Ned Porter
Faculty Member
Last active: 5/29/2014


None provided


The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. Reactivities and products of free radical oxidation of cholestadienols. Xu L, Porter NA (2014) J Am Chem Soc 136(14): 5443-50
    › Primary publication · 24625033 (PubMed) · PMC4004278 (PubMed Central)
  2. Rational Design of Novel Pyridinol-Fused Ring Acetaminophen Analogues. Shchepin RV, Liu W, Yin H, Zagol-Ikapitte I, Amin T, Jeong BS, Roberts LJ, Oates JA, Porter NA, Boutaud O (2013) ACS Med Chem Lett 4(8): 710-714
    › Primary publication · 24482730 (PubMed) · PMC3904457 (PubMed Central)
  3. Alkylation damage by lipid electrophiles targets functional protein systems. Codreanu SG, Ullery JC, Zhu J, Tallman KA, Beavers WN, Porter NA, Marnett LJ, Zhang B, Liebler DC (2014) Mol Cell Proteomics 13(3): 849-59
    › Primary publication · 24429493 (PubMed) · PMC3945913 (PubMed Central)
  4. Unusual kinetic isotope effects of deuterium reinforced polyunsaturated fatty acids in tocopherol-mediated free radical chain oxidations. Lamberson CR, Xu L, Muchalski H, Montenegro-Burke JR, Shmanai VV, Bekish AV, McLean JA, Clarke CF, Shchepinov MS, Porter NA (2014) J Am Chem Soc 136(3): 838-41
    › Primary publication · 24380377 (PubMed) · PMC4578730 (PubMed Central)
  5. A highly sensitive method for analysis of 7-dehydrocholesterol for the study of Smith-Lemli-Opitz syndrome. Liu W, Xu L, Lamberson C, Haas D, Korade Z, Porter NA (2014) J Lipid Res 55(2): 329-37
    › Primary publication · 24259532 (PubMed) · PMC3886672 (PubMed Central)
  6. Assays of plasma dehydrocholesteryl esters and oxysterols from Smith-Lemli-Opitz syndrome patients. Liu W, Xu L, Lamberson CR, Merkens LS, Steiner RD, Elias ER, Haas D, Porter NA (2013) J Lipid Res 54(1): 244-53
    › Primary publication · 23072947 (PubMed) · PMC3520531 (PubMed Central)
  7. Measuring electrophile stress. Tallman KA, Vila A, Porter NA, Marnett LJ (2009) Curr Protoc Toxicol : Unit17.11
    › Primary publication · 23045010 (PubMed)
  8. Small amounts of isotope-reinforced polyunsaturated fatty acids suppress lipid autoxidation. Hill S, Lamberson CR, Xu L, To R, Tsui HS, Shmanai VV, Bekish AV, Awad AM, Marbois BN, Cantor CR, Porter NA, Clarke CF, Shchepinov MS (2012) Free Radic Biol Med 53(4): 893-906
    › Primary publication · 22705367 (PubMed) · PMC3437768 (PubMed Central)
  9. 7-Dehydrocholesterol-derived oxysterols and retinal degeneration in a rat model of Smith-Lemli-Opitz syndrome. Xu L, Sheflin LG, Porter NA, Fliesler SJ (2012) Biochim Biophys Acta 1821(6): 877-83
    › Primary publication · 22425966 (PubMed) · PMC3340457 (PubMed Central)
  10. Activity-based probes linked with laser-cleavable mass tags for signal amplification in imaging mass spectrometry: analysis of serine hydrolase enzymes in mammalian tissue. Yang J, Chaurand P, Norris JL, Porter NA, Caprioli RM (2012) Anal Chem 84(8): 3689-95
    › Primary publication · 22424244 (PubMed) · PMC3328658 (PubMed Central)
  11. Tyrosine-lipid peroxide adducts from radical termination: para coupling and intramolecular Diels-Alder cyclization. Shchepin R, Möller MN, Kim HY, Hatch DM, Bartesaghi S, Kalyanaraman B, Radi R, Porter NA (2010) J Am Chem Soc 132(49): 17490-500
    › Primary publication · 21090613 (PubMed) · PMC3677824 (PubMed Central)
  12. Formation of 4-hydroxynonenal from cardiolipin oxidation: Intramolecular peroxyl radical addition and decomposition. Liu W, Porter NA, Schneider C, Brash AR, Yin H (2011) Free Radic Biol Med 50(1): 166-78
