PGE2 and PGD2 in cystic fibrosis: correlation with disease severity. Jabr S, Gartner S, Milne GL, Roca-Ferrer J, Casas J, Moreno A, Gelpí E, Picado C (2013) Prostaglandins Leukot Essent Fatty Acids 89(2-3): 121-6
    › Primary publication · 23791427 (PubMed)
  12. Effect of zileuton and celecoxib on urinary LTE4 and PGE-M levels in smokers. Mohebati A, Milne GL, Zhou XK, Duffield-Lillico AJ, Boyle JO, Knutson A, Bosworth BP, Kingsley PJ, Marnett LJ, Brown PH, Akpa EG, Szabo E, Dannenberg AJ (2013) Cancer Prev Res (Phila) 6(7): 646-55
    › Primary publication · 23682075 (PubMed) · PMC3707304 (PubMed Central)
  13. Association between urinary prostaglandin E2 metabolite and breast cancer risk: a prospective, case-cohort study of postmenopausal women. Kim S, Taylor JA, Milne GL, Sandler DP (2013) Cancer Prev Res (Phila) 6(6): 511-8
    › Primary publication · 23636050 (PubMed) · PMC3677792 (PubMed Central)
  14. Increased levels of urinary PGE-M, a biomarker of inflammation, occur in association with obesity, aging, and lung metastases in patients with breast cancer. Morris PG, Zhou XK, Milne GL, Goldstein D, Hawks LC, Dang CT, Modi S, Fornier MN, Hudis CA, Dannenberg AJ (2013) Cancer Prev Res (Phila) 6(5): 428-36
    › Primary publication · 23531446 (PubMed) · PMC3752669 (PubMed Central)
  15. Differential stem- and progenitor-cell trafficking by prostaglandin E2. Hoggatt J, Mohammad KS, Singh P, Hoggatt AF, Chitteti BR, Speth JM, Hu P, Poteat BA, Stilger KN, Ferraro F, Silberstein L, Wong FK, Farag SS, Czader M, Milne GL, Breyer RM, Serezani CH, Scadden DT, Guise TA, Srour EF, Pelus LM (2013) Nature 495(7441): 365-9
    › Primary publication · 23485965 (PubMed) · PMC3606692 (PubMed Central)
  16. Human cytochrome P450 2E1 mutations that alter mitochondrial targeting efficiency and susceptibility to ethanol-induced toxicity in cellular models. Bansal S, Anandatheerthavarada HK, Prabu GK, Milne GL, Martin MV, Guengerich FP, Avadhani NG (2013) J Biol Chem 288(18): 12627-44
    › Primary publication · 23471973 (PubMed) · PMC3642310 (PubMed Central)
  17. Alteration of isocitrate dehydrogenase following acute ischemic injury as a means to improve cellular energetic status in neuroadaptation. Grelli KN, Palubinsky AM, Kale AC, Lizama-Manibusan BN, Stankowski JN, Milne GL, Singer R, McLaughlin B (2013) CNS Neurol Disord Drug Targets 12(6): 849-60
    › Primary publication · 23469839 (PubMed) · PMC3770751 (PubMed Central)
  18. Chronic cyclic bladder over distention up-regulates hypoxia dependent pathways. Stephany HA, Strand DW, Ching CB, Tanaka ST, Milne GL, Cajaiba MM, Thomas JC, Pope JC, Adams MC, Brock JW, Hayward SW, Matusik RJ, Clayton DB (2013) J Urol 190(4 Suppl): 1603-9
    › Primary publication · 23429070 (PubMed) · PMC4085185 (PubMed Central)
  19. Adiposity and fat distribution in relation to inflammation and oxidative stress in a relatively lean population of Chinese women. Wu SH, Shu XO, Chow WH, Xiang YB, Zhang X, Cai Q, Li HL, Milne G, Wen W, Ji BT, Rothman N, Gao YT, Zheng W, Yang G (2013) Dis Markers 34(4): 279-93
    › Primary publication · 23396296 (PubMed) · PMC3740559 (PubMed Central)
  20. NADPH:quinone oxidoreductase 1 regulates host susceptibility to ozone via isoprostane generation. Kummarapurugu AB, Fischer BM, Zheng S, Milne GL, Ghio AJ, Potts-Kant EN, Foster WM, Soderblom EJ, Dubois LG, Moseley MA, Thompson JW, Voynow JA (2013) J Biol Chem 288(7): 4681-91
    › Primary publication · 23275341 (PubMed) · PMC3576073 (PubMed Central)
  21. Changes in Inflammation, Oxidative Stress, Mitochondrial DNA Content after Rosiglitazone in HIV Lipoatrophy. Tungsiripat M, El-Bejjani D, Rizk N, Hu B, Ross AC, Walker UA, Lebrecht D, Milne G, Storer N, McComsey GA (2012) J AIDS Clin Res 3(8): 174
