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Keith Wilson
Faculty Member
Last active: 9/12/2018

Profile

My laboratory is focused on gastrointestinal mucosal inflammation and carcinogenesis. We study the host immune response to the gastric pathogen Helicobacter pylori that causes peptic ulcer disease and gastric cancer. This includes the innate immune response in macrophages and the identification of ways that this response is ineffective. We have also elucidated mechanisms whereby epithelial responses are inappropriate, leading to risk for cancer development. We study novel mechanisms for inflammation and cellular/DNA damage, which leads to increased cancer risk.

We have reported that H. pylori induces the enzyme spermine oxidase (SMOX), originally known as polyamine oxidase 1, which utilizes the polyamine spermine as substrate. Generation of H2O2 by SMOX results in mitochondrial membrane depolarization, cytochrome c release, and apoptosis. Spermine itself contributes to the inadequacy of the host response, by blocking translation of inducible nitric oxide (NO) synthase (iNOS; NOS2) and hence NO production that is needed for the killing of H. pylori. Upregulation of SMOX causes oxidative stress in gastric epithelial cells that leads to both apoptosis and DNA damage. Induction of ornithine decarboxylase (ODC) that generates polyamines also leads to apoptosis of macrophages, contributing to loss of host innate immunity to H. pylori. We have shown that induction of the transcription factor c-Myc by H. pylori enhances ODC transcription and has a causal role in macrophage apoptosis. We have also implicated formation of a specific AP-1 complex in the activation of c-Myc.

We are utilizing clinical material from a large cohort of human subjects from Colombia, South America where H. pylori infection prevalence is very high, but gastric cancer risk is 25-fold higher in the Andean mountains when compared to the coastal region. We have found that SMOX-dependent oxidative stress is increased in gastric epithelial cells in vivo in the subjects at high risk for gastric cancer and that H. pylori clinical strains from these subjects induce more SMOX and oxidative DNA damage both in vitro and in vivo in a gerbil model. Studies are ongoing to pursue the mechanisms involved in the differential induction of SMOX and DNA damage.

We are also pursuing studies on immune dysregulation in inflammatory bowel disease. This includes work on arginine availability/transport, polyamines, and nitric oxide. We have reported that levels of the amino acid L-arginine are increased in the serum of humans with ulcerative colitis. Because L-arginine is important in regulation of epithelial integrity and immune function a defect in the utilization of L-arginine could contribute to the disease pathogenesis. Consistent with this, we have shown that treatment with L-arginine improves colitis in mouse models and that mice lacking an inducible L-arginine transporter have increased disease activity.

Our funded studies are focused on:
1) Mechanisms of H. pylori induced DNA damage and immune dysregulation, with an emphasis on the effects of polyamines and their oxidation (PI, R01 grant)
2) The role oxidative and nitrosative stress in the development of gastric cancer in Colombia, and the importance of H. pylori strains from regions of low and high gastric cancer risk in modulation of host responses (PI, P01 grant and P01 project)
3) Importance of arginine metabolism in the immune response and disease progression associated with H. pylori infection (PI, VA Merit Review Grant)
4) Role of SMOX in EGF signaling and epithelial dysfunction in H. pylori infection (PI, project on second P01)