    › Primary publication · 21047551 (PubMed) · PMC3014443 (PubMed Central)
  13. Preparation and investigation of vitamin B6-derived aminopyridinol antioxidants. Serwa R, Nam TG, Valgimigli L, Culbertson S, Rector CL, Jeong BS, Pratt DA, Porter NA (2010) Chemistry 16(47): 14106-14
    › Primary publication · 20967898 (PubMed)
  14. Action of 6-amino-3-pyridinols as novel antioxidants against free radicals and oxidative stress in solution, plasma, and cultured cells. Omata Y, Saito Y, Yoshida Y, Jeong BS, Serwa R, Nam TG, Porter NA, Niki E (2010) Free Radic Biol Med 48(10): 1358-65
    › Primary publication · 20172025 (PubMed)
  15. Pyridine and pyrimidine analogs of acetaminophen as inhibitors of lipid peroxidation and cyclooxygenase and lipoxygenase catalysis. Nam TG, Nara SJ, Zagol-Ikapitte I, Cooper T, Valgimigli L, Oates JA, Porter NA, Boutaud O, Pratt DA (2009) Org Biomol Chem 7(24): 5103-12
    › Primary publication · 20024105 (PubMed) · PMC2873786 (PubMed Central)
  16. Simultaneous analysis of multiple lipid oxidation products in vivo by liquid chromatographic-mass spectrometry (LC-MS). Yin H, Davis T, Porter NA (2010) Methods Mol Biol : 375-86
    › Primary publication · 20013190 (PubMed)
  17. Rate constants for peroxidation of polyunsaturated fatty acids and sterols in solution and in liposomes. Xu L, Davis TA, Porter NA (2009) J Am Chem Soc 131(36): 13037-44
    › Primary publication · 19705847 (PubMed) · PMC3656724 (PubMed Central)
  18. Identification of proteins adducted by lipid peroxidation products in plasma and modifications of apolipoprotein A1 with a novel biotinylated phospholipid probe. Szapacs ME, Kim HY, Porter NA, Liebler DC (2008) J Proteome Res 7(10): 4237-46
    › Primary publication · 18778096 (PubMed) · PMC2664612 (PubMed Central)
  19. Intermolecular peroxyl radical reactions during autoxidation of hydroxy and hydroperoxy arachidonic acids generate a novel series of epoxidized products. Schneider C, Boeglin WE, Yin H, Porter NA, Brash AR (2008) Chem Res Toxicol 21(4): 895-903
    › Primary publication · 18324788 (PubMed)
  20. Routes to 4-hydroxynonenal: fundamental issues in the mechanisms of lipid peroxidation. Schneider C, Porter NA, Brash AR (2008) J Biol Chem 283(23): 15539-43
    › Primary publication · 18285327 (PubMed) · PMC2414272 (PubMed Central)
  21. Identification of protein targets of 4-hydroxynonenal using click chemistry for ex vivo biotinylation of azido and alkynyl derivatives. Vila A, Tallman KA, Jacobs AT, Liebler DC, Porter NA, Marnett LJ (2008) Chem Res Toxicol 21(2): 432-44
    › Primary publication · 18232660 (PubMed) · PMC2760080 (PubMed Central)
  22. Enzymatic synthesis of a bicyclobutane fatty acid by a hemoprotein lipoxygenase fusion protein from the cyanobacterium Anabaena PCC 7120. Schneider C, Niisuke K, Boeglin WE, Voehler M, Stec DF, Porter NA, Brash AR (2007) Proc Natl Acad Sci U S A 104(48): 18941-5
    › Primary publication · 18025466 (PubMed) · PMC2141887 (PubMed Central)
  23. Identification of intact lipid peroxides by Ag+ coordination ion-spray mass spectrometry (CIS-MS). Yin H, Porter NA (2007) Methods Enzymol : 193-211
    › Primary publication · 17954236 (PubMed)
  24. Identification of the peroxidation products of 13-hydroxy-gamma-linolenate and 15-hydroxyarachidonate: mechanistic studies on the formation of leukotriene-like diols. Rector CL, Stec DF, Brash AR, Porter NA (2007) Chem Res Toxicol 20(11): 1582-93
