Profile

The research interests of this laboratory are aimed at the investigation of biological processes involving the synthesis, modification, storage and degradation of certain peptides and proteins using modern mass spectrometric methods of analysis to follow molecular events. In recent years there has been a great amount of interest in investigating the biochemical events involved in the metabolism of peptides, primarily in the brain and gut of mammals, encompassing the enzymatic breakdown of these peptides, their production from peptide and protein precursors, and the disruption of these processes by certain xenobiotics. Modern mass spectrometric techniques are used in these studies, including electrospray and matrix-assisted laser desorption ionization mass spectrometry. This research is generally carried out with two experimental approaches.

The first involves in vivo metabolic studies in live animals (rats) using microdialysis sampling procedures together with molecular identification and quantitation by electrospray tandem mass spectrometry. This experimental approach allows us to measure metabolic events that occur in freely moving animals at a level of 50-100 attomoles in the tissue dialysate. Integrated technology for microdialysis/mass spectrometry utilizes quadrupole mass spectrometry (MS/MS) and micro-electrospray ionization (micro-ESI) for very high sensitivity measurements. The micro-ESI source has been optimized to produce ions from the electrospray process at sub-microliter per min flow rates. The application of combined microdialysis/ESI mass spectrometry is ongoing in four areas, i) Investigation of the kinetics and quantitative aspects of the in vivo metabolism of the neuropeptides and enkephalin neuropeptides, ii) Studies of the kinetics and differential processing of opioid peptide fragment precursors in vivo, iii) Investigation of the in vivo quantitative production and enzymatic degradation of N-acetylaspartyl-glutamate in seizure disorders using a rat model, and iv) Development and measurements of in vivo drug pharmacokinetics, using the drugs haloperidol, valproic acid, cocaine, amphetamine, and the new GABA antagonist n-butyl-3 aminopropylphosphinic acid.

The second experimental approach used in the study of cellular peptide metabolism utilizes new molecular imaging technology that is being developed in our lab. This method involves molecular mapping of animal tissue through the production of ion images obtained from the analysis of mammalian tissue slices by matrix-assisted laser desorption mass spectrometry (MALDI MS)12. This technique permits a tissue section to be mapped in multiple molecular weight values, localizing the molecules in an X, Y coordinate representation of the sample. Ion images are produced by repetitive exposure of the sample to the laser beam, where adjacent spots are irradiated, resulting in an ordered array of mass spectra that are keyed to specific locations in the sample. From one raster of the sample, a specific ion image, at any chosen m/z value, could be produced to give the spatial arrangement of molecules of interest. Current work involves; i) Instrument development involving modifications to an existing commercial MALDI (TOF) mass spectrometer, including changes to the laser optics, target movement system, and instrument control hardware and software, ii) Development of methods for sample preparation and target surface modifications to achieve high sensitivity and high image resolution, with molecular specificity, and iii) Applications to specific research areas involving questions about certain spatial distributions of molecules within specific tissues.

Publications