    › Primary publication · 23227444 (PubMed) · PMC3515063 (PubMed Central)
  22. Fish oil and postoperative atrial fibrillation: the Omega-3 Fatty Acids for Prevention of Post-operative Atrial Fibrillation (OPERA) randomized trial. Mozaffarian D, Marchioli R, Macchia A, Silletta MG, Ferrazzi P, Gardner TJ, Latini R, Libby P, Lombardi F, O'Gara PT, Page RL, Tavazzi L, Tognoni G, OPERA Investigators (2012) JAMA 308(19): 2001-11
    › Primary publication · 23128104 (PubMed) · PMC3694745 (PubMed Central)
  23. Cyclooxygenase-1, not cyclooxygenase-2, is responsible for physiological production of prostacyclin in the cardiovascular system. Kirkby NS, Lundberg MH, Harrington LS, Leadbeater PD, Milne GL, Potter CM, Al-Yamani M, Adeyemi O, Warner TD, Mitchell JA (2012) Proc Natl Acad Sci U S A 109(43): 17597-602
    › Primary publication · 23045674 (PubMed) · PMC3491520 (PubMed Central)
  24. Measurement of F2- isoprostanes and isofurans using gas chromatography-mass spectrometry. Milne GL, Gao B, Terry ES, Zackert WE, Sanchez SC (2013) Free Radic Biol Med : 36-44
    › Primary publication · 23044261 (PubMed) · PMC4306329 (PubMed Central)
  25. Elevated D-dimer is independently associated with endothelial dysfunction: a cross-sectional study in HIV-infected adults on antiretroviral therapy. Hileman CO, Longenecker CT, Carman TL, Milne GL, Labbato DE, Storer NJ, White CA, McComsey GA (2012) Antivir Ther 17(7): 1345-9
    › Primary publication · 22878464 (PubMed)
  26. Fish oil and indomethacin in combination potently reduce dyslipidemia and hepatic steatosis in LDLR(-/-) mice. Murali G, Milne GL, Webb CD, Stewart AB, McMillan RP, Lyle BC, Hulver MW, Saraswathi V (2012) J Lipid Res 53(10): 2186-2197
    › Primary publication · 22847176 (PubMed) · PMC3435551 (PubMed Central)
  27. Prostaglandin E2 deficiency uncovers a dominant role for thromboxane A2 in house dust mite-induced allergic pulmonary inflammation. Liu T, Laidlaw TM, Feng C, Xing W, Shen S, Milne GL, Boyce JA (2012) Proc Natl Acad Sci U S A 109(31): 12692-7
    › Primary publication · 22802632 (PubMed) · PMC3411985 (PubMed Central)
  28. Major metabolite of F2-isoprostane in urine may be a more sensitive biomarker of oxidative stress than isoprostane itself. Dorjgochoo T, Gao YT, Chow WH, Shu XO, Yang G, Cai Q, Rothman N, Cai H, Li H, Deng X, Franke A, Roberts LJ, Milne G, Zheng W, Dai Q (2012) Am J Clin Nutr 96(2): 405-14
    › Primary publication · 22760572 (PubMed) · PMC3396448 (PubMed Central)
  29. Menhaden oil decreases high-fat diet-induced markers of hepatic damage, steatosis, inflammation, and fibrosis in obese Ldlr-/- mice. Depner CM, Torres-Gonzalez M, Tripathy S, Milne G, Jump DB (2012) J Nutr 142(8): 1495-503
    › Primary publication · 22739374 (PubMed) · PMC3397337 (PubMed Central)
  30. Natural-source d-α-tocopheryl acetate inhibits oxidant stress and modulates atopic asthma in humans in vivo. Hoskins A, Roberts JL, Milne G, Choi L, Dworski R (2012) Allergy 67(5): 676-82
    › Primary publication · 22435735 (PubMed) · PMC3476459 (PubMed Central)
  31. The short-term effects of antioxidant and zinc supplements on oxidative stress biomarker levels in plasma: a pilot investigation. Brantley MA, Osborn MP, Sanders BJ, Rezaei KA, Lu P, Li C, Milne GL, Cai J, Sternberg P (2012) Am J Ophthalmol 153(6): 1104-9.e2
    › Primary publication · 22381365 (PubMed) · PMC3358482 (PubMed Central)
  32. Perioperative plasma F(2)-Isoprostane levels correlate with markers of impaired ventilation in infants with single-ventricle physiology undergoing stage 2 surgical palliation on the cardiopulmonary bypass. Albers E, Donahue BS, Milne G, Saville BR, Wang W, Bichell D, McLaughlin B (2012) Pediatr Cardiol 33(4): 562-8
