F. Guengerich
Faculty Member
Last active: 3/3/2020


Mechanisms of activation and detoxication of chemical carcinogens and toxicants; characterization of enzymes involved in these processes

Major areas of interest include the metabolism of carcinogens and drugs by cytochrome P450 enzymes, the bioactivation of halogenated hydrocarbons, and polymerase interactions with carcinogen-modified DNA. Several approaches are being used to understand the catalytic mechanisms of the human cytochrome P450 enzymes, including site-directed and random mutagenesis, kinetic analysis, isotope effects, and substrate-activity relationships. Work on halogenated hydrocarbons is done with trichloroethylene, ethylene dibromide, and methylene dihalides and the adducts they form. Glutathione transferase-mediated bioactivation is under investigation, as well as in the case of some bifunctional electrophiles. Studies on the polymerases involve the use of modified oligonucleotides, steady-state and pre-steady-state kinetics, and physical approaches such as x-ray diffraction. A major goal is to understand how carcinogen-DNA adducts cause polymerases to stall and misincorporate bases. See website at www.toxicology.mc.vanderbilt.edu/CenterInvest/guengerich.


The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. Engineering cytochrome P450 enzyme systems for biomedical and biotechnological applications. Li Z, Jiang Y, Guengerich FP, Ma L, Li S, Zhang W (2020) J Biol Chem 295(3): 833-849
    › Primary publication · 31811088 (PubMed) · PMC6970918 (PubMed Central)
  2. FEMA GRAS assessment of natural flavor complexes: Cinnamomum and Myroxylon-derived flavoring ingredients. Rietjens IMCM, Cohen SM, Eisenbrand G, Fukushima S, Gooderham NJ, Guengerich FP, Hecht SS, Rosol TJ, Davidsen JM, Harman CL, Murray IJ, Taylor SV (2020) Food Chem Toxicol : 110949
    › Primary publication · 31751643 (PubMed)
  3. Validation of Human Sterol 14α-Demethylase (CYP51) Druggability: Structure-Guided Design, Synthesis, and Evaluation of Stoichiometric, Functionally Irreversible Inhibitors. Friggeri L, Hargrove TY, Wawrzak Z, Guengerich FP, Lepesheva GI (2019) J Med Chem 62(22): 10391-10401
    › Primary publication · 31663733 (PubMed) · PMC6881533 (PubMed Central)
  4. In Vitro Activation of Cytochrome P450 46A1 (CYP46A1) by Efavirenz-Related Compounds. Mast N, Verwilst P, Wilkey CJ, Guengerich FP, Pikuleva IA (2020) J Med Chem 63(12): 6477-6488
    › Primary publication · 31617715 (PubMed) · PMC7226586 (PubMed Central)
  5. FEMA GRAS assessment of natural flavor complexes: Mint, buchu, dill and caraway derived flavoring ingredients. Cohen SM, Eisenbrand G, Fukushima S, Gooderham NJ, Guengerich FP, Hecht SS, Rietjens IMCM, Bastaki M, Davidsen JM, Harman CL, McGowen MM, Taylor SV (2020) Food Chem Toxicol : 110870
    › Primary publication · 31604112 (PubMed)
  6. A Role for the Orphan Human Cytochrome P450 2S1 in Polyunsaturated Fatty Acid -1 Hydroxylation Using an Untargeted Metabolomic Approach. Fekry MI, Xiao Y, Berg JZ, Guengerich FP (2019) Drug Metab Dispos 47(11): 1325-1332
    › Primary publication · 31511258 (PubMed) · PMC6800448 (PubMed Central)
  7. Kinetic Modeling of Steady-State Situations in Cytochrome P450 Enzyme Reactions. Guengerich FP (2019) Drug Metab Dispos 47(11): 1232-1239
    › Primary publication · 31427434 (PubMed) · PMC6815944 (PubMed Central)
  8. Human cytochrome P450 11B2 produces aldosterone by a processive mechanism due to the lactol form of the intermediate 18-hydroxycorticosterone. Reddish MJ, Guengerich FP (2019) J Biol Chem 294(35): 12975-12991
    › Primary publication · 31296661 (PubMed) · PMC6721951 (PubMed Central)
  9. Human cytochrome P450 enzymes bind drugs and other substrates mainly through conformational-selection modes. Guengerich FP, Wilkey CJ, Phan TTN (2019) J Biol Chem 294(28): 10928-10941
    › Primary publication · 31147443 (PubMed) · PMC6635447 (PubMed Central)
  10. Mitochondrially targeted cytochrome P450 2D6 is involved in monomethylamine-induced neuronal damage in mouse models. Chattopadhyay M, Chowdhury AR, Feng T, Assenmacher CA, Radaelli E, Guengerich FP, Avadhani NG (2019) J Biol Chem 294(26): 10336-10348
    › Primary publication · 31113867 (PubMed) · PMC6664168 (PubMed Central)
  11. Mechanisms of Cytochrome P450-Catalyzed Oxidations. Guengerich FP (2018) ACS Catal 8(12): 10964-10976
    › Primary publication · 31105987 (PubMed) · PMC6519473 (PubMed Central)
  12. The abundant DNA adduct -methyl deoxyguanosine contributes to miscoding during replication by human DNA polymerase η. Njuma OJ, Su Y, Guengerich FP (2019) J Biol Chem 294(26): 10253-10265
    › Primary publication · 31101656 (PubMed) · PMC6664181 (PubMed Central)
  13. Conformational selection dominates binding of steroids to human cytochrome P450 17A1. Guengerich FP, Wilkey CJ, Glass SM, Reddish MJ (2019) J Biol Chem 294(26): 10028-10041
    › Primary publication · 31072872 (PubMed) · PMC6664176 (PubMed Central)
  14. Drug Metabolism and Toxicology Special Issue Call for Papers. Guengerich FP, Georg GI, Wang S (2019) J Med Chem 62(3): 1077
    › Primary publication · 30990043 (PubMed)
  15. Oxidation of Flavone, 5-Hydroxyflavone, and 5,7-Dihydroxyflavone to Mono-, Di-, and Tri-Hydroxyflavones by Human Cytochrome P450 Enzymes. Nagayoshi H, Murayama N, Kakimoto K, Tsujino M, Takenaka S, Katahira J, Lim YR, Kim D, Yamazaki H, Komori M, Guengerich FP, Shimada T (2019) Chem Res Toxicol 32(6): 1268-1280
    › Primary publication · 30964977 (PubMed)
  16. Isotopic tagging of oxidized and reduced cysteines (iTORC) for detecting and quantifying sulfenic acids, disulfides, and free thiols in cells. Albertolle ME, Glass SM, Trefts E, Guengerich FP (2019) J Biol Chem 294(16): 6522-6530
    › Primary publication · 30850396 (PubMed) · PMC6484142 (PubMed Central)
  17. Human DNA polymerase η has reverse transcriptase activity in cellular environments. Su Y, Ghodke PP, Egli M, Li L, Wang Y, Guengerich FP (2019) J Biol Chem 294(15): 6073-6081
    › Primary publication · 30842261 (PubMed) · PMC6463694 (PubMed Central)
  18. Glutamine-451 Confers Sensitivity to Oxidative Inhibition and Heme-Thiolate Sulfenylation of Cytochrome P450 4B1. Albertolle ME, Song HD, Wilkey CJ, Segrest JP, Guengerich FP (2019) Chem Res Toxicol 32(3): 484-492
    › Primary publication · 30701961 (PubMed) · PMC7279892 (PubMed Central)
  19. Synthesis and Characterization of Site-Specific O -Alkylguanine DNA-Alkyl Transferase-Oligonucleotide Crosslinks. Ghodke PP, Albertolle ME, Johnson KM, Guengerich FP (2019) Curr Protoc Nucleic Acid Chem 76(1): e74
    › Primary publication · 30657645 (PubMed) · PMC6504252 (PubMed Central)
  20. Introduction to Metals in Biology 2018: Copper homeostasis and utilization in redox enzymes. Guengerich FP (2018) J Biol Chem 293(13): 4603-4605
    › Primary publication · 29425098 (PubMed) · PMC5880126 (PubMed Central)
  21. Sulfenylation of Human Liver and Kidney Microsomal Cytochromes P450 and Other Drug-Metabolizing Enzymes as a Response to Redox Alteration. Albertolle ME, Phan TTN, Pozzi A, Guengerich FP (2018) Mol Cell Proteomics 17(5): 889-900
    › Primary publication · 29374135 (PubMed) · PMC5930400 (PubMed Central)
  22. Updated procedure for the safety evaluation of natural flavor complexes used as ingredients in food. Cohen SM, Eisenbrand G, Fukushima S, Gooderham NJ, Guengerich FP, Hecht SS, Rietjens IMCM, Davidsen JM, Harman CL, Taylor SV (2018) Food Chem Toxicol : 171-178
    › Primary publication · 29355624 (PubMed)
  23. Cytochrome P450 2A6 and other human P450 enzymes in the oxidation of flavone and flavanone. Kakimoto K, Murayama N, Takenaka S, Nagayoshi H, Lim YR, Kim V, Kim D, Yamazaki H, Komori M, Guengerich FP, Shimada T (2019) Xenobiotica 49(2): 131-142
    › Primary publication · 29310511 (PubMed) · PMC6430112 (PubMed Central)
  24. Development and Uses of Offline and Web-Searchable Metabolism Databases - The Case of Benzo[a]pyrene. Rendic SP, Guengerich FP (2018) Curr Drug Metab 19(1): 3-46
    › Primary publication · 29219051 (PubMed) · PMC5886801 (PubMed Central)
  25. Inherent steroid 17α,20-lyase activity in defunct cytochrome P450 17A enzymes. Gonzalez E, Johnson KM, Pallan PS, Phan TTN, Zhang W, Lei L, Wawrzak Z, Yoshimoto FK, Egli M, Guengerich FP (2018) J Biol Chem 293(2): 541-556
    › Primary publication · 29212707 (PubMed) · PMC5767860 (PubMed Central)
  26. 7-ketocholesterol and 27-hydroxycholesterol decreased doxorubicin sensitivity in breast cancer cells: estrogenic activity and mTOR pathway. Wang CW, Huang CC, Chou PH, Chang YP, Wei S, Guengerich FP, Chou YC, Wang SF, Lai PS, Souček P, Ueng YF (2017) Oncotarget 8(39): 66033-66050
    › Primary publication · 29029490 (PubMed) · PMC5630390 (PubMed Central)
  27. Human DNA polymerase η accommodates RNA for strand extension. Su Y, Egli M, Guengerich FP (2017) J Biol Chem 292(44): 18044-18051
    › Primary publication · 28972162 (PubMed) · PMC5672030 (PubMed Central)
  28. Selective changes in cholesterol metabolite levels in plasma of breast cancer patients after tumor removal. Soucek P, Vrana D, Ueng YF, Wei S, Kozevnikovova R, Guengerich FP (2018) Clin Chem Lab Med 56(3): e78-e81
    › Primary publication · 28915107 (PubMed) · PMC5792305 (PubMed Central)
  29. Kinetic Deuterium Isotope Effects in Cytochrome P450 Reactions. Guengerich FP (2017) Methods Enzymol : 217-238
    › Primary publication · 28911772 (PubMed) · PMC5776663 (PubMed Central)
  30. The Dihydroxy Metabolite of the Teratogen Thalidomide Causes Oxidative DNA Damage. Wani TH, Chakrabarty A, Shibata N, Yamazaki H, Guengerich FP, Chowdhury G (2017) Chem Res Toxicol 30(8): 1622-1628
    › Primary publication · 28745489 (PubMed) · PMC5776664 (PubMed Central)
  31. Human mitochondrial cytochrome P450 27C1 is localized in skin and preferentially desaturates -retinol to 3,4-dehydroretinol. Johnson KM, Phan TTN, Albertolle ME, Guengerich FP (2017) J Biol Chem 292(33): 13672-13687
    › Primary publication · 28701464 (PubMed) · PMC5566523 (PubMed Central)
  32. Kinetic processivity of the two-step oxidations of progesterone and pregnenolone to androgens by human cytochrome P450 17A1. Gonzalez E, Guengerich FP (2017) J Biol Chem 292(32): 13168-13185
    › Primary publication · 28684414 (PubMed) · PMC5555180 (PubMed Central)
  33. Oxidation of 1-chloropyrene by human CYP1 family and CYP2A subfamily cytochrome P450 enzymes: catalytic roles of two CYP1B1 and five CYP2A13 allelic variants. Shimada T, Murayama N, Kakimoto K, Takenaka S, Lim YR, Yeom S, Kim D, Yamazaki H, Guengerich FP, Komori M (2018) Xenobiotica 48(6): 565-575
    › Primary publication · 28648140 (PubMed) · PMC5780263 (PubMed Central)
  34. cytochrome P450 46A1 (CYP46A1) activation by neuroactive compounds. Mast N, Anderson KW, Johnson KM, Phan TTN, Guengerich FP, Pikuleva IA (2017) J Biol Chem 292(31): 12934-12946
    › Primary publication · 28642370 (PubMed) · PMC5546033 (PubMed Central)
  35. Introduction to Metals in Biology 2017: Iron transport, storage, and the ramifications. Guengerich FP (2017) J Biol Chem 292(31): 12725-12726
    › Primary publication · 28615455 (PubMed) · PMC5546012 (PubMed Central)
  36. Functional analysis of human cytochrome P450 21A2 variants involved in congenital adrenal hyperplasia. Wang C, Pallan PS, Zhang W, Lei L, Yoshimoto FK, Waterman MR, Egli M, Guengerich FP (2017) J Biol Chem 292(26): 10767-10778
    › Primary publication · 28539365 (PubMed) · PMC5491764 (PubMed Central)
  37. Heme-thiolate sulfenylation of human cytochrome P450 4A11 functions as a redox switch for catalytic inhibition. Albertolle ME, Kim D, Nagy LD, Yun CH, Pozzi A, Savas Ü, Johnson EF, Guengerich FP (2017) J Biol Chem 292(27): 11230-11242
    › Primary publication · 28533430 (PubMed) · PMC5500791 (PubMed Central)
  38. Induction of human cytochrome P450 3A enzymes in cultured placental cells by thalidomide and relevance to bioactivation and toxicity. Murayama N, Kazuki Y, Satoh D, Arata K, Harada T, Shibata N, Guengerich FP, Yamazaki H (2017) J Toxicol Sci 42(3): 343-348
    › Primary publication · 28496040 (PubMed) · PMC5776038 (PubMed Central)
  39. The Role of Oxysterols in Human Cancer. Kloudova A, Guengerich FP, Soucek P (2017) Trends Endocrinol Metab 28(7): 485-496
    › Primary publication · 28410994 (PubMed) · PMC5474130 (PubMed Central)
  40. Formation of S-[2-(N-Deoxyadenosinyl)ethyl]glutathione in DNA and Replication Past the Adduct by Translesion DNA Polymerases. Sedgeman CA, Su Y, Guengerich FP (2017) Chem Res Toxicol 30(5): 1188-1196
    › Primary publication · 28395138 (PubMed) · PMC5768145 (PubMed Central)
  41. 7,8-benzoflavone binding to human cytochrome P450 3A4 reveals complex fluorescence quenching, suggesting binding at multiple protein sites. Marsch GA, Carlson BT, Guengerich FP (2018) J Biomol Struct Dyn 36(4): 841-860
    › Primary publication · 28278026 (PubMed) · PMC5785493 (PubMed Central)
  42. Structural analyses of sterol 14α-demethylase complexed with azole drugs address the molecular basis of azole-mediated inhibition of fungal sterol biosynthesis. Hargrove TY, Friggeri L, Wawrzak Z, Qi A, Hoekstra WJ, Schotzinger RJ, York JD, Guengerich FP, Lepesheva GI (2017) J Biol Chem 292(16): 6728-6743
    › Primary publication · 28258218 (PubMed) · PMC5399120 (PubMed Central)
  43. What Happens When You Submit a Paper to JBC? Guengerich FP, Gierasch LM (2017) J Biol Chem 292(3): 1535-1537
    › Primary publication · 28108617 (PubMed) · PMC5247650 (PubMed Central)
  44. Mechanism of 17α,20-lyase and new hydroxylation reactions of human cytochrome P450 17A1. 18O LABELING AND OXYGEN SURROGATE EVIDENCE FOR A ROLE OF A PERFERRYL OXYGEN. Yoshimoto FK, Gonzalez E, Auchus RJ, Guengerich FP (2016) J Biol Chem 291(51): 26587
    › Primary publication · 27986869 (PubMed) · PMC5159517 (PubMed Central)
