Nipun Merchant
Faculty Member
Last active: 5/27/2014

Profile

My lab seeks to understand tumor-stromal interactions involved in the initiation and progression of colorectal (CRC) to liver metastasis. Using an in vitro system which simulates in vivo conditions, we seek to determine the mechanism by which bile acids stimulate release of EGFR ligands from the cell surface and activate the EGFR and COX-2 expression in polarized epithelial CRC cells. This work is complemented using an in vivo mouse model of liver metastasis. With our mouse model we are also trying to identify genes involved in the metastasic process of CRC using genomic and proteomic approaches with microarray and imaging mass spectrometry as well as a reversible gene-trap method of identifying tumor suppresor genes involved in metastasis. In addition we are studying different methods of in vivo small animal imaging of tumors and their metastasis using In Vivo Bioluminescence Imaging with a luciferase reporter, CT scanning and PET scanning through a mutant dopamine receptor. This work is further translated into the clinical forum through several clinical trials involving COX-2 inhibitors, EGFR inhibitors and angiogenesis inhibitors in patients with CRC. Tumors obtained from patients with CRC are further analyzed to help determine the mechanisms by which these agents function and also to develop a comprehensive genomic and proteomic profile of tumors to identify the molecular signatures of these tumors.

Publications

The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. Hepatic uterus-like mass misdiagnosed as hepatic abscess. Sopha SC, Rosado FG, Smith JJ, Merchant NB, Shi C (2015) Int J Surg Pathol 23(2): 134-9
    › Primary publication · 24827588 (PubMed)
  2. Postbrushing and fine-needle aspiration biopsy follow-up and treatment options for patients with pancreatobiliary lesions: the Papanicolaou Society of Cytopathology guidelines. Kurtycz D, Tabatabai ZL, Michaels C, Young N, Schmidt CM, Farrell J, Gopal D, Simeone D, Merchant NB, Field A, Pitman MB, Papanicolaou Society of Cytopathology (2014) Diagn Cytopathol 42(4): 363-71
    › Primary publication · 24639399 (PubMed)
  3. Loss of HNF6 expression correlates with human pancreatic cancer progression. Pekala KR, Ma X, Kropp PA, Petersen CP, Hudgens CW, Chung CH, Shi C, Merchant NB, Maitra A, Means AL, Gannon MA (2014) Lab Invest 94(5): 517-27
    › Primary publication · 24638272 (PubMed) · PMC4068339 (PubMed Central)
  4. Clinical evaluation, imaging studies, indications for cytologic study, and preprocedural requirements for duct brushing studies and pancreatic FNA: the Papanicolaou Society of Cytopathology recommendations for pancreatic and biliary cytology. Adler D, Max Schmidt C, Al-Haddad M, Barthel JS, Ljung BM, Merchant NB, Romagnuolo J, Shaaban AM, Simeone D, Bishop Pitman M, Field A, Layfield LJ, Papanicolaou Society of Cytopathology (2014) Diagn Cytopathol 42(4): 325-32
    › Primary publication · 24554480 (PubMed)
  5. Novel mechanistic insights into ectodomain shedding of EGFR Ligands Amphiregulin and TGF-╬▒: impact on gastrointestinal cancers driven by secondary bile acids. Nagathihalli NS, Beesetty Y, Lee W, Washington MK, Chen X, Lockhart AC, Merchant NB (2014) Cancer Res 74(7): 2062-72
    › Primary publication · 24520077 (PubMed) · PMC3975694 (PubMed Central)
