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During embryogenesis, animals develop complex structures, but they often have to modify their morphology to meet the demands of continuing growth or environmental challenge. This is known as tissue remodeling. Tissue remodeling is also required for animals to heal wounds, and it goes awry during cancer when tumors usurp tissue remodeling functions to promote metastasis. The matrix metalloproteinase (MMP) family of extracellular proteases is required for tissue remodeling events throughout the animal kingdom. These proteases are also upregulated in cancer and many inflammatory conditions such as arthritis. Understanding how MMPs promote tissue remodeling, both in normal and pathological circumstances, is a central question in my laboratory.

Drosophila melanogaster (the common fruitfly) has been an important model organism for understanding cell and developmental biology because of their advanced genetics and beautiful cytology. Although mammals have about 24 MMPs with overlapping substrate specificity and functional redundancy, Drosophila has only two MMPs, greatly simplifying genetic analysis of MMP function. We have found MMPs to be absolutley required for developmental tissue remodeling and epidermal wound healing in our system. We are currently investigating how basement membrane is modified and expanded in coordination with tissue growth during development.

Publications

The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. Wnt Signaling in Stem Cell Maintenance and Differentiation in the Drosophila Germarium. Waghmare I, Page-McCaw A (2018) Genes (Basel) 9(3)
    › Primary publication · 29495453 (PubMed) · PMC5867848 (PubMed Central)
  2. Wnt6 maintains anterior escort cells as an integral component of the germline stem cell niche. Wang X, Page-McCaw A (2018) Development 145(3)
    › Primary publication · 29361569 (PubMed) · PMC5818006 (PubMed Central)
  3. Multiple Mechanisms Drive Calcium Signal Dynamics around Laser-Induced Epithelial Wounds. Shannon EK, Stevens A, Edrington W, Zhao Y, Jayasinghe AK, Page-McCaw A, Hutson MS (2017) Biophys J 113(7): 1623-1635
    › Primary publication · 28978452 (PubMed) · PMC5627067 (PubMed Central)
  4. Both Drosophila matrix metalloproteinases have released and membrane-tethered forms but have different substrates. LaFever KS, Wang X, Page-McCaw P, Bhave G, Page-McCaw A (2017) Sci Rep : 44560
    › Primary publication · 28300207 (PubMed) · PMC5353688 (PubMed Central)
  5. A matrix metalloproteinase mediates long-distance attenuation of stem cell proliferation. Wang X, Page-McCaw A (2014) J Cell Biol 206(7): 923-36
    › Primary publication · 25267296 (PubMed) · PMC4178971 (PubMed Central)
  6. Bromine is an essential trace element for assembly of collagen IV scaffolds in tissue development and architecture. McCall AS, Cummings CF, Bhave G, Vanacore R, Page-McCaw A, Hudson BG (2014) Cell 157(6): 1380-92
    › Primary publication · 24906154 (PubMed) · PMC4144415 (PubMed Central)
  7. Cleavage of PGRP-LC receptor in the Drosophila IMD pathway in response to live bacterial infection in S2 cells. Schmidt RL, Rinaldo FM, Hesse SE, Hamada M, Ortiz Z, Beleford DT, Page-McCaw A, Platt JL, Tang AH (2011) Self Nonself 2(3): 125-141
    › Primary publication · 22496930 (PubMed) · PMC3323661 (PubMed Central)