  45. Metabolic profiles of pomalidomide in human plasma simulated with pharmacokinetic data in control and humanized-liver mice. Shimizu M, Suemizu H, Mitsui M, Shibata N, Guengerich FP, Yamazaki H (2017) Xenobiotica 47(10): 844-848
    › Primary publication · 27852146 (PubMed) · PMC5433912 (PubMed Central)
  46. Safety evaluation of substituted thiophenes used as flavoring ingredients. Cohen SM, Fukushima S, Gooderham NJ, Guengerich FP, Hecht SS, Rietjens IM, Smith RL, Bastaki M, Harman CL, McGowen MM, Valerio LG, Taylor SV (2017) Food Chem Toxicol : 40-59
    › Primary publication · 27836750 (PubMed)
  47. FEMA expert panel review of p-mentha-1,8-dien-7-al genotoxicity testing results. Cohen SM, Fukushima S, Gooderham NJ, Guengerich FP, Hecht SS, Rietjens IMCM, Smith RL, Bastaki M, Harman CL, McGowen MM, Taylor SV (2016) Food Chem Toxicol 98(Pt B): 201-209
    › Primary publication · 27773699 (PubMed)
  48. Mechanisms of Insertion of dCTP and dTTP Opposite the DNA Lesion O6-Methyl-2'-deoxyguanosine by Human DNA Polymerase η. Patra A, Zhang Q, Guengerich FP, Egli M (2016) J Biol Chem 291(46): 24304-24313
    › Primary publication · 27694439 (PubMed) · PMC5104950 (PubMed Central)
  49. Roles of Human CYP2A6 and Monkey CYP2A24 and 2A26 Cytochrome P450 Enzymes in the Oxidation of 2,5,2',5'-Tetrachlorobiphenyl. Shimada T, Kakimoto K, Takenaka S, Koga N, Uehara S, Murayama N, Yamazaki H, Kim D, Guengerich FP, Komori M (2016) Drug Metab Dispos 44(12): 1899-1909
    › Primary publication · 27625140 (PubMed) · PMC6047209 (PubMed Central)
  50. Bypass of DNA-Protein Cross-links Conjugated to the 7-Deazaguanine Position of DNA by Translesion Synthesis Polymerases. Wickramaratne S, Ji S, Mukherjee S, Su Y, Pence MG, Lior-Hoffmann L, Fu I, Broyde S, Guengerich FP, Distefano M, Schärer OD, Sham YY, Tretyakova N (2016) J Biol Chem 291(45): 23589-23603
    › Primary publication · 27621316 (PubMed) · PMC5095413 (PubMed Central)
  51. Six Germline Genetic Variations Impair the Translesion Synthesis Activity of Human DNA Polymerase κ. Kim JK, Yeom M, Hong JK, Song I, Lee YS, Guengerich FP, Choi JY (2016) Chem Res Toxicol 29(10): 1741-1754
    › Primary publication · 27603496 (PubMed) · PMC5116392 (PubMed Central)
  52. Lesion Orientation of -Alkylthymidine Influences Replication by Human DNA Polymerase . O'Flaherty DK, Patra A, Su Y, Guengerich FP, Egli M, Wilds CJ (2016) Chem Sci 7(8): 4896-4904
    › Primary publication · 27574558 (PubMed) · PMC5001687 (PubMed Central)
  53. Isotope-Labeling Studies Support the Electrophilic Compound I Iron Active Species, FeO(3+), for the Carbon-Carbon Bond Cleavage Reaction of the Cholesterol Side-Chain Cleavage Enzyme, Cytochrome P450 11A1. Yoshimoto FK, Jung IJ, Goyal S, Gonzalez E, Guengerich FP (2016) J Am Chem Soc 138(37): 12124-41
    › Primary publication · 27571509 (PubMed) · PMC5289895 (PubMed Central)
  54. Kinetic and Structural Impact of Metal Ions and Genetic Variations on Human DNA Polymerase ι. Choi JY, Patra A, Yeom M, Lee YS, Zhang Q, Egli M, Guengerich FP (2016) J Biol Chem 291(40): 21063-21073
    › Primary publication · 27555320 (PubMed) · PMC5076516 (PubMed Central)
  55. Specificity of Protein Covalent Modification by the Electrophilic Proteasome Inhibitor Carfilzomib in Human Cells. Federspiel JD, Codreanu SG, Goyal S, Albertolle ME, Lowe E, Teague J, Wong H, Guengerich FP, Liebler DC (2016) Mol Cell Proteomics 15(10): 3233-3242
    › Primary publication · 27503896 (PubMed) · PMC5054346 (PubMed Central)
  56. Intersection of the Roles of Cytochrome P450 Enzymes with Xenobiotic and Endogenous Substrates: Relevance to Toxicity and Drug Interactions. Guengerich FP (2017) Chem Res Toxicol 30(1): 2-12
    › Primary publication · 27472660 (PubMed) · PMC5293730 (PubMed Central)
  57. Assessment of Protein Binding of 5-Hydroxythalidomide Bioactivated in Humanized Mice with Human P450 3A-Chromosome or Hepatocytes by Two-Dimensional Electrophoresis/Accelerator Mass Spectrometry. Yamazaki H, Suemizu H, Kazuki Y, Oofusa K, Kuribayashi S, Shimizu M, Ninomiya S, Horie T, Shibata N, Guengerich FP (2016) Chem Res Toxicol 29(8): 1279-81
    › Primary publication · 27464947 (PubMed) · PMC5282975 (PubMed Central)
  58. Metals in Biology 2016: Molecular Basis of Selection of Metals by Enzymes. Guengerich FP (2016) J Biol Chem 291(40): 20838-20839
    › Primary publication · 27462079 (PubMed) · PMC5076496 (PubMed Central)
  59. Mechanism of 17α,20-Lyase and New Hydroxylation Reactions of Human Cytochrome P450 17A1: 18O LABELING AND OXYGEN SURROGATE EVIDENCE FOR A ROLE OF A PERFERRYL OXYGEN. Yoshimoto FK, Gonzalez E, Auchus RJ, Guengerich FP (2016) J Biol Chem 291(33): 17143-64
    › Primary publication · 27339894 (PubMed) · PMC5016118 (PubMed Central)
  60. Combining Chimeric Mice with Humanized Liver, Mass Spectrometry, and Physiologically-Based Pharmacokinetic Modeling in Toxicology. Yamazaki H, Suemizu H, Mitsui M, Shimizu M, Guengerich FP (2016) Chem Res Toxicol 29(12): 1903-1911
    › Primary publication · 27337115 (PubMed) · PMC5292139 (PubMed Central)
  61. Cytochrome P450 metabolism of the post-lanosterol intermediates explains enigmas of cholesterol synthesis. Ačimovič J, Goyal S, Košir R, Goličnik M, Perše M, Belič A, Urlep Ž, Guengerich FP, Rozman D (2016) Sci Rep : 28462
    › Primary publication · 27334049 (PubMed) · PMC4917857 (PubMed Central)
  62. Human sterol 14α-demethylase as a target for anticancer chemotherapy: towards structure-aided drug design. Hargrove TY, Friggeri L, Wawrzak Z, Sivakumaran S, Yazlovitskaya EM, Hiebert SW, Guengerich FP, Waterman MR, Lepesheva GI (2016) J Lipid Res 57(8): 1552-63
    › Primary publication · 27313059 (PubMed) · PMC4959870 (PubMed Central)
  63. 20-Hydroxyeicosatetraenoic Acid (HETE)-dependent Hypertension in Human Cytochrome P450 (CYP) 4A11 Transgenic Mice: NORMALIZATION OF BLOOD PRESSURE BY SODIUM RESTRICTION, HYDROCHLOROTHIAZIDE, OR BLOCKADE OF THE TYPE 1 ANGIOTENSIN II RECEPTOR. Savas Ü, Wei S, Hsu MH, Falck JR, Guengerich FP, Capdevila JH, Johnson EF (2016) J Biol Chem 291(32): 16904-19
    › Primary publication · 27298316 (PubMed) · PMC4974402 (PubMed Central)
  64. Recent Structural Insights into Cytochrome P450 Function. Guengerich FP, Waterman MR, Egli M (2016) Trends Pharmacol Sci 37(8): 625-640
    › Primary publication · 27267697 (PubMed) · PMC4961565 (PubMed Central)
  65. Mechanisms of mutagenesis: DNA replication in the presence of DNA damage. Liu B, Xue Q, Tang Y, Cao J, Guengerich FP, Zhang H (2016) Mutat Res Rev Mutat Res : 53-67
    › Primary publication · 27234563 (PubMed) · PMC5237373 (PubMed Central)
  66. Structural and Kinetic Analysis of Miscoding Opposite the DNA Adduct 1,N6-Ethenodeoxyadenosine by Human Translesion DNA Polymerase η. Patra A, Su Y, Zhang Q, Johnson KM, Guengerich FP, Egli M (2016) J Biol Chem 291(27): 14134-14145
    › Primary publication · 27226627 (PubMed) · PMC4933172 (PubMed Central)
  67. Structure-Function Studies of Naphthalene, Phenanthrene, Biphenyl, and Their Derivatives in Interaction with and Oxidation by Cytochromes P450 2A13 and 2A6. Shimada T, Takenaka S, Kakimoto K, Murayama N, Lim YR, Kim D, Foroozesh MK, Yamazaki H, Guengerich FP, Komori M (2016) Chem Res Toxicol 29(6): 1029-40
    › Primary publication · 27137136 (PubMed) · PMC5293596 (PubMed Central)
  68. Toxicology Strategies for Drug Discovery - Present and Future: Introduction. Humphreys WG, Will Y, Guengerich FP (2016) Chem Res Toxicol 29(4): 437
    › Primary publication · 27087588 (PubMed) · PMC6377067 (PubMed Central)
  69. Human cytochrome P450 27C1 catalyzes 3,4-desaturation of retinoids. Kramlinger VM, Nagy LD, Fujiwara R, Johnson KM, Phan TT, Xiao Y, Enright JM, Toomey MB, Corbo JC, Guengerich FP (2016) FEBS Lett 590(9): 1304-12
    › Primary publication · 27059013 (PubMed) · PMC4864060 (PubMed Central)
  70. Effects of Twelve Germline Missense Variations on DNA Lesion and G-Quadruplex Bypass Activities of Human DNA Polymerase REV1. Yeom M, Kim IH, Kim JK, Kang K, Eoff RL, Guengerich FP, Choi JY (2016) Chem Res Toxicol 29(3): 367-79
    › Primary publication · 26914252 (PubMed) · PMC5116390 (PubMed Central)
  71. Mechanism of Ribonucleotide Incorporation by Human DNA Polymerase η. Su Y, Egli M, Guengerich FP (2016) J Biol Chem 291(8): 3747-56
    › Primary publication · 26740629 (PubMed) · PMC4759156 (PubMed Central)
  72. Kinetic analysis of bypass of 7,8-dihydro-8-oxo-2'-deoxyguanosine by the catalytic core of yeast DNA polymerase η. Xue Q, Zhong M, Liu B, Tang Y, Wei Z, Guengerich FP, Zhang H (2016) Biochimie : 161-9
    › Primary publication · 26700143 (PubMed) · PMC5193378 (PubMed Central)
  73. Backbone Flexibility Influences Nucleotide Incorporation by Human Translesion DNA Polymerase η opposite Intrastrand Cross-Linked DNA. O'Flaherty DK, Guengerich FP, Egli M, Wilds CJ (2015) Biochemistry 54(51): 7449-56
    › Primary publication · 26624500 (PubMed) · PMC4889123 (PubMed Central)
  74. Cyp27c1 Red-Shifts the Spectral Sensitivity of Photoreceptors by Converting Vitamin A1 into A2. Enright JM, Toomey MB, Sato SY, Temple SE, Allen JR, Fujiwara R, Kramlinger VM, Nagy LD, Johnson KM, Xiao Y, How MJ, Johnson SL, Roberts NW, Kefalov VJ, Guengerich FP, Corbo JC (2015) Curr Biol 25(23): 3048-57
    › Primary publication · 26549260 (PubMed) · PMC4910640 (PubMed Central)
  75. Simulation of Human Plasma Concentrations of Thalidomide and Primary 5-Hydroxylated Metabolites Explored with Pharmacokinetic Data in Humanized TK-NOG Mice. Nishiyama S, Suemizu H, Shibata N, Guengerich FP, Yamazaki H (2015) Chem Res Toxicol 28(11): 2088-90
    › Primary publication · 26492539 (PubMed) · PMC6345571 (PubMed Central)
  76. Introduction to thematic series: protein interactions, structures, and networks. Appella E, Jenkins LM, Guengerich FP (2015) J Biol Chem 290(44): 26393-4
    › Primary publication · 26354433 (PubMed) · PMC4646296 (PubMed Central)
  77. Structure-Functional Characterization of Cytochrome P450 Sterol 14α-Demethylase (CYP51B) from Aspergillus fumigatus and Molecular Basis for the Development of Antifungal Drugs. Hargrove TY, Wawrzak Z, Lamb DC, Guengerich FP, Lepesheva GI (2015) J Biol Chem 290(39): 23916-34
    › Primary publication · 26269599 (PubMed) · PMC4583043 (PubMed Central)
  78. Oxidation of pyrene, 1-hydroxypyrene, 1-nitropyrene and 1-acetylpyrene by human cytochrome P450 2A13. Shimada T, Takenaka S, Murayama N, Kramlinger VM, Kim JH, Kim D, Liu J, Foroozesh MK, Yamazaki H, Guengerich FP, Komori M (2016) Xenobiotica 46(3): 211-24
    › Primary publication · 26247835 (PubMed) · PMC5270756 (PubMed Central)
  79. Research Resource: Correlating Human Cytochrome P450 21A2 Crystal Structure and Phenotypes of Mutations in Congenital Adrenal Hyperplasia. Pallan PS, Lei L, Wang C, Waterman MR, Guengerich FP, Egli M (2015) Mol Endocrinol 29(9): 1375-84
    › Primary publication · 26172259 (PubMed) · PMC4552440 (PubMed Central)
  80. Introduction: Metals in Biology: α-Ketoglutarate/Iron-Dependent Dioxygenases. Guengerich FP (2015) J Biol Chem 290(34): 20700-20701
    › Primary publication · 26152720 (PubMed) · PMC4543631 (PubMed Central)
  81. Polymerase Bypass of N(6)-Deoxyadenosine Adducts Derived from Epoxide Metabolites of 1,3-Butadiene. Kotapati S, Wickramaratne S, Esades A, Boldry EJ, Quirk Dorr D, Pence MG, Guengerich FP, Tretyakova NY (2015) Chem Res Toxicol 28(7): 1496-507
    › Primary publication · 26098310 (PubMed) · PMC4704788 (PubMed Central)
  82. Introduction: Metals in Biology: METALS AT THE HOST-PATHOGEN INTERFACE. Guengerich FP (2015) J Biol Chem 290(31): 18943-4
    › Primary publication · 26055725 (PubMed) · PMC4521014 (PubMed Central)
  83. Roles of Residues Arg-61 and Gln-38 of Human DNA Polymerase η in Bypass of Deoxyguanosine and 7,8-Dihydro-8-oxo-2'-deoxyguanosine. Su Y, Patra A, Harp JM, Egli M, Guengerich FP (2015) J Biol Chem 290(26): 15921-33
    › Primary publication · 25947374 (PubMed) · PMC4481197 (PubMed Central)
  84. Human Cytochrome P450 21A2, the Major Steroid 21-Hydroxylase: STRUCTURE OF THE ENZYME·PROGESTERONE SUBSTRATE COMPLEX AND RATE-LIMITING C-H BOND CLEAVAGE. Pallan PS, Wang C, Lei L, Yoshimoto FK, Auchus RJ, Waterman MR, Guengerich FP, Egli M (2015) J Biol Chem 290(21): 13128-43
    › Primary publication · 25855791 (PubMed) · PMC4505568 (PubMed Central)
  85. Aromatic hydroxylation of salicylic acid and aspirin by human cytochromes P450. Bojić M, Sedgeman CA, Nagy LD, Guengerich FP (2015) Eur J Pharm Sci : 49-56
    › Primary publication · 25840124 (PubMed) · PMC4414920 (PubMed Central)
  86. Next-generation sequencing reveals the biological significance of the N(2),3-ethenoguanine lesion in vivo. Chang SC, Fedeles BI, Wu J, Delaney JC, Li D, Zhao L, Christov PP, Yau E, Singh V, Jost M, Drennan CL, Marnett LJ, Rizzo CJ, Levine SS, Guengerich FP, Essigmann JM (2015) Nucleic Acids Res 43(11): 5489-500
    › Primary publication · 25837992 (PubMed) · PMC4477646 (PubMed Central)
  87. Differential repair of etheno-DNA adducts by bacterial and human AlkB proteins. Zdżalik D, Domańska A, Prorok P, Kosicki K, van den Born E, Falnes PØ, Rizzo CJ, Guengerich FP, Tudek B (2015) DNA Repair (Amst) : 1-10
    › Primary publication · 25797601 (PubMed) · PMC4451939 (PubMed Central)
  88. Characterization of thioether-linked protein adducts of DNA using a Raney-Ni-mediated desulfurization method and liquid chromatography-electrospray-tandem mass spectrometry. Chowdhury G, Guengerich FP (2015) Curr Protoc Nucleic Acid Chem : 10.15.1-10.15.14
    › Primary publication · 25754888 (PubMed) · PMC4374425 (PubMed Central)
  89. Structural and kinetic analysis of nucleoside triphosphate incorporation opposite an abasic site by human translesion DNA polymerase η. Patra A, Zhang Q, Lei L, Su Y, Egli M, Guengerich FP (2015) J Biol Chem 290(13): 8028-38
