Bryan Venters
Faculty Member
Last active: 2/12/2015

Bryan J Venters, PhD

Official Affiliation: Molecular Physiology and Biophysics

Profile

A fundamental question in molecular biology is how human disease is programmed into the genome. The overarching goal of my laboratory is to elucidate the transcription regulatory networks underlying oncogenic signaling pathways. STAT transcription factors in the JAK-STAT pathway (Janus Kinase-Signal Transducer and Activator of Transcription) are among the most frequently activated oncogenic proteins in cancer cells. My current research is focused on discovering how the JAK-STAT pathway is involved in the disease process using genetic, molecular, and next-gen sequencing approaches.

The goals of some current projects in my laboratory are to:

- Understand how STATs direct aberrant transcriptional programs in leukemia using stat-of-the-art functional genomics approaches

- Dissect the functional interdependencies among STATs on a genome-wide scale

- Identifying regulatory complexes that are recruited by the STAT transcription factors

- Discover novel molecular signatures in clinical samples with the future goal to better predict patient prognosis and identify new therapeutic targets

Publications

The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. A comprehensive genomic binding map of gene and chromatin regulatory proteins in Saccharomyces. Venters BJ, Wachi S, Mavrich TN, Andersen BE, Jena P, Sinnamon AJ, Jain P, Rolleri NS, Jiang C, Hemeryck-Walsh C, Pugh BF (2011) Mol Cell 41(4): 480-92
    › Primary publication · 21329885 (PubMed) · PMC3057419 (PubMed Central)
  2. Nucleosome organization in the Drosophila genome. Mavrich TN, Jiang C, Ioshikhes IP, Li X, Venters BJ, Zanton SJ, Tomsho LP, Qi J, Glaser RL, Schuster SC, Gilmour DS, Albert I, Pugh BF (2008) Nature 453(7193): 358-62
    › Primary publication · 18408708 (PubMed) · PMC2735122 (PubMed Central)

Featured Affiliation

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Contact Information

2200 Pierce Ave
746 RRB, Robinson Research Building
Nashville, TN 37232
United States
(615) 322-4761 (p)
Email

Keywords & MeSH Terms

MeSH terms are retrieved from PubMed records. Learn more.

Key: MeSH Term Keyword

3' Untranslated Regions Apoptosis Arginine Base Sequence Binding Sites Cancer Cell Line, Tumor ChIP-exo Chromatin Assembly and Disassembly DNA DNA, Fungal DNA Damage DNA Polymerase II Endopeptidase Clp epigenetics Gene Expression Regulation Gene regulation Genes, Insect Genome, Human Histones Humans JAK-STAT pathway Microarray Analysis Mutation Next-gen sequencing Nucleosomes Peptide Library Promoter Regions, Genetic Protein-Arginine Deiminase Type 4 Protein Binding Protein Structure, Tertiary RNA, Messenger RNA-seq Sequence Alignment Substrate Specificity transcription Transcriptional Activation Transcription Factors