The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. Integrated molecular imaging reveals tissue heterogeneity driving host-pathogen interactions. Cassat JE, Moore JL, Wilson KJ, Stark Z, Prentice BM, Van de Plas R, Perry WJ, Zhang Y, Virostko J, Colvin DC, Rose KL, Judd AM, Reyzer ML, Spraggins JM, Grunenwald CM, Gore JC, Caprioli RM, Skaar EP (2018) Sci Transl Med 10(432)
    › Primary publication · 29540616 (PubMed) · PMC6005374 (PubMed Central)
  2. Single-Cell Mass Spectrometry Reveals Changes in Lipid and Metabolite Expression in RAW 264.7 Cells upon Lipopolysaccharide Stimulation. Yang B, Patterson NH, Tsui T, Caprioli RM, Norris JL (2018) J Am Soc Mass Spectrom 29(5): 1012-1020
    › Primary publication · 29536413 (PubMed) · PMC5943162 (PubMed Central)
  3. Yale School of Public Health Symposium on tissue imaging mass spectrometry: illuminating phenotypic heterogeneity and drug disposition at the molecular level. Charkoftaki G, Rattray NJW, Andrén PE, Caprioli RM, Castellino S, Duncan MW, Goodwin RJA, Schey KL, Shahidi-Latham SK, Veselkov KA, Johnson CH, Vasiliou V (2018) Hum Genomics 12(1): 10
    › Primary publication · 29482659 (PubMed) · PMC5828306 (PubMed Central)
  4. Enhanced Ion Transmission Efficiency up to m/ z 24 000 for MALDI Protein Imaging Mass Spectrometry. Prentice BM, Ryan DJ, Van de Plas R, Caprioli RM, Spraggins JM (2018) Anal Chem 90(8): 5090-5099
    › Primary publication · 29444410 (PubMed)
  5. Optic Nerve Regeneration After Crush Remodels the Injury Site: Molecular Insights From Imaging Mass Spectrometry. Stark DT, Anderson DMG, Kwong JMK, Patterson NH, Schey KL, Caprioli RM, Caprioli J (2018) Invest Ophthalmol Vis Sci 59(1): 212-222
    › Primary publication · 29340649 (PubMed) · PMC5770179 (PubMed Central)
  6. Pyruvate induces torpor in obese mice. Soto M, Orliaguet L, Reyzer ML, Manier ML, Caprioli RM, Kahn CR (2018) Proc Natl Acad Sci U S A 115(4): 810-815
    › Primary publication · 29311303 (PubMed) · PMC5789941 (PubMed Central)
  7. Bis(monoacylglycero)phosphate lipids in the retinal pigment epithelium implicate lysosomal/endosomal dysfunction in a model of Stargardt disease and human retinas. Anderson DMG, Ablonczy Z, Koutalos Y, Hanneken AM, Spraggins JM, Calcutt MW, Crouch RK, Caprioli RM, Schey KL (2017) Sci Rep 7(1): 17352
    › Primary publication · 29229934 (PubMed) · PMC5725462 (PubMed Central)
  8. Protein identification in imaging mass spectrometry through spatially targeted liquid micro-extractions. Ryan DJ, Nei D, Prentice BM, Rose KL, Caprioli RM, Spraggins JM (2018) Rapid Commun Mass Spectrom 32(5): 442-450
    › Primary publication · 29226434 (PubMed) · PMC5812809 (PubMed Central)
  9. Dietary Manganese Promotes Staphylococcal Infection of the Heart. Juttukonda LJ, Berends ETM, Zackular JP, Moore JL, Stier MT, Zhang Y, Schmitz JE, Beavers WN, Wijers CD, Gilston BA, Kehl-Fie TE, Atkinson J, Washington MK, Peebles RS, Chazin WJ, Torres VJ, Caprioli RM, Skaar EP (2017) Cell Host Microbe 22(4): 531-542.e8
    › Primary publication · 28943329 (PubMed) · PMC5638708 (PubMed Central)
  10. Label-free molecular imaging of the kidney. Prentice BM, Caprioli RM, Vuiblet V (2017) Kidney Int 92(3): 580-598
    › Primary publication · 28750926 (PubMed) · PMC6193761 (PubMed Central)
  11. Imaging MS of Rodent Ocular Tissues and the Optic Nerve. Anderson DMG, Lambert W, Calkins DJ, Ablonczy Z, Crouch RK, Caprioli RM, Schey KL (2017) Methods Mol Biol : 15-27
    › Primary publication · 28523496 (PubMed)
  12. Connecting imaging mass spectrometry and magnetic resonance imaging-based anatomical atlases for automated anatomical interpretation and differential analysis. Verbeeck N, Spraggins JM, Murphy MJM, Wang HD, Deutch AY, Caprioli RM, Van de Plas R (2017) Biochim Biophys Acta Proteins Proteom 1865(7): 967-977