    › Primary publication · 25666608 (PubMed) · PMC4375460 (PubMed Central)
  90. Oxidation of Acenaphthene and Acenaphthylene by Human Cytochrome P450 Enzymes. Shimada T, Takenaka S, Murayama N, Yamazaki H, Kim JH, Kim D, Yoshimoto FK, Guengerich FP, Komori M (2015) Chem Res Toxicol 28(2): 268-78
    › Primary publication · 25642975 (PubMed) · PMC4755721 (PubMed Central)
  91. Carcinogenesis of urethane: simulation versus experiment. Lajovic A, Nagy LD, Guengerich FP, Bren U (2015) Chem Res Toxicol 28(4): 691-701
    › Primary publication · 25642734 (PubMed) · PMC4731881 (PubMed Central)
  92. Structural and kinetic basis of steroid 17α,20-lyase activity in teleost fish cytochrome P450 17A1 and its absence in cytochrome P450 17A2. Pallan PS, Nagy LD, Lei L, Gonzalez E, Kramlinger VM, Azumaya CM, Wawrzak Z, Waterman MR, Guengerich FP, Egli M (2015) J Biol Chem 290(6): 3248-68
    › Primary publication · 25533464 (PubMed) · PMC4318999 (PubMed Central)
  93. Steady-state kinetic analysis of DNA polymerase single-nucleotide incorporation products. O'Flaherty DK, Guengerich FP (2014) Curr Protoc Nucleic Acid Chem : 7.21.1-13
    › Primary publication · 25501593 (PubMed) · PMC4274652 (PubMed Central)
  94. Survey of Human Oxidoreductases and Cytochrome P450 Enzymes Involved in the Metabolism of Xenobiotic and Natural Chemicals. Rendic S, Guengerich FP (2015) Chem Res Toxicol 28(1): 38-42
    › Primary publication · 25485457 (PubMed) · PMC4303333 (PubMed Central)
  95. Mechanism of the third oxidative step in the conversion of androgens to estrogens by cytochrome P450 19A1 steroid aromatase. Yoshimoto FK, Guengerich FP (2014) J Am Chem Soc 136(42): 15016-25
    › Primary publication · 25252141 (PubMed) · PMC4210144 (PubMed Central)
  96. Kinetic analysis of lauric acid hydroxylation by human cytochrome P450 4A11. Kim D, Cha GS, Nagy LD, Yun CH, Guengerich FP (2014) Biochemistry 53(39): 6161-72
    › Primary publication · 25203493 (PubMed) · PMC4188250 (PubMed Central)
  97. Biochemical analysis of six genetic variants of error-prone human DNA polymerase ι involved in translesion DNA synthesis. Kim J, Song I, Jo A, Shin JH, Cho H, Eoff RL, Guengerich FP, Choi JY (2014) Chem Res Toxicol 27(10): 1837-52
    › Primary publication · 25162224 (PubMed) · PMC4203391 (PubMed Central)
  98. Thematic minireview series: metals in biology 2014. Guengerich FP (2014) J Biol Chem 289(41): 28094
    › Primary publication · 25160633 (PubMed) · PMC4192463 (PubMed Central)
  99. Targeting of splice variants of human cytochrome P450 2C8 (CYP2C8) to mitochondria and their role in arachidonic acid metabolism and respiratory dysfunction. Bajpai P, Srinivasan S, Ghosh J, Nagy LD, Wei S, Guengerich FP, Avadhani NG (2014) J Biol Chem 289(43): 29614-30
    › Primary publication · 25160618 (PubMed) · PMC4207977 (PubMed Central)
  100. Elucidation of kinetic mechanisms of human translesion DNA polymerase κ using tryptophan mutants. Zhao L, Pence MG, Eoff RL, Yuan S, Fercu CA, Guengerich FP (2014) FEBS J 281(19): 4394-410
    › Primary publication · 25065501 (PubMed) · PMC4182141 (PubMed Central)
  101. Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1. Goyal S, Xiao Y, Porter NA, Xu L, Guengerich FP (2014) J Lipid Res 55(9): 1933-43
    › Primary publication · 25017465 (PubMed) · PMC4617353 (PubMed Central)
  102. Time- and NADPH-dependent inhibition of cytochrome P450 3A4 by the cyclopentapeptide cilengitide: significance of the guanidine group and accompanying spectral changes. Bojić M, Barbero L, Dolgos H, Freisleben A, Gallemann D, Riva S, Guengerich FP (2014) Drug Metab Dispos 42(9): 1438-46
    › Primary publication · 24985702 (PubMed)
  103. On the formation of 7-ketocholesterol from 7-dehydrocholesterol in patients with CTX and SLO. Björkhem I, Diczfalusy U, Lövgren-Sandblom A, Starck L, Jonsson M, Tallman K, Schirmer H, Ousager LB, Crick PJ, Wang Y, Griffiths WJ, Guengerich FP (2014) J Lipid Res 55(6): 1165-72
    › Primary publication · 24771866 (PubMed) · PMC4031947 (PubMed Central)
  104. Kinetics, structure, and mechanism of 8-Oxo-7,8-dihydro-2'-deoxyguanosine bypass by human DNA polymerase η. Patra A, Nagy LD, Zhang Q, Su Y, Müller L, Guengerich FP, Egli M (2014) J Biol Chem 289(24): 16867-82
    › Primary publication · 24759104 (PubMed) · PMC4059130 (PubMed Central)
  105. Biochemical characterization of eight genetic variants of human DNA polymerase κ involved in error-free bypass across bulky N(2)-guanyl DNA adducts. Song I, Kim EJ, Kim IH, Park EM, Lee KE, Shin JH, Guengerich FP, Choi JY (2014) Chem Res Toxicol 27(5): 919-30
    › Primary publication · 24725253 (PubMed) · PMC7002036 (PubMed Central)
  106. Oxidation of endogenous N-arachidonoylserotonin by human cytochrome P450 2U1. Siller M, Goyal S, Yoshimoto FK, Xiao Y, Wei S, Guengerich FP (2014) J Biol Chem 289(15): 10476-10487
    › Primary publication · 24563460 (PubMed) · PMC4036169 (PubMed Central)
  107. Mitochondrial targeting of cytochrome P450 (CYP) 1B1 and its role in polycyclic aromatic hydrocarbon-induced mitochondrial dysfunction. Bansal S, Leu AN, Gonzalez FJ, Guengerich FP, Chowdhury AR, Anandatheerthavarada HK, Avadhani NG (2014) J Biol Chem 289(14): 9936-51
    › Primary publication · 24497629 (PubMed) · PMC3975038 (PubMed Central)
  108. Thalidomide increases human hepatic cytochrome P450 3A enzymes by direct activation of the pregnane X receptor. Murayama N, van Beuningen R, Suemizu H, Guillouzo CG, Shibata N, Yajima K, Utoh M, Shimizu M, Chesné C, Nakamura M, Guengerich FP, Houtman R, Yamazaki H (2014) Chem Res Toxicol 27(2): 304-308
    › Primary publication · 24460184 (PubMed) · PMC4020009 (PubMed Central)
  109. Human cytochrome P450 oxidation of 5-hydroxythalidomide and pomalidomide, an amino analogue of thalidomide. Chowdhury G, Shibata N, Yamazaki H, Guengerich FP (2014) Chem Res Toxicol 27(1): 147-56
    › Primary publication · 24350712 (PubMed) · PMC3929586 (PubMed Central)
  110. Kinetic deuterium isotope effects in cytochrome P450 oxidation reactions. Guengerich FP (2013) J Labelled Comp Radiopharm 56(9-10): 428-31
    › Primary publication · 24285515 (PubMed) · PMC4861049 (PubMed Central)
  111. In vivo roles of conjugation with glutathione and O6-alkylguanine DNA-alkyltransferase in the mutagenicity of the bis-electrophiles 1,2-dibromoethane and 1,2,3,4-diepoxybutane in mice. Cho SH, Guengerich FP (2013) Chem Res Toxicol 26(11): 1765-74
    › Primary publication · 24191644 (PubMed) · PMC3889014 (PubMed Central)
  112. Replication, repair, and translesion polymerase bypass of N⁶-oxopropenyl-2'-deoxyadenosine. Maddukuri L, Shuck SC, Eoff RL, Zhao L, Rizzo CJ, Guengerich FP, Marnett LJ (2013) Biochemistry 52(48): 8766-76
    › Primary publication · 24171480 (PubMed) · PMC3925671 (PubMed Central)
  113. Cytochrome P450-dependent catabolism of vitamin K: ω-hydroxylation catalyzed by human CYP4F2 and CYP4F11. Edson KZ, Prasad B, Unadkat JD, Suhara Y, Okano T, Guengerich FP, Rettie AE (2013) Biochemistry 52(46): 8276-85
    › Primary publication · 24138531 (PubMed) · PMC3900248 (PubMed Central)
  114. Detection and characterization of 1,2-dibromoethane-derived DNA crosslinks formed with O(6) -alkylguanine-DNA alkyltransferase. Chowdhury G, Cho SH, Pegg AE, Guengerich FP (2013) Angew Chem Int Ed Engl 52(49): 12879-82
    › Primary publication · 24130045 (PubMed) · PMC4048925 (PubMed Central)
  115. Incorporation of nucleoside probes opposite O⁶-methylguanine by Sulfolobus solfataricus DNA polymerase Dpo4: importance of hydrogen bonding. Stornetta A, Angelov T, Guengerich FP, Sturla SJ (2013) Chembiochem 14(13): 1634-9
    › Primary publication · 23959784 (PubMed) · PMC3896954 (PubMed Central)
  116. 7-Ketocholesterol induces P-glycoprotein through PI3K/mTOR signaling in hepatoma cells. Wang SF, Chou YC, Mazumder N, Kao FJ, Nagy LD, Guengerich FP, Huang C, Lee HC, Lai PS, Ueng YF (2013) Biochem Pharmacol 86(4): 548-60
    › Primary publication · 23792120 (PubMed) · PMC4164904 (PubMed Central)
  117. Replication past the butadiene diepoxide-derived DNA adduct S-[4-(N(6)-deoxyadenosinyl)-2,3-dihydroxybutyl]glutathione by DNA polymerases. Cho SH, Guengerich FP (2013) Chem Res Toxicol 26(6): 1005-13
    › Primary publication · 23701509 (PubMed) · PMC4049171 (PubMed Central)
  118. Reduction of aromatic and heterocyclic aromatic N-hydroxylamines by human cytochrome P450 2S1. Wang K, Guengerich FP (2013) Chem Res Toxicol 26(6): 993-1004
    › Primary publication · 23682735 (PubMed) · PMC3707514 (PubMed Central)
  119. CYP3A4 intron 6 C>T polymorphism (CYP3A4*22) is associated with reduced CYP3A4 protein level and function in human liver microsomes. Okubo M, Murayama N, Shimizu M, Shimada T, Guengerich FP, Yamazaki H (2013) J Toxicol Sci 38(3): 349-54
    › Primary publication · 23665933 (PubMed) · PMC4018728 (PubMed Central)
  120. Unusual cytochrome p450 enzymes and reactions. Guengerich FP, Munro AW (2013) J Biol Chem 288(24): 17065-73
    › Primary publication · 23632016 (PubMed) · PMC3682512 (PubMed Central)
  121. New trends in cytochrome p450 research at the half-century mark. Guengerich FP (2013) J Biol Chem 288(24): 17063-4
    › Primary publication · 23632015 (PubMed) · PMC3682511 (PubMed Central)
  122. Thematic minireview series: metals in biology 2013. Guengerich FP (2013) J Biol Chem 288(19): 13164
    › Primary publication · 23539620 (PubMed) · PMC3650354 (PubMed Central)
  123. High-throughput fluorescence assay of cytochrome P450 3A4. Cheng Q, Guengerich FP (2013) Methods Mol Biol : 157-62
    › Primary publication · 23475676 (PubMed) · PMC4024206 (PubMed Central)
  124. Identification of endogenous substrates of orphan cytochrome P450 enzymes through the use of untargeted metabolomics approaches. Cheng Q, Guengerich FP (2013) Methods Mol Biol : 71-7
    › Primary publication · 23475668 (PubMed) · PMC3846702 (PubMed Central)
  125. Human cytochrome P450 2E1 mutations that alter mitochondrial targeting efficiency and susceptibility to ethanol-induced toxicity in cellular models. Bansal S, Anandatheerthavarada HK, Prabu GK, Milne GL, Martin MV, Guengerich FP, Avadhani NG (2013) J Biol Chem 288(18): 12627-44
    › Primary publication · 23471973 (PubMed) · PMC3642310 (PubMed Central)
  126. Metabolic activation of polycyclic aromatic hydrocarbons and aryl and heterocyclic amines by human cytochromes P450 2A13 and 2A6. Shimada T, Murayama N, Yamazaki H, Tanaka K, Takenaka S, Komori M, Kim D, Guengerich FP (2013) Chem Res Toxicol 26(4): 529-37
    › Primary publication · 23432465 (PubMed) · PMC3713097 (PubMed Central)
  127. Binding of diverse environmental chemicals with human cytochromes P450 2A13, 2A6, and 1B1 and enzyme inhibition. Shimada T, Kim D, Murayama N, Tanaka K, Takenaka S, Nagy LD, Folkman LM, Foroozesh MK, Komori M, Yamazaki H, Guengerich FP (2013) Chem Res Toxicol 26(4): 517-28
    › Primary publication · 23432429 (PubMed) · PMC4026275 (PubMed Central)
  128. In vivo drug interactions of the teratogen thalidomide with midazolam: heterotropic cooperativity of human cytochrome P450 in humanized TK-NOG mice. Yamazaki H, Suemizu H, Murayama N, Utoh M, Shibata N, Nakamura M, Guengerich FP (2013) Chem Res Toxicol 26(3): 486-9
    › Primary publication · 23419139 (PubMed) · PMC4049203 (PubMed Central)
  129. Cytochrome P450 107U1 is required for sporulation and antibiotic production in Streptomyces coelicolor. Tian Z, Cheng Q, Yoshimoto FK, Lei L, Lamb DC, Guengerich FP (2013) Arch Biochem Biophys 530(2): 101-7
    › Primary publication · 23357279 (PubMed) · PMC3600146 (PubMed Central)
  130. Metabolism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by mitochondrion-targeted cytochrome P450 2D6: implications in Parkinson disease. Bajpai P, Sangar MC, Singh S, Tang W, Bansal S, Chowdhury G, Cheng Q, Fang JK, Martin MV, Guengerich FP, Avadhani NG (2013) J Biol Chem 288(6): 4436-51
    › Primary publication · 23258538 (PubMed) · PMC3567693 (PubMed Central)
  131. Oxidation of methyl and ethyl nitrosamines by cytochrome P450 2E1 and 2B1. Chowdhury G, Calcutt MW, Nagy LD, Guengerich FP (2012) Biochemistry 51(50): 9995-10007
    › Primary publication · 23186213 (PubMed) · PMC3525961 (PubMed Central)
  132. Purification of cytochrome P-450 enzymes. Bell-Parikh LC, Hosea NA, Martin MV, Guengerich FP (2002) Curr Protoc Toxicol : Unit4.2
    › Primary publication · 23045082 (PubMed)
  133. Translesion synthesis across 1,N6-(2-hydroxy-3-hydroxymethylpropan-1,3-diyl)-2'-deoxyadenosine (1,N6-γ-HMHP-dA) adducts by human and archebacterial DNA polymerases. Kotapati S, Maddukuri L, Wickramaratne S, Seneviratne U, Goggin M, Pence MG, Villalta P, Guengerich FP, Marnett L, Tretyakova N (2012) J Biol Chem 287(46): 38800-11
    › Primary publication · 22977231 (PubMed) · PMC3493922 (PubMed Central)
  134. Basis of miscoding of the DNA adduct N2,3-ethenoguanine by human Y-family DNA polymerases. Zhao L, Pence MG, Christov PP, Wawrzak Z, Choi JY, Rizzo CJ, Egli M, Guengerich FP (2012) J Biol Chem 287(42): 35516-35526
    › Primary publication · 22910910 (PubMed) · PMC3471744 (PubMed Central)
  135. Effects of N(2)-alkylguanine, O(6)-alkylguanine, and abasic lesions on DNA binding and bypass synthesis by the euryarchaeal B-family DNA polymerase vent (exo(-)). Lim S, Song I, Guengerich FP, Choi JY (2012) Chem Res Toxicol 25(8): 1699-707
    › Primary publication · 22793782 (PubMed) · PMC3683241 (PubMed Central)
  136. Oxidation of dihydrotestosterone by human cytochromes P450 19A1 and 3A4. Cheng Q, Sohl CD, Yoshimoto FK, Guengerich FP (2012) J Biol Chem 287(35): 29554-67
    › Primary publication · 22773874 (PubMed) · PMC3436178 (PubMed Central)
  137. Bioactivation of fluorinated 2-aryl-benzothiazole antitumor molecules by human cytochrome P450s 1A1 and 2W1 and deactivation by cytochrome P450 2S1. Wang K, Guengerich FP (2012) Chem Res Toxicol 25(8): 1740-51