    › Primary publication · 17907784 (PubMed)
  25. Identification of novel autoxidation products of the omega-3 fatty acid eicosapentaenoic acid in vitro and in vivo. Yin H, Brooks JD, Gao L, Porter NA, Morrow JD (2007) J Biol Chem 282(41): 29890-901
    › Primary publication · 17711863 (PubMed)
  26. Tetrahydro-1,8-naphthyridinol analogues of alpha-tocopherol as antioxidants in lipid membranes and low-density lipoproteins. Nam TG, Rector CL, Kim HY, Sonnen AF, Meyer R, Nau WM, Atkinson J, Rintoul J, Pratt DA, Porter NA (2007) J Am Chem Soc 129(33): 10211-9
    › Primary publication · 17655300 (PubMed)
  27. Control of oxygenation in lipoxygenase and cyclooxygenase catalysis. Schneider C, Pratt DA, Porter NA, Brash AR (2007) Chem Biol 14(5): 473-88
    › Primary publication · 17524979 (PubMed) · PMC2692746 (PubMed Central)
  28. Free radical-induced site-specific peptide cleavage in the gas phase: low-energy collision-induced dissociation in ESI- and MALDI mass spectrometry. Yin H, Chacon A, Porter NA, Masterson DS (2007) J Am Soc Mass Spectrom 18(5): 807-16
    › Primary publication · 17307363 (PubMed)
  29. Phospholipid-protein adducts of lipid peroxidation: synthesis and study of new biotinylated phosphatidylcholines. Tallman KA, Kim HY, Ji JX, Szapacs ME, Yin H, McIntosh TJ, Liebler DC, Porter NA (2007) Chem Res Toxicol 20(2): 227-34
    › Primary publication · 17305406 (PubMed)
  30. Urinary prostaglandin F2alpha is generated from the isoprostane pathway and not the cyclooxygenase in humans. Yin H, Gao L, Tai HH, Murphey LJ, Porter NA, Morrow JD (2007) J Biol Chem 282(1): 329-36
    › Primary publication · 17107953 (PubMed)
  31. In vivo and in vitro lipid peroxidation of arachidonate esters: the effect of fish oil omega-3 lipids on product distribution. Davis TA, Gao L, Yin H, Morrow JD, Porter NA (2006) J Am Chem Soc 128(46): 14897-904
    › Primary publication · 17105300 (PubMed)
  32. Visible light excitation of CdSe nanocrystals triggers the release of coumarin from cinnamate surface ligands. Wijtmans M, Rosenthal SJ, Zwanenburg B, Porter NA (2006) J Am Chem Soc 128(35): 11720-6
    › Primary publication · 16939297 (PubMed)
  33. N-Terminal amino acid side-chain cleavage of chemically modified peptides in the gas phase: a mass spectrometry technique for N-terminus identification. Chacon A, Masterson DS, Yin H, Liebler DC, Porter NA (2006) Bioorg Med Chem 14(18): 6213-22
    › Primary publication · 16784867 (PubMed)
  34. Peroxyl radical clocks. Roschek B, Tallman KA, Rector CL, Gillmore JG, Pratt DA, Punta C, Porter NA (2006) J Org Chem 71(9): 3527-32
    › Primary publication · 16626136 (PubMed)
  35. Formation of F-ring isoprostane-like compounds (F3-isoprostanes) in vivo from eicosapentaenoic acid. Gao L, Yin H, Milne GL, Porter NA, Morrow JD (2006) J Biol Chem 281(20): 14092-9
    › Primary publication · 16569632 (PubMed)
  36. Molecular dynamics simulations of arachidonic acid-derived pentadienyl radical intermediate complexes with COX-1 and COX-2: insights into oxygenation regio- and stereoselectivity. Furse KE, Pratt DA, Schneider C, Brash AR, Porter NA, Lybrand TP (2006) Biochemistry 45(10): 3206-18
    › Primary publication · 16519515 (PubMed) · PMC2504531 (PubMed Central)
  37. Molecular dynamics simulations of arachidonic acid complexes with COX-1 and COX-2: insights into equilibrium behavior. Furse KE, Pratt DA, Porter NA, Lybrand TP (2006) Biochemistry 45(10): 3189-205