  6. Differentiation of pancreatic ductal adenocarcinoma from chronic pancreatitis by PAM4 immunohistochemistry. Shi C, Merchant N, Newsome G, Goldenberg DM, Gold DV (2014) Arch Pathol Lab Med 138(2): 220-8
    › Primary publication · 24476519 (PubMed) · PMC4037743 (PubMed Central)
  7. Gastric duplication cyst masquerading as a mucinous pancreatic cyst: case report and literature review. Bailey CE, Fritz MB, Webb L, Merchant NB, Parikh AA (2014) Ann R Coll Surg Engl 96(1): 88E-90E
    › Primary publication · 24417851 (PubMed)
  8. Pancreatic ductal adenocarcinoma radiology reporting template: consensus statement of the society of abdominal radiology and the american pancreatic association. Al-Hawary MM, Francis IR, Chari ST, Fishman EK, Hough DM, Lu DS, Macari M, Megibow AJ, Miller FH, Mortele KJ, Merchant NB, Minter RM, Tamm EP, Sahani DV, Simeone DM (2014) Gastroenterology 146(1): 291-304.e1
    › Primary publication · 24355035 (PubMed)
  9. Pancreatic ductal adenocarcinoma radiology reporting template: consensus statement of the Society of Abdominal Radiology and the American Pancreatic Association. Al-Hawary MM, Francis IR, Chari ST, Fishman EK, Hough DM, Lu DS, Macari M, Megibow AJ, Miller FH, Mortele KJ, Merchant NB, Minter RM, Tamm EP, Sahani DV, Simeone DM (2014) Radiology 270(1): 248-60
    › Primary publication · 24354378 (PubMed)
  10. Evidence of multimeric forms of HSP70 with phosphorylation on serine and tyrosine residues--implications for roles of HSP70 in detection of GI cancers. Dutta A, Girotra M, Merchant N, Nair P, Dutta SK (2013) Asian Pac J Cancer Prev 14(10): 5741-5
    › Primary publication · 24289572 (PubMed) · PMC4193537 (PubMed Central)
  11. Evidence for enhanced telomerase activity in Barrett's esophagus with dysplasia and adenocarcinoma. Merchant NB, Dutta SK, Girotra M, Arora M, Meltzer SJ (2013) Asian Pac J Cancer Prev 14(2): 679-83
    › Primary publication · 23621218 (PubMed)
  12. Terminal ileal carcinoid tumor without hepatic or extrahepatic metastasis causing carcinoid syndrome. Datta J, Merchant NB (2013) Am Surg 79(4): 439-41
    › Primary publication · 23574858 (PubMed)
  13. 53BP1 expression is a modifier of the prognostic value of lymph node ratio and CA 19-9 in pancreatic adenocarcinoma. Ausborn NL, Wang T, Wentz SC, Washington MK, Merchant NB, Zhao Z, Shyr Y, Chakravarthy AB, Xia F (2013) BMC Cancer : 155
    › Primary publication · 23530749 (PubMed) · PMC3636043 (PubMed Central)
  14. Lymph node ratio and preoperative CA 19-9 levels predict overall survival and recurrence-free survival in patients with resected pancreatic adenocarcinoma. Wentz SC, Zhao ZG, Shyr Y, Shi CJ, Merchant NB, Washington K, Xia F, Chakravarthy AB (2012) World J Gastrointest Oncol 4(10): 207-15
    › Primary publication · 23444312 (PubMed) · PMC3581835 (PubMed Central)
  15. A cancer-specific variant of the SLCO1B3 gene encodes a novel human organic anion transporting polypeptide 1B3 (OATP1B3) localized mainly in the cytoplasm of colon and pancreatic cancer cells. Thakkar N, Kim K, Jang ER, Han S, Kim K, Kim D, Merchant N, Lockhart AC, Lee W (2013) Mol Pharm 10(1): 406-16
    › Primary publication · 23215050 (PubMed)
  16. A phase I study of cetuximab in combination with gemcitabine and radiation for locally advanced pancreatic cancer. Chakravarthy AB, Tsai CJ, O'Brien N, Lockhart AC, Chan E, Parikh A, Berlin JD, Merchant N (2012) Gastrointest Cancer Res 5(4): 112-8