    › Primary publication · 22734839 (PubMed) · PMC3850770 (PubMed Central)
  138. Replication of the 2,6-diamino-4-hydroxy-N(5)-(methyl)-formamidopyrimidine (MeFapy-dGuo) adduct by eukaryotic DNA polymerases. Christov PP, Yamanaka K, Choi JY, Takata K, Wood RD, Guengerich FP, Lloyd RS, Rizzo CJ (2012) Chem Res Toxicol 25(8): 1652-61
    › Primary publication · 22721435 (PubMed) · PMC3682502 (PubMed Central)
  139. Mutation spectra of S-(2-hydroxy-3,4-epoxybutyl)glutathione: comparison with 1,3-butadiene and its metabolites in the Escherichia coli rpoB gene. Cho SH, Guengerich FP (2012) Chem Res Toxicol 25(7): 1522-30
    › Primary publication · 22670845 (PubMed) · PMC3848527 (PubMed Central)
  140. Metabolomic analysis and identification of a role for the orphan human cytochrome P450 2W1 in selective oxidation of lysophospholipids. Xiao Y, Guengerich FP (2012) J Lipid Res 53(8): 1610-7
    › Primary publication · 22591743 (PubMed) · PMC3540858 (PubMed Central)
  141. Summary of information on the effects of ionizing and non-ionizing radiation on cytochrome P450 and other drug metabolizing enzymes and transporters. Rendic S, Guengerich FP (2012) Curr Drug Metab 13(6): 787-814
    › Primary publication · 22571481 (PubMed) · PMC4007673 (PubMed Central)
  142. Contributions of human enzymes in carcinogen metabolism. Rendic S, Guengerich FP (2012) Chem Res Toxicol 25(7): 1316-83
    › Primary publication · 22531028 (PubMed) · PMC3398241 (PubMed Central)
  143. Replication of N2,3-ethenoguanine by DNA polymerases. Zhao L, Christov PP, Kozekov ID, Pence MG, Pallan PS, Rizzo CJ, Egli M, Guengerich FP (2012) Angew Chem Int Ed Engl 51(22): 5466-9
    › Primary publication · 22488769 (PubMed) · PMC3671877 (PubMed Central)
  144. Thematic minireview series: Metals in Biology 2012. Guengerich FP (2012) J Biol Chem 287(17): 13508-9
    › Primary publication · 22389507 (PubMed) · PMC3340140 (PubMed Central)
  145. In vivo formation of dihydroxylated and glutathione conjugate metabolites derived from thalidomide and 5-Hydroxythalidomide in humanized TK-NOG mice. Yamazaki H, Suemizu H, Shimizu M, Igaya S, Shibata N, Nakamura M, Chowdhury G, Guengerich FP (2012) Chem Res Toxicol 25(2): 274-6
    › Primary publication · 22268628 (PubMed) · PMC3976424 (PubMed Central)
  146. Three-dimensional structure of steroid 21-hydroxylase (cytochrome P450 21A2) with two substrates reveals locations of disease-associated variants. Zhao B, Lei L, Kagawa N, Sundaramoorthy M, Banerjee S, Nagy LD, Guengerich FP, Waterman MR (2012) J Biol Chem 287(13): 10613-10622
    › Primary publication · 22262854 (PubMed) · PMC3323056 (PubMed Central)
  147. Conjugation of butadiene diepoxide with glutathione yields DNA adducts in vitro and in vivo. Cho SH, Guengerich FP (2012) Chem Res Toxicol 25(3): 706-12
    › Primary publication · 22181695 (PubMed) · PMC3850785 (PubMed Central)
  148. Liquid chromatography-mass spectrometry analysis of DNA polymerase reaction products. Chowdhury G, Guengerich FP (2011) Curr Protoc Nucleic Acid Chem : Unit 7.16.1-11
    › Primary publication · 22147421 (PubMed) · PMC3678528 (PubMed Central)
  149. Conversion of 7-dehydrocholesterol to 7-ketocholesterol is catalyzed by human cytochrome P450 7A1 and occurs by direct oxidation without an epoxide intermediate. Shinkyo R, Xu L, Tallman KA, Cheng Q, Porter NA, Guengerich FP (2011) J Biol Chem 286(38): 33021-8
    › Primary publication · 21813643 (PubMed) · PMC3190903 (PubMed Central)
  150. Roles of the four DNA polymerases of the crenarchaeon Sulfolobus solfataricus and accessory proteins in DNA replication. Choi JY, Eoff RL, Pence MG, Wang J, Martin MV, Kim EJ, Folkmann LM, Guengerich FP (2011) J Biol Chem 286(36): 31180-93
    › Primary publication · 21784862 (PubMed) · PMC3173079 (PubMed Central)
  151. Cytochromes P450 catalyze the reduction of α,β-unsaturated aldehydes. Amunom I, Dieter LJ, Tamasi V, Cai J, Conklin DJ, Srivastava S, Martin MV, Guengerich FP, Prough RA (2011) Chem Res Toxicol 24(8): 1223-30
    › Primary publication · 21766881 (PubMed) · PMC3180908 (PubMed Central)
  152. Orphans in the human cytochrome P450 superfamily: approaches to discovering functions and relevance in pharmacology. Guengerich FP, Cheng Q (2011) Pharmacol Rev 63(3): 684-99
    › Primary publication · 21737533 (PubMed) · PMC3141877 (PubMed Central)
  153. Spectral modification and catalytic inhibition of human cytochromes P450 1A1, 1A2, 1B1, 2A6, and 2A13 by four chemopreventive organoselenium compounds. Shimada T, Murayama N, Tanaka K, Takenaka S, Guengerich FP, Yamazaki H, Komori M (2011) Chem Res Toxicol 24(8): 1327-37
    › Primary publication · 21732699 (PubMed) · PMC3156385 (PubMed Central)
  154. 1,N2-Etheno-2'-deoxyguanosine adopts the syn conformation about the glycosyl bond when mismatched with deoxyadenosine. Shanmugam G, Kozekov ID, Guengerich FP, Rizzo CJ, Stone MP (2011) Chem Res Toxicol 24(7): 1071-9
    › Primary publication · 21675798 (PubMed) · PMC3138413 (PubMed Central)
  155. Thematic minireview series on biological applications of mass spectrometry. Guengerich FP (2011) J Biol Chem 286(29): 25417
    › Primary publication · 21632545 (PubMed) · PMC3138286 (PubMed Central)
  156. A tricistronic human adrenodoxin reductase-adrenodoxin-cytochrome P450 27A1 vector system for substrate hydroxylation in Escherichia coli. Salamanca-Pinzón SG, Guengerich FP (2011) Protein Expr Purif 79(2): 231-6
    › Primary publication · 21621619 (PubMed) · PMC3155662 (PubMed Central)
  157. Inhibition of human cytochrome P450 3A4 by cholesterol. Shinkyo R, Guengerich FP (2011) J Biol Chem 286(21): 18426-33
    › Primary publication · 21471209 (PubMed) · PMC3099659 (PubMed Central)
  158. Cytochrome P450 2S1 is reduced by NADPH-cytochrome P450 reductase. Xiao Y, Shinkyo R, Guengerich FP (2011) Drug Metab Dispos 39(6): 944-6
    › Primary publication · 21430234 (PubMed) · PMC3100906 (PubMed Central)
  159. Guest editor's introduction. Special issue on catalytic mechanisms. Guengerich FP (2011) Arch Biochem Biophys 507(1): 1-2
    › Primary publication · 21324387 (PubMed)
  160. In vivo formation of a glutathione conjugate derived from thalidomide in humanized uPA-NOG mice. Yamazaki H, Suemizu H, Igaya S, Shimizu M, Shibata N, Nakamura M, Chowdhury G, Guengerich FP (2011) Chem Res Toxicol 24(3): 287-9
    › Primary publication · 21299192 (PubMed) · PMC3838788 (PubMed Central)
  161. Comparison of the inhibitory profiles of itraconazole and cimetidine in cytochrome P450 3A4 genetic variants. Akiyoshi T, Saito T, Murase S, Miyazaki M, Murayama N, Yamazaki H, Guengerich FP, Nakamura K, Yamamoto K, Ohtani H (2011) Drug Metab Dispos 39(4): 724-8
    › Primary publication · 21212239 (PubMed) · PMC3063718 (PubMed Central)
  162. Cytochrome P450 7A1 cholesterol 7alpha-hydroxylation: individual reaction steps in the catalytic cycle and rate-limiting ferric iron reduction. Shinkyo R, Guengerich FP (2011) J Biol Chem 286(6): 4632-43
    › Primary publication · 21147774 (PubMed) · PMC3039343 (PubMed Central)
  163. Structure-function relationships of inhibition of human cytochromes P450 1A1, 1A2, 1B1, 2C9, and 3A4 by 33 flavonoid derivatives. Shimada T, Tanaka K, Takenaka S, Murayama N, Martin MV, Foroozesh MK, Yamazaki H, Guengerich FP, Komori M (2010) Chem Res Toxicol 23(12): 1921-35
    › Primary publication · 21053930 (PubMed) · PMC3072440 (PubMed Central)
  164. Cyclization of a cellular dipentaenone by Streptomyces coelicolor cytochrome P450 154A1 without oxidation/reduction. Cheng Q, Lamb DC, Kelly SL, Lei L, Guengerich FP (2010) J Am Chem Soc 132(43): 15173-5
    › Primary publication · 20979426 (PubMed) · PMC3118511 (PubMed Central)
  165. Mechanisms of drug toxicity and relevance to pharmaceutical development. Guengerich FP (2011) Drug Metab Pharmacokinet 26(1): 3-14
    › Primary publication · 20978361 (PubMed) · PMC4707670 (PubMed Central)
  166. Structural basis for proficient incorporation of dTTP opposite O6-methylguanine by human DNA polymerase iota. Pence MG, Choi JY, Egli M, Guengerich FP (2010) J Biol Chem 285(52): 40666-72
    › Primary publication · 20961860 (PubMed) · PMC3003365 (PubMed Central)
  167. Mechanistic Studies with DNA Polymerases Reveal Complex Outcomes following Bypass of DNA Damage. Eoff RL, Choi JY, Guengerich FP (2010) J Nucleic Acids
    › Primary publication · 20936119 (PubMed) · PMC2948923 (PubMed Central)
  168. Translesion synthesis across abasic lesions by human B-family and Y-family DNA polymerases α, δ, η, ι, κ, and REV1. Choi JY, Lim S, Kim EJ, Jo A, Guengerich FP (2010) J Mol Biol 404(1): 34-44
    › Primary publication · 20888339 (PubMed) · PMC3018708 (PubMed Central)
  169. Mutagenicity of a glutathione conjugate of butadiene diepoxide. Cho SH, Loecken EM, Guengerich FP (2010) Chem Res Toxicol 23(10): 1544-6
    › Primary publication · 20879737 (PubMed) · PMC3848503 (PubMed Central)
  170. Metal-ion dependence of the active-site conformation of the translesion DNA polymerase Dpo4 from Sulfolobus solfataricus. Irimia A, Loukachevitch LV, Eoff RL, Guengerich FP, Egli M (2010) Acta Crystallogr Sect F Struct Biol Cryst Commun 66(Pt 9): 1013-8
    › Primary publication · 20823515 (PubMed) · PMC2935216 (PubMed Central)
  171. Selective modulation of DNA polymerase activity by fixed-conformation nucleoside analogues. Eoff RL, McGrath CE, Maddukuri L, Salamanca-Pinzón SG, Marquez VE, Marnett LJ, Guengerich FP, Egli M (2010) Angew Chem Int Ed Engl 49(41): 7481-5
    › Primary publication · 20814997 (PubMed) · PMC3011974 (PubMed Central)
  172. Multi-step oxidations catalyzed by cytochrome P450 enzymes: Processive vs. distributive kinetics and the issue of carbonyl oxidation in chemical mechanisms. Guengerich FP, Sohl CD, Chowdhury G (2011) Arch Biochem Biophys 507(1): 126-34
    › Primary publication · 20804723 (PubMed) · PMC3010332 (PubMed Central)
  173. Dansylation of unactivated alcohols for improved mass spectral sensitivity and application to analysis of cytochrome P450 oxidation products in tissue extracts. Tang Z, Guengerich FP (2010) Anal Chem 82(18): 7706-12
    › Primary publication · 20795636 (PubMed) · PMC2941762 (PubMed Central)
  174. In vitro bypass of the major malondialdehyde- and base propenal-derived DNA adduct by human Y-family DNA polymerases κ, ι, and Rev1. Maddukuri L, Eoff RL, Choi JY, Rizzo CJ, Guengerich FP, Marnett LJ (2010) Biochemistry 49(38): 8415-24
    › Primary publication · 20726503 (PubMed) · PMC2943251 (PubMed Central)
  175. Comparison of the in vitro replication of the 7-(2-oxoheptyl)-1,N2-etheno-2'-deoxyguanosine and 1,N2-etheno-2'-deoxyguanosine lesions by Sulfolobus solfataricus P2 DNA polymerase IV (Dpo4). Christov PP, Petrova KV, Shanmugam G, Kozekov ID, Kozekova A, Guengerich FP, Stone MP, Rizzo CJ (2010) Chem Res Toxicol 23(8): 1330-41
    › Primary publication · 20578729 (PubMed) · PMC2922457 (PubMed Central)
  176. Characterizing proteins of unknown function: orphan cytochrome p450 enzymes as a paradigm. Guengerich FP, Tang Z, Salamanca-Pinzón SG, Cheng Q (2010) Mol Interv 10(3): 153-63
    › Primary publication · 20539034 (PubMed) · PMC2895278 (PubMed Central)
  177. Systematic genetic and genomic analysis of cytochrome P450 enzyme activities in human liver. Yang X, Zhang B, Molony C, Chudin E, Hao K, Zhu J, Gaedigk A, Suver C, Zhong H, Leeder JS, Guengerich FP, Strom SC, Schuetz E, Rushmore TH, Ulrich RG, Slatter JG, Schadt EE, Kasarskis A, Lum PY (2010) Genome Res 20(8): 1020-36
    › Primary publication · 20538623 (PubMed) · PMC2909567 (PubMed Central)
  178. Mitochondria-targeted cytochrome P450 2E1 induces oxidative damage and augments alcohol-mediated oxidative stress. Bansal S, Liu CP, Sepuri NB, Anandatheerthavarada HK, Selvaraj V, Hoek J, Milne GL, Guengerich FP, Avadhani NG (2010) J Biol Chem 285(32): 24609-19
    › Primary publication · 20529841 (PubMed) · PMC2915697 (PubMed Central)
  179. Thematic minireview series: metals in biology 2010. Guengerich FP (2010) J Biol Chem 285(35): 26727
    › Primary publication · 20522544 (PubMed) · PMC2930669 (PubMed Central)
  180. Approaches to deorphanization of human and microbial cytochrome P450 enzymes. Guengerich FP, Tang Z, Cheng Q, Salamanca-Pinzón SG (2011) Biochim Biophys Acta 1814(1): 139-45
    › Primary publication · 20493973 (PubMed) · PMC2939962 (PubMed Central)
  181. Human liver microsomal cytochrome P450 3A enzymes involved in thalidomide 5-hydroxylation and formation of a glutathione conjugate. Chowdhury G, Murayama N, Okada Y, Uno Y, Shimizu M, Shibata N, Guengerich FP, Yamazaki H (2010) Chem Res Toxicol 23(6): 1018-24
    › Primary publication · 20443640 (PubMed) · PMC3843493 (PubMed Central)
  182. Kinetic analysis of the three-step steroid aromatase reaction of human cytochrome P450 19A1. Sohl CD, Guengerich FP (2010) J Biol Chem 285(23): 17734-43
    › Primary publication · 20385561 (PubMed) · PMC2878537 (PubMed Central)
  183. The C8-2'-deoxyguanosine adduct of 2-amino-3-methylimidazo[1,2-d]naphthalene, a carbocyclic analogue of the potent mutagen 2-amino-3-methylimidazo[4,5-f]quinoline, is a block to replication in vitro. Christov PP, Chowdhury G, Garmendia CA, Wang F, Stover JS, Elmquist CE, Kozekova A, Angel KC, Turesky RJ, Stone MP, Guengerich FP, Rizzo CJ (2010) Chem Res Toxicol 23(6): 1076-88
    › Primary publication · 20377178 (PubMed) · PMC2891123 (PubMed Central)
  184. Evolution of the scientific literature of cytochrome P450 from 1977 to 2008. Robert C, Wilson CS, Guengerich FP, Arreto CD (2010) Curr Drug Metab 11(2): 162-70
    › Primary publication · 20359288 (PubMed)
