My research interest concentrates on genetic and molecular epidemiology of cancer and other complex diseases, with an emphasis on colorectal and pancreatic cancers, melanoma, neuropsycheatric disorders. I try to identify and characterize genetic variants associated with cancer, understand how genetic susceptibility may be modified by environmental exposures and gene-gene interactions, and translate these findings into public health applications. I also have a particular interest in evaluating novel molecular prognostic markers and studying the molecular pathogenesis of cancer as an integrated part of genetic epidemiology. It is becoming increasingly evident that cancer represents a heterogeneous set of diseases with highly specific molecular signatures and phenotypes, and my research strategy is to exploit these specific phenotypes to gain insight into the epidemiology and pathogenesis of cancers.
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Nashville, TN 37203
MeSH terms are retrieved from PubMed records. Learn more.
Key: MeSH Term KeywordAcid Anhydride Hydrolases Algorithms Analysis of Variance Aromatase BRCA1 Protein Case-Control Studies Chromosome Aberrations Colon Colorectal Cancer Connexins DNA Primers Gene Expression Regulation, Neoplastic Gene Knockdown Techniques Genes, p16 Genetic Association Studies Humans Immunosuppressive Agents Leisure Activities melanoma Membrane Transport Proteins Microsatellite Instability Microsatellite Repeats MRE11 Homologue Protein Mutation Neoplasms Nuclear Proteins pancreatic cancer Pancreatic Neoplasms Papillomavirus Infections Proportional Hazards Models Receptor, Fibroblast Growth Factor, Type 2 Skin Neoplasms Young Adult