    › Primary publication · 16519514 (PubMed) · PMC2504530 (PubMed Central)
  38. Synthesis of dihydroperoxides of linoleic and linolenic acids and studies on their transformation to 4-hydroperoxynonenal. Schneider C, Boeglin WE, Yin H, Ste DF, Hachey DL, Porter NA, Brash AR (2005) Lipids 40(11): 1155-62
    › Primary publication · 16459928 (PubMed)
  39. Lipid-soluble 3-pyridinol antioxidants spare alpha-tocopherol and do not efficiently mediate peroxidation of cholesterol esters in human low-density lipoprotein. Kim HY, Pratt DA, Seal JR, Wijtmans M, Porter NA (2005) J Med Chem 48(22): 6787-9
    › Primary publication · 16250637 (PubMed)
  40. Nonacid cleavable detergents applied to MALDI mass spectrometry profiling of whole cells. Norris JL, Hangauer MJ, Porter NA, Caprioli RM (2005) J Mass Spectrom 40(10): 1319-26
    › Primary publication · 16220468 (PubMed)
  41. Combination detergent/MALDI matrix: functional cleavable detergents for mass spectrometry. Norris JL, Porter NA, Caprioli RM (2005) Anal Chem 77(15): 5036-40
    › Primary publication · 16053319 (PubMed)
  42. Regiochemistry of neuroprostanes generated from the peroxidation of docosahexaenoic acid in vitro and in vivo. Yin H, Musiek ES, Gao L, Porter NA, Morrow JD (2005) J Biol Chem 280(28): 26600-11
    › Primary publication · 15894799 (PubMed)
  43. Separation and identification of F2-isoprostane regioisomers and diastereomers by novel liquid chromatographic/mass spectrometric methods. Yin H, Porter NA, Morrow JD (2005) J Chromatogr B Analyt Technol Biomed Life Sci 827(1): 157-64
    › Primary publication · 15890564 (PubMed)
  44. Peroxidation of polyunsaturated fatty acid methyl esters catalyzed by N-methyl benzohydroxamic acid: a new and convenient method for selective synthesis of hydroperoxides and alcohols. Punta C, Rector CL, Porter NA (2005) Chem Res Toxicol 18(2): 349-56
    › Primary publication · 15720142 (PubMed)
  45. New insights regarding the autoxidation of polyunsaturated fatty acids. Yin H, Porter NA (2005) Antioxid Redox Signal 7(1-2): 170-84
    › Primary publication · 15650406 (PubMed)
  46. Synthesis and reactivity of some 6-substituted-2,4-dimethyl-3-pyridinols, a novel class of chain-breaking antioxidants. Wijtmans M, Pratt DA, Brinkhorst J, Serwa R, Valgimigli L, Pedulli GF, Porter NA (2004) J Org Chem 69(26): 9215-23
    › Primary publication · 15609958 (PubMed)
  47. Identification and analysis of products formed from phospholipids in the free radical oxidation of human low density lipoproteins. Milne GL, Seal JR, Havrilla CM, Wijtmans M, Porter NA (2005) J Lipid Res 46(2): 307-19
    › Primary publication · 15547297 (PubMed)
  48. Liquid chromatography coordination ion-spray mass spectrometry (LC-CIS-MS) of docosahexaenoate ester hydroperoxides. Seal JR, Porter NA (2004) Anal Bioanal Chem 380(2): 356
    › Primary publication · 15338093 (PubMed)
  49. Factors influencing the autoxidation of fatty acids: effect of olefin geometry of the nonconjugated diene. Tallman KA, Roschek B, Porter NA (2004) J Am Chem Soc 126(30): 9240-7
    › Primary publication · 15281813 (PubMed)
  50. Autoxidative transformation of chiral omega6 hydroxy linoleic and arachidonic acids to chiral 4-hydroxy-2E-nonenal. Schneider C, Porter NA, Brash AR (2004) Chem Res Toxicol 17(7): 937-41
    › Primary publication · 15257619 (PubMed)