    › Primary publication · 28254588 (PubMed)
  13. Mass Spectrometry Imaging Can Distinguish on a Proteomic Level Between Proliferative Nodules Within a Benign Congenital Nevus and Malignant Melanoma. Lazova R, Yang Z, El Habr C, Lim Y, Choate KA, Seeley EH, Caprioli RM, Yangqun L (2017) Am J Dermatopathol 39(9): 689-695
    › Primary publication · 28248717 (PubMed) · PMC5647999 (PubMed Central)
  14. High-speed MALDI MS/MS imaging mass spectrometry using continuous raster sampling. Prentice BM, Chumbley CW, Caprioli RM (2016) J Mass Spectrom 51(8): 665
    › Primary publication · 28239976 (PubMed)
  15. Enhanced Spatially Resolved Proteomics Using On-Tissue Hydrogel-Mediated Protein Digestion. Rizzo DG, Prentice BM, Moore JL, Norris JL, Caprioli RM (2017) Anal Chem 89(5): 2948-2955
    › Primary publication · 28193007 (PubMed)
  16. Integrated, High-Throughput, Multiomics Platform Enables Data-Driven Construction of Cellular Responses and Reveals Global Drug Mechanisms of Action. Norris JL, Farrow MA, Gutierrez DB, Palmer LD, Muszynski N, Sherrod SD, Pino JC, Allen JL, Spraggins JM, Lubbock AL, Jordan A, Burns W, Poland JC, Romer C, Manier ML, Nei YW, Prentice BM, Rose KL, Hill S, Van de Plas R, Tsui T, Braman NM, Keller MR, Rutherford SA, Lobdell N, Lopez CF, Lacy DB, McLean JA, Wikswo JP, Skaar EP, Caprioli RM (2017) J Proteome Res 16(3): 1364-1375
    › Primary publication · 28088864 (PubMed)
  17. MALDI Imaging Mass Spectrometry as a Lipidomic Approach to Heart Valve Research. Angel PM, Bayoumi AS, Hinton RB, Ru Su Y, Bichell D, Mayer JE, Scott Baldwin H, Caprioli RM (2016) J Heart Valve Dis 25(2): 240-252
    › Primary publication · 27989075 (PubMed)
  18. Life history linked to immune investment in developing amphibians. Woodhams DC, Bell SC, Bigler L, Caprioli RM, Chaurand P, Lam BA, Reinert LK, Stalder U, Vazquez VM, Schliep K, Hertz A, Rollins-Smith LA (2016) Conserv Physiol 4(1): cow025
    › Primary publication · 27928507 (PubMed) · PMC5001151 (PubMed Central)
  19. Erratum: Dietary zinc alters the microbiota and decreases resistance to Clostridium difficile infection. Zackular JP, Moore JL, Jordan AT, Juttukonda LJ, Noto MJ, Nicholson MR, Crews JD, Semler MW, Zhang Y, Ware LB, Washington MK, Chazin WJ, Caprioli RM, Skaar EP (2016) Nat Med 22(12): 1502
    › Primary publication · 27923021 (PubMed) · PMC5453636 (PubMed Central)
  20. Spatial distributions of glutathione and its endogenous conjugates in normal bovine lens and a model of lens aging. Nye-Wood MG, Spraggins JM, Caprioli RM, Schey KL, Donaldson PJ, Grey AC (2017) Exp Eye Res : 70-78
    › Primary publication · 27838309 (PubMed) · PMC5359059 (PubMed Central)
  21. Trypsin and MALDI matrix pre-coated targets simplify sample preparation for mapping proteomic distributions within biological tissues by imaging mass spectrometry. Zubair F, Laibinis PE, Swisher WG, Yang J, Spraggins JM, Norris JL, Caprioli RM (2016) J Mass Spectrom 51(12): 1168-1179
    › Primary publication · 27676701 (PubMed) · PMC5687832 (PubMed Central)
  22. Dietary zinc alters the microbiota and decreases resistance to Clostridium difficile infection. Zackular JP, Moore JL, Jordan AT, Juttukonda LJ, Noto MJ, Nicholson MR, Crews JD, Semler MW, Zhang Y, Ware LB, Washington MK, Chazin WJ, Caprioli RM, Skaar EP (2016) Nat Med 22(11): 1330-1334
    › Primary publication · 27668938 (PubMed) · PMC5101143 (PubMed Central)
  23. Absolute Quantification of Rifampicin by MALDI Imaging Mass Spectrometry Using Multiple TOF/TOF Events in a Single Laser Shot. Prentice BM, Chumbley CW, Caprioli RM (2017) J Am Soc Mass Spectrom 28(1): 136-144