    › Primary publication · 23077684 (PubMed) · PMC3433259 (PubMed Central)
  17. Factors influencing readmission after pancreaticoduodenectomy: a multi-institutional study of 1302 patients. Ahmad SA, Edwards MJ, Sutton JM, Grewal SS, Hanseman DJ, Maithel SK, Patel SH, Bentram DJ, Weber SM, Cho CS, Winslow ER, Scoggins CR, Martin RC, Kim HJ, Baker JJ, Merchant NB, Parikh AA, Kooby DA (2012) Ann Surg 256(3): 529-37
    › Primary publication · 22868373 (PubMed)
  18. Pancreatic Adenocarcinoma, version 2.2012: featured updates to the NCCN Guidelines. Tempero MA, Arnoletti JP, Behrman SW, Ben-Josef E, Benson AB, Casper ES, Cohen SJ, Czito B, Ellenhorn JD, Hawkins WG, Herman J, Hoffman JP, Ko A, Komanduri S, Koong A, Ma WW, Malafa MP, Merchant NB, Mulvihill SJ, Muscarella P, Nakakura EK, Obando J, Pitman MB, Sasson AR, Tally A, Thayer SP, Whiting S, Wolff RA, Wolpin BM, Freedman-Cass DA, Shead DA, National Comprehensive Cancer Networks (2012) J Natl Compr Canc Netw 10(6): 703-13
    › Primary publication · 22679115 (PubMed) · PMC3807091 (PubMed Central)
  19. Multi-institutional analysis of pancreatic adenocarcinoma demonstrating the effect of diabetes status on survival after resection. Cannon RM, LeGrand R, Chagpar RB, Ahmad SA, McClaine R, Kim HJ, Rupp C, Cho CS, Brinkman A, Weber S, Winslow ER, Kooby DA, Chu CK, Staley CA, Glenn I, Hawkins WG, Parikh AA, Merchant NB, McMasters KM, Martin RC, Callender GG, Scoggins CR (2012) HPB (Oxford) 14(4): 228-35
    › Primary publication · 22404260 (PubMed) · PMC3371208 (PubMed Central)
  20. Serum HSP70: a novel biomarker for early detection of pancreatic cancer. Dutta SK, Girotra M, Singla M, Dutta A, Otis Stephen F, Nair PP, Merchant NB (2012) Pancreas 41(4): 530-4
    › Primary publication · 22158074 (PubMed) · PMC4193547 (PubMed Central)
  21. Statistical methods for assays with limits of detection: Serum bile acid as a differentiator between patients with normal colons, adenomas, and colorectal cancer. Lafleur B, Lee W, Billhiemer D, Lockhart C, Liu J, Merchant N (2011) J Carcinog : 12
    › Primary publication · 21712958 (PubMed) · PMC3122101 (PubMed Central)
  22. Organic anion transporting polypeptide 1B3 (OATP1B3) is overexpressed in colorectal tumors and is a predictor of clinical outcome. Lockhart AC, Harris E, Lafleur BJ, Merchant NB, Washington MK, Resnick MB, Yeatman TJ, Lee W (2008) Clin Exp Gastroenterol : 1-7
    › Primary publication · 21677819 (PubMed) · PMC3108628 (PubMed Central)
  23. Report of the 2010 Australia and New Zealand traveling fellow. Merchant NB (2010) Bull Am Coll Surg 95(12): 34-7
    › Primary publication · 21449265 (PubMed)
  24. Synchronous bone marrow metastasis from primary splenic angiosarcoma. Datta J, Toro TZ, Keedy VL, Merchant NB (2010) Am Surg 76(9): E160-2
    › Primary publication · 21396272 (PubMed)
  25. Laparoscopic versus open left pancreatectomy: can preoperative factors indicate the safer technique? Cho CS, Kooby DA, Schmidt CM, Nakeeb A, Bentrem DJ, Merchant NB, Parikh AA, Martin RC, Scoggins CR, Ahmad SA, Kim HJ, Hamilton N, Hawkins WG, Weber SM (2011) Ann Surg 253(5): 975-80
    › Primary publication · 21394014 (PubMed)
  26. Electronic synoptic operative reporting for pancreatic resection. Brower ST, Katz M, Pisters P, Merchant N, Weber S, Posner M (2011) J Am Coll Surg 212(3): 425-6; author reply 426