  185. Update information on drug metabolism systems--2009, part II: summary of information on the effects of diseases and environmental factors on human cytochrome P450 (CYP) enzymes and transporters. Rendic S, Guengerich FP (2010) Curr Drug Metab 11(1): 4-84
    › Primary publication · 20302566 (PubMed) · PMC4167379 (PubMed Central)
  186. Update Information on Drug Metabolism Systems-2009, Part I. Guengerich FP, Rendic S (2010) Curr Drug Metab
    › Primary publication · 20236049 (PubMed)
  187. Structure of the 1,N(2)-etheno-2'-deoxyguanosine lesion in the 3'-G(epsilon dG)T-5' sequence opposite a one-base deletion. Shanmugam G, Kozekov ID, Guengerich FP, Rizzo CJ, Stone MP (2010) Biochemistry 49(12): 2615-26
    › Primary publication · 20201499 (PubMed) · PMC2844103 (PubMed Central)
  188. Cataloging the Repertoire of Nature's Blowtorch, P450. Guengerich FP (2009) Chem Biol 16(12): 1215-6
    › Primary publication · 20064429 (PubMed)
  189. Oxidation of N-Nitrosoalkylamines by human cytochrome P450 2A6: sequential oxidation to aldehydes and carboxylic acids and analysis of reaction steps. Chowdhury G, Calcutt MW, Guengerich FP (2010) J Biol Chem 285(11): 8031-44
    › Primary publication · 20061389 (PubMed) · PMC2832954 (PubMed Central)
  190. Effect of N2-guanyl modifications on early steps in catalysis of polymerization by Sulfolobus solfataricus P2 DNA polymerase Dpo4 T239W. Zhang H, Guengerich FP (2010) J Mol Biol 395(5): 1007-18
    › Primary publication · 19969000 (PubMed) · PMC2814591 (PubMed Central)
  191. Human cytochrome P450 4F11: heterologous expression in bacteria, purification, and characterization of catalytic function. Tang Z, Salamanca-Pinzón SG, Wu ZL, Xiao Y, Guengerich FP (2010) Arch Biochem Biophys 494(1): 86-93
    › Primary publication · 19932081 (PubMed) · PMC2812615 (PubMed Central)
  192. D-amino acid oxidase generates agonists of the aryl hydrocarbon receptor from D-tryptophan. Nguyen LP, Hsu EL, Chowdhury G, Dostalek M, Guengerich FP, Bradfield CA (2009) Chem Res Toxicol 22(12): 1897-904
    › Primary publication · 19860415 (PubMed) · PMC2923838 (PubMed Central)
  193. Structural identification of Diindole agonists of the aryl hydrocarbon receptor derived from degradation of indole-3-pyruvic acid. Chowdhury G, Dostalek M, Hsu EL, Nguyen LP, Stec DF, Bradfield CA, Guengerich FP (2009) Chem Res Toxicol 22(12): 1905-12
    › Primary publication · 19860413 (PubMed) · PMC2801742 (PubMed Central)
  194. Frameshift deletion by Sulfolobus solfataricus P2 DNA polymerase Dpo4 T239W is selective for purines and involves normal conformational change followed by slow phosphodiester bond formation. Zhang H, Beckman JW, Guengerich FP (2009) J Biol Chem 284(50): 35144-53
    › Primary publication · 19837980 (PubMed) · PMC2787375 (PubMed Central)
  195. Identification of genetic variants of human cytochrome P450 2D6 with impaired mitochondrial targeting. Sangar MC, Anandatheerthavarada HK, Martin MV, Guengerich FP, Avadhani NG (2010) Mol Genet Metab 99(1): 90-7
    › Primary publication · 19781968 (PubMed) · PMC2794965 (PubMed Central)
  196. Metal ion interactions in the DNA cleavage/ligation active site of human topoisomerase IIalpha. Deweese JE, Guengerich FP, Burgin AB, Osheroff N (2009) Biochemistry 48(38): 8940-7
    › Primary publication · 19697956 (PubMed) · PMC2782489 (PubMed Central)
  197. High-throughput fluorescence assay of cytochrome P450 3A4. Cheng Q, Sohl CD, Guengerich FP (2009) Nat Protoc 4(9): 1258-61
    › Primary publication · 19661996 (PubMed) · PMC3843962 (PubMed Central)
  198. Chromatographic assays of drug oxidation by human cytochrome P450 3A4. Sohl CD, Cheng Q, Guengerich FP (2009) Nat Protoc 4(9): 1252-7
    › Primary publication · 19661995 (PubMed) · PMC3883453 (PubMed Central)
  199. Measurement of cytochrome P450 and NADPH-cytochrome P450 reductase. Guengerich FP, Martin MV, Sohl CD, Cheng Q (2009) Nat Protoc 4(9): 1245-51
    › Primary publication · 19661994 (PubMed) · PMC3843963 (PubMed Central)
  200. Steric and electrostatic effects at the C2 atom substituent influence replication and miscoding of the DNA deamination product deoxyxanthosine and analogs by DNA polymerases. Zhang H, Bren U, Kozekov ID, Rizzo CJ, Stec DF, Guengerich FP (2009) J Mol Biol 392(2): 251-69
    › Primary publication · 19607842 (PubMed) · PMC2755575 (PubMed Central)
  201. Inter-individual variation in flavin-containing monooxygenase 3 in livers from Japanese: correlation with hepatic transcription factors. Nagashima S, Shimizu M, Yano H, Murayama N, Kumai T, Kobayashi S, Guengerich FP, Yamazaki H (2009) Drug Metab Pharmacokinet 24(3): 218-25
    › Primary publication · 19571433 (PubMed) · PMC4755719 (PubMed Central)
  202. Reverse type I binding spectra of human cytochrome P450 1B1 induced by flavonoid, stilbene, pyrene, naphthalene, phenanthrene, and biphenyl derivatives that inhibit catalytic activity: a structure-function relationship study. Shimada T, Tanaka K, Takenaka S, Foroozesh MK, Murayama N, Yamazaki H, Guengerich FP, Komori M (2009) Chem Res Toxicol 22(7): 1325-33
    › Primary publication · 19563207 (PubMed) · PMC3845904 (PubMed Central)
  203. Mammalian cytochrome P450 enzymes catalyze the phenol-coupling step in endogenous morphine biosynthesis. Grobe N, Zhang B, Fisinger U, Kutchan TM, Zenk MH, Guengerich FP (2009) J Biol Chem 284(36): 24425-31
    › Primary publication · 19561069 (PubMed) · PMC2782035 (PubMed Central)
  204. Enhanced bacterial expression of several mammalian cytochrome P450s by codon optimization and chaperone coexpression. Wu ZL, Qiao J, Zhang ZG, Guengerich FP, Liu Y, Pei XQ (2009) Biotechnol Lett 31(10): 1589-93
    › Primary publication · 19557307 (PubMed) · PMC4188451 (PubMed Central)
  205. Interaction of polycyclic aromatic hydrocarbons with human cytochrome P450 1B1 in inhibiting catalytic activity. Shimada T, Murajama N, Tanaka K, Takenaka S, Imai Y, Hopkins NE, Foroozesh MK, Alworth WL, Yamazaki H, Guengerich FP, Komori M (2008) Chem Res Toxicol 21(12): 2313-23
    › Primary publication · 19548353 (PubMed) · PMC2772130 (PubMed Central)
  206. Structure-function relationships in miscoding by Sulfolobus solfataricus DNA polymerase Dpo4: guanine N2,N2-dimethyl substitution produces inactive and miscoding polymerase complexes. Zhang H, Eoff RL, Kozekov ID, Rizzo CJ, Egli M, Guengerich FP (2009) J Biol Chem 284(26): 17687-99
    › Primary publication · 19542237 (PubMed) · PMC2719408 (PubMed Central)
  207. Structural and functional elucidation of the mechanism promoting error-prone synthesis by human DNA polymerase kappa opposite the 7,8-dihydro-8-oxo-2'-deoxyguanosine adduct. Irimia A, Eoff RL, Guengerich FP, Egli M (2009) J Biol Chem 284(33): 22467-22480
    › Primary publication · 19542228 (PubMed) · PMC2755968 (PubMed Central)
  208. Conformational changes during nucleotide selection by Sulfolobus solfataricus DNA polymerase Dpo4. Eoff RL, Sanchez-Ponce R, Guengerich FP (2009) J Biol Chem 284(31): 21090-9
    › Primary publication · 19515847 (PubMed) · PMC2742873 (PubMed Central)
  209. Tandem mass spectrometry-based detection of c4'-oxidized abasic sites at specific positions in DNA fragments. Chowdhury G, Guengerich FP (2009) Chem Res Toxicol 22(7): 1310-9
    › Primary publication · 19496605 (PubMed) · PMC3838791 (PubMed Central)
  210. Structural and functional analysis of Sulfolobus solfataricus Y-family DNA polymerase Dpo4-catalyzed bypass of the malondialdehyde-deoxyguanosine adduct. Eoff RL, Stafford JB, Szekely J, Rizzo CJ, Egli M, Guengerich FP, Marnett LJ (2009) Biochemistry 48(30): 7079-88
    › Primary publication · 19492857 (PubMed) · PMC2717710 (PubMed Central)
  211. Human liver mitochondrial cytochrome P450 2D6--individual variations and implications in drug metabolism. Sangar MC, Anandatheerthavarada HK, Tang W, Prabu SK, Martin MV, Dostalek M, Guengerich FP, Avadhani NG (2009) FEBS J 276(13): 3440-53
    › Primary publication · 19438707 (PubMed) · PMC2789264 (PubMed Central)
  212. Modulation of the structure, catalytic activity, and fidelity of African swine fever virus DNA polymerase X by a reversible disulfide switch. Voehler MW, Eoff RL, McDonald WH, Guengerich FP, Stone MP (2009) J Biol Chem 284(27): 18434-44
    › Primary publication · 19419958 (PubMed) · PMC2709365 (PubMed Central)
  213. Replication past the N5-methyl-formamidopyrimidine lesion of deoxyguanosine by DNA polymerases and an improved procedure for sequence analysis of in vitro bypass products by mass spectrometry. Christov PP, Angel KC, Guengerich FP, Rizzo CJ (2009) Chem Res Toxicol 22(6): 1086-95
    › Primary publication · 19397282 (PubMed) · PMC2754150 (PubMed Central)
  214. Kinetic analysis of base-pairing preference for nucleotide incorporation opposite template pyrimidines by human DNA polymerase iota. Choi JY, Lim S, Eoff RL, Guengerich FP (2009) J Mol Biol 389(2): 264-74
    › Primary publication · 19376129 (PubMed) · PMC4010588 (PubMed Central)
  215. The bis-electrophile diepoxybutane cross-links DNA to human histones but does not result in enhanced mutagenesis in recombinant systems. Loecken EM, Dasari S, Hill S, Tabb DL, Guengerich FP (2009) Chem Res Toxicol 22(6): 1069-76
    › Primary publication · 19364102 (PubMed) · PMC2696559 (PubMed Central)
  216. Thematic minireview series: metals in biology. Guengerich FP (2009) J Biol Chem 284(28): 18557
    › Primary publication · 19363036 (PubMed) · PMC2707207 (PubMed Central)
  217. Elucidation of functions of human cytochrome P450 enzymes: identification of endogenous substrates in tissue extracts using metabolomic and isotopic labeling approaches. Tang Z, Martin MV, Guengerich FP (2009) Anal Chem 81(8): 3071-8
    › Primary publication · 19301915 (PubMed) · PMC3354960 (PubMed Central)
  218. Inherent stereospecificity in the reaction of aflatoxin B(1) 8,9-epoxide with deoxyguanosine and efficiency of DNA catalysis. Brown KL, Bren U, Stone MP, Guengerich FP (2009) Chem Res Toxicol 22(5): 913-7
    › Primary publication · 19301826 (PubMed) · PMC3141577 (PubMed Central)
  219. Introduction: Human metabolites in safety testing (MIST) issue. Guengerich FP (2009) Chem Res Toxicol 22(2): 237-8
    › Primary publication · 19216576 (PubMed)
  220. Oxidation and glycolytic cleavage of etheno and propano DNA base adducts. Knutson CG, Rubinson EH, Akingbade D, Anderson CS, Stec DF, Petrova KV, Kozekov ID, Guengerich FP, Rizzo CJ, Marnett LJ (2009) Biochemistry 48(4): 800-9
    › Primary publication · 19132922 (PubMed) · PMC2975463 (PubMed Central)
  221. Translesion DNA synthesis by human DNA polymerase eta on templates containing a pyrimidopurinone deoxyguanosine adduct, 3-(2'-deoxy-beta-d-erythro-pentofuranosyl)pyrimido-[1,2-a]purin-10(3H)-one. Stafford JB, Eoff RL, Kozekova A, Rizzo CJ, Guengerich FP, Marnett LJ (2009) Biochemistry 48(2): 471-80
    › Primary publication · 19108641 (PubMed) · PMC2651650 (PubMed Central)
  222. Versatility of Y-family Sulfolobus solfataricus DNA polymerase Dpo4 in translesion synthesis past bulky N2-alkylguanine adducts. Zhang H, Eoff RL, Kozekov ID, Rizzo CJ, Egli M, Guengerich FP (2009) J Biol Chem 284(6): 3563-76
    › Primary publication · 19059910 (PubMed) · PMC2636699 (PubMed Central)
  223. Kinetic analysis of correct nucleotide insertion by a Y-family DNA polymerase reveals conformational changes both prior to and following phosphodiester bond formation as detected by tryptophan fluorescence. Beckman JW, Wang Q, Guengerich FP (2008) J Biol Chem 283(52): 36711-23
    › Primary publication · 18984592 (PubMed) · PMC2605995 (PubMed Central)
  224. Identification of amino acid residues involved in 4-chloroindole 3-hydroxylation by cytochrome P450 2A6 using screening of random libraries. Zhang ZG, Liu Y, Guengerich FP, Matse JH, Chen J, Wu ZL (2009) J Biotechnol 139(1): 12-8
    › Primary publication · 18984015 (PubMed) · PMC4755720 (PubMed Central)
  225. Drug interactions of thalidomide with midazolam and cyclosporine A: heterotropic cooperativity of human cytochrome P450 3A5. Okada Y, Murayama N, Yanagida C, Shimizu M, Guengerich FP, Yamazaki H (2009) Drug Metab Dispos 37(1): 18-23
    › Primary publication · 18948377 (PubMed) · PMC2719675 (PubMed Central)
  226. Repair of O6-G-alkyl-O6-G interstrand cross-links by human O6-alkylguanine-DNA alkyltransferase. Fang Q, Noronha AM, Murphy SP, Wilds CJ, Tubbs JL, Tainer JA, Chowdhury G, Guengerich FP, Pegg AE (2008) Biochemistry 47(41): 10892-903
    › Primary publication · 18803403 (PubMed) · PMC2632579 (PubMed Central)
  227. Structure of the 1,N2-ethenodeoxyguanosine adduct opposite cytosine in duplex DNA: Hoogsteen base pairing at pH 5.2. Shanmugam G, Kozekov ID, Guengerich FP, Rizzo CJ, Stone MP (2008) Chem Res Toxicol 21(9): 1795-805
    › Primary publication · 18693701 (PubMed) · PMC2646752 (PubMed Central)
  228. Defective activity of recombinant cytochromes P450 3A4.2 and 3A4.16 in oxidation of midazolam, nifedipine, and testosterone. Miyazaki M, Nakamura K, Fujita Y, Guengerich FP, Horiuchi R, Yamamoto K (2008) Drug Metab Dispos 36(11): 2287-91
    › Primary publication · 18669585 (PubMed)
  229. Substrate binding to cytochromes P450. Isin EM, Guengerich FP (2008) Anal Bioanal Chem 392(6): 1019-30
    › Primary publication · 18622598 (PubMed) · PMC4756639 (PubMed Central)
  230. Kinetic analysis of translesion synthesis opposite bulky N2- and O6-alkylguanine DNA adducts by human DNA polymerase REV1. Choi JY, Guengerich FP (2008) J Biol Chem 283(35): 23645-55
    › Primary publication · 18591245 (PubMed) · PMC2527099 (PubMed Central)
  231. Expression and purification of orphan cytochrome P450 4X1 and oxidation of anandamide. Stark K, Dostalek M, Guengerich FP (2008) FEBS J 275(14): 3706-17
    › Primary publication · 18549450 (PubMed) · PMC4765179 (PubMed Central)
  232. mRNA distribution and heterologous expression of orphan cytochrome P450 20A1. Stark K, Wu ZL, Bartleson CJ, Guengerich FP (2008) Drug Metab Dispos 36(9): 1930-7
