Eric Grogan
Faculty Member
Last active: 3/11/2014


A recently recruited member of the Department of Thoracic Surgery, Eric L. Grogan, M.D., M.P.H., has also been awarded the VPSD grant. His grant entitled “Predicting Lung Cancer with a Serum Protein Test” is a translational research project that is using serum proteomics, epidemiology, and imaging techniques to predict lung cancer in patients with pulmonary nodules. “With the increasing use of Computed Tomography (CT scan), we are finding more pulmonary nodules. Most of these nodules are benign, but some are malignant and determining which ones are cancerous is challenging. Currently we use a combination of the patient’s risk factors and imaging to decide which nodules are high risk for cancer and need surgical excision. However, 20 percent of our operations on these suspicious nodules result in a benign diagnosis. This puts our patients at risk and is costly to the medical system.”
“Using a multidisciplinary approach, we have a team of basic scientists, translational scientists pulmonologists, thoracic surgeons, epidemiologists, and health economists. We are working together to develop a cost-effective blood test for patients with suspected lung cancer. Dr. Pierre Massion’s laboratory (VICC Spore Grant) has developed a simple blood test that can predict patients who have all stages of lung cancer. Using MALDI – MS techniques, they have identified a seven protein signature that is highly predictive of lung cancer. Together, we are determining the accuracy of this serum proteomic test in patients with lung nodules and are combining this serum proteomic test with the patient’s risk factors and imaging characteristics. A highly specific test will help reduce unnecessary surgery while not missing any cases of lung cancer. We are also evaluating the accuracy of this test in predicting lung cancer recurrence.”


The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. Accuracy of fluorodeoxyglucose-positron emission tomography within the clinical practice of the American College of Surgeons Oncology Group Z4031 trial to diagnose clinical stage I non-small cell lung cancer. Grogan EL, Deppen SA, Ballman KV, Andrade GM, Verdial FC, Aldrich MC, Chen CL, Decker PA, Harpole DH, Cerfolio RJ, Keenan RJ, Jones DR, D'Amico TA, Shrager JB, Meyers BF, Putnam JB (2014) Ann Thorac Surg 97(4): 1142-8
    › Primary publication · 24576597 (PubMed) · PMC4008142 (PubMed Central)
  2. Stage-adjusted lung cancer survival does not differ between low-income Blacks and Whites. Aldrich MC, Grogan EL, Munro HM, Signorello LB, Blot WJ (2013) J Thorac Oncol 8(10): 1248-54
    › Primary publication · 24457235 (PubMed) · PMC3901948 (PubMed Central)
  3. Invited commentary. Deppen SA, Grogan EL (2012) Ann Thorac Surg 93(4): 1068-9
    › Primary publication · 22450060 (PubMed)
  4. Added value of a serum proteomic signature in the diagnostic evaluation of lung nodules. Pecot CV, Li M, Zhang XJ, Rajanbabu R, Calitri C, Bungum A, Jett JR, Putnam JB, Callaway-Lane C, Deppen S, Grogan EL, Carbone DP, Worrell JA, Moons KG, Shyr Y, Massion PP (2012) Cancer Epidemiol Biomarkers Prev 21(5): 786-92
    › Primary publication · 22374995 (PubMed) · PMC3660018 (PubMed Central)
  5. Thoracic operations for pulmonary nodules are frequently not futile in patients with benign disease. Grogan EL, Weinstein JJ, Deppen SA, Putnam JB, Nesbitt JC, Lambright ES, Walker RC, Dittus RS, Massion PP (2011) J Thorac Oncol 6(10): 1720-5
    › Primary publication · 21760552 (PubMed) · PMC3712870 (PubMed Central)
  6. Successful treatment of atrioesophageal fistula by cervical esophageal ligation and decompression. St Julien J, Putnam JB, Nesbitt JC, Lambright ES, Petracek MR, Grogan EL (2011) Ann Thorac Surg 91(6): e85-6
    › Primary publication · 21619954 (PubMed) · PMC4154501 (PubMed Central)
  7. Accuracy of FDG-PET to diagnose lung cancer in a region of endemic granulomatous disease. Deppen S, Putnam JB, Andrade G, Speroff T, Nesbitt JC, Lambright ES, Massion PP, Walker R, Grogan EL (2011) Ann Thorac Surg 92(2): 428-32; discussion 433
    › Primary publication · 21592456 (PubMed) · PMC3186439 (PubMed Central)
  8. Existing general population models inaccurately predict lung cancer risk in patients referred for surgical evaluation. Isbell JM, Deppen S, Putnam JB, Nesbitt JC, Lambright ES, Dawes A, Massion PP, Speroff T, Jones DR, Grogan EL (2011) Ann Thorac Surg 91(1): 227-33; discussion 233
    › Primary publication · 21172518 (PubMed) · PMC3748597 (PubMed Central)