Qi Dai
Faculty Member
Last active: 4/26/2017


Dr. Qi Dai has over 20 years of experience in etiologic research of cancer and other chronic diseases, including dementia. Dr. Dai’s research programs focuses on evaluating gene-environment interactions in the etiology of chronic diseases and develop strategies for the personalized prevention of these diseases. Dr. Dai obtained his first R01 grant as PI in 2004 to investigate the effect of oxidative stress, antioxidants, polymorphisms of genes in detoxifying reactive oxygen species, and their interactions in the development of breast cancer. Over the years, Dr. Dai has expanded the research theme into the research area of Alzheimer’s disease.

Over the past four years Dr. Dai has been investigating a novel hypothesis regarding the interaction of magnesium and calcium and polymorphisms in magnesium and calcium re(absorption) genes in the risk of colorectal adenomas and other chronic diseases. Based on the promising finding, Dr. Dai and his team are working on three two R01 grants, a grant from the American Institute for Cancer Research (AICR), and two CTSA grants to further investigate the effect of magnesium and calcium in relation to colorectal adenoma and prostate cancer over the past two years.

The following are the ongoing research projects and those completed over the past three years.

Research Support Ongoing

1) R01 CA149633-01 (PI, Qi Dai, Chang Yu) 04/01/10 - 03/31/15
NIH/NCI: Personalized Prevention of Colorectal Cancer
Role: PI

2) R01 AT004660-02 (PI, Qi Dai) 06/01/08 - 05/31/12
NIH : Dietary Calcium and Magnesium, Genetics, and Colorectal Adenoma
Role: PI

3) AICR #08A074-REV 01/01/09 - 12/31/10
Research project: Magnesium, Calcium and Colorectal Adenoma Risk
Role: PI

4) Project supported by UL1 RR024975 (NCRR/NIH) 7/1/10 - 06/30/15
NIH (The Vanderbilt CTSA grant): Personalized Prevention of Colorectal Cancer Trial
The major goal of this project is to provide supports of clinical space and nurses for the ongoing R01 project (CA149633-01).
Role: Project Leader

5) Project supported by UL1 RR024975 (NCRR/NIH) 09/01/10 - 08/31/11
NIH (The Vanderbilt CTSA grant): Oxidative stress, Inflammation and Pathogenesis of Alzheimer's disease
Role: Project Leader

6) Project supported by UL1 RR024975 (NCRR/NIH) 07/17/08 - 07/17/11
NIH (The Vanderbilt CTSA grant): Magnesium, calcium and risk of PIN and prostate cancer
Role: Project Leader

7) R01 CA082729-07A1 (PI, Xiao-Ou Shu) 09/28/07 - 05/31/12
NCI: Cohort Study of Cancer-Inhibitory Dietary Factors in Men
The objectives of this study are to study the dietary cancer-inhibitory factors in a cohort of 67,500 men and to establish biospecimen repository for future genetic and molecular epidemiological study of cancers
Role: Co-I

8) R01 CA141307 (PI, Hua Xu) 09/03/09 - 07/31/13
NCI: An In-Silico Method for Epidemiological Studies Using Electronic Medical Records
Role: Co-I

Completed Research Projects for the Past Three Years

1) R01 CA106591-01 (PI, Qi Dai) 04/01/04 - 03/31/10
NIH: Oxidative Stress, Antioxidants, and Breast Cancer Risk
Role: PI

2) R21AG028182-01 (PI, Amy R Borenstein) 05/15/07- 02/28/10
NIA: Risk factors for brain atrophy, mild cognitive impairment and dementia in Shanghai
Role: PI of the subcontract

3) R01 CA70867 (PI, Wei Zheng) 07/16/09 - 03/31/10
NCI: Cancer Risk Reduction and Diet: A Cohort Study of Women
The major goal of this population-based prospective cohort study is to identify protective dietary factors for cancer and other chronic diseases in a cohort of 75,000 adult women.
Role: Co-I

4) R01 CA 92585 (PI, Xiao-Ou Shu) 09/1/01 - 8/31/07
NIH: Soyfood, gene polymorphisms and risk of endometrial cancer
Role: Co-I