5) Arginine and other amino acids as immunomodulatory agents and potential therapies in colitis and colitis-associated cancer (PI, R01 grant)
6) Prospective clinical study investigating alterations in arginine and other amino acids in ulcerative colitis (PI, R01 supplement; funding completed, analysis ongoing)

Publications

The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. Loss of solute carrier family 7 member 2 exacerbates inflammation-associated colon tumorigenesis. Coburn LA, Singh K, Asim M, Barry DP, Allaman MM, Al-Greene NT, Hardbower DM, Polosukhina D, Williams CS, Delgado AG, Piazuelo MB, Washington MK, Gobert AP, Wilson KT (2018) Oncogene
    › Primary publication · 30202097 (PubMed)
  2. Epithelial Smad4 Deletion Up-Regulates Inflammation and Promotes Inflammation-Associated Cancer. Means AL, Freeman TJ, Zhu J, Woodbury LG, Marincola-Smith P, Wu C, Meyer AR, Weaver CJ, Padmanabhan C, An H, Zi J, Wessinger BC, Chaturvedi R, Brown TD, Deane NG, Coffey RJ, Wilson KT, Smith JJ, Sawyers CL, Goldenring JR, Novitskiy SV, Washington MK, Shi C, Beauchamp RD (2018) Cell Mol Gastroenterol Hepatol 6(3): 257-276
    › Primary publication · 30109253 (PubMed) · PMC6083016 (PubMed Central)
  3. Distinct Immunomodulatory Effects of Spermine Oxidase in Colitis Induced by Epithelial Injury or Infection. Gobert AP, Al-Greene NT, Singh K, Coburn LA, Sierra JC, Verriere TG, Luis PB, Schneider C, Asim M, Allaman MM, Barry DP, Cleveland JL, Destefano Shields CE, Casero RA, Washington MK, Piazuelo MB, Wilson KT (2018) Front Immunol : 1242
    › Primary publication · 29922289 (PubMed) · PMC5996034 (PubMed Central)
  4. BVES is required for maintenance of colonic epithelial integrity in experimental colitis by modifying intestinal permeability. Choksi YA, Reddy VK, Singh K, Barrett CW, Short SP, Parang B, Keating CE, Thompson JJ, Verriere TG, Brown RE, Piazuelo MB, Bader DM, Washington MK, Mittal MK, Brand T, Gobert AP, Coburn LA, Wilson KT, Williams CS (2018) Mucosal Immunol
    › Primary publication · 29907869 (PubMed)
  5. Supplementation of p40, a Lactobacillus rhamnosus GG-derived protein, in early life promotes epidermal growth factor receptor-dependent intestinal development and long-term health outcomes. Shen X, Liu L, Peek RM, Acra SA, Moore DJ, Wilson KT, He F, Polk DB, Yan F (2018) Mucosal Immunol
    › Primary publication · 29875401 (PubMed)
  6. Ornithine Decarboxylase in Macrophages Exacerbates Colitis and Promotes Colitis-Associated Colon Carcinogenesis by Impairing M1 Immune Responses. Singh K, Coburn LA, Asim M, Barry DP, Allaman MM, Shi C, Washington MK, Luis PB, Schneider C, Delgado AG, Piazuelo MB, Cleveland JL, Gobert AP, Wilson KT (2018) Cancer Res
    › Primary publication · 29853605 (PubMed)
  7. Alterations in Lipid, Amino Acid, and Energy Metabolism Distinguish Crohn's Disease from Ulcerative Colitis and Control Subjects by Serum Metabolomic Profiling. Scoville EA, Allaman MM, Brown CT, Motley AK, Horst SN, Williams CS, Koyama T, Zhao Z, Adams DW, Beaulieu DB, Schwartz DA, Wilson KT, Coburn LA (2018) Metabolomics 14(1)
    › Primary publication · 29681789 (PubMed) · PMC5907923 (PubMed Central)
  8. Pan-genomic analyses identify keypathogenic loci modified by carcinogenic host microenvironments. Noto JM, Chopra A, Loh JT, Romero-Gallo J, Piazuelo MB, Watson M, Leary S, Beckett AC, Wilson KT, Cover TL, Mallal S, Israel DA, Peek RM (2017) Gut
    › Primary publication · 28924022 (PubMed) · PMC5857411 (PubMed Central)
  9. MTG16 is a tumor suppressor in colitis-associated carcinoma. McDonough EM, Barrett CW, Parang B, Mittal MK, Smith JJ, Bradley AM, Choksi YA, Coburn LA, Short SP, Thompson JJ, Zhang B, Poindexter SV, Fischer MA, Chen X, Li J, Revetta FL, Naik R, Washington MK, Rosen MJ, Hiebert SW, Wilson KT, Williams CS (2017) JCI Insight 2(16)