    › Primary publication · 22327227 (PubMed) · PMC3641818 (PubMed Central)
  33. Sex differences in urinary biomarkers of vascular and endothelial function in HIV-infected persons receiving antiretroviral therapy. Boger MS, Bian A, Shintani A, Milne GL, Morrow JD, Erdem H, Mitchell V, Haas DW, Hulgan T (2012) Antivir Ther 17(3): 485-93
    › Primary publication · 22293574 (PubMed) · PMC3766979 (PubMed Central)
  34. Dietary intake of PUFAs and colorectal polyp risk. Murff HJ, Shrubsole MJ, Cai Q, Smalley WE, Dai Q, Milne GL, Ness RM, Zheng W (2012) Am J Clin Nutr 95(3): 703-12
    › Primary publication · 22277551 (PubMed) · PMC3278245 (PubMed Central)
  35. Cysteinyl leukotriene overproduction in aspirin-exacerbated respiratory disease is driven by platelet-adherent leukocytes. Laidlaw TM, Kidder MS, Bhattacharyya N, Xing W, Shen S, Milne GL, Castells MC, Chhay H, Boyce JA (2012) Blood 119(16): 3790-8
    › Primary publication · 22262771 (PubMed) · PMC3335383 (PubMed Central)
  36. Urinary prostaglandin E2 metabolite and risk for colorectal adenoma. Shrubsole MJ, Cai Q, Wen W, Milne G, Smalley WE, Chen Z, Ness RM, Zheng W (2012) Cancer Prev Res (Phila) 5(2): 336-42
    › Primary publication · 22166248 (PubMed) · PMC3273609 (PubMed Central)
  37. The effect of HIV and HPV coinfection on cervical COX-2 expression and systemic prostaglandin E2 levels. Fitzgerald DW, Bezak K, Ocheretina O, Riviere C, Wright TC, Milne GL, Zhou XK, Du B, Subbaramaiah K, Byrt E, Goodwin ML, Rafii A, Dannenberg AJ (2012) Cancer Prev Res (Phila) 5(1): 34-40
    › Primary publication · 22135046 (PubMed) · PMC3252428 (PubMed Central)
  38. Effect of blueberry ingestion on natural killer cell counts, oxidative stress, and inflammation prior to and after 2.5 h of running. McAnulty LS, Nieman DC, Dumke CL, Shooter LA, Henson DA, Utter AC, Milne G, McAnulty SR (2011) Appl Physiol Nutr Metab 36(6): 976-84
    › Primary publication · 22111516 (PubMed)
  39. Plasma biomarkers of oxidative stress and genetic variants in age-related macular degeneration. Brantley MA, Osborn MP, Sanders BJ, Rezaei KA, Lu P, Li C, Milne GL, Cai J, Sternberg P (2012) Am J Ophthalmol 153(3): 460-467.e1
    › Primary publication · 22035603 (PubMed) · PMC3288635 (PubMed Central)
  40. Elevation of prostaglandin E2 in lung cancer patients with digital clubbing. Kozak KR, Milne GL, Bentzen SM, Yock TI (2012) J Thorac Oncol 7(12): 1877-1878
    › Primary publication · 22024643 (PubMed) · PMC3371124 (PubMed Central)
  41. Isoprostane generation and function. Milne GL, Yin H, Hardy KD, Davies SS, Roberts LJ (2011) Chem Rev 111(10): 5973-96
    › Primary publication · 21848345 (PubMed) · PMC3192249 (PubMed Central)
  42. The fatty acid oxidation product 15-A3t-isoprostane is a potent inhibitor of NFκB transcription and macrophage transformation. Brooks JD, Musiek ES, Koestner TR, Stankowski JN, Howard JR, Brunoldi EM, Porta A, Zanoni G, Vidari G, Morrow JD, Milne GL, McLaughlin B (2011) J Neurochem 119(3): 604-16
    › Primary publication · 21838782 (PubMed) · PMC3640263 (PubMed Central)
  43. Amniotic fluid eicosanoids in preterm and term births: effects of risk factors for spontaneous preterm labor. Menon R, Fortunato SJ, Milne GL, Brou L, Carnevale C, Sanchez SC, Hubbard L, Lappas M, Drobek CO, Taylor RN (2011) Obstet Gynecol 118(1): 121-134
    › Primary publication · 21691170 (PubMed) · PMC3286836 (PubMed Central)
  44. Oxidative stress measured by urine F2-isoprostane level is associated with prostate cancer. Barocas DA, Motley S, Cookson MS, Chang SS, Penson DF, Dai Q, Milne G, Roberts LJ, Morrow J, Concepcion RS, Smith JA, Fowke JH (2011) J Urol 185(6): 2102-7