    › Primary publication · 27655354 (PubMed) · PMC5177505 (PubMed Central)
  24. Multiple Time-of-Flight/Time-of-Flight Events in a Single Laser Shot for Improved Matrix-Assisted Laser Desorption/Ionization Tandem Mass Spectrometry Quantification. Prentice BM, Chumbley CW, Hachey BC, Norris JL, Caprioli RM (2016) Anal Chem 88(19): 9780-9788
    › Primary publication · 27573922 (PubMed) · PMC5672909 (PubMed Central)
  25. The Need for Speed in Matrix-Assisted Laser Desorption/Ionization Imaging Mass Spectrometry. Prentice BM, Caprioli RM (2016) Postdoc J 4(3): 3-13
    › Primary publication · 27570788 (PubMed) · PMC4996283 (PubMed Central)
  26. Correction to Absolute Quantitative MALDI Imaging Mass Spectrometry: A Case of Rifampicin in Liver Tissues. Chumbley CW, Reyzer ML, Allen JL, Marriner GA, Via LE, Barry CE, Caprioli RM (2016) Anal Chem 88(17): 8920
    › Primary publication · 27540623 (PubMed) · PMC6398159 (PubMed Central)
  27. Imaging mass spectrometry assists in the classification of diagnostically challenging atypical Spitzoid neoplasms. Lazova R, Seeley EH, Kutzner H, Scolyer RA, Scott G, Cerroni L, Fried I, Kozovska ME, Rosenberg AS, Prieto VG, Shehata BM, Durham MM, Henry G, Rodriguez-Peralto JL, Riveiro-Falkenbach E, Schaefer JT, Danialan R, Fraitag S, Vollenweider-Roten S, Sepehr A, Sangueza M, Hijazi N, Corredoira Y, Kowal R, Harris OM, Bravo F, Boyd AS, Gueorguieva R, Caprioli RM (2016) J Am Acad Dermatol 75(6): 1176-1186.e4
    › Primary publication · 27502312 (PubMed) · PMC5112112 (PubMed Central)
  28. The innate immune protein calprotectin promotes Pseudomonas aeruginosa and Staphylococcus aureus interaction. Wakeman CA, Moore JL, Noto MJ, Zhang Y, Singleton MD, Prentice BM, Gilston BA, Doster RS, Gaddy JA, Chazin WJ, Caprioli RM, Skaar EP (2016) Nat Commun : 11951
    › Primary publication · 27301800 (PubMed) · PMC4912628 (PubMed Central)
  29. Standard Reticle Slide To Objectively Evaluate Spatial Resolution and Instrument Performance in Imaging Mass Spectrometry. Zubair F, Prentice BM, Norris JL, Laibinis PE, Caprioli RM (2016) Anal Chem 88(14): 7302-11
    › Primary publication · 27299987 (PubMed) · PMC5672908 (PubMed Central)
  30. Next-generation technologies for spatial proteomics: Integrating ultra-high speed MALDI-TOF and high mass resolution MALDI FTICR imaging mass spectrometry for protein analysis. Spraggins JM, Rizzo DG, Moore JL, Noto MJ, Skaar EP, Caprioli RM (2016) Proteomics 16(11-12): 1678-89
    › Primary publication · 27060368 (PubMed) · PMC5117945 (PubMed Central)
  31. 3-D imaging mass spectrometry of protein distributions in mouse Neurofibromatosis 1 (NF1)-associated optic glioma. Anderson DM, Van de Plas R, Rose KL, Hill S, Schey KL, Solga AC, Gutmann DH, Caprioli RM (2016) J Proteomics : 77-84
    › Primary publication · 26883872 (PubMed) · PMC4983271 (PubMed Central)
  32. Phospholipid profiling identifies acyl chain elongation as a ubiquitous trait and potential target for the treatment of lung squamous cell carcinoma. Marien E, Meister M, Muley T, Gomez Del Pulgar T, Derua R, Spraggins JM, Van de Plas R, Vanderhoydonc F, Machiels J, Binda MM, Dehairs J, Willette-Brown J, Hu Y, Dienemann H, Thomas M, Schnabel PA, Caprioli RM, Lacal JC, Waelkens E, Swinnen JV (2016) Oncotarget 7(11): 12582-97
    › Primary publication · 26862848 (PubMed) · PMC4914306 (PubMed Central)
  33. Pragmatic pharmacology: population pharmacokinetic analysis of fentanyl using remnant samples from children after cardiac surgery. Van Driest SL, Marshall MD, Hachey B, Beck C, Crum K, Owen J, Smith AH, Kannankeril PJ, Woodworth A, Caprioli RM, Choi L (2016) Br J Clin Pharmacol 81(6): 1165-74