    › Primary publication · 18541694 (PubMed) · PMC4694639 (PubMed Central)
  233. Mapping the genetic architecture of gene expression in human liver. Schadt EE, Molony C, Chudin E, Hao K, Yang X, Lum PY, Kasarskis A, Zhang B, Wang S, Suver C, Zhu J, Millstein J, Sieberts S, Lamb J, GuhaThakurta D, Derry J, Storey JD, Avila-Campillo I, Kruger MJ, Johnson JM, Rohl CA, van Nas A, Mehrabian M, Drake TA, Lusis AJ, Smith RC, Guengerich FP, Strom SC, Schuetz E, Rushmore TH, Ulrich R (2008) PLoS Biol 6(5): e107
    › Primary publication · 18462017 (PubMed) · PMC2365981 (PubMed Central)
  234. Development of oxidative stress by cytochrome P450 induction in rodents is selective for barbiturates and related to loss of pyridine nucleotide-dependent protective systems. Dostalek M, Hardy KD, Milne GL, Morrow JD, Chen C, Gonzalez FJ, Gu J, Ding X, Johnson DA, Johnson JA, Martin MV, Guengerich FP (2008) J Biol Chem 283(25): 17147-57
    › Primary publication · 18442974 (PubMed) · PMC2427356 (PubMed Central)
  235. Protection against aflatoxin B1-induced cytotoxicity by expression of the cloned aflatoxin B1-aldehyde reductases rat AKR7A1 and human AKR7A3. Bodreddigari S, Jones LK, Egner PA, Groopman JD, Sutter CH, Roebuck BD, Guengerich FP, Kensler TW, Sutter TR (2008) Chem Res Toxicol 21(5): 1134-42
    › Primary publication · 18416522 (PubMed) · PMC3838790 (PubMed Central)
  236. Cooperativity of cytochrome P450 1A2: interactions of 1,4-phenylene diisocyanide and 1-isopropoxy-4-nitrobenzene. Isin EM, Sohl CD, Eoff RL, Guengerich FP (2008) Arch Biochem Biophys 473(1): 69-75
    › Primary publication · 18328798 (PubMed) · PMC4662254 (PubMed Central)
  237. Cooperativity in oxidation reactions catalyzed by cytochrome P450 1A2: highly cooperative pyrene hydroxylation and multiphasic kinetics of ligand binding. Sohl CD, Isin EM, Eoff RL, Marsch GA, Stec DF, Guengerich FP (2008) J Biol Chem 283(11): 7293-308
    › Primary publication · 18187423 (PubMed)
  238. Reactions of glyceraldehyde 3-phosphate dehydrogenase sulfhydryl groups with bis-electrophiles produce DNA-protein cross-links but not mutations. Loecken EM, Guengerich FP (2008) Chem Res Toxicol 21(2): 453-8
    › Primary publication · 18163542 (PubMed) · PMC4049368 (PubMed Central)
  239. Cytochrome p450 and chemical toxicology. Guengerich FP (2008) Chem Res Toxicol 21(1): 70-83
    › Primary publication · 18052394 (PubMed)
  240. Heterologous expression and characterization of wild-type human cytochrome P450 1A2 without conventional N-terminal modification in Escherichia coli. Kim DH, Kim KH, Isin EM, Guengerich FP, Chae HZ, Ahn T, Yun CH (2008) Protein Expr Purif 57(2): 188-200
    › Primary publication · 18032064 (PubMed)
  241. Direct detection and mapping of sites of base modification in DNA fragments by tandem mass spectrometry. Chowdhury G, Guengerich FP (2008) Angew Chem Int Ed Engl 47(2): 381-4
    › Primary publication · 18022988 (PubMed)
  242. Transcription processing at 1,N2-ethenoguanine by human RNA polymerase II and bacteriophage T7 RNA polymerase. Dimitri A, Goodenough AK, Guengerich FP, Broyde S, Scicchitano DA (2008) J Mol Biol 375(2): 353-66
    › Primary publication · 18022639 (PubMed) · PMC2262288 (PubMed Central)
  243. Cytochromes P450 and drug discovery. Lamb DC, Waterman MR, Kelly SL, Guengerich FP (2007) Curr Opin Biotechnol 18(6): 504-12
    › Primary publication · 18006294 (PubMed)
  244. Structure and activity of Y-class DNA polymerase DPO4 from Sulfolobus solfataricus with templates containing the hydrophobic thymine analog 2,4-difluorotoluene. Irimia A, Eoff RL, Pallan PS, Guengerich FP, Egli M (2007) J Biol Chem 282(50): 36421-33
    › Primary publication · 17951245 (PubMed)
  245. Structure of the 1,N2-etheno-2'-deoxyguanosine adduct in duplex DNA at pH 8.6. Shanmugam G, Goodenough AK, Kozekov ID, Guengerich FP, Rizzo CJ, Stone MP (2007) Chem Res Toxicol 20(11): 1601-11
    › Primary publication · 17941687 (PubMed) · PMC2546360 (PubMed Central)
  246. Mechanisms of cytochrome P450 substrate oxidation: MiniReview. Guengerich FP (2007) J Biochem Mol Toxicol 21(4): 163-8
    › Primary publication · 17936929 (PubMed)
  247. Analysis of DNA adducts formed in vivo in rats and mice from 1,2-dibromoethane, 1,2-dichloroethane, dibromomethane, and dichloromethane using HPLC/accelerator mass spectrometry and relevance to risk estimates. Watanabe K, Liberman RG, Skipper PL, Tannenbaum SR, Guengerich FP (2007) Chem Res Toxicol 20(11): 1594-600
    › Primary publication · 17907789 (PubMed)
  248. In vivo oxidative damage in rats is associated with barbiturate response but not other cytochrome P450 inducers. Dostalek M, Brooks JD, Hardy KD, Milne GL, Moore MM, Sharma S, Morrow JD, Guengerich FP (2007) Mol Pharmacol 72(6): 1419-24
    › Primary publication · 17898314 (PubMed)
  249. Characterization of orphan human cytochromes P450. Stark K, Guengerich FP (2007) Drug Metab Rev 39(2-3): 627-37
    › Primary publication · 17786643 (PubMed)
  250. Guanine alkylation by the potent carcinogen aflatoxin B1: quantum chemical calculations. Bren U, Guengerich FP, Mavri J (2007) Chem Res Toxicol 20(8): 1134-40
    › Primary publication · 17630712 (PubMed)
  251. Involvement of human cytochrome P450 2B6 in the omega- and 4-hydroxylation of the anesthetic agent propofol. Murayama N, Minoshima M, Shimizu M, Guengerich FP, Yamazaki H (2007) Xenobiotica 37(7): 717-24
    › Primary publication · 17620218 (PubMed)
  252. Cytochromes P450 catalyze oxidation of alpha,beta-unsaturated aldehydes. Amunom I, Stephens LJ, Tamasi V, Cai J, Pierce WM, Conklin DJ, Bhatnagar A, Srivastava S, Martin MV, Guengerich FP, Prough RA (2007) Arch Biochem Biophys 464(2): 187-96
    › Primary publication · 17599801 (PubMed) · PMC1994811 (PubMed Central)
  253. Degradation pathway of bisphenol A: does ipso substitution apply to phenols containing a quaternary alpha-carbon structure in the para position? Kolvenbach B, Schlaich N, Raoui Z, Prell J, Zühlke S, Schäffer A, Guengerich FP, Corvini PF (2007) Appl Environ Microbiol 73(15): 4776-84
    › Primary publication · 17557840 (PubMed) · PMC1951029 (PubMed Central)
  254. Hydrogen bonding of 7,8-dihydro-8-oxodeoxyguanosine with a charged residue in the little finger domain determines miscoding events in Sulfolobus solfataricus DNA polymerase Dpo4. Eoff RL, Irimia A, Angel KC, Egli M, Guengerich FP (2007) J Biol Chem 282(27): 19831-43
    › Primary publication · 17468100 (PubMed)
  255. Effects of N-terminal modification of recombinant human cytochrome P450 1A2 on catalytic activity. Kim HJ, Lee SB, Guengerich FP, Park YI, Dong MS (2007) Xenobiotica 37(4): 356-65
    › Primary publication · 17455110 (PubMed)
  256. Electron transport pathway for a Streptomyces cytochrome P450: cytochrome P450 105D5-catalyzed fatty acid hydroxylation in Streptomyces coelicolor A3(2). Chun YJ, Shimada T, Sanchez-Ponce R, Martin MV, Lei L, Zhao B, Kelly SL, Waterman MR, Lamb DC, Guengerich FP (2007) J Biol Chem 282(24): 17486-500
    › Primary publication · 17446171 (PubMed)
  257. Untargeted analysis of mass spectrometry data for elucidation of metabolites and function of enzymes. Sanchez-Ponce R, Guengerich FP (2007) Anal Chem 79(9): 3355-62
    › Primary publication · 17408243 (PubMed) · PMC3357132 (PubMed Central)
  258. Molecular basis of selectivity of nucleoside triphosphate incorporation opposite O6-benzylguanine by sulfolobus solfataricus DNA polymerase Dpo4: steady-state and pre-steady-state kinetics and x-ray crystallography of correct and incorrect pairing. Eoff RL, Angel KC, Egli M, Guengerich FP (2007) J Biol Chem 282(18): 13573-84
    › Primary publication · 17337730 (PubMed)
  259. Applying mechanisms of chemical toxicity to predict drug safety. Guengerich FP, MacDonald JS (2007) Chem Res Toxicol 20(3): 344-69
    › Primary publication · 17302443 (PubMed)
  260. Different mechanisms for inhibition of human cytochromes P450 1A1, 1A2, and 1B1 by polycyclic aromatic inhibitors. Shimada T, Murayama N, Okada K, Funae Y, Yamazaki H, Guengerich FP (2007) Chem Res Toxicol 20(3): 489-96
    › Primary publication · 17291012 (PubMed)
  261. Complex reactions catalyzed by cytochrome P450 enzymes. Isin EM, Guengerich FP (2007) Biochim Biophys Acta 1770(3): 314-29
    › Primary publication · 17239540 (PubMed)
  262. Effect of alterations of key active site residues in O6-alkylguanine-DNA Alkyltransferase on its ability to modulate the genotoxicity of 1,2-dibromoethane. Liu L, Watanabe K, Fang Q, Williams KM, Guengerich FP, Pegg AE (2007) Chem Res Toxicol 20(1): 155-63
    › Primary publication · 17226938 (PubMed)
  263. Formation of the indigo precursor indican in genetically engineered tobacco plants and cell cultures. Warzecha H, Frank A, Peer M, Gillam EM, Guengerich FP, Unger M (2007) Plant Biotechnol J 5(1): 185-91
    › Primary publication · 17207267 (PubMed)
  264. Multiple sequential steps involved in the binding of inhibitors to cytochrome P450 3A4. Isin EM, Guengerich FP (2007) J Biol Chem 282(9): 6863-74
    › Primary publication · 17200113 (PubMed)
  265. Biosynthesis of new indigoid inhibitors of protein kinases using recombinant cytochrome P450 2A6. Wu ZL, Aryal P, Lozach O, Meijer L, Guengerich FP (2005) Chem Biodivers 2(1): 51-65
    › Primary publication · 17191919 (PubMed)
  266. Inter-individual variation of cytochrome P4502J2 expression and catalytic activities in liver microsomes from Japanese and Caucasian populations. Yamazaki H, Okayama A, Imai N, Guengerich FP, Shimizu M (2006) Xenobiotica 36(12): 1201-9
    › Primary publication · 17162467 (PubMed)
  267. Translesion synthesis past the C8- and N2-deoxyguanosine adducts of the dietary mutagen 2-Amino-3-methylimidazo[4,5-f]quinoline in the NarI recognition sequence by prokaryotic DNA polymerases. Stover JS, Chowdhury G, Zang H, Guengerich FP, Rizzo CJ (2006) Chem Res Toxicol 19(11): 1506-17
    › Primary publication · 17112239 (PubMed) · PMC3150502 (PubMed Central)
  268. Sulfolobus solfataricus DNA polymerase Dpo4 is partially inhibited by "wobble" pairing between O6-methylguanine and cytosine, but accurate bypass is preferred. Eoff RL, Irimia A, Egli M, Guengerich FP (2007) J Biol Chem 282(2): 1456-67
    › Primary publication · 17105728 (PubMed)
  269. Understanding electron transport systems of Streptomyces cytochrome P450. Chun YJ, Shimada T, Waterman MR, Guengerich FP (2006) Biochem Soc Trans 34(Pt 6): 1183-5
    › Primary publication · 17073781 (PubMed)
  270. Activation of aminophenylnorharman, aminomethylphenylnorharman and aminophenylharman to genotoxic metabolites by human N-acetyltransferases and cytochrome P450 enzymes expressed in Salmonella typhimurium umu tester strains. Oda Y, Totsuka Y, Wakabayashi K, Guengerich FP, Shimada T (2006) Mutagenesis 21(6): 411-6
    › Primary publication · 17067997 (PubMed)
  271. Translesion synthesis across O6-alkylguanine DNA adducts by recombinant human DNA polymerases. Choi JY, Chowdhury G, Zang H, Angel KC, Vu CC, Peterson LA, Guengerich FP (2006) J Biol Chem 281(50): 38244-56
    › Primary publication · 17050527 (PubMed)
  272. A malleable catalyst dominates the metabolism of drugs. Guengerich FP (2006) Proc Natl Acad Sci U S A 103(37): 13565-6
    › Primary publication · 16954196 (PubMed) · PMC1564253 (PubMed Central)
  273. Limited reactivity of formyl chloride with glutathione and relevance to metabolism and toxicity of dichloromethane. Watanabe K, Guengerich FP (2006) Chem Res Toxicol 19(8): 1091-6
    › Primary publication · 16918250 (PubMed)
  274. Exploiting Streptomyces coelicolor A3(2) P450s as a model for application in drug discovery. Lamb DC, Guengerich FP, Kelly SL, Waterman MR (2006) Expert Opin Drug Metab Toxicol 2(1): 27-40
    › Primary publication · 16863466 (PubMed)
  275. Biochemical basis of genotoxicity of heterocyclic arylamine food mutagens: Human DNA polymerase eta selectively produces a two-base deletion in copying the N2-guanyl adduct of 2-amino-3-methylimidazo[4,5-f]quinoline but not the C8 adduct at the NarI G3 site. Choi JY, Stover JS, Angel KC, Chowdhury G, Rizzo CJ, Guengerich FP (2006) J Biol Chem 281(35): 25297-306
    › Primary publication · 16835218 (PubMed)
  276. Translesion synthesis across 1,N2-ethenoguanine by human DNA polymerases. Choi JY, Zang H, Angel KC, Kozekov ID, Goodenough AK, Rizzo CJ, Guengerich FP (2006) Chem Res Toxicol 19(6): 879-86
    › Primary publication · 16780368 (PubMed) · PMC3130186 (PubMed Central)
  277. Translesion synthesis across polycyclic aromatic hydrocarbon diol epoxide adducts of deoxyadenosine by Sulfolobus solfataricus DNA polymerase Dpo4. Zang H, Chowdhury G, Angel KC, Harris TM, Guengerich FP (2006) Chem Res Toxicol 19(6): 859-67
    › Primary publication · 16780366 (PubMed)
  278. Translesion synthesis across bulky N2-alkyl guanine DNA adducts by human DNA polymerase kappa. Choi JY, Angel KC, Guengerich FP (2006) J Biol Chem 281(30): 21062-21072
    › Primary publication · 16751196 (PubMed)
  279. Purification of cytochromes P450: products of bacterial recombinant expression systems. Guengerich FP, Martin MV (2006) Methods Mol Biol : 31-7
    › Primary publication · 16719372 (PubMed)
  280. Chemical reactivity as a tool to study carcinogenicity: reaction between chloroethylene oxide and guanine. Bren U, Zupan M, Guengerich FP, Mavri J (2006) J Org Chem 71(11): 4078-84
    › Primary publication · 16709046 (PubMed)
  281. Calcium is a cofactor of polymerization but inhibits pyrophosphorolysis by the Sulfolobus solfataricus DNA polymerase Dpo4. Irimia A, Zang H, Loukachevitch LV, Eoff RL, Guengerich FP, Egli M (2006) Biochemistry 45(19): 5949-56
    › Primary publication · 16681366 (PubMed)