  51. Mechanism of beta-silyl diacyl peroxide decomposition: a mild and stereoselective synthesis of beta-silyl esters. Masterson DS, Porter NA (2004) J Org Chem 69(11): 3693-9
    › Primary publication · 15152998 (PubMed)
  52. Lysine peroxycarbamates: free radical-promoted peptide cleavage. Masterson DS, Yin H, Chacon A, Hachey DL, Norris JL, Porter NA (2004) J Am Chem Soc 126(3): 720-1
    › Primary publication · 14733538 (PubMed)
  53. Quantification of F-ring isoprostane-like compounds (F4-neuroprostanes) derived from docosahexaenoic acid in vivo in humans by a stable isotope dilution mass spectrometric assay. Musiek ES, Cha JK, Yin H, Zackert WE, Terry ES, Porter NA, Montine TJ, Morrow JD (2004) J Chromatogr B Analyt Technol Biomed Life Sci 799(1): 95-102
    › Primary publication · 14659440 (PubMed)
  54. Mass spectrometry of intracellular and membrane proteins using cleavable detergents. Norris JL, Porter NA, Caprioli RM (2003) Anal Chem 75(23): 6642-7
    › Primary publication · 14640740 (PubMed)
  55. Liquid chromatography coordination ion-spray mass spectrometry (LC-CIS-MS) of docosahexaenoate ester hydroperoxides. Seal JR, Porter NA (2004) Anal Bioanal Chem 378(4): 1007-13
    › Primary publication · 14634702 (PubMed)
  56. Identification of a novel class of endoperoxides from arachidonate autoxidation. Yin H, Morrow JD, Porter NA (2004) J Biol Chem 279(5): 3766-76
    › Primary publication · 14594817 (PubMed)
  57. 6-Amino-3-pyridinols: towards diffusion-controlled chain-breaking antioxidants. Wijtmans M, Pratt DA, Valgimigli L, DiLabio GA, Pedulli GF, Porter NA (2003) Angew Chem Int Ed Engl 42(36): 4370-3
    › Primary publication · 14502714 (PubMed)
  58. Analysis of unsaturated compounds by Ag+ coordination ionspray mass spectrometry: studies of the formation of the Ag+/lipid complex. Seal JR, Havrilla CM, Porter NA, Hachey DL (2003) J Am Soc Mass Spectrom 14(8): 872-80
    › Primary publication · 12892911 (PubMed)
  59. Formation of prostaglandins E2 and D2 via the isoprostane pathway: a mechanism for the generation of bioactive prostaglandins independent of cyclooxygenase. Gao L, Zackert WE, Hasford JJ, Danekis ME, Milne GL, Remmert C, Reese J, Yin H, Tai HH, Dey SK, Porter NA, Morrow JD (2003) J Biol Chem 278(31): 28479-89
    › Primary publication · 12746435 (PubMed)
  60. Theoretical calculations of carbon-oxygen bond dissociation enthalpies of peroxyl radicals formed in the autoxidation of lipids. Pratt DA, Mills JH, Porter NA (2003) J Am Chem Soc 125(19): 5801-10
    › Primary publication · 12733921 (PubMed)
  61. Mechanisms for the formation of isoprostane endoperoxides from arachidonic acid. "Dioxetane" intermediate versus beta-fragmentation of peroxyl radicals. Yin H, Havrilla CM, Gao L, Morrow JD, Porter NA (2003) J Biol Chem 278(19): 16720-5
    › Primary publication · 12609993 (PubMed)
  62. Specificity of the ferrous oxidation of xylenol orange assay: analysis of autoxidation products of cholesteryl arachidonate. Yin H, Porter NA (2003) Anal Biochem 313(2): 319-26
    › Primary publication · 12605870 (PubMed)
  63. Role of hyperconjugation in determining carbon-oxygen bond dissociation enthalpies in alkylperoxyl radicals. Pratt DA, Porter NA (2003) Org Lett 5(4): 387-90
    › Primary publication · 12583725 (PubMed)
  64. Antioxidants significantly affect the formation of different classes of isoprostanes and neuroprostanes in rat cerebral synaptosomes. Montine TJ, Montine KS, Reich EE, Terry ES, Porter NA, Morrow JD (2003) Biochem Pharmacol 65(4): 611-7