    › Primary publication · 21496850 (PubMed) · PMC3093434 (PubMed Central)
  45. Altered inflammatory, oxidative, and metabolic responses to exercise in pediatric obesity and type 1 diabetes. Rosa JS, Oliver SR, Flores RL, Ngo J, Milne GL, Zaldivar FP, Galassetti PR (2011) Pediatr Diabetes 12(5): 464-72
    › Primary publication · 21443585 (PubMed) · PMC2945245 (PubMed Central)
  46. Obesity, age, and oxidative stress in middle-aged and older women. Dorjgochoo T, Gao YT, Chow WH, Shu XO, Yang G, Cai Q, Rothman N, Cai H, Li H, Deng X, Shrubsole MJ, Murff H, Milne G, Zheng W, Dai Q (2011) Antioxid Redox Signal 14(12): 2453-60
    › Primary publication · 21043829 (PubMed) · PMC3096497 (PubMed Central)
  47. Nonenzymatic free radical-catalyzed generation of 15-deoxy-Δ(12,14)-prostaglandin J₂-like compounds (deoxy-J₂-isoprostanes) in vivo. Hardy KD, Cox BE, Milne GL, Yin H, Roberts LJ (2011) J Lipid Res 52(1): 113-24
    › Primary publication · 20944061 (PubMed) · PMC2999919 (PubMed Central)
  48. Biomarker-based phase I dose-escalation, pharmacokinetic, and pharmacodynamic study of oral apricoxib in combination with erlotinib in advanced nonsmall cell lung cancer. Reckamp K, Gitlitz B, Chen LC, Patel R, Milne G, Syto M, Jezior D, Zaknoen S (2011) Cancer 117(4): 809-18
    › Primary publication · 20922800 (PubMed)
  49. p66(shc)'s role as an essential mitophagic molecule in controlling neuronal redox and energetic tone. Kleman AM, Brown JE, Zeiger SL, Hettinger JC, Brooks JD, Holt B, Morrow JD, Musiek ES, Milne GL, McLaughlin B (2010) Autophagy 6(7): 948-9
    › Primary publication · 20724835 (PubMed) · PMC3679093 (PubMed Central)
  50. Mitochondria-targeted cytochrome P450 2E1 induces oxidative damage and augments alcohol-mediated oxidative stress. Bansal S, Liu CP, Sepuri NB, Anandatheerthavarada HK, Selvaraj V, Hoek J, Milne GL, Guengerich FP, Avadhani NG (2010) J Biol Chem 285(32): 24609-19
    › Primary publication · 20529841 (PubMed) · PMC2915697 (PubMed Central)
  51. Interaction between oxidative stress and high-density lipoprotein cholesterol is associated with severity of coronary artery calcification in rheumatoid arthritis. Rho YH, Chung CP, Oeser A, Solus JF, Gebretsadik T, Shintani A, Raggi P, Milne GL, Stein CM (2010) Arthritis Care Res (Hoboken) 62(10): 1473-80
    › Primary publication · 20506360 (PubMed) · PMC2933413 (PubMed Central)
  52. Essential role of the redox-sensitive kinase p66shc in determining energetic and oxidative status and cell fate in neuronal preconditioning. Brown JE, Zeiger SL, Hettinger JC, Brooks JD, Holt B, Morrow JD, Musiek ES, Milne G, McLaughlin B (2010) J Neurosci 30(15): 5242-52
    › Primary publication · 20392947 (PubMed) · PMC2869196 (PubMed Central)
  53. Intra-person variation of urinary biomarkers of oxidative stress and inflammation. Wu X, Cai H, Xiang YB, Cai Q, Yang G, Liu D, Sanchez S, Zheng W, Milne G, Shu XO (2010) Cancer Epidemiol Biomarkers Prev 19(4): 947-52
    › Primary publication · 20332256 (PubMed) · PMC2874066 (PubMed Central)
  54. Increased oxidative stress and altered substrate metabolism in obese children. Oliver SR, Rosa JS, Milne GL, Pontello AM, Borntrager HL, Heydari S, Galassetti PR (2010) Int J Pediatr Obes 5(5): 436-44
    › Primary publication · 20233149 (PubMed) · PMC3110748 (PubMed Central)
  55. Elevated ratio of urinary metabolites of thromboxane and prostacyclin is associated with adverse cardiovascular events in ADAPT. Montine TJ, Sonnen JA, Milne G, Baker LD, Breitner JC (2010) PLoS One 5(2): e9340
    › Primary publication · 20174466 (PubMed) · PMC2824826 (PubMed Central)
  56. Role of inflammation and oxidative stress in atrial fibrillation. Li J, Solus J, Chen Q, Rho YH, Milne G, Stein CM, Darbar D (2010) Heart Rhythm 7(4): 438-44