    › Primary publication · 28814670 (PubMed) · PMC5621889 (PubMed Central)
  10. Dynamics ofinfection as a determinant of progression of gastric precancerous lesions: 16-year follow-up of an eradication trial. Mera RM, Bravo LE, Camargo MC, Bravo JC, Delgado AG, Romero-Gallo J, Yepez MC, Realpe JL, Schneider BG, Morgan DR, Peek RM, Correa P, Wilson KT, Piazuelo MB (2017) Gut
    › Primary publication · 28647684 (PubMed) · PMC5742304 (PubMed Central)
  11. Effect of COon Peroxynitrite-Mediated Bacteria Killing: Response to Tsikas et al. Gobert AP, Wilson KT (2017) Trends Microbiol 25(8): 602-603
    › Primary publication · 28610877 (PubMed) · PMC5628050 (PubMed Central)
  12. Epidermal growth factor receptor inhibition downregulates-induced epithelial inflammatory responses, DNA damage and gastric carcinogenesis. Sierra JC, Asim M, Verriere TG, Piazuelo MB, Suarez G, Romero-Gallo J, Delgado AG, Wroblewski LE, Barry DP, Peek RM, Gobert AP, Wilson KT (2017) Gut
    › Primary publication · 28473630 (PubMed) · PMC5671361 (PubMed Central)
  13. Increased expression of deleted in malignant brain tumors (DMBT1) gene in precancerous gastric lesions: Findings from human and animal studies. Garay J, Piazuelo MB, Lopez-Carrillo L, Leal YA, Majumdar S, Li L, Cruz-Rodriguez N, Serrano-Gomez SJ, Busso CS, Schneider BG, Delgado AG, Bravo LE, Crist AM, Meadows SM, Camargo MC, Wilson KT, Correa P, Zabaleta J (2017) Oncotarget 8(29): 47076-47089
    › Primary publication · 28423364 (PubMed) · PMC5564545 (PubMed Central)
  14. Draft Genome Sequences of 13 ColombianStrains Isolated from Pacific Coast and Andean Residents. Pazos A, Kodaman N, Piazuelo MB, Romero-Gallo J, Sobota RS, Israel DA, Bravo LE, Morgan DR, Wilson KT, Correa P, Peek RM, Williams SM, Schneider BG (2017) Genome Announc 5(15)
    › Primary publication · 28408665 (PubMed) · PMC5391403 (PubMed Central)
  15. BVES regulates c-Myc stability via PP2A and suppresses colitis-induced tumourigenesis. Parang B, Kaz AM, Barrett CW, Short SP, Ning W, Keating CE, Mittal MK, Naik RD, Washington MK, Revetta FL, Smith JJ, Chen X, Wilson KT, Brand T, Bader DM, Tansey WP, Chen R, Brentnall TA, Grady WM, Williams CS (2017) Gut 66(5): 852-862
    › Primary publication · 28389570 (PubMed) · PMC5385850 (PubMed Central)
  16. EGFR-mediated macrophage activation promotes colitis-associated tumorigenesis. Hardbower DM, Coburn LA, Asim M, Singh K, Sierra JC, Barry DP, Gobert AP, Piazuelo MB, Washington MK, Wilson KT (2017) Oncogene 36(27): 3807-3819
    › Primary publication · 28263971 (PubMed) · PMC5501754 (PubMed Central)
  17. Genetic Manipulation ofVirulence Function by Host Carcinogenic Phenotypes. Suarez G, Romero-Gallo J, Sierra JC, Piazuelo MB, Krishna US, Gomez MA, Wilson KT, Peek RM (2017) Cancer Res 77(9): 2401-2412
    › Primary publication · 28209611 (PubMed) · PMC5413443 (PubMed Central)
  18. Mucosal Expression of Type 2 and Type 17 Immune Response Genes Distinguishes Ulcerative Colitis From Colon-Only Crohn's Disease in Treatment-Naive Pediatric Patients. Rosen MJ, Karns R, Vallance JE, Bezold R, Waddell A, Collins MH, Haberman Y, Minar P, Baldassano RN, Hyams JS, Baker SS, Kellermayer R, Noe JD, Griffiths AM, Rosh JR, Crandall WV, Heyman MB, Mack DR, Kappelman MD, Markowitz J, Moulton DE, Leleiko NS, Walters TD, Kugathasan S, Wilson KT, Hogan SP, Denson LA (2017) Gastroenterology 152(6): 1345-1357.e7
    › Primary publication · 28132889 (PubMed) · PMC5406257 (PubMed Central)
  19. Human and Helicobacter pylori Interactions Determine the Outcome of Gastric Diseases. Gobert AP, Wilson KT (2017) Curr Top Microbiol Immunol : 27-52
