Melissa Skala
Faculty Member
Last active: 2/4/2016


None provided


The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. Drug response in organoids generated from frozen primary tumor tissues. Walsh AJ, Cook RS, Sanders ME, Arteaga CL, Skala MC (2016) Sci Rep : 18889
    › Primary publication · 26738962 (PubMed) · PMC4703961 (PubMed Central)
  2. In Vivo Autofluorescence Imaging of Tumor Heterogeneity in Response to Treatment. Shah AT, Diggins KE, Walsh AJ, Irish JM, Skala MC (2015) Neoplasia 17(12): 862-870
    › Primary publication · 26696368 (PubMed) · PMC4688562 (PubMed Central)
  3. Optical Imaging of Drug-Induced Metabolism Changes in Murine and Human Pancreatic Cancer Organoids Reveals Heterogeneous Drug Response. Walsh AJ, Castellanos JA, Nagathihalli NS, Merchant NB, Skala MC (2016) Pancreas 45(6): 863-9
    › Primary publication · 26495796 (PubMed) · PMC4874911 (PubMed Central)
  4. Deconvolution of fluorescence lifetime imaging microscopy by a library of exponentials. Campos-Delgado DU, Navarro OG, Arce-Santana ER, Walsh AJ, Skala MC, Jo JA (2015) Opt Express 23(18): 23748-67
    › Primary publication · 26368470 (PubMed) · PMC4646519 (PubMed Central)
  5. Signal Transducer and Activator of Transcription 3, Mediated Remodeling of the Tumor Microenvironment Results in Enhanced Tumor Drug Delivery in a Mouse Model of Pancreatic Cancer. Nagathihalli NS, Castellanos JA, Shi C, Beesetty Y, Reyzer ML, Caprioli R, Chen X, Walsh AJ, Skala MC, Moses HL, Merchant NB (2015) Gastroenterology 149(7): 1932-1943.e9
    › Primary publication · 26255562 (PubMed) · PMC4863449 (PubMed Central)
  6. Blind deconvolution estimation of fluorescence measurements through quadratic programming. Campos-Delgado DU, Gutierrez-Navarro O, Arce-Santana ER, Skala MC, Walsh AJ, Jo JA (2015) J Biomed Opt 20(7): 075010
    › Primary publication · 26222960 (PubMed) · PMC5998001 (PubMed Central)
  7. Photothermal optical lock-in optical coherence tomography for in vivo imaging. Tucker-Schwartz JM, Lapierre-Landry M, Patil CA, Skala MC (2015) Biomed Opt Express 6(6): 2268-82
    › Primary publication · 26114045 (PubMed) · PMC4473760 (PubMed Central)
  8. Optical metabolic imaging quantifies heterogeneous cell populations. Walsh AJ, Skala MC (2015) Biomed Opt Express 6(2): 559-73
    › Primary publication · 25780745 (PubMed) · PMC4354590 (PubMed Central)
  9. Collagen density and alignment in responsive and resistant trastuzumab-treated breast cancer xenografts. Walsh AJ, Cook RS, Lee JH, Arteaga CL, Skala MC (2015) J Biomed Opt 20(2): 26004
    › Primary publication · 25700233 (PubMed) · PMC4335617 (PubMed Central)
  10. High-throughput measurements of the optical redox ratio using a commercial microplate reader. Cannon TM, Shah AT, Walsh AJ, Skala MC (2015) J Biomed Opt 20(1): 010503
    › Primary publication · 25634108 (PubMed) · PMC4311137 (PubMed Central)
  11. Quantifying the vascular response to ischemia with speckle variance optical coherence tomography. Poole KM, McCormack DR, Patil CA, Duvall CL, Skala MC (2014) Biomed Opt Express 5(12): 4118-30
    › Primary publication · 25574425 (PubMed) · PMC4285592 (PubMed Central)
  12. ROS-responsive microspheres for on demand antioxidant therapy in a model of diabetic peripheral arterial disease. Poole KM, Nelson CE, Joshi RV, Martin JR, Gupta MK, Haws SC, Kavanaugh TE, Skala MC, Duvall CL (2015) Biomaterials : 166-75
    › Primary publication · 25522975 (PubMed) · PMC4274772 (PubMed Central)
  13. Uncoupling angiogenesis and inflammation in peripheral artery disease with therapeutic peptide-loaded microgels. Zachman AL, Wang X, Tucker-Schwartz JM, Fitzpatrick ST, Lee SH, Guelcher SA, Skala MC, Sung HJ (2014) Biomaterials 35(36): 9635-48