  282. Kinetic deuterium isotope effects for 7-alkoxycoumarin O-dealkylation reactions catalyzed by human cytochromes P450 and in liver microsomes. Rate-limiting C-H bond breaking in cytochrome P450 1A2 substrate oxidation. Kim KH, Isin EM, Yun CH, Kim DH, Guengerich FP (2006) FEBS J 273(10): 2223-31
    › Primary publication · 16649998 (PubMed)
  283. Search for an association between the human CYP1A2 genotype and CYP1A2 metabolic phenotype. Jiang Z, Dragin N, Jorge-Nebert LF, Martin MV, Guengerich FP, Aklillu E, Ingelman-Sundberg M, Hammons GJ, Lyn-Cook BD, Kadlubar FF, Saldana SN, Sorter M, Vinks AA, Nassr N, von Richter O, Jin L, Nebert DW (2006) Pharmacogenet Genomics 16(5): 359-67
    › Primary publication · 16609368 (PubMed)
  284. Cytochrome P450s and other enzymes in drug metabolism and toxicity. Guengerich FP (2006) AAPS J 8(1): E101-11
    › Primary publication · 16584116 (PubMed) · PMC2751428 (PubMed Central)
  285. Recombinant enzymes overexpressed in bacteria show broad catalytic specificity of human cytochrome P450 2W1 and limited activity of human cytochrome P450 2S1. Wu ZL, Sohl CD, Shimada T, Guengerich FP (2006) Mol Pharmacol 69(6): 2007-14
    › Primary publication · 16551781 (PubMed)
  286. Kinetic evidence for inefficient and error-prone bypass across bulky N2-guanine DNA adducts by human DNA polymerase iota. Choi JY, Guengerich FP (2006) J Biol Chem 281(18): 12315-24
    › Primary publication · 16527824 (PubMed)
  287. Inhibition of human cytochrome P450 1A1-, 1A2-, and 1B1-mediated activation of procarcinogens to genotoxic metabolites by polycyclic aromatic hydrocarbons. Shimada T, Guengerich FP (2006) Chem Res Toxicol 19(2): 288-94
    › Primary publication · 16485905 (PubMed)
  288. Kinetics and thermodynamics of ligand binding by cytochrome P450 3A4. Isin EM, Guengerich FP (2006) J Biol Chem 281(14): 9127-36
    › Primary publication · 16467307 (PubMed)
  289. Interactions of carcinogen-bound DNA with individual DNA polymerases. Guengerich FP (2006) Chem Rev 106(2): 420-52
    › Primary publication · 16464013 (PubMed)
  290. Activation of alkyl halides by glutathione transferases. Guengerich FP (2005) Methods Enzymol : 342-53
    › Primary publication · 16399396 (PubMed)
  291. Heterologous expression, purification, and properties of human cytochrome P450 27C1. Wu ZL, Bartleson CJ, Ham AJ, Guengerich FP (2006) Arch Biochem Biophys 445(1): 138-46
    › Primary publication · 16360114 (PubMed)
  292. Efficient and high fidelity incorporation of dCTP opposite 7,8-dihydro-8-oxodeoxyguanosine by Sulfolobus solfataricus DNA polymerase Dpo4. Zang H, Irimia A, Choi JY, Angel KC, Loukachevitch LV, Egli M, Guengerich FP (2006) J Biol Chem 281(4): 2358-72
    › Primary publication · 16306039 (PubMed)
  293. Site specific synthesis and polymerase bypass of oligonucleotides containing a 6-hydroxy-3,5,6,7-tetrahydro-9H-imidazo[1,2-a]purin-9-one base, an intermediate in the formation of 1,N2-etheno-2'-deoxyguanosine. Goodenough AK, Kozekov ID, Zang H, Choi JY, Guengerich FP, Harris TM, Rizzo CJ (2005) Chem Res Toxicol 18(11): 1701-14
    › Primary publication · 16300379 (PubMed) · PMC3135970 (PubMed Central)
  294. Role of active site water molecules and substrate hydroxyl groups in oxygen activation by cytochrome P450 158A2: a new mechanism of proton transfer. Zhao B, Guengerich FP, Voehler M, Waterman MR (2005) J Biol Chem 280(51): 42188-97
    › Primary publication · 16239228 (PubMed)
  295. How I became a biochemist. Guengerich FP (2005) IUBMB Life 57(10): 705-7
    › Primary publication · 16223712 (PubMed)
  296. Expansion of substrate specificity of cytochrome P450 2A6 by random and site-directed mutagenesis. Wu ZL, Podust LM, Guengerich FP (2005) J Biol Chem 280(49): 41090-100
    › Primary publication · 16215230 (PubMed)
  297. Analysis of coumarin 7-hydroxylation activity of cytochrome P450 2A6 using random mutagenesis. Kim D, Wu ZL, Guengerich FP (2005) J Biol Chem 280(48): 40319-27
    › Primary publication · 16207711 (PubMed)
  298. Function of human cytochrome P450s: characterization of the orphans. Guengerich FP, Wu ZL, Bartleson CJ (2005) Biochem Biophys Res Commun 338(1): 465-9
    › Primary publication · 16126164 (PubMed)
  299. Adduct size limits efficient and error-free bypass across bulky N2-guanine DNA lesions by human DNA polymerase eta. Choi JY, Guengerich FP (2005) J Mol Biol 352(1): 72-90
    › Primary publication · 16061253 (PubMed)
  300. Modified nicotine metabolism in transgenic tobacco plants expressing the human cytochrome P450 2A6 cDNA. Dueckershoff K, Unger M, Frank A, Gillam EM, Guengerich FP, Warzecha H (2005) FEBS Lett 579(11): 2480-4
    › Primary publication · 15848192 (PubMed)
  301. Non-specific inhibition of human cytochrome P450-catalyzed reactions by hemin. Kim EY, Kim JS, Kim MY, Koh WS, Guengerich FP, Yun CH (2004) Toxicol Lett 153(2): 239-46
    › Primary publication · 15451555 (PubMed)
  302. Expression of cytochromes P450 1A1 and 1B1 in human lung from smokers, non-smokers, and ex-smokers. Kim JH, Sherman ME, Curriero FC, Guengerich FP, Strickland PT, Sutter TR (2004) Toxicol Appl Pharmacol 199(3): 210-9
    › Primary publication · 15364538 (PubMed)
  303. Human cytochromes P450 1A1 and 1B1 catalyze ring oxidation but not nitroreduction of environmental pollutant mononitropyrene isomers in primary cultures of human breast cells and cultured MCF-10A and MCF-7 cell lines. Sun YW, Guengerich FP, Sharma AK, Boyiri T, Amin S, el-Bayoumy K (2004) Chem Res Toxicol 17(8): 1077-85
    › Primary publication · 15310239 (PubMed)
  304. O6-alkylguanine-DNA alkyltransferase has opposing effects in modulating the genotoxicity of dibromomethane and bromomethyl acetate. Liu L, Williams KM, Guengerich FP, Pegg AE (2004) Chem Res Toxicol 17(6): 742-52
    › Primary publication · 15206895 (PubMed)
  305. Different in vitro metabolism of paclitaxel and docetaxel in humans, rats, pigs, and minipigs. Vaclavikova R, Soucek P, Svobodova L, Anzenbacher P, Simek P, Guengerich FP, Gut I (2004) Drug Metab Dispos 32(6): 666-74
    › Primary publication · 15155559 (PubMed)
  306. Aryl hydrocarbon receptor activation and cytochrome P450 1A induction by the mitogen-activated protein kinase inhibitor U0126 in hepatocytes. Andrieux L, Langouët S, Fautrel A, Ezan F, Krauser JA, Savouret JF, Guengerich FP, Baffet G, Guillouzo A (2004) Mol Pharmacol 65(4): 934-43
    › Primary publication · 15044623 (PubMed)
  307. The human CYP1A1 gene is regulated in a developmental and tissue-specific fashion in transgenic mice. Galijatovic A, Beaton D, Nguyen N, Chen S, Bonzo J, Johnson R, Maeda S, Karin M, Guengerich FP, Tukey RH (2004) J Biol Chem 279(23): 23969-76
    › Primary publication · 15037607 (PubMed)
  308. Characterization of a mutagenic DNA adduct formed from 1,2-dibromoethane by O6-alkylguanine-DNA alkyltransferase. Liu L, Hachey DL, Valadez G, Williams KM, Guengerich FP, Loktionova NA, Kanugula S, Pegg AE (2004) J Biol Chem 279(6): 4250-9
    › Primary publication · 14645247 (PubMed)
  309. Stability of cytochrome P450 enzymes in human liver samples stored in different tissue preservation buffers. Nishimura Y, Kurata N, Hanna IH, Guengerich FP, Yasuhara H (2002) Res Commun Mol Pathol Pharmacol 111(1-4): 13-26
    › Primary publication · 14632311 (PubMed)
  310. Decreased coumarin 7-hydroxylase activities and CYP2A6 expression levels in humans caused by genetic polymorphism in CYP2A6 promoter region (CYP2A6*9). Kiyotani K, Yamazaki H, Fujieda M, Iwano S, Matsumura K, Satarug S, Ujjin P, Shimada T, Guengerich FP, Parkinson A, Honda G, Nakagawa K, Ishizaki T, Kamataki T (2003) Pharmacogenetics 13(11): 689-95
    › Primary publication · 14583682 (PubMed)
  311. Hydroperoxy-10,12-octadecadienoic acid stimulates cytochrome P450 3A protein aggregation by a mechanism that is inhibited by substrate. Kimzey AL, Weitz KK, Guengerich FP, Zangar RC (2003) Biochemistry 42(43): 12691-9
    › Primary publication · 14580217 (PubMed)
  312. Rate-limiting steps in cytochrome P450 catalysis. Guengerich FP (2002) Biol Chem 383(10): 1553-64
    › Primary publication · 12452431 (PubMed)
  313. Metabolism of heterocyclic aromatic amines by human hepatocytes and cytochrome P4501A2. Turesky RJ, Guengerich FP, Guillouzo A, Langouët S (2002) Mutat Res : 187-95
    › Primary publication · 12351158 (PubMed)
  314. Paradoxical enhancement of the toxicity of 1,2-dibromoethane by O6-alkylguanine-DNA alkyltransferase. Liu L, Pegg AE, Williams KM, Guengerich FP (2002) J Biol Chem 277(40): 37920-8
    › Primary publication · 12151404 (PubMed)
  315. 1,N(2)-ethenoguanine, a mutagenic DNA adduct, is a primary substrate of Escherichia coli mismatch-specific uracil-DNA glycosylase and human alkylpurine-DNA-N-glycosylase. Saparbaev M, Langouët S, Privezentzev CV, Guengerich FP, Cai H, Elder RH, Laval J (2002) J Biol Chem 277(30): 26987-93
    › Primary publication · 12016206 (PubMed)
  316. Roles of NADPH-P450 reductase and apo- and holo-cytochrome b5 on xenobiotic oxidations catalyzed by 12 recombinant human cytochrome P450s expressed in membranes of Escherichia coli. Yamazaki H, Nakamura M, Komatsu T, Ohyama K, Hatanaka N, Asahi S, Shimada N, Guengerich FP, Shimada T, Nakajima M, Yokoi T (2002) Protein Expr Purif 24(3): 329-37
    › Primary publication · 11922748 (PubMed)
  317. Exploiting the versatility of human cytochrome P450 enzymes: the promise of blue roses from biotechnology. Gillam EM, Guengerich FP (2001) IUBMB Life 52(6): 271-7
    › Primary publication · 11895075 (PubMed)
  318. The alkaloid rutaecarpine is a selective inhibitor of cytochrome P450 1A in mouse and human liver microsomes. Ueng YF, Jan WC, Lin LC, Chen TL, Guengerich FP, Chen CF (2002) Drug Metab Dispos 30(3): 349-53
    › Primary publication · 11854157 (PubMed)
  319. Pig and minipig cytochromes P450. Anzenbacher P, Anzerbacherová E, Zuber R, Soucek P, Guengerich F (2002) Drug Metab Dispos 30(1): 100-2
    › Primary publication · 11776951 (PubMed)
  320. Metabolism of the food mutagen 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in human hepatocytes. Langouët S, Welti DH, Kerriguy N, Fay LB, Guengerich FP, Guillouzo A, Turesky RJ (2001) Adv Exp Med Biol : 459-62
    › Primary publication · 11764981 (PubMed)
  321. Minipig cytochrome P450 3A, 2A and 2C enzymes have similar properties to human analogs. Soucek P, Zuber R, Anzenbacherová E, Anzenbacher P, Guengerich FP (2001) BMC Pharmacol : 11
    › Primary publication · 11737866 (PubMed) · PMC60991 (PubMed Central)
  322. A new selective and potent inhibitor of human cytochrome P450 1B1 and its application to antimutagenesis. Chun YJ, Kim S, Kim D, Lee SK, Guengerich FP (2001) Cancer Res 61(22): 8164-70
    › Primary publication · 11719446 (PubMed)
  323. Metabolic activation of carcinogenic 1-nitropyrene by human cytochrome P450 1B1 in Salmonella typhimurium strain expressing an O-acetyltransferase in SOS/umu assay. Hatanaka N, Yamazaki H, Oda Y, Guengerich FP, Nakajima M, Yokoi T (2001) Mutat Res 497(1-2): 223-33
    › Primary publication · 11525925 (PubMed)
  324. Metabolic activation of polycyclic aromatic hydrocarbons and other procarcinogens by cytochromes P450 1A1 and P450 1B1 allelic variants and other human cytochromes P450 in Salmonella typhimurium NM2009. Shimada T, Oda Y, Gillam EM, Guengerich FP, Inoue K (2001) Drug Metab Dispos 29(9): 1176-82
    › Primary publication · 11502724 (PubMed)
  325. Specificity of 17beta-oestradiol and benzo[a]pyrene oxidation by polymorphic human cytochrome P4501B1 variants substituted at residues 48, 119 and 432. Shimada T, Watanabe J, Inoue K, Guengerich FP, Gillam EM (2001) Xenobiotica 31(3): 163-76
    › Primary publication · 11465393 (PubMed)
  326. Regioselective differences in C(8)- and N-oxidation of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline by human and rat liver microsomes and cytochromes P450 1A2. Turesky RJ, Parisod V, Huynh-Ba T, Langouët S, Guengerich FP (2001) Chem Res Toxicol 14(7): 901-11
    › Primary publication · 11453738 (PubMed)
  327. Stimulation of cytochrome P450 reactions by apo-cytochrome b5: evidence against transfer of heme from cytochrome P450 3A4 to apo-cytochrome b5 or heme oxygenase. Yamazaki H, Shimada T, Martin MV, Guengerich FP (2001) J Biol Chem 276(33): 30885-91
    › Primary publication · 11413149 (PubMed)
  328. Metabolic activation of benzo[c]phenanthrene by cytochrome P450 enzymes in human liver and lung. Baum M, Amin S, Guengerich FP, Hecht SS, Köhl W, Eisenbrand G (2001) Chem Res Toxicol 14(6): 686-93
    › Primary publication · 11409939 (PubMed)
  329. Metabolic activation of heterocyclic amines and other procarcinogens in Salmonella typhimurium umu tester strains expressing human cytochrome P4501A1, 1A2, 1B1, 2C9, 2D6, 2E1, and 3A4 and human NADPH-P450 reductase and bacterial O-acetyltransferase. Oda Y, Aryal P, Terashita T, Gillam EM, Guengerich FP, Shimada T (2001) Mutat Res 492(1-2): 81-90
    › Primary publication · 11377247 (PubMed)
  330. The contribution of UDP-glucuronosyltransferase 1A9 on CYP1A2-mediated genotoxicity by aromatic and heterocyclic amines. Yueh MF, Nguyen N, Famourzadeh M, Strassburg CP, Oda Y, Guengerich FP, Tukey RH (2001) Carcinogenesis 22(6): 943-50
    › Primary publication · 11375903 (PubMed)
  331. Characterization of (+/-)-bufuralol hydroxylation activities in liver microsomes of Japanese and Caucasian subjects genotyped for CYP2D6. Shimada T, Tsumura F, Yamazaki H, Guengerich FP, Inoue K (2001) Pharmacogenetics 11(2): 143-56
    › Primary publication · 11266079 (PubMed)
  332. Metabolism of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in human hepatocytes: 2-amino-3-methylimidazo[4,5-f]quinoxaline-8-carboxylic acid is a major detoxification pathway catalyzed by cytochrome P450 1A2. Langouët S, Welti DH, Kerriguy N, Fay LB, Huynh-Ba T, Markovic J, Guengerich FP, Guillouzo A, Turesky RJ (2001) Chem Res Toxicol 14(2): 211-21