    › Primary publication · 21356498 (PubMed)
  27. Combined blockade of Src kinase and epidermal growth factor receptor with gemcitabine overcomes STAT3-mediated resistance of inhibition of pancreatic tumor growth. Nagaraj NS, Washington MK, Merchant NB (2011) Clin Cancer Res 17(3): 483-93
    › Primary publication · 21266529 (PubMed) · PMC3079196 (PubMed Central)
  28. Dual blockade of the EGFR and COX-2 pathways: a phase II trial of cetuximab and celecoxib in patients with chemotherapy refractory metastatic colorectal cancer. Chan E, Lafleur B, Rothenberg ML, Merchant N, Lockhart AC, Trivedi B, Chung CH, Coffey RJ, Berlin JD (2011) Am J Clin Oncol 34(6): 581-6
    › Primary publication · 21217396 (PubMed) · PMC3133812 (PubMed Central)
  29. Analysis of 6,747 pancreatic neuroendocrine tumors for a proposed staging system. Martin RC, Kooby DA, Weber SM, Merchant NB, Parikh AA, Cho CS, Ahmad SA, Kim HJ, Hawkins W, Scoggins CR (2011) J Gastrointest Surg 15(1): 175-83
    › Primary publication · 21103949 (PubMed)
  30. Adjuvant chemoradiation therapy for pancreas cancer: who really benefits? Merchant NB, Parikh AA, Liu EH (2010) Adv Surg : 149-64
    › Primary publication · 20919520 (PubMed)
  31. Standardization of surgical and pathologic variables is needed in multicenter trials of adjuvant therapy for pancreatic cancer: results from the ACOSOG Z5031 trial. Katz MH, Merchant NB, Brower S, Branda M, Posner MC, William Traverso L, Abrams RA, Picozzi VJ, Pisters PW, American College of Surgeons Oncology Group (2011) Ann Surg Oncol 18(2): 337-44
    › Primary publication · 20811779 (PubMed) · PMC3922125 (PubMed Central)
  32. Proteomics: a strategy to understand the novel targets in protein misfolding and cancer therapy. Nagaraj NS, Singh OV, Merchant NB (2010) Expert Rev Proteomics 7(4): 613-23
    › Primary publication · 20653514 (PubMed) · PMC4339030 (PubMed Central)
  33. Appendiceal adenocarcinoma presenting as venous thromboembolism: an unusual presentation of a rare carcinoma. Castellanos JA, Edwards CM, Shaver A, Merchant NB, Parikh AA (2010) Am Surg 76(5): 543-4
    › Primary publication · 20506889 (PubMed) · PMC4157457 (PubMed Central)
  34. A multicenter analysis of distal pancreatectomy for adenocarcinoma: is laparoscopic resection appropriate? Kooby DA, Hawkins WG, Schmidt CM, Weber SM, Bentrem DJ, Gillespie TW, Sellers JB, Merchant NB, Scoggins CR, Martin RC, Kim HJ, Ahmad S, Cho CS, Parikh AA, Chu CK, Hamilton NA, Doyle CJ, Pinchot S, Hayman A, McClaine R, Nakeeb A, Staley CA, McMasters KM, Lillemoe KD (2010) J Am Coll Surg 210(5): 779-85, 786-7
    › Primary publication · 20421049 (PubMed)
  35. Should all distal pancreatectomies be performed laparoscopically? Merchant NB, Parikh AA, Kooby DA (2009) Adv Surg : 283-300
    › Primary publication · 19845186 (PubMed)
  36. Laparoscopic left pancreatectomy: complication risk score correlates with morbidity and risk for pancreatic fistula. Weber SM, Cho CS, Merchant N, Pinchot S, Rettammel R, Nakeeb A, Bentrem D, Parikh A, Mazo AE, Martin RC, Scoggins CR, Ahmad SA, Kim HJ, Hamilton N, Hawkins W, Max Schmidt C, Kooby DA (2009) Ann Surg Oncol 16(10): 2825-33
    › Primary publication · 19609621 (PubMed)