    › Primary publication · 20153266 (PubMed) · PMC2843774 (PubMed Central)
  57. Comparison of three oxidative stress biomarkers in a sample of healthy adults. Watters JL, Satia JA, da Costa KA, Boysen G, Collins LB, Morrow JD, Milne GL, Swenberg JA (2009) Biomarkers 14(8): 587-95
    › Primary publication · 20001708 (PubMed) · PMC3290341 (PubMed Central)
  58. Urinary prostaglandin E2 metabolite and gastric cancer risk in the Shanghai women's health study. Dong LM, Shu XO, Gao YT, Milne G, Ji BT, Yang G, Li HL, Rothman N, Zheng W, Chow WH, Abnet CC (2009) Cancer Epidemiol Biomarkers Prev 18(11): 3075-8
    › Primary publication · 19861525 (PubMed) · PMC2783404 (PubMed Central)
  59. Elevated levels of urinary prostaglandin e metabolite indicate a poor prognosis in ever smoker head and neck squamous cell carcinoma patients. Kekatpure VD, Boyle JO, Zhou XK, Duffield-Lillico AJ, Gross ND, Lee NY, Subbaramaiah K, Morrow JD, Milne G, Lippman SM, Dannenberg AJ (2009) Cancer Prev Res (Phila) 2(11): 957-65
    › Primary publication · 19843689 (PubMed) · PMC2784194 (PubMed Central)
  60. Cyclosporine A suppresses keratinocyte cell death through MPTP inhibition in a model for skin cancer in organ transplant recipients. Norman KG, Canter JA, Shi M, Milne GL, Morrow JD, Sligh JE (2010) Mitochondrion 10(2): 94-101
    › Primary publication · 19836469 (PubMed) · PMC6917037 (PubMed Central)
  61. Oxidant stress in HIV-infected women from the Women's Interagency HIV Study. Glesby MJ, Hoover DR, Raiszadeh F, Lee I, Shi Q, Milne G, Sanchez SC, Gao W, Kaplan RC, Morrow JD, Anastos K (2009) Antivir Ther 14(6): 763-9
    › Primary publication · 19812438 (PubMed) · PMC2760028 (PubMed Central)
  62. Two pathways for cyclooxygenase-2 protein degradation in vivo. Wada M, Saunders TL, Morrow J, Milne GL, Walker KP, Dey SK, Brock TG, Opp MR, Aronoff DM, Smith WL (2009) J Biol Chem 284(45): 30742-53
    › Primary publication · 19758985 (PubMed) · PMC2781473 (PubMed Central)
  63. Neurotoxic lipid peroxidation species formed by ischemic stroke increase injury. Zeiger SL, Musiek ES, Zanoni G, Vidari G, Morrow JD, Milne GJ, McLaughlin B (2009) Free Radic Biol Med 47(10): 1422-31
    › Primary publication · 19699297 (PubMed) · PMC2767385 (PubMed Central)
  64. Drugs Used in the Treatment of Rheumatoid Arthritis: Relationship between Current Use and Cardiovascular Risk Factors. Rho YH, Oeser A, Chung CP, Milne GL, Stein CM (2009) Arch Drug Inf 2(2): 34-40
    › Primary publication · 19684849 (PubMed) · PMC2721969 (PubMed Central)
  65. Oxidative stress, obesity, and breast cancer risk: results from the Shanghai Women's Health Study. Dai Q, Gao YT, Shu XO, Yang G, Milne G, Cai Q, Wen W, Rothman N, Cai H, Li H, Xiang Y, Chow WH, Zheng W (2009) J Clin Oncol 27(15): 2482-8
    › Primary publication · 19380446 (PubMed) · PMC2684853 (PubMed Central)
  66. Levels of prostaglandin E metabolite and leukotriene E(4) are increased in the urine of smokers: evidence that celecoxib shunts arachidonic acid into the 5-lipoxygenase pathway. Duffield-Lillico AJ, Boyle JO, Zhou XK, Ghosh A, Butala GS, Subbaramaiah K, Newman RA, Morrow JD, Milne GL, Dannenberg AJ (2009) Cancer Prev Res (Phila) 2(4): 322-9
    › Primary publication · 19336727 (PubMed) · PMC2745265 (PubMed Central)
  67. S1P/S1P2 signaling induces cyclooxygenase-2 expression in Wilms tumor. Li MH, Sanchez T, Milne GL, Morrow JD, Hla T, Ferrer F (2009) J Urol 181(3): 1347-52
    › Primary publication · 19157443 (PubMed) · PMC4132875 (PubMed Central)
  68. The enteropathy of prostaglandin deficiency. Adler DH, Phillips JA, Cogan JD, Iverson TM, Schnetz-Boutaud N, Stein JA, Brenner DA, Milne GL, Morrow JD, Boutaud O, Oates JA (2009) J Gastroenterol : 1-7