    › Primary publication · 11258970 (PubMed)
  333. Differential induction of rat hepatic cytochromes P450 3A1, 3A2, 2B1, 2B2, and 2E1 in response to pyridine treatment. Kim H, Putt DA, Zangar RC, Wolf CR, Guengerich FP, Edwards RJ, Hollenberg PF, Novak RF (2001) Drug Metab Dispos 29(3): 353-60
    › Primary publication · 11181506 (PubMed)
  334. Metabolism of ochratoxin A: absence of formation of genotoxic derivatives by human and rat enzymes. Gautier J, Richoz J, Welti DH, Markovic J, Gremaud E, Guengerich FP, Turesky RJ (2001) Chem Res Toxicol 14(1): 34-45
    › Primary publication · 11170506 (PubMed)
  335. Bioactivation of diesel exhaust particle extracts and their major nitrated polycyclic aromatic hydrocarbon components, 1-nitropyrene and dinitropyrenes, by human cytochromes P450 1A1, 1A2, and 1B1. Yamazaki H, Hatanaka N, Kizu R, Hayakawa K, Shimada N, Guengerich FP, Nakajima M, Yokoi T (2000) Mutat Res 472(1-2): 129-38
    › Primary publication · 11113705 (PubMed)
  336. Response letter from ACSH phthalate panel. Koop CE, Juberg DR, Benedek EP, Brecher RW, Brent RL, Cole P, Corn M, Covello V, Downes TW, Gad SC, Gold LS, Guengerich FP, Higginson J, Konemann WH, Lamb IV JC, Lioy PJ, Thompson KM (2000) MedGenMed 2(2): E20
    › Primary publication · 11104466 (PubMed)
  337. A Scientific Evaluation of Health Effects of Two Plasticizers Used in Medical Devices and Toys: A Report from the American Council on Science and Health. Koop CE, Juberg DR, Benedek EP, Brecher RW, Brent RL, Cole P, Corn M, Covello V, Downes TW, Gad SC, Gold LS, Guengerich FP, Higginson J, Konemann WH, Lamb IV, Lioy PJ, Lundberg GD, Thompson KM (1999) MedGenMed : E14
    › Primary publication · 11104416 (PubMed)
  338. Oxidation of indole by cytochrome P450 enzymes. Gillam EM, Notley LM, Cai H, De Voss JJ, Guengerich FP (2000) Biochemistry 39(45): 13817-24
    › Primary publication · 11076521 (PubMed)
  339. Formation of a dihydroxy metabolite of phenytoin in human liver microsomes/cytosol: roles of cytochromes P450 2C9, 2C19, and 3A4. Komatsu T, Yamazaki H, Asahi S, Gillam EM, Guengerich FP, Nakajima M, Yokoi T (2000) Drug Metab Dispos 28(11): 1361-8
    › Primary publication · 11038165 (PubMed)
  340. Roles of NADPH-P450 reductase in the O-deethylation of 7-ethoxycoumarin by recombinant human cytochrome P450 1B1 variants in Escherichia coli. Shimada T, Tsumura F, Gillam EM, Guengerich FP, Inoue K (2000) Protein Expr Purif 20(1): 73-80
    › Primary publication · 11035953 (PubMed)
  341. Use of genetically engineered Salmonella typhimurium OY1002/1A2 strain coexpressing human cytochrome P450 1A2 and NADPH-cytochrome P450 reductase and bacterial O-acetyltransferase in SOS/umu assay. Aryal P, Terashita T, Guengerich FP, Shimada T, Oda Y (2000) Environ Mol Mutagen 36(2): 121-6
    › Primary publication · 11013410 (PubMed)
  342. Cytochromes P450 are expressed in proliferating cells in Barrett's metaplasia. Hughes SJ, Morse MA, Weghorst CM, Kim H, Watkins PB, Guengerich FP, Orringer MB, Beer DG (1999) Neoplasia 1(2): 145-53
    › Primary publication · 10933049 (PubMed) · PMC1508133 (PubMed Central)
  343. Formation and metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol enantiomers in vitro in mouse, rat and human tissues. Upadhyaya P, Carmella SG, Guengerich FP, Hecht SS (2000) Carcinogenesis 21(6): 1233-8
    › Primary publication · 10837015 (PubMed)
  344. Inhibition of human cytochrome P450 enzymes by 1,2-dithiole-3-thione, oltipraz and its derivatives, and sulforaphane. Langouët S, Furge LL, Kerriguy N, Nakamura K, Guillouzo A, Guengerich FP (2000) Chem Res Toxicol 13(4): 245-52
    › Primary publication · 10775323 (PubMed)
  345. Molecular modelling of CYP1 family enzymes CYP1A1, CYP1A2, CYP1A6 and CYP1B1 based on sequence homology with CYP102. Lewis DF, Lake BG, George SG, Dickins M, Eddershaw PJ, Tarbit MH, Beresford AP, Goldfarb PS, Guengerich FP (1999) Toxicology 139(1-2): 53-79
    › Primary publication · 10614688 (PubMed)
  346. Formation of indigo by recombinant mammalian cytochrome P450. Gillam EM, Aguinaldo AM, Notley LM, Kim D, Mundkowski RG, Volkov AA, Arnold FH, Soucek P, DeVoss JJ, Guengerich FP (1999) Biochem Biophys Res Commun 265(2): 469-72
    › Primary publication · 10558891 (PubMed)
  347. Oxidation of troglitazone to a quinone-type metabolite catalyzed by cytochrome P-450 2C8 and P-450 3A4 in human liver microsomes. Yamazaki H, Shibata A, Suzuki M, Nakajima M, Shimada N, Guengerich FP, Yokoi T (1999) Drug Metab Dispos 27(11): 1260-6
    › Primary publication · 10534310 (PubMed)
  348. Plasmid-mediated expression of the UmuDC mutagenesis proteins in an Escherichia coli strain engineered for human cytochrome P450 1A2-catalyzed activation of aromatic amines. Josephy PD, Evans DH, Williamson V, Henry T, Guengerich FP (1999) Mutat Res 429(2): 199-208
    › Primary publication · 10526205 (PubMed)
  349. Interspecies differences in metabolism of heterocyclic aromatic amines by rat and human P450 1A2. Turesky RJ, Constable A, Fay LB, Guengerich FP (1999) Cancer Lett 143(2): 109-12
    › Primary publication · 10503887 (PubMed)
  350. Low frequency of CYP2A6 gene polymorphism as revealed by a one-step polymerase chain reaction method. Chen GF, Tang YM, Green B, Lin DX, Guengerich FP, Daly AK, Caporaso NE, Kadlubar FF (1999) Pharmacogenetics 9(3): 327-32
    › Primary publication · 10471064 (PubMed)
  351. Enhancement of cytochrome P-450 3A4 catalytic activities by cytochrome b(5) in bacterial membranes. Yamazaki H, Nakajima M, Nakamura M, Asahi S, Shimada N, Gillam EM, Guengerich FP, Shimada T, Yokoi T (1999) Drug Metab Dispos 27(9): 999-1004
    › Primary publication · 10460798 (PubMed)
  352. Resveratrol is a selective human cytochrome P450 1A1 inhibitor. Chun YJ, Kim MY, Guengerich FP (1999) Biochem Biophys Res Commun 262(1): 20-4
    › Primary publication · 10448061 (PubMed)
  353. Catalytic properties of polymorphic human cytochrome P450 1B1 variants. Shimada T, Watanabe J, Kawajiri K, Sutter TR, Guengerich FP, Gillam EM, Inoue K (1999) Carcinogenesis 20(8): 1607-13
    › Primary publication · 10426814 (PubMed)
  354. Metabolism of benzo[a]pyrene to trans-7,8-dihydroxy-7, 8-dihydrobenzo[a]pyrene by recombinant human cytochrome P450 1B1 and purified liver epoxide hydrolase. Shimada T, Gillam EM, Oda Y, Tsumura F, Sutter TR, Guengerich FP, Inoue K (1999) Chem Res Toxicol 12(7): 623-9
    › Primary publication · 10409402 (PubMed)
  355. Development of a new genotoxicity test system with Salmonella typhimurium OY1001/1A2 expressing human CYP1A2 and NADPH-P450 reductase. Aryal P, Yoshikawa K, Terashita T, Guengerich FP, Shimada T, Oda Y (1999) Mutat Res 442(2): 113-20
    › Primary publication · 10393280 (PubMed)
  356. Phospholipase D activity of cytochrome P450 in human liver endoplasmic reticulum. Yun CH, Ahn T, Guengerich FP, Yamazaki H, Shimada T (1999) Arch Biochem Biophys 367(1): 81-8
    › Primary publication · 10375402 (PubMed)
  357. Symposium overview: Characterization of xenobiotic metabolizing enzyme function using heterologous expression systems. Townsend AJ, Kiningham KK, St Clair D, Tephly TR, Morrow CS, Guengerich FP (1999) Toxicol Sci 48(2): 143-50
    › Primary publication · 10353304 (PubMed)
  358. Metabolism of benzene in human liver microsomes: individual variations in relation to CYP2E1 expression. Nedelcheva V, Gut I, Soucek P, Tichavská B, Týnkova L, Mráz J, Guengerich FP, Ingelman-Sundberg M (1999) Arch Toxicol 73(1): 33-40
    › Primary publication · 10207612 (PubMed)
  359. Comparative metabolism of 1-, 2-, and 4-nitropyrene by human hepatic and pulmonary microsomes. Chae YH, Thomas T, Guengerich FP, Fu PP, El-Bayoumy K (1999) Cancer Res 59(7): 1473-80
    › Primary publication · 10197616 (PubMed)
  360. Membrane insertion of cytochrome P450 1A2 promoted by anionic phospholipids. Ahn T, Guengerich FP, Yun CH (1998) Biochemistry 37(37): 12860-6
    › Primary publication · 9737864 (PubMed)
  361. Effects of motorcycle exhaust on cytochrome P-450-dependent monooxygenases and glutathione S-transferase in rat tissues. Ueng TH, Hwang WP, Chen RM, Wang HW, Kuo ML, Park SS, Guengerich FP (1998) J Toxicol Environ Health A 54(7): 509-27
    › Primary publication · 9726777 (PubMed)
  362. Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) metabolism in human hepatic microsomes by ipomeanol analogs--an exploratory study. Nunes MG, Desai D, Koehl W, Spratt TE, Guengerich FP, Amin S (1998) Cancer Lett 129(2): 131-8
    › Primary publication · 9719453 (PubMed)
  363. Activation of heterocyclic aromatic amines by rat and human liver microsomes and by purified rat and human cytochrome P450 1A2. Turesky RJ, Constable A, Richoz J, Varga N, Markovic J, Martin MV, Guengerich FP (1998) Chem Res Toxicol 11(8): 925-36
    › Primary publication · 9705755 (PubMed)
  364. Conformational change and activation of cytochrome P450 2B1 induced by salt and phospholipid. Yun CH, Ahn T, Guengerich FP (1998) Arch Biochem Biophys 356(2): 229-38
    › Primary publication · 9705213 (PubMed)
  365. Comparative studies on the catalytic roles of cytochrome P450 2C9 and its Cys- and Leu-variants in the oxidation of warfarin, flurbiprofen, and diclofenac by human liver microsomes. Yamazaki H, Inoue K, Chiba K, Ozawa N, Kawai T, Suzuki Y, Goldstein JA, Guengerich FP, Shimada T (1998) Biochem Pharmacol 56(2): 243-51
    › Primary publication · 9698079 (PubMed)
  366. 16Alpha-hydroxylation of estrone by human cytochrome P4503A4/5. Huang Z, Guengerich FP, Kaminsky LS (1998) Carcinogenesis 19(5): 867-72
    › Primary publication · 9635876 (PubMed)
  367. Roles of cytochromes P450 1A2 and 3A4 in the oxidation of estradiol and estrone in human liver microsomes. Yamazaki H, Shaw PM, Guengerich FP, Shimada T (1998) Chem Res Toxicol 11(6): 659-65
    › Primary publication · 9625734 (PubMed)
  368. Immunohistochemical demonstration of beta-naphthoflavone-inducible cytochrome P450 1A1/1A2 in rat intrahepatic biliary epithelial cells. Shen J, Moy JA, Green MD, Guengerich FP, Baron J (1998) Hepatology 27(6): 1483-91
    › Primary publication · 9620317 (PubMed)
  369. The dose-response model for dioxin. Byrd DM, Allen DO, Beamer RL, Besch HR, Bylund DB, Doull J, Fleming WW, Fries A, Guengerich FP, Hornbrook R, Lasagna L, Lum BK, Michaelis EK, Morgan ET, Poland A, Rozman KK, Smith JB, Swanson HI, Waddell W, Wilson JD (1998) Risk Anal 18(1): 1-2
    › Primary publication · 9556441 (PubMed)
  370. Metabolic activation of aromatic amine mutagens by simultaneous expression of human cytochrome P450 1A2, NADPH-cytochrome P450 reductase, and N-acetyltransferase in Escherichia coli. Josephy PD, Evans DH, Parikh A, Guengerich FP (1998) Chem Res Toxicol 11(1): 70-4
    › Primary publication · 9477228 (PubMed)
  371. Reconstitution premixes for assays using purified recombinant human cytochrome P450, NADPH-cytochrome P450 reductase, and cytochrome b5. Shaw PM, Hosea NA, Thompson DV, Lenius JM, Guengerich FP (1997) Arch Biochem Biophys 348(1): 107-15
    › Primary publication · 9390180 (PubMed)
  372. Detection of free radicals produced from the reaction of cytochrome P-450 with linoleic acid hydroperoxide. Rota C, Barr DP, Martin MV, Guengerich FP, Tomasi A, Mason RP (1997) Biochem J : 565-71
    › Primary publication · 9371716 (PubMed) · PMC1218956 (PubMed Central)
  373. Inhibition of human cytochrome P450-catalyzed oxidations of xenobiotics and procarcinogens by synthetic organoselenium compounds. Shimada T, El-Bayoumy K, Upadhyaya P, Sutter TR, Guengerich FP, Yamazaki H (1997) Cancer Res 57(21): 4757-64
    › Primary publication · 9354437 (PubMed)
  374. Different contributions of cytochrome P450 2C19 and 3A4 in the oxidation of omeprazole by human liver microsomes: effects of contents of these two forms in individual human samples. Yamazaki H, Inoue K, Shaw PM, Checovich WJ, Guengerich FP, Shimada T (1997) J Pharmacol Exp Ther 283(2): 434-42
    › Primary publication · 9353355 (PubMed)
  375. Expression of cytochrome P450 3A7 in Escherichia coli: effects of 5' modification and catalytic characterization of recombinant enzyme expressed in bicistronic format with NADPH-cytochrome P450 reductase. Gillam EM, Wunsch RM, Ueng YF, Shimada T, Reilly PE, Kamataki T, Guengerich FP (1997) Arch Biochem Biophys 346(1): 81-90
    › Primary publication · 9328287 (PubMed)
  376. Reconstitution of recombinant cytochrome P450 2C10(2C9) and comparison with cytochrome P450 3A4 and other forms: effects of cytochrome P450-P450 and cytochrome P450-b5 interactions. Yamazaki H, Gillam EM, Dong MS, Johnson WW, Guengerich FP, Shimada T (1997) Arch Biochem Biophys 342(2): 329-37
    › Primary publication · 9186495 (PubMed)
  377. Relationship between CYP2C9 and 2C19 genotypes and tolbutamide methyl hydroxylation and S-mephenytoin 4'-hydroxylation activities in livers of Japanese and Caucasian populations. Inoue K, Yamazaki H, Imiya K, Akasaka S, Guengerich FP, Shimada T (1997) Pharmacogenetics 7(2): 103-13
    › Primary publication · 9170147 (PubMed)
  378. Aflatoxin B1 activation in human lung. Kelly JD, Eaton DL, Guengerich FP, Coulombe RA (1997) Toxicol Appl Pharmacol 144(1): 88-95
    › Primary publication · 9169073 (PubMed)
  379. Metabolic activation of aromatic amines by human pancreas. Anderson KE, Hammons GJ, Kadlubar FF, Potter JD, Kaderlik KR, Ilett KF, Minchin RF, Teitel CH, Chou HC, Martin MV, Guengerich FP, Barone GW, Lang NP, Peterson LA (1997) Carcinogenesis 18(5): 1085-92
    › Primary publication · 9163700 (PubMed)
  380. Oxidation of xenobiotics by recombinant human cytochrome P450 1B1. Shimada T, Gillam EM, Sutter TR, Strickland PT, Guengerich FP, Yamazaki H (1997) Drug Metab Dispos 25(5): 617-22
    › Primary publication · 9152602 (PubMed)