    › Primary publication · 25154665 (PubMed) · PMC4164579 (PubMed Central)
  14. Quantitative optical imaging of primary tumor organoid metabolism predicts drug response in breast cancer. Walsh AJ, Cook RS, Sanders ME, Aurisicchio L, Ciliberto G, Arteaga CL, Skala MC (2014) Cancer Res 74(18): 5184-94
    › Primary publication · 25100563 (PubMed) · PMC4167558 (PubMed Central)
  15. In vivo hyperspectral imaging of microvessel response to trastuzumab treatment in breast cancer xenografts. McCormack DR, Walsh AJ, Sit W, Arteaga CL, Chen J, Cook RS, Skala MC (2014) Biomed Opt Express 5(7): 2247-61
    › Primary publication · 25071962 (PubMed) · PMC4102362 (PubMed Central)
  16. In vivo imaging of nanoparticle delivery and tumor microvasculature with multimodal optical coherence tomography. Tucker-Schwartz JM, Beavers KR, Sit WW, Shah AT, Duvall CL, Skala MC (2014) Biomed Opt Express 5(6): 1731-43
    › Primary publication · 24940536 (PubMed) · PMC4052907 (PubMed Central)
  17. Optical metabolic imaging of treatment response in human head and neck squamous cell carcinoma. Shah AT, Demory Beckler M, Walsh AJ, Jones WP, Pohlmann PR, Skala MC (2014) PLoS One 9(3): e90746
    › Primary publication · 24595244 (PubMed) · PMC3942493 (PubMed Central)
  18. The NADH oxidase ENOX1, a critical mediator of endothelial cell radiosensitization, is crucial for vascular development. Venkateswaran A, Sekhar KR, Levic DS, Melville DB, Clark TA, Rybski WM, Walsh AJ, Skala MC, Crooks PA, Knapik EW, Freeman ML (2014) Cancer Res 74(1): 38-43
    › Primary publication · 24247717 (PubMed) · PMC3947320 (PubMed Central)
  19. Optical metabolic imaging identifies glycolytic levels, subtypes, and early-treatment response in breast cancer. Walsh AJ, Cook RS, Manning HC, Hicks DJ, Lafontant A, Arteaga CL, Skala MC (2013) Cancer Res 73(20): 6164-74
    › Primary publication · 24130112 (PubMed) · PMC3801432 (PubMed Central)
  20. Quantitative optical imaging of vascular response in vivo in a model of peripheral arterial disease. Poole KM, Tucker-Schwartz JM, Sit WW, Walsh AJ, Duvall CL, Skala MC (2013) Am J Physiol Heart Circ Physiol 305(8): H1168-80
    › Primary publication · 23955718 (PubMed) · PMC3798791 (PubMed Central)
  21. Three-dimensional molecular imaging with photothermal optical coherence tomography. Skala MC, Crow MJ, Wax A, Izatt JA (2013) Methods Mol Biol : 85-92
    › Primary publication · 23749571 (PubMed) · PMC4465835 (PubMed Central)
  22. Cross-sectional tracking of particle motion in evaporating drops: flow fields and interfacial accumulation. Trantum JR, Eagleton ZE, Patil CA, Tucker-Schwartz JM, Baglia ML, Skala MC, Haselton FR (2013) Langmuir 29(21): 6221-31
    › Primary publication · 23611508 (PubMed) · PMC4915780 (PubMed Central)
  23. Dual pH- and temperature-responsive microparticles for protein delivery to ischemic tissues. Joshi RV, Nelson CE, Poole KM, Skala MC, Duvall CL (2013) Acta Biomater 9(5): 6526-34
    › Primary publication · 23402764 (PubMed) · PMC3702271 (PubMed Central)
  24. In vivo photothermal optical coherence tomography of gold nanorod contrast agents. Tucker-Schwartz JM, Meyer TA, Patil CA, Duvall CL, Skala MC (2012) Biomed Opt Express 3(11): 2881-95
    › Primary publication · 23162726 (PubMed) · PMC3493242 (PubMed Central)
  25. Ex vivo optical metabolic measurements from cultured tissue reflect in vivo tissue status. Walsh AJ, Poole KM, Duvall CL, Skala MC (2012) J Biomed Opt 17(11): 116015