    › Primary publication · 26861166 (PubMed) · PMC4876191 (PubMed Central)
  34. Absolute Quantitative MALDI Imaging Mass Spectrometry: A Case of Rifampicin in Liver Tissues. Chumbley CW, Reyzer ML, Allen JL, Marriner GA, Via LE, Barry CE, Caprioli RM (2016) Anal Chem 88(4): 2392-8
    › Primary publication · 26814665 (PubMed) · PMC5080977 (PubMed Central)
  35. Decellularization of intact tissue enables MALDI imaging mass spectrometry analysis of the extracellular matrix. Gessel M, Spraggins JM, Voziyan P, Hudson BG, Caprioli RM (2015) J Mass Spectrom 50(11): 1288-93
    › Primary publication · 26505774 (PubMed) · PMC5320948 (PubMed Central)
  36. Histology-guided protein digestion/extraction from formalin-fixed and paraffin-embedded pressure ulcer biopsies. Taverna D, Pollins AC, Nanney LB, Sindona G, Caprioli RM (2016) Exp Dermatol 25(2): 143-6
    › Primary publication · 26440596 (PubMed) · PMC4724279 (PubMed Central)
  37. Signal Transducer and Activator of Transcription 3, Mediated Remodeling of the Tumor Microenvironment Results in Enhanced Tumor Drug Delivery in a Mouse Model of Pancreatic Cancer. Nagathihalli NS, Castellanos JA, Shi C, Beesetty Y, Reyzer ML, Caprioli R, Chen X, Walsh AJ, Skala MC, Moses HL, Merchant NB (2015) Gastroenterology 149(7): 1932-1943.e9
    › Primary publication · 26255562 (PubMed) · PMC4863449 (PubMed Central)
  38. Are clear cell carcinomas of the ovary and endometrium phenotypically identical? A proteomic analysis. Fata CR, Seeley EH, Desouki MM, Du L, Gwin K, Hanley KZ, Hecht JL, Jarboe EA, Liang SX, Parkash V, Quick CM, Zheng W, Shyr Y, Caprioli RM, Fadare O (2015) Hum Pathol 46(10): 1427-36
    › Primary publication · 26243671 (PubMed)
  39. High-speed MALDI MS/MS imaging mass spectrometry using continuous raster sampling. Prentice BM, Chumbley CW, Caprioli RM (2015) J Mass Spectrom 50(4): 703-10
    › Primary publication · 26149115 (PubMed) · PMC4498415 (PubMed Central)
  40. EXIMS: an improved data analysis pipeline based on a new peak picking method for EXploring Imaging Mass Spectrometry data. Wijetunge CD, Saeed I, Boughton BA, Spraggins JM, Caprioli RM, Bacic A, Roessner U, Halgamuge SK (2015) Bioinformatics 31(19): 3198-206
    › Primary publication · 26063840 (PubMed)
  41. Congenital nevi versus metastatic melanoma in a newborn to a mother with malignant melanoma - diagnosis supported by sex chromosome analysis and Imaging Mass Spectrometry. Alomari AK, Glusac EJ, Choi J, Hui P, Seeley EH, Caprioli RM, Watsky KL, Urban J, Lazova R (2015) J Cutan Pathol 42(10): 757-64
    › Primary publication · 25989266 (PubMed)
  42. MALDI FTICR IMS of Intact Proteins: Using Mass Accuracy to Link Protein Images with Proteomics Data. Spraggins JM, Rizzo DG, Moore JL, Rose KL, Hammer ND, Skaar EP, Caprioli RM (2015) J Am Soc Mass Spectrom 26(6): 974-85
    › Primary publication · 25904064 (PubMed) · PMC4442642 (PubMed Central)
  43. Peptide spectra in Wilms tumor that associate with adverse outcomes. Murphy AJ, Pierce J, Seeley EH, Sullivan LM, Ruchelli ED, Nance ML, Caprioli RM, Lovvorn HN (2015) J Surg Res 196(2): 332-8
    › Primary publication · 25868780 (PubMed) · PMC4599776 (PubMed Central)
  44. Imaging mass spectrometry: enabling a new age of discovery in biology and medicine through molecular microscopy. Caprioli RM (2015) J Am Soc Mass Spectrom 26(6): 850-2
    › Primary publication · 25801587 (PubMed) · PMC4425622 (PubMed Central)
  45. Non-small cell lung cancer is characterized by dramatic changes in phospholipid profiles. Marien E, Meister M, Muley T, Fieuws S, Bordel S, Derua R, Spraggins J, Van de Plas R, Dehairs J, Wouters J, Bagadi M, Dienemann H, Thomas M, Schnabel PA, Caprioli RM, Waelkens E, Swinnen JV (2015) Int J Cancer 137(7): 1539-48