    › Primary publication · 19148786 (PubMed) · PMC2799331 (PubMed Central)
  69. Identification of intact oxidation products of glycerophospholipids in vitro and in vivo using negative ion electrospray iontrap mass spectrometry. Yin H, Cox BE, Liu W, Porter NA, Morrow JD, Milne GL (2009) J Mass Spectrom 44(5): 672-80
    › Primary publication · 19125398 (PubMed) · PMC2715274 (PubMed Central)
  70. Oxidative stress in fibromyalgia and its relationship to symptoms. Chung CP, Titova D, Oeser A, Randels M, Avalos I, Milne GL, Morrow JD, Stein CM (2009) Clin Rheumatol 28(4): 435-8
    › Primary publication · 19089486 (PubMed) · PMC2654204 (PubMed Central)
  71. Isoprostanes. Roberts LJ, Milne GL (2009) J Lipid Res : S219-23
    › Primary publication · 18957694 (PubMed) · PMC2674741 (PubMed Central)
  72. Increased dietary NaCl induces renal medullary PGE2 production and natriuresis via the EP2 receptor. Chen J, Zhao M, He W, Milne GL, Howard JR, Morrow J, Hébert RL, Breyer RM, Chen J, Hao CM (2008) Am J Physiol Renal Physiol 295(3): F818-25
    › Primary publication · 18632796 (PubMed) · PMC2653111 (PubMed Central)
  73. Electrophilic cyclopentenone neuroprostanes are anti-inflammatory mediators formed from the peroxidation of the omega-3 polyunsaturated fatty acid docosahexaenoic acid. Musiek ES, Brooks JD, Joo M, Brunoldi E, Porta A, Zanoni G, Vidari G, Blackwell TS, Montine TJ, Milne GL, McLaughlin B, Morrow JD (2008) J Biol Chem 283(29): 19927-35
    › Primary publication · 18490445 (PubMed) · PMC2459280 (PubMed Central)
  74. The effect of vitamins C and E on biomarkers of oxidative stress depends on baseline level. Block G, Jensen CD, Morrow JD, Holland N, Norkus EP, Milne GL, Hudes M, Dalvi TB, Crawford PB, Fung EB, Schumacher L, Harmatz P (2008) Free Radic Biol Med 45(4): 377-84
    › Primary publication · 18455517 (PubMed) · PMC2750000 (PubMed Central)
  75. Inherited human cPLA(2alpha) deficiency is associated with impaired eicosanoid biosynthesis, small intestinal ulceration, and platelet dysfunction. Adler DH, Cogan JD, Phillips JA, Schnetz-Boutaud N, Milne GL, Iverson T, Stein JA, Brenner DA, Morrow JD, Boutaud O, Oates JA (2008) J Clin Invest 118(6): 2121-31
    › Primary publication · 18451993 (PubMed) · PMC2350426 (PubMed Central)
  76. Development of oxidative stress by cytochrome P450 induction in rodents is selective for barbiturates and related to loss of pyridine nucleotide-dependent protective systems. Dostalek M, Hardy KD, Milne GL, Morrow JD, Chen C, Gonzalez FJ, Gu J, Ding X, Johnson DA, Johnson JA, Martin MV, Guengerich FP (2008) J Biol Chem 283(25): 17147-57
    › Primary publication · 18442974 (PubMed) · PMC2427356 (PubMed Central)
  77. Chronic quercetin ingestion and exercise-induced oxidative damage and inflammation. McAnulty SR, McAnulty LS, Nieman DC, Quindry JC, Hosick PA, Hudson MH, Still L, Henson DA, Milne GL, Morrow JD, Dumke CL, Utter AC, Triplett NT, Dibarnardi A (2008) Appl Physiol Nutr Metab 33(2): 254-62
    › Primary publication · 18347680 (PubMed)
  78. Human biochemistry of the isoprostane pathway. Milne GL, Yin H, Morrow JD (2008) J Biol Chem 283(23): 15533-7
    › Primary publication · 18285331 (PubMed) · PMC2414280 (PubMed Central)
  79. Formation of highly reactive cyclopentenone isoprostane compounds (A3/J3-isoprostanes) in vivo from eicosapentaenoic acid. Brooks JD, Milne GL, Yin H, Sanchez SC, Porter NA, Morrow JD (2008) J Biol Chem 283(18): 12043-55
    › Primary publication · 18263929 (PubMed) · PMC2335341 (PubMed Central)
  80. Trans-4-hydroxy-2-hexenal is a neurotoxic product of docosahexaenoic (22:6; n-3) acid oxidation. Long EK, Murphy TC, Leiphon LJ, Watt J, Morrow JD, Milne GL, Howard JR, Picklo MJ (2008) J Neurochem 105(3): 714-24