  37. Pancreatic acinar cell carcinoma: a multi-institutional study. Matos JM, Schmidt CM, Turrini O, Agaram NP, Niedergethmann M, Saeger HD, Merchant N, Johnson CS, Lillemoe KD, Gr├╝tzmann R (2009) J Gastrointest Surg 13(8): 1495-502
    › Primary publication · 19495891 (PubMed)
  38. Adjuvant chemoradiation therapy for pancreatic adenocarcinoma: who really benefits? Merchant NB, Rymer J, Koehler EA, Ayers GD, Castellanos J, Kooby DA, Weber SH, Cho CS, Schmidt CM, Nakeeb A, Matos JM, Scoggins CR, Martin RC, Kim HJ, Ahmad SA, Chu CK, McClaine R, Bednarski BK, Staley CA, Sharp K, Parikh AA (2009) J Am Coll Surg 208(5): 829-38; discussion 838-41
    › Primary publication · 19476845 (PubMed) · PMC4167601 (PubMed Central)
  39. Improvement of survival with response to neoadjuvant radiation therapy for rectal cancer. Castaldo ET, Parikh AA, Pinson CW, Feurer ID, Merchant NB (2009) Arch Surg 144(2): 129-34; discussion 134-5
    › Primary publication · 19221323 (PubMed)
  40. Overexpression of OATP1B3 confers apoptotic resistance in colon cancer. Lee W, Belkhiri A, Lockhart AC, Merchant N, Glaeser H, Harris EI, Washington MK, Brunt EM, Zaika A, Kim RB, El-Rifai W (2008) Cancer Res 68(24): 10315-23
    › Primary publication · 19074900 (PubMed) · PMC2605661 (PubMed Central)
  41. Molecular imaging of therapeutic response to epidermal growth factor receptor blockade in colorectal cancer. Manning HC, Merchant NB, Foutch AC, Virostko JM, Wyatt SK, Shah C, McKinley ET, Xie J, Mutic NJ, Washington MK, LaFleur B, Tantawy MN, Peterson TE, Ansari MS, Baldwin RM, Rothenberg ML, Bornhop DJ, Gore JC, Coffey RJ (2008) Clin Cancer Res 14(22): 7413-22
    › Primary publication · 19010858 (PubMed) · PMC2657180 (PubMed Central)
  42. A clinical comparative analysis of crush/clamp, stapler, and dissecting sealer hepatic transection methods. Castaldo ET, Earl TM, Chari RS, Gorden DL, Merchant NB, Wright JK, Feurer ID, Pinson CW (2008) HPB (Oxford) 10(5): 321-6
    › Primary publication · 18982146 (PubMed) · PMC2575677 (PubMed Central)
  43. Left-sided pancreatectomy: a multicenter comparison of laparoscopic and open approaches. Kooby DA, Gillespie T, Bentrem D, Nakeeb A, Schmidt MC, Merchant NB, Parikh AA, Martin RC, Scoggins CR, Ahmad S, Kim HJ, Park J, Johnston F, Strouch MJ, Menze A, Rymer J, McClaine R, Strasberg SM, Talamonti MS, Staley CA, McMasters KM, Lowy AM, Byrd-Sellers J, Wood WC, Hawkins WG (2008) Ann Surg 248(3): 438-46
    › Primary publication · 18791364 (PubMed)
  44. Gastric schwannoma. Snyder RA, Harris E, Hansen EN, Merchant NB, Parikh AA (2008) Am Surg 74(8): 753-6
    › Primary publication · 18705581 (PubMed)
  45. Past and future of pancreas cancer: are we ready to move forward together? Merchant N, Berlin J (2008) J Clin Oncol 26(21): 3478-80
    › Primary publication · 18640927 (PubMed)
  46. Genomics and proteomics in predicting cancer outcomes. Parikh AA, Johnson JC, Merchant NB (2008) Surg Oncol Clin N Am 17(2): 257-77, vii
    › Primary publication · 18375352 (PubMed)
  47. Full-dose gemcitabine with concurrent radiation therapy in patients with nonmetastatic pancreatic cancer: a multicenter phase II trial. Small W, Berlin J, Freedman GM, Lawrence T, Talamonti MS, Mulcahy MF, Chakravarthy AB, Konski AA, Zalupski MM, Philip PA, Kinsella TJ, Merchant NB, Hoffman JP, Benson AB, Nicol S, Xu RM, Gill JF, McGinn CJ (2008) J Clin Oncol 26(6): 942-7