The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. Essential Nutrient Interactions: Does Low or Suboptimal Magnesium Status Interact with Vitamin D and/or Calcium Status? Rosanoff A, Dai Q, Shapses SA (2016) Adv Nutr 7(1): 25-43
    › Primary publication · 26773013 (PubMed) · PMC4717874 (PubMed Central)
  2. Physical activity, sedentary behavior, and vitamin D metabolites. Hibler EA, Sardo Molmenti CL, Dai Q, Kohler LN, Warren Anderson S, Jurutka PW, Jacobs ET (2016) Bone : 248-255
    › Primary publication · 26620084 (PubMed) · PMC4795004 (PubMed Central)
  3. Dietary magnesium, calcium:magnesium ratio and risk of reflux oesophagitis, Barrett's oesophagus and oesophageal adenocarcinoma: a population-based case-control study. Dai Q, Cantwell MM, Murray LJ, Zheng W, Anderson LA, Coleman HG, FINBAR study group (2016) Br J Nutr 115(2): 342-50
    › Primary publication · 26563986 (PubMed)
  4. Polyunsaturated fat intake and mortality in non-statin users, is there an independent relationship? The authors reply. Kiage JN, Sampson UK, Lipworth L, Fazio S, Mensah GA, Yu Q, Munro H, Akwo EA, Dai Q, Blot WJ, Kabagambe EK (2016) Nutr Metab Cardiovasc Dis 26(1): 78-9
    › Primary publication · 26552741 (PubMed) · PMC4807849 (PubMed Central)
  5. Calcium/magnesium intake ratio, but not magnesium intake, interacts with genetic polymorphism in relation to colorectal neoplasia in a two-phase study. Zhu X, Shrubsole MJ, Ness RM, Hibler EA, Cai Q, Long J, Chen Z, Li G, Jiang M, Hou L, Kabagambe EK, Zhang B, Smalley WE, Edwards TL, Giovannucci EL, Zheng W, Dai Q (2016) Mol Carcinog 55(10): 1449-57
    › Primary publication · 26333203 (PubMed) · PMC4775445 (PubMed Central)
  6. Intake of polyunsaturated fat in relation to mortality among statin users and non-users in the Southern Community Cohort Study. Kiage JN, Sampson UK, Lipworth L, Fazio S, Mensah GA, Yu Q, Munro H, Akwo EA, Dai Q, Blot WJ, Kabagambe EK (2015) Nutr Metab Cardiovasc Dis 25(11): 1016-24
    › Primary publication · 26298428 (PubMed) · PMC4637133 (PubMed Central)
  7. Blood Telomere Length Attrition and Cancer Development in the Normative Aging Study Cohort. Hou L, Joyce BT, Gao T, Liu L, Zheng Y, Penedo FJ, Liu S, Zhang W, Bergan R, Dai Q, Vokonas P, Hoxha M, Schwartz J, Baccarelli A (2015) EBioMedicine 2(6): 591-6
    › Primary publication · 26288820 (PubMed) · PMC4535161 (PubMed Central)
  8. Longitudinal Study of DNA Methylation of Inflammatory Genes and Cancer Risk. Joyce BT, Gao T, Liu L, Zheng Y, Liu S, Zhang W, Penedo F, Dai Q, Schwartz J, Baccarelli AA, Hou L (2015) Cancer Epidemiol Biomarkers Prev 24(10): 1531-8
    › Primary publication · 26265203 (PubMed) · PMC4592468 (PubMed Central)
  9. Are dietary antioxidant intake indices correlated to oxidative stress and inflammatory marker levels? Luu HN, Wen W, Li H, Dai Q, Yang G, Cai Q, Xiang YB, Gao YT, Zheng W, Shu XO (2015) Antioxid Redox Signal 22(11): 951-9
    › Primary publication · 25602689 (PubMed) · PMC4376488 (PubMed Central)
  10. The isoprostanes--25 years later. Milne GL, Dai Q, Roberts LJ (2015) Biochim Biophys Acta 1851(4): 433-45
    › Primary publication · 25449649 (PubMed) · PMC5404383 (PubMed Central)
  11. Calcium intake and ion transporter genetic polymorphisms interact in human colorectal neoplasia risk in a 2-phase study. Zhu X, Liang J, Shrubsole MJ, Ness RM, Cai Q, Long J, Chen Z, Li G, Wiese D, Zhang B, Smalley WE, Edwards TL, Giovannucci E, Zheng W, Dai Q (2014) J Nutr 144(11): 1734-41
    › Primary publication · 25165391 (PubMed) · PMC4195417 (PubMed Central)
  12. Validating drug repurposing signals using electronic health records: a case study of metformin associated with reduced cancer mortality. Xu H, Aldrich MC, Chen Q, Liu H, Peterson NB, Dai Q, Levy M, Shah A, Han X, Ruan X, Jiang M, Li Y, Julien JS, Warner J, Friedman C, Roden DM, Denny JC (2015) J Am Med Inform Assoc 22(1): 179-91
    › Primary publication · 25053577 (PubMed) · PMC4433365 (PubMed Central)
  13. Urinary biomarkers of oxidative stress and breast cancer survival. Nechuta S, Cai Q, Zheng Y, Milne GL, Cai H, Dai Q, Yang G, Zheng W, Lu W, Shu XO (2014) Cancer Causes Control 25(6): 701-7
    › Primary publication · 24820618 (PubMed) · PMC4031460 (PubMed Central)
  14. Associations of reproductive time events and intervals with breast cancer risk: a report from the Shanghai Breast Cancer Study. Huang Z, Beeghly-Fadiel A, Gao YT, Zheng Y, Dai Q, Lu W, Zheng W, Shu XO (2014) Int J Cancer 135(1): 186-95
    › Primary publication · 24323821 (PubMed) · PMC4591050 (PubMed Central)