    › Primary publication · 18194211 (PubMed)
  81. Oxidative stress and matrix metalloproteinase-9 in acute ischemic stroke: the Biomarker Evaluation for Antioxidant Therapies in Stroke (BEAT-Stroke) study. Kelly PJ, Morrow JD, Ning M, Koroshetz W, Lo EH, Terry E, Milne GL, Hubbard J, Lee H, Stevenson E, Lederer M, Furie KL (2008) Stroke 39(1): 100-4
    › Primary publication · 18063832 (PubMed)
  82. Aspirin therapy and thromboxane biosynthesis in systemic lupus erythematosus. Avalos I, Chung CP, Oeser A, Milne GL, Borntrager H, Morrow JD, Raggi P, Solus J, Stein CM (2007) Lupus 16(12): 981-6
    › Primary publication · 18042592 (PubMed)
  83. Quantification of F2-isoprostanes in biological fluids and tissues as a measure of oxidant stress. Milne GL, Yin H, Brooks JD, Sanchez S, Jackson Roberts L, Morrow JD (2007) Methods Enzymol : 113-26
    › Primary publication · 17954231 (PubMed)
  84. In vivo oxidative damage in rats is associated with barbiturate response but not other cytochrome P450 inducers. Dostalek M, Brooks JD, Hardy KD, Milne GL, Moore MM, Sharma S, Morrow JD, Guengerich FP (2007) Mol Pharmacol 72(6): 1419-24
    › Primary publication · 17898314 (PubMed)
  85. Cyclopentenone prostaglandin, 15-deoxy-Delta12,14-PGJ2, is metabolized by HepG2 cells via conjugation with glutathione. Brunoldi EM, Zanoni G, Vidari G, Sasi S, Freeman ML, Milne GL, Morrow JD (2007) Chem Res Toxicol 20(10): 1528-35
    › Primary publication · 17854155 (PubMed)
  86. Ibuprofen use during extreme exercise: effects on oxidative stress and PGE2. McAnulty SR, Owens JT, McAnulty LS, Nieman DC, Morrow JD, Dumke CL, Milne GL (2007) Med Sci Sports Exerc 39(7): 1075-9
    › Primary publication · 17596774 (PubMed)
  87. Quantification of F2-isoprostanes as a biomarker of oxidative stress. Milne GL, Sanchez SC, Musiek ES, Morrow JD (2007) Nat Protoc 2(1): 221-6
    › Primary publication · 17401357 (PubMed)
  88. Energy expenditure, inflammation, and oxidative stress in steady-state adolescents with sickle cell anemia. Akohoue SA, Shankar S, Milne GL, Morrow J, Chen KY, Ajayi WU, Buchowski MS (2007) Pediatr Res 61(2): 233-8
    › Primary publication · 17237728 (PubMed)
  89. Hypertrophic osteoarthropathy pathogenesis: a case highlighting the potential role for cyclo-oxygenase-2-derived prostaglandin E2. Kozak KR, Milne GL, Morrow JD, Cuiffo BP (2006) Nat Clin Pract Rheumatol 2(8): 452-6; quiz following 456
    › Primary publication · 16932737 (PubMed)
  90. Isoprostanes and related compounds: update 2006. Milne GL, Morrow JD (2006) Antioxid Redox Signal 8(7-8): 1379-84
    › Primary publication · 16910785 (PubMed)
  91. Elevated oxidation of docosahexaenoic acid, 22:6 (n-3), in brain regions of rats undergoing ethanol withdrawal. Milne GL, Morrow JD, Picklo MJ (2006) Neurosci Lett 405(3): 172-4
    › Primary publication · 16875780 (PubMed)
  92. A phase I trial to determine the optimal biological dose of celecoxib when combined with erlotinib in advanced non-small cell lung cancer. Reckamp KL, Krysan K, Morrow JD, Milne GL, Newman RA, Tucker C, Elashoff RM, Dubinett SM, Figlin RA (2006) Clin Cancer Res 12(11 Pt 1): 3381-8
    › Primary publication · 16740761 (PubMed)
  93. Cyclopentenone isoprostanes are novel bioactive products of lipid oxidation which enhance neurodegeneration. Musiek ES, Breeding RS, Milne GL, Zanoni G, Morrow JD, McLaughlin B (2006) J Neurochem 97(5): 1301-13
    › Primary publication · 16638022 (PubMed) · PMC2881557 (PubMed Central)
  94. Formation of F-ring isoprostane-like compounds (F3-isoprostanes) in vivo from eicosapentaenoic acid. Gao L, Yin H, Milne GL, Porter NA, Morrow JD (2006) J Biol Chem 281(20): 14092-9