    › Primary publication · 12566089 (PubMed)
  65. Discovery of lipid peroxidation products formed in vivo with a substituted tetrahydrofuran ring (isofurans) that are favored by increased oxygen tension. Fessel JP, Porter NA, Moore KP, Sheller JR, Roberts LJ (2002) Proc Natl Acad Sci U S A 99(26): 16713-8
    › Primary publication · 12482927 (PubMed) · PMC139209 (PubMed Central)
  66. Diastereoselective free radical halogenation, azidation, and rearrangement of beta-silyl Barton esters. Masterson DS, Porter NA (2002) Org Lett 4(24): 4253-6
    › Primary publication · 12443071 (PubMed)
  67. Formation of highly reactive A-ring and J-ring isoprostane-like compounds (A4/J4-neuroprostanes) in vivo from docosahexaenoic acid. Fam SS, Murphey LJ, Terry ES, Zackert WE, Chen Y, Gao L, Pandalai S, Milne GL, Roberts LJ, Porter NA, Montine TJ, Morrow JD (2002) J Biol Chem 277(39): 36076-84
    › Primary publication · 12133837 (PubMed)
  68. Formation of isoprostane bicyclic endoperoxides from the autoxidation of cholesteryl arachidonate. Yin H, Havrilla CM, Morrow JD, Porter NA (2002) J Am Chem Soc 124(26): 7745-54
    › Primary publication · 12083928 (PubMed)
  69. Determination of the alpha-tocopherol inhibition rate constant for peroxidation in low-density lipoprotein. Culbertson SM, Antunes F, Havrilla CM, Milne GL, Porter NA (2002) Chem Res Toxicol 15(6): 870-6
    › Primary publication · 12067255 (PubMed)
  70. Comparative study of the active site caging of serine proteases: thrombin and factor Xa. Thuring JW, Li H, Porter NA (2002) Biochemistry 41(6): 2002-13
    › Primary publication · 11827547 (PubMed)
  71. Separation and identification of phospholipid peroxidation products. Milne GL, Porter NA (2001) Lipids 36(11): 1265-75
    › Primary publication · 11795860 (PubMed)
  72. Kinetic products of linoleate peroxidation: rapid beta-fragmentation of nonconjugated peroxyls. Tallman KA, Pratt DA, Porter NA (2001) J Am Chem Soc 123(47): 11827-8
    › Primary publication · 11716752 (PubMed)
  73. Minimizing tocopherol-mediated radical phase transfer in low-density lipoprotein oxidation with an amphiphilic unsymmetrical azo initiator. Culbertson SM, Vinqvist MR, Barclay LR, Porter NA (2001) J Am Chem Soc 123(37): 8951-60
    › Primary publication · 11552801 (PubMed)
  74. Analysis of diacyl peroxides by Ag+ coordination ionspray tandem mass spectrometry: free radical pathways of complex decomposition. Yin H, Hachey DL, Porter NA (2001) J Am Soc Mass Spectrom 12(4): 449-55
    › Primary publication · 11322191 (PubMed)
  75. Two distinct pathways of formation of 4-hydroxynonenal. Mechanisms of nonenzymatic transformation of the 9- and 13-hydroperoxides of linoleic acid to 4-hydroxyalkenals. Schneider C, Tallman KA, Porter NA, Brash AR (2001) J Biol Chem 276(24): 20831-8
    › Primary publication · 11259420 (PubMed)
  76. Design of unsymmetrical azo initiators to increase radical generation efficiency in low-density lipoproteins. Culbertson SM, Porter NA (2000) Free Radic Res 33(6): 705-18
    › Primary publication · 11237093 (PubMed)
  77. Structural analysis of diacyl peroxides by electrospray tandem mass spectrometry with ammonium acetate: bond homolysis of peroxide-ammonium and peroxide-proton adducts. Yin H, Hachey DL, Porter NA (2000) Rapid Commun Mass Spectrom 14(14): 1248-54
    › Primary publication · 10918375 (PubMed)