    › Primary publication · 28124148 (PubMed) · PMC5316293 (PubMed Central)
  20. Ornithine decarboxylase regulates M1 macrophage activation and mucosal inflammation via histone modifications. Hardbower DM, Asim M, Luis PB, Singh K, Barry DP, Yang C, Steeves MA, Cleveland JL, Schneider C, Piazuelo MB, Gobert AP, Wilson KT (2017) Proc Natl Acad Sci U S A 114(5): E751-E760
    › Primary publication · 28096401 (PubMed) · PMC5293075 (PubMed Central)
  21. The L-Arginine Transporter Solute Carrier Family 7 Member 2 Mediates the Immunopathogenesis of Attaching and Effacing Bacteria. Singh K, Al-Greene NT, Verriere TG, Coburn LA, Asim M, Barry DP, Allaman MM, Hardbower DM, Delgado AG, Piazuelo MB, Vallance BA, Gobert AP, Wilson KT (2016) PLoS Pathog 12(10): e1005984
    › Primary publication · 27783672 (PubMed) · PMC5081186 (PubMed Central)
  22. TLR9 activation suppresses inflammation in response to Helicobacter pylori infection. Varga MG, Piazuelo MB, Romero-Gallo J, Delgado AG, Suarez G, Whitaker ME, Krishna US, Patel RV, Skaar EP, Wilson KT, Algood HM, Peek RM (2016) Am J Physiol Gastrointest Liver Physiol 311(5): G852-G858
    › Primary publication · 27758771 (PubMed) · PMC5130555 (PubMed Central)
  23. Polyamine- and NADPH-dependent generation of ROS during Helicobacter pylori infection: A blessing in disguise. Gobert AP, Wilson KT (2017) Free Radic Biol Med : 16-27
    › Primary publication · 27682363 (PubMed) · PMC5366100 (PubMed Central)
  24. EGFR regulates macrophage activation and function in bacterial infection. Hardbower DM, Singh K, Asim M, Verriere TG, Olivares-Villagómez D, Barry DP, Allaman MM, Washington MK, Peek RM, Piazuelo MB, Wilson KT (2016) J Clin Invest 126(9): 3296-312
    › Primary publication · 27482886 (PubMed) · PMC5004944 (PubMed Central)
  25. TRPM2 ion channels regulate macrophage polarization and gastric inflammation during Helicobacter pylori infection. Beceiro S, Radin JN, Chatuvedi R, Piazuelo MB, Horvarth DJ, Cortado H, Gu Y, Dixon B, Gu C, Lange I, Koomoa DL, Wilson KT, Algood HM, Partida-Sánchez S (2017) Mucosal Immunol 10(2): 493-507
    › Primary publication · 27435104 (PubMed) · PMC5250617 (PubMed Central)
  26. Erratum to: Epigenetic and genetic variation in GATA5 is associated with gastric disease risk. Sobota RS, Kodaman N, Mera R, Piazuelo MB, Bravo LE, Pazos A, Zabaleta J, Delgado AG, El-Rifai W, Morgan DR, Wilson KT, Correa P, Williams SM, Schneider BG (2016) Hum Genet 135(8): 907-908
    › Primary publication · 27417435 (PubMed)
  27. Myeloid translocation genes differentially regulate colorectal cancer programs. Parang B, Bradley AM, Mittal MK, Short SP, Thompson JJ, Barrett CW, Naik RD, Bilotta AJ, Washington MK, Revetta FL, Smith JJ, Chen X, Wilson KT, Hiebert SW, Williams CS (2016) Oncogene 35(49): 6341-6349
    › Primary publication · 27270437 (PubMed) · PMC5140770 (PubMed Central)
  28. Serum Fatty Acids Are Correlated with Inflammatory Cytokines in Ulcerative Colitis. Wiese DM, Horst SN, Brown CT, Allaman MM, Hodges ME, Slaughter JC, Druce JP, Beaulieu DB, Schwartz DA, Wilson KT, Coburn LA (2016) PLoS One 11(5): e0156387
    › Primary publication · 27227540 (PubMed) · PMC4882051 (PubMed Central)
  29. Epigenetic and genetic variation in GATA5 is associated with gastric disease risk. Sobota RS, Kodaman N, Mera R, Piazuelo MB, Bravo LE, Pazos A, Zabaleta J, Delgado AG, El-Rifai W, Morgan DR, Wilson KT, Correa P, Williams SM, Schneider BG (2016) Hum Genet 135(8): 895-906
    › Primary publication · 27225266 (PubMed) · PMC4947561 (PubMed Central)