    › Primary publication · 23117810 (PubMed) · PMC3484268 (PubMed Central)
  26. The novel antiangiogenic VJ115 inhibits the NADH oxidase ENOX1 and cytoskeleton-remodeling proteins. Venkateswaran A, Friedman DB, Walsh AJ, Skala MC, Sasi S, Rachakonda G, Crooks PA, Freeman ML, Sekhar KR (2013) Invest New Drugs 31(3): 535-44
    › Primary publication · 23054211 (PubMed) · PMC3553230 (PubMed Central)
  27. Dual-modality photothermal optical coherence tomography and magnetic-resonance imaging of carbon nanotubes. Tucker-Schwartz JM, Hong T, Colvin DC, Xu Y, Skala MC (2012) Opt Lett 37(5): 872-4
    › Primary publication · 22378422 (PubMed) · PMC3390748 (PubMed Central)
  28. Optical imaging of metabolism in HER2 overexpressing breast cancer cells. Walsh A, Cook RS, Rexer B, Arteaga CL, Skala MC (2012) Biomed Opt Express 3(1): 75-85
    › Primary publication · 22254170 (PubMed) · PMC3255344 (PubMed Central)
  29. Longitudinal optical imaging of tumor metabolism and hemodynamics. Skala MC, Fontanella A, Lan L, Izatt JA, Dewhirst MW (2010) J Biomed Opt 15(1): 011112
    › Primary publication · 20210438 (PubMed) · PMC2816992 (PubMed Central)
  30. Multiphoton redox ratio imaging for metabolic monitoring in vivo. Skala M, Ramanujam N (2010) Methods Mol Biol : 155-62
    › Primary publication · 20072916 (PubMed) · PMC2874879 (PubMed Central)
  31. Combined hyperspectral and spectral domain optical coherence tomography microscope for noninvasive hemodynamic imaging. Skala MC, Fontanella A, Hendargo H, Dewhirst MW, Izatt JA (2009) Opt Lett 34(3): 289-91
    › Primary publication · 19183634 (PubMed) · PMC2715151 (PubMed Central)
  32. Photothermal optical coherence tomography of epidermal growth factor receptor in live cells using immunotargeted gold nanospheres. Skala MC, Crow MJ, Wax A, Izatt JA (2008) Nano Lett 8(10): 3461-7
    › Primary publication · 18767886 (PubMed) · PMC2574829 (PubMed Central)
  33. In vivo multiphoton microscopy of NADH and FAD redox states, fluorescence lifetimes, and cellular morphology in precancerous epithelia. Skala MC, Riching KM, Gendron-Fitzpatrick A, Eickhoff J, Eliceiri KW, White JG, Ramanujam N (2007) Proc Natl Acad Sci U S A 104(49): 19494-9
    › Primary publication · 18042710 (PubMed) · PMC2148317 (PubMed Central)
  34. Comparison of a physical model and principal component analysis for the diagnosis of epithelial neoplasias in vivo using diffuse reflectance spectroscopy. Skala MC, Palmer GM, Vrotsos KM, Gendron-Fitzpatrick A, Ramanujam N (2007) Opt Express 15(12): 7863-75
    › Primary publication · 17912337 (PubMed) · PMC1999391 (PubMed Central)
  35. In vivo multiphoton fluorescence lifetime imaging of protein-bound and free nicotinamide adenine dinucleotide in normal and precancerous epithelia. Skala MC, Riching KM, Bird DK, Gendron-Fitzpatrick A, Eickhoff J, Eliceiri KW, Keely PJ, Ramanujam N (2007) J Biomed Opt 12(2): 024014
    › Primary publication · 17477729 (PubMed) · PMC2743958 (PubMed Central)
  36. Multiphoton microscopy of endogenous fluorescence differentiates normal, precancerous, and cancerous squamous epithelial tissues. Skala MC, Squirrell JM, Vrotsos KM, Eickhoff JC, Gendron-Fitzpatrick A, Eliceiri KW, Ramanujam N (2005) Cancer Res 65(4): 1180-6
    › Primary publication · 15735001 (PubMed) · PMC4189807 (PubMed Central)
  37. Investigation of fiber-optic probe designs for optical spectroscopic diagnosis of epithelial pre-cancers. Skala MC, Palmer GM, Zhu C, Liu Q, Vrotsos KM, Marshek-Stone CL, Gendron-Fitzpatrick A, Ramanujam N (2004) Lasers Surg Med 34(1): 25-38
    › Primary publication · 14755422 (PubMed) · PMC2768119 (PubMed Central)