    › Primary publication · 18281668 (PubMed)
  48. TACE/ADAM-17: a component of the epidermal growth factor receptor axis and a promising therapeutic target in colorectal cancer. Merchant NB, Voskresensky I, Rogers CM, Lafleur B, Dempsey PJ, Graves-Deal R, Revetta F, Foutch AC, Rothenberg ML, Washington MK, Coffey RJ (2008) Clin Cancer Res 14(4): 1182-91
    › Primary publication · 18281553 (PubMed) · PMC3718282 (PubMed Central)
  49. Risk of malignancy in resected cystic tumors of the pancreas < or =3 cm in size: is it safe to observe asymptomatic patients? A multi-institutional report. Lee CJ, Scheiman J, Anderson MA, Hines OJ, Reber HA, Farrell J, Kochman ML, Foley PJ, Drebin J, Oh YS, Ginsberg G, Ahmad N, Merchant NB, Isbell J, Parikh AA, Stokes JB, Bauer T, Adams RB, Simeone DM (2008) J Gastrointest Surg 12(2): 234-42
    › Primary publication · 18040749 (PubMed)
  50. Endoscopic ultrasound and computed tomography predictors of pancreatic cancer resectability. Bao PQ, Johnson JC, Lindsey EH, Schwartz DA, Arildsen RC, Grzeszczak E, Parikh AA, Merchant NB (2008) J Gastrointest Surg 12(1): 10-6; discussion 16
    › Primary publication · 17955311 (PubMed)
  51. Variability of in situ proteomic profiling and implications for study design in colorectal tumors. Li JQ, Xu BJ, Shakhtour B, Deane N, Merchant N, Heslin MJ, Washington K, Coffey RJ, Beauchamp RD, Shyr Y, Billheimer D (2007) Int J Oncol 31(1): 103-11
    › Primary publication · 17549410 (PubMed)
  52. Critical evaluation of esophageal dilation in nonobstructive dysphagia with and without esophageal rings. Naini P, Dutta SK, Karhadkar AS, Rengen M, Nanavati S, Arora M, Merchant N (2007) J Clin Gastroenterol 41(4): 362-5
    › Primary publication · 17413602 (PubMed)
  53. Urine PGE-M: A metabolite of prostaglandin E2 as a potential biomarker of advanced colorectal neoplasia. Johnson JC, Schmidt CR, Shrubsole MJ, Billheimer DD, Joshi PR, Morrow JD, Heslin MJ, Washington MK, Ness RM, Zheng W, Schwartz DA, Coffey RJ, Beauchamp RD, Merchant NB (2006) Clin Gastroenterol Hepatol 4(11): 1358-65
    › Primary publication · 16996805 (PubMed)
  54. Lymphoepithelial cyst of the pancreas. Castaldo ET, Stumph JR, Merchant N (2006) Surgery 140(3): 476-8
    › Primary publication · 16934614 (PubMed)
  55. Level-adjusted perioperative risk of sacral amputations. Devin C, Chong PY, Holt GE, Feurer I, Gonzalez A, Merchant N, Schwartz HS (2006) J Surg Oncol 94(3): 203-11
    › Primary publication · 16900511 (PubMed)
  56. Endoscopic ultrasound diagnosis of pelvic lipoma causing neurologic symptoms. Shepherd BD, Merchant N, Fasig J, Schwartz DA (2006) Dig Dis Sci 51(8): 1364-6
    › Primary publication · 16868819 (PubMed)
  57. Ligand-dependent activation of the epidermal growth factor receptor by secondary bile acids in polarizing colon cancer cells. Merchant NB, Rogers CM, Trivedi B, Morrow J, Coffey RJ (2005) Surgery 138(3): 415-21
    › Primary publication · 16213893 (PubMed)
  58. A phase I study of concurrent 9-nitro-20(s)-camptothecin (9NC/Orathecin) and radiation therapy in the treatment of locally advanced adenocarcinoma of the pancreas. Tedesco KL, Berlin J, Rothenberg M, Choy H, Wyman K, Scott Pearson A, Daniel Beauchamp R, Merchant N, Lockhart AC, Shyr Y, Caillouette C, Chakravarthy B (2005) Radiother Oncol 76(1): 54-8
    › Primary publication · 15921772 (PubMed)