  30. Pathogenic Helicobacter pylori strains translocate DNA and activate TLR9 via the cancer-associated cag type IV secretion system. Varga MG, Shaffer CL, Sierra JC, Suarez G, Piazuelo MB, Whitaker ME, Romero-Gallo J, Krishna US, Delgado A, Gomez MA, Good JA, Almqvist F, Skaar EP, Correa P, Wilson KT, Hadjifrangiskou M, Peek RM (2016) Oncogene 35(48): 6262-6269
    › Primary publication · 27157617 (PubMed) · PMC5102820 (PubMed Central)
  31. L-Arginine Availability and Metabolism Is Altered in Ulcerative Colitis. Coburn LA, Horst SN, Allaman MM, Brown CT, Williams CS, Hodges ME, Druce JP, Beaulieu DB, Schwartz DA, Wilson KT (2016) Inflamm Bowel Dis 22(8): 1847-58
    › Primary publication · 27104830 (PubMed) · PMC4956554 (PubMed Central)
  32. Arginase 2 deletion leads to enhanced M1 macrophage activation and upregulated polyamine metabolism in response to Helicobacter pylori infection. Hardbower DM, Asim M, Murray-Stewart T, Casero RA, Verriere T, Lewis ND, Chaturvedi R, Piazuelo MB, Wilson KT (2016) Amino Acids 48(10): 2375-88
    › Primary publication · 27074721 (PubMed) · PMC5042810 (PubMed Central)
  33. Epigenetic silencing of miR-124 prevents spermine oxidase regulation: implications for Helicobacter pylori-induced gastric cancer. Murray-Stewart T, Sierra JC, Piazuelo MB, Mera RM, Chaturvedi R, Bravo LE, Correa P, Schneider BG, Wilson KT, Casero RA (2016) Oncogene 35(42): 5480-5488
    › Primary publication · 27041578 (PubMed) · PMC5050049 (PubMed Central)
  34. The Immune Battle against Helicobacter pylori Infection: NO Offense. Gobert AP, Wilson KT (2016) Trends Microbiol 24(5): 366-376
    › Primary publication · 26916789 (PubMed) · PMC4841705 (PubMed Central)
  35. Different gastric microbiota compositions in two human populations with high and low gastric cancer risk in Colombia. Yang I, Woltemate S, Piazuelo MB, Bravo LE, Yepez MC, Romero-Gallo J, Delgado AG, Wilson KT, Peek RM, Correa P, Josenhans C, Fox JG, Suerbaum S (2016) Sci Rep : 18594
    › Primary publication · 26729566 (PubMed) · PMC4700446 (PubMed Central)
  36. The homing receptor CD44 is involved in the progression of precancerous gastric lesions in patients infected with Helicobacter pylori and in development of mucous metaplasia in mice. Garay J, Piazuelo MB, Majumdar S, Li L, Trillo-Tinoco J, Del Valle L, Schneider BG, Delgado AG, Wilson KT, Correa P, Zabaleta J (2016) Cancer Lett 371(1): 90-8
    › Primary publication · 26639196 (PubMed) · PMC4714604 (PubMed Central)
  37. Dual role of arginine metabolism in establishing pathogenesis. Gogoi M, Datey A, Wilson KT, Chakravortty D (2016) Curr Opin Microbiol : 43-8
    › Primary publication · 26610300 (PubMed) · PMC4755812 (PubMed Central)
  38. IL-33 Signaling Protects from Murine Oxazolone Colitis by Supporting Intestinal Epithelial Function. Waddell A, Vallance JE, Moore PD, Hummel AT, Wu D, Shanmukhappa SK, Fei L, Washington MK, Minar P, Coburn LA, Nakae S, Wilson KT, Denson LA, Hogan SP, Rosen MJ (2015) Inflamm Bowel Dis 21(12): 2737-46
    › Primary publication · 26313694 (PubMed) · PMC4654638 (PubMed Central)
  39. DNA Methylation Predicts Progression of Human Gastric Lesions. Schneider BG, Mera R, Piazuelo MB, Bravo JC, Zabaleta J, Delgado AG, Bravo LE, Wilson KT, El-Rifai W, Peek RM, Correa P (2015) Cancer Epidemiol Biomarkers Prev 24(10): 1607-13
    › Primary publication · 26269563 (PubMed) · PMC4592454 (PubMed Central)
  40. Hepatic TLR4 signaling in obese NAFLD. Sharifnia T, Antoun J, Verriere TG, Suarez G, Wattacheril J, Wilson KT, Peek RM, Abumrad NN, Flynn CR (2015) Am J Physiol Gastrointest Liver Physiol 309(4): G270-8
    › Primary publication · 26113297 (PubMed) · PMC4537925 (PubMed Central)
  41. Draft Genome Sequence of Gerbil-Adapted Carcinogenic Helicobacter pylori Strain 7.13. Asim M, Chikara SK, Ghosh A, Vudathala S, Romero-Gallo J, Krishna US, Wilson KT, Israel DA, Peek RM, Chaturvedi R (2015) Genome Announc 3(3)
