Profile
The molecular mechanisms of cell-substrate adhesion and the
biologic roles of cellular adhesion are the foci of our research
program. Most of our studies are centered on the alpha 2/beta 1
integrin, a cell surface receptor for collagen that was originally
identified and characterized in our laboratory. Current efforts are
devoted to elucidation of the structural basis of ligand
recognition by the integrin, the structural basis of integrin
activation and the roles of the alpha 2/beta 1 and related
integrins in complex biological processes such as differentiation,
development, wound healing and repair, tumor cell invasion and
metastasis, and hemostasis and thrombosis.
Ongoing projects include: 1) elucidation of the structural basis by
which the integrin recognizes and binds both collagenous and
noncollagenous ligands, 2) elucidation of the structural basis of
integrin activation that permits higher affinity binding of some
ligands or that is required for the binding of other ligands, 3)
exploration of the role of altered integrin expression in the
invasive and metastatic behavior of tumor cells, 4) definition of
the structural and biologic basis of MMP-1 (matrix
metalloproteinase-1) interactions with the integrin and the role of
the interaction in regulating cell surface matrix metalloproteinase
activity in wound repair and related events, 5) examination of the
role of integrin-mediated cell-matrix interactions in the
establishment and maintenance of the differentiated epithelial
phenotype, and 6) and elucidation of the structural basis and
pathbiologic function of the alpha 2/beta 1 integrin as a receptor
for echoviruses and reoviruses. In addition, we continue to
identify new ligands that implicate the alpha 2/beta 1 integrin in
novel facets of biology and pathology.
Our studies combine the application of modern protein and peptide
biochemistry, immunochemical and molecular genetic approaches
(including knockout mice) to address the fundamental roles and
mechanisms of cellular adhesion in complex cell biological
processes. .
Publications
The following timeline graph is generated from all co-authored publications.
Featured publications are shown below:
- α2β1 integrin, GPVI receptor, and common FcRγ chain on mouse platelets mediate distinct responses to collagen in models of thrombosis. Marjoram RJ, Li Z, He L, Tollefsen DM, Kunicki TJ, Dickeson SK, Santoro SA, Zutter MM (2014) PLoS One 9(11): e114035
› Primary publication · 25415203 (PubMed) · PMC4240667 (PubMed Central) - α2β1 Integrin. Madamanchi A, Santoro SA, Zutter MM (2014) Adv Exp Med Biol : 41-60
› Primary publication · 25023166 (PubMed) - Optimizing personalized bone marrow testing using an evidence-based, interdisciplinary team approach. Seegmiller AC, Kim AS, Mosse CA, Levy MA, Thompson MA, Kressin MK, Jagasia MH, Strickland SA, Reddy NM, Marx ER, Sinkfield KJ, Pollard HN, Plummer WD, Dupont WD, Shultz EK, Dittus RS, Stead WW, Santoro SA, Zutter MM (2013) Am J Clin Pathol 140(5): 643-50
› Primary publication · 24124142 (PubMed) · PMC4159763 (PubMed Central)