    › Primary publication · 16569632 (PubMed)
  95. Interaction of electrophilic lipid oxidation products with mitochondria in endothelial cells and formation of reactive oxygen species. Landar A, Zmijewski JW, Dickinson DA, Le Goffe C, Johnson MS, Milne GL, Zanoni G, Vidari G, Morrow JD, Darley-Usmar VM (2006) Am J Physiol Heart Circ Physiol 290(5): H1777-87
    › Primary publication · 16387790 (PubMed)
  96. Recent advances in the biochemistry and clinical relevance of the isoprostane pathway. Musiek ES, Yin H, Milne GL, Morrow JD (2005) Lipids 40(10): 987-94
    › Primary publication · 16382569 (PubMed)
  97. F2-isoprostanes as markers of oxidative stress in vivo: an overview. Milne GL, Musiek ES, Morrow JD (2005) Biomarkers : S10-23
    › Primary publication · 16298907 (PubMed)
  98. Cyclopentenone isoprostanes inhibit the inflammatory response in macrophages. Musiek ES, Gao L, Milne GL, Han W, Everhart MB, Wang D, Backlund MG, DuBois RN, Zanoni G, Vidari G, Blackwell TS, Morrow JD (2005) J Biol Chem 280(42): 35562-70
    › Primary publication · 16100121 (PubMed)
  99. Cyclopentenone eicosanoids as mediators of neurodegeneration: a pathogenic mechanism of oxidative stress-mediated and cyclooxygenase-mediated neurotoxicity. Musiek ES, Milne GL, McLaughlin B, Morrow JD (2005) Brain Pathol 15(2): 149-58
    › Primary publication · 15912888 (PubMed) · PMC2881556 (PubMed Central)
  100. Identification of the major urinary metabolite of the highly reactive cyclopentenone isoprostane 15-A(2t)-isoprostane in vivo. Milne GL, Gao L, Porta A, Zanoni G, Vidari G, Morrow JD (2005) J Biol Chem 280(26): 25178-84
    › Primary publication · 15878849 (PubMed)
  101. The cyclopentenone (A2/J2) isoprostanes--unique, highly reactive products of arachidonate peroxidation. Milne GL, Musiek ES, Morrow JD (2005) Antioxid Redox Signal 7(1-2): 210-20
    › Primary publication · 15650409 (PubMed)
  102. Identification and analysis of products formed from phospholipids in the free radical oxidation of human low density lipoproteins. Milne GL, Seal JR, Havrilla CM, Wijtmans M, Porter NA (2005) J Lipid Res 46(2): 307-19
    › Primary publication · 15547297 (PubMed)
  103. 15-Hydroxyprostaglandin dehydrogenase is down-regulated in colorectal cancer. Backlund MG, Mann JR, Holla VR, Buchanan FG, Tai HH, Musiek ES, Milne GL, Katkuri S, DuBois RN (2005) J Biol Chem 280(5): 3217-23
    › Primary publication · 15542609 (PubMed) · PMC1847633 (PubMed Central)
  104. The cyclopentenone product of lipid peroxidation, 15-A2t-isoprostane, is efficiently metabolized by HepG2 cells via conjugation with glutathione. Milne GL, Zanoni G, Porta A, Sasi S, Vidari G, Musiek ES, Freeman ML, Morrow JD (2004) Chem Res Toxicol 17(1): 17-25
    › Primary publication · 14727915 (PubMed)
  105. Formation of prostaglandins E2 and D2 via the isoprostane pathway: a mechanism for the generation of bioactive prostaglandins independent of cyclooxygenase. Gao L, Zackert WE, Hasford JJ, Danekis ME, Milne GL, Remmert C, Reese J, Yin H, Tai HH, Dey SK, Porter NA, Morrow JD (2003) J Biol Chem 278(31): 28479-89
    › Primary publication · 12746435 (PubMed)
  106. Formation of highly reactive A-ring and J-ring isoprostane-like compounds (A4/J4-neuroprostanes) in vivo from docosahexaenoic acid. Fam SS, Murphey LJ, Terry ES, Zackert WE, Chen Y, Gao L, Pandalai S, Milne GL, Roberts LJ, Porter NA, Montine TJ, Morrow JD (2002) J Biol Chem 277(39): 36076-84
    › Primary publication · 12133837 (PubMed)
  107. Determination of the alpha-tocopherol inhibition rate constant for peroxidation in low-density lipoprotein. Culbertson SM, Antunes F, Havrilla CM, Milne GL, Porter NA (2002) Chem Res Toxicol 15(6): 870-6
    › Primary publication · 12067255 (PubMed)