    › Primary publication · 26067974 (PubMed) · PMC4463538 (PubMed Central)
  42. Selenoprotein P influences colitis-induced tumorigenesis by mediating stemness and oxidative damage. Barrett CW, Reddy VK, Short SP, Motley AK, Lintel MK, Bradley AM, Freeman T, Vallance J, Ning W, Parang B, Poindexter SV, Fingleton B, Chen X, Washington MK, Wilson KT, Shroyer NF, Hill KE, Burk RF, Williams CS (2015) J Clin Invest 125(7): 2646-60
    › Primary publication · 26053663 (PubMed) · PMC4563672 (PubMed Central)
  43. Transcriptional corepressor MTG16 regulates small intestinal crypt proliferation and crypt regeneration after radiation-induced injury. Poindexter SV, Reddy VK, Mittal MK, Williams AM, Washington MK, Harris E, Mah A, Hiebert SW, Singh K, Chaturvedi R, Wilson KT, Lund PK, Williams CS (2015) Am J Physiol Gastrointest Liver Physiol 308(6): G562-71
    › Primary publication · 25573176 (PubMed) · PMC4360050 (PubMed Central)
  44. CD8αα⁺ innate-type lymphocytes in the intestinal epithelium mediate mucosal immunity. Van Kaer L, Algood HMS, Singh K, Parekh VV, Greer MJ, Piazuelo MB, Weitkamp JH, Matta P, Chaturvedi R, Wilson KT, Olivares-Villagómez D (2014) Immunity 41(3): 451-464
    › Primary publication · 25220211 (PubMed) · PMC4169715 (PubMed Central)
  45. Increased Helicobacter pylori-associated gastric cancer risk in the Andean region of Colombia is mediated by spermine oxidase. Chaturvedi R, de Sablet T, Asim M, Piazuelo MB, Barry DP, Verriere TG, Sierra JC, Hardbower DM, Delgado AG, Schneider BG, Israel DA, Romero-Gallo J, Nagy TA, Morgan DR, Murray-Stewart T, Bravo LE, Peek RM, Fox JG, Woster PM, Casero RA, Correa P, Wilson KT (2015) Oncogene 34(26): 3429-40
    › Primary publication · 25174398 (PubMed) · PMC4345146 (PubMed Central)
  46. Helicobacter pylori targets cancer-associated apical-junctional constituents in gastroids and gastric epithelial cells. Wroblewski LE, Piazuelo MB, Chaturvedi R, Schumacher M, Aihara E, Feng R, Noto JM, Delgado A, Israel DA, Zavros Y, Montrose MH, Shroyer N, Correa P, Wilson KT, Peek RM (2015) Gut 64(5): 720-30
    › Primary publication · 25123931 (PubMed) · PMC4329117 (PubMed Central)
  47. Heme oxygenase-1 dysregulates macrophage polarization and the immune response to Helicobacter pylori. Gobert AP, Verriere T, Asim M, Barry DP, Piazuelo MB, de Sablet T, Delgado AG, Bravo LE, Correa P, Peek RM, Chaturvedi R, Wilson KT (2014) J Immunol 193(6): 3013-22
    › Primary publication · 25108023 (PubMed) · PMC4171064 (PubMed Central)
  48. Systems modeling of the role of interleukin-21 in the maintenance of effector CD4+ T cell responses during chronic Helicobacter pylori infection. Carbo A, Olivares-Villagómez D, Hontecillas R, Bassaganya-Riera J, Chaturvedi R, Piazuelo MB, Delgado A, Washington MK, Wilson KT, Algood HM (2014) MBio 5(4): e01243-14
    › Primary publication · 25053783 (PubMed) · PMC4120195 (PubMed Central)
  49. At the Bench: Helicobacter pylori, dysregulated host responses, DNA damage, and gastric cancer. Hardbower DM, Peek RM, Wilson KT (2014) J Leukoc Biol 96(2): 201-12
    › Primary publication · 24868089 (PubMed) · PMC4101087 (PubMed Central)
  50. Matrix metalloproteinase 7 restrains Helicobacter pylori-induced gastric inflammation and premalignant lesions in the stomach by altering macrophage polarization. Krakowiak MS, Noto JM, Piazuelo MB, Hardbower DM, Romero-Gallo J, Delgado A, Chaturvedi R, Correa P, Wilson KT, Peek RM (2015) Oncogene 34(14): 1865-71
    › Primary publication · 24837365 (PubMed) · PMC4237684 (PubMed Central)
