Research projects in the Cover laboratory are focused on
investigating molecular mechanisms by which pathogenic bacteria
cause disease in humans. We are particularly interested in the
bacterium Helicobacter pylori and its role as a causative agent of
stomach cancer. H. pylori is the only bacterial pathogen that
commonly causes cancer in humans and has been designated as a Class
I carcinogen by the World Health Organization. H. pylori colonizes
the stomach in about half of the global population, and stomach
cancer is the third leading cause of cancer mortality
worldwide.
Examples of projects currently underway in the lab include (i)
investigation of two secreted H. pylori toxins (VacA and CagA),
(ii) investigation of the H. pylori type IV secretion system that
delivers CagA into gastric epithelial cells, (iii) investigation of
dietary composition as a determinant of gastric cancer risk, and
(iv) identification of strain-specific H. pylori constituents that
contribute to gastric cancer pathogenesis.
Lab website: https://my.vanderbilt.edu/coverlab/
The following timeline graph is generated from all co-authored publications.
Featured publications are shown below:View all affiliations
- Vanderbilt-Ingram Cancer Center
Faculty Member
Vanderbilt University School of Medicine
Division of Infectious Diseases A2200 Medical Center North
Nashville, TN 37232
U.S.
615-343-8753 (p)
MeSH terms are retrieved from PubMed records. Learn more.
Key: MeSH Term Keyword
Amidohydrolases Antigenic Variation Bacteria Bacteria-host interactions Bacterial protein toxins Bacterial virulence determinants Cancer CD8-Positive T-Lymphocytes Cell Cycle Child Connexin 43 Cricetulus Cyclins DNA, Bacterial European Continental Ancestry Group Evasion of host defenses Gastric cancer Gastric Mucosa Genomics Genomics H(+)-K(+)-Exchanging ATPase Helicobacter pylori Hydrogen Immunoglobulin G Immunoglobulin Variable Region Immunology Infectious disease Kinetics Lactic Acid Luminescent Proteins Microbiology Microscopy, Electron, Scanning Mitogen-Activated Protein Kinase 1 Molecular Epidemiology Mucous Membrane Natural Killer T-Cells Neutral Red Nucleic Acid Hybridization Pathogenesis of bacterial infections Peptidomimetics Protein Domains Protein structure Quinazolines src-Family Kinases Yersinia Infections