  51. Peroxisome proliferator-activated receptor δ promotes colonic inflammation and tumor growth. Wang D, Fu L, Ning W, Guo L, Sun X, Dey SK, Chaturvedi R, Wilson KT, DuBois RN (2014) Proc Natl Acad Sci U S A 111(19): 7084-9
    › Primary publication · 24763687 (PubMed) · PMC4024916 (PubMed Central)
  52. Targeted colonic claudin-2 expression renders resistance to epithelial injury, induces immune suppression, and protects from colitis. Ahmad R, Chaturvedi R, Olivares-Villagómez D, Habib T, Asim M, Shivesh P, Polk DB, Wilson KT, Washington MK, Van Kaer L, Dhawan P, Singh AB (2014) Mucosal Immunol 7(6): 1340-53
    › Primary publication · 24670427 (PubMed) · PMC4221190 (PubMed Central)
  53. Fibrogenesis in pancreatic cancer is a dynamic process regulated by macrophage-stellate cell interaction. Shi C, Washington MK, Chaturvedi R, Drosos Y, Revetta FL, Weaver CJ, Buzhardt E, Yull FE, Blackwell TS, Sosa-Pineda B, Whitehead RH, Beauchamp RD, Wilson KT, Means AL (2014) Lab Invest 94(4): 409-21
    › Primary publication · 24535260 (PubMed) · PMC3992484 (PubMed Central)
  54. Activation of EGFR and ERBB2 by Helicobacter pylori results in survival of gastric epithelial cells with DNA damage. Chaturvedi R, Asim M, Piazuelo MB, Yan F, Barry DP, Sierra JC, Delgado AG, Hill S, Casero RA, Bravo LE, Dominguez RL, Correa P, Polk DB, Washington MK, Rose KL, Schey KL, Morgan DR, Peek RM, Wilson KT (2014) Gastroenterology 146(7): 1739-51.e14
    › Primary publication · 24530706 (PubMed) · PMC4035375 (PubMed Central)
  55. Human and Helicobacter pylori coevolution shapes the risk of gastric disease. Kodaman N, Pazos A, Schneider BG, Piazuelo MB, Mera R, Sobota RS, Sicinschi LA, Shaffer CL, Romero-Gallo J, de Sablet T, Harder RH, Bravo LE, Peek RM, Wilson KT, Cover TL, Williams SM, Correa P (2014) Proc Natl Acad Sci U S A 111(4): 1455-60
    › Primary publication · 24474772 (PubMed) · PMC3910595 (PubMed Central)
  56. Activation of the epidermal growth factor receptor in macrophages regulates cytokine production and experimental colitis. Lu N, Wang L, Cao H, Liu L, Van Kaer L, Washington MK, Rosen MJ, Dubé PE, Wilson KT, Ren X, Hao X, Polk DB, Yan F (2014) J Immunol 192(3): 1013-23
    › Primary publication · 24391216 (PubMed) · PMC4006992 (PubMed Central)
  57. High-throughput multi-analyte Luminex profiling implicates eotaxin-1 in ulcerative colitis. Coburn LA, Horst SN, Chaturvedi R, Brown CT, Allaman MM, Scull BP, Singh K, Piazuelo MB, Chitnavis MV, Hodges ME, Rosen MJ, Williams CS, Slaughter JC, Beaulieu DB, Schwartz DA, Wilson KT (2013) PLoS One 8(12): e82300
    › Primary publication · 24367513 (PubMed) · PMC3867379 (PubMed Central)
  58. Strain-specific suppression of microRNA-320 by carcinogenic Helicobacter pylori promotes expression of the antiapoptotic protein Mcl-1. Noto JM, Piazuelo MB, Chaturvedi R, Bartel CA, Thatcher EJ, Delgado A, Romero-Gallo J, Wilson KT, Correa P, Patton JG, Peek RM (2013) Am J Physiol Gastrointest Liver Physiol 305(11): G786-96
    › Primary publication · 24136787 (PubMed) · PMC3882435 (PubMed Central)
  59. Virulence of infecting Helicobacter pylori strains and intensity of mononuclear cell infiltration are associated with levels of DNA hypermethylation in gastric mucosae. Schneider BG, Piazuelo MB, Sicinschi LA, Mera R, Peng DF, Roa JC, Romero-Gallo J, Delgado AG, de Sablet T, Bravo LE, Wilson KT, El-Rifai W, Peek RM, Correa P (2013) Epigenetics 8(11): 1153-61
    › Primary publication · 24128875 (PubMed) · PMC3927747 (PubMed Central)
  60. Draft Genome Sequences of Helicobacter pylori Strains Isolated from Regions of Low and High Gastric Cancer Risk in Colombia. Sheh A, Piazuelo MB, Wilson KT, Correa P, Fox JG (2013) Genome Announc 1(5)
    › Primary publication · 24051318 (PubMed) · PMC3778201 (PubMed Central)
  61. Outcomes following infliximab therapy for pediatric patients hospitalized with refractory colitis-predominant IBD. Falaiye TO, Mitchell KR, Lu Z, Saville BR, Horst SN, Moulton DE, Schwartz DA, Wilson KT, Rosen MJ (2014) J Pediatr Gastroenterol Nutr 58(2): 213-9
    › Primary publication · 24048170 (PubMed) · PMC3946904 (PubMed Central)
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  142. Microsatellite instability in inflammatory bowel disease-associated neoplastic lesions is associated with hypermethylation and diminished expression of the DNA mismatch repair gene, hMLH1. Fleisher AS, Esteller M, Harpaz N, Leytin A, Rashid A, Xu Y, Liang J, Stine OC, Yin J, Zou TT, Abraham JM, Kong D, Wilson KT, James SP, Herman JG, Meltzer SJ (2000) Cancer Res 60(17): 4864-8
    › Primary publication · 10987299 (PubMed)
  143. Distinct methylation patterns of two APC gene promoters in normal and cancerous gastric epithelia. Tsuchiya T, Tamura G, Sato K, Endoh Y, Sakata K, Jin Z, Motoyama T, Usuba O, Kimura W, Nishizuka S, Wilson KT, James SP, Yin J, Fleisher AS, Zou T, Silverberg SG, Kong D, Meltzer SJ (2000) Oncogene 19(32): 3642-6
    › Primary publication · 10951570 (PubMed)
  144. E-Cadherin gene promoter hypermethylation in primary human gastric carcinomas. Tamura G, Yin J, Wang S, Fleisher AS, Zou T, Abraham JM, Kong D, Smolinski KN, Wilson KT, James SP, Silverberg SG, Nishizuka S, Terashima M, Motoyama T, Meltzer SJ (2000) J Natl Cancer Inst 92(7): 569-73
    › Primary publication · 10749913 (PubMed)
  145. Increased expression and cellular localization of inducible nitric oxide synthase and cyclooxygenase 2 in Helicobacter pylori gastritis. Fu S, Ramanujam KS, Wong A, Fantry GT, Drachenberg CB, James SP, Meltzer SJ, Wilson KT (1999) Gastroenterology 116(6): 1319-29
    › Primary publication · 10348815 (PubMed)
  146. Hypermethylation of the hMLH1 gene promoter in human gastric cancers with microsatellite instability. Fleisher AS, Esteller M, Wang S, Tamura G, Suzuki H, Yin J, Zou TT, Abraham JM, Kong D, Smolinski KN, Shi YQ, Rhyu MG, Powell SM, James SP, Wilson KT, Herman JG, Meltzer SJ (1999) Cancer Res 59(5): 1090-5
    › Primary publication · 10070967 (PubMed)
  147. Decreased prevalence of Helicobacter pylori infection in gastroesophageal reflux disease. Varanasi RV, Fantry GT, Wilson KT (1998) Helicobacter 3(3): 188-94
    › Primary publication · 9731990 (PubMed)
  148. iNOS expression in human intestinal microvascular endothelial cells inhibits leukocyte adhesion. Binion DG, Fu S, Ramanujam KS, Chai YC, Dweik RA, Drazba JA, Wade JG, Ziats NP, Erzurum SC, Wilson KT (1998) Am J Physiol 275(3 Pt 1): G592-603
    › Primary publication · 9724273 (PubMed)
  149. Increased expression of inducible nitric oxide synthase and cyclooxygenase-2 in Barrett's esophagus and associated adenocarcinomas. Wilson KT, Fu S, Ramanujam KS, Meltzer SJ (1998) Cancer Res 58(14): 2929-34
    › Primary publication · 9679948 (PubMed)
  150. Helicobacter pylori stimulates inducible nitric oxide synthase expression and activity in a murine macrophage cell line. Wilson KT, Ramanujam KS, Mobley HL, Musselman RF, James SP, Meltzer SJ (1996) Gastroenterology 111(6): 1524-33
    › Primary publication · 8942731 (PubMed)
  151. Production and localization of cGMP and PGE2 in nitroprusside-stimulated rat colonic ion transport. Wilson KT, Vaandrager AB, De Vente J, Musch MW, De Jonge HR, Chang EB (1996) Am J Physiol 270(3 Pt 1): C832-40
    › Primary publication · 8638664 (PubMed)
  152. Sodium nitroprusside stimulates anion secretion and inhibits sodium chloride absorption in rat colon. Wilson KT, Xie Y, Musch MW, Chang EB (1993) J Pharmacol Exp Ther 266(1): 224-30
    › Primary publication · 8331560 (PubMed)