    › Primary publication · 25784292 (PubMed) · PMC4503522 (PubMed Central)
  46. High spatial resolution proteomic comparison of the brain in humans and chimpanzees. Bauernfeind AL, Reyzer ML, Caprioli RM, Ely JJ, Babbitt CC, Wray GA, Hof PR, Sherwood CC (2015) J Comp Neurol 523(14): 2043-61
    › Primary publication · 25779868 (PubMed) · PMC4801118 (PubMed Central)
  47. Adhesive fiber stratification in uropathogenic Escherichia coli biofilms unveils oxygen-mediated control of type 1 pili. Floyd KA, Moore JL, Eberly AR, Good JA, Shaffer CL, Zaver H, Almqvist F, Skaar EP, Caprioli RM, Hadjifrangiskou M (2015) PLoS Pathog 11(3): e1004697
    › Primary publication · 25738819 (PubMed) · PMC4349694 (PubMed Central)
  48. Image fusion of mass spectrometry and microscopy: a multimodality paradigm for molecular tissue mapping. Van de Plas R, Yang J, Spraggins J, Caprioli RM (2015) Nat Methods 12(4): 366-72
    › Primary publication · 25707028 (PubMed) · PMC4382398 (PubMed Central)
  49. Tissue protein imaging at 1 μm laser spot diameter for high spatial resolution and high imaging speed using transmission geometry MALDI TOF MS. Zavalin A, Yang J, Hayden K, Vestal M, Caprioli RM (2015) Anal Bioanal Chem 407(8): 2337-42
    › Primary publication · 25673247 (PubMed) · PMC4359058 (PubMed Central)
  50. Histology-directed and imaging mass spectrometry: An emerging technology in ectopic calcification. Taverna D, Boraldi F, De Santis G, Caprioli RM, Quaglino D (2015) Bone : 83-94
    › Primary publication · 25595835 (PubMed) · PMC4355241 (PubMed Central)
  51. Imaging mass spectrometry for assessing cutaneous wound healing: analysis of pressure ulcers. Taverna D, Pollins AC, Sindona G, Caprioli RM, Nanney LB (2015) J Proteome Res 14(2): 986-96
    › Primary publication · 25488653 (PubMed) · PMC4324443 (PubMed Central)
  52. Histology-directed microwave assisted enzymatic protein digestion for MALDI MS analysis of mammalian tissue. Taverna D, Norris JL, Caprioli RM (2015) Anal Chem 87(1): 670-6
    › Primary publication · 25427280 (PubMed) · PMC4287167 (PubMed Central)
  53. Towards automated discrimination of lipids versus peptides from full scan mass spectra. Dittwald P, Nghia VT, Harris GA, Caprioli RM, Van de Plas R, Laukens K, Gambin A, Valkenborg D (2014) EuPA Open Proteom : 87-100
    › Primary publication · 25414814 (PubMed) · PMC4234154 (PubMed Central)
  54. Automated anatomical interpretation of ion distributions in tissue: linking imaging mass spectrometry to curated atlases. Verbeeck N, Yang J, De Moor B, Caprioli RM, Waelkens E, Van de Plas R (2014) Anal Chem 86(18): 8974-82
    › Primary publication · 25153352 (PubMed) · PMC4165455 (PubMed Central)
  55. A derivatization and validation strategy for determining the spatial localization of endogenous amine metabolites in tissues using MALDI imaging mass spectrometry. Manier ML, Spraggins JM, Reyzer ML, Norris JL, Caprioli RM (2014) J Mass Spectrom 49(8): 665-73
    › Primary publication · 25044893 (PubMed) · PMC4126081 (PubMed Central)
  56. Advanced mass spectrometry technologies for the study of microbial pathogenesis. Moore JL, Caprioli RM, Skaar EP (2014) Curr Opin Microbiol : 45-51
    › Primary publication · 24997399 (PubMed) · PMC4125470 (PubMed Central)
  57. Diabetic nephropathy induces alterations in the glomerular and tubule lipid profiles. Grove KJ, Voziyan PA, Spraggins JM, Wang S, Paueksakon P, Harris RC, Hudson BG, Caprioli RM (2014) J Lipid Res 55(7): 1375-85
    › Primary publication · 24864273 (PubMed) · PMC4076088 (PubMed Central)
  58. Acyl-coenzyme A-binding protein regulates Beta-oxidation required for growth and survival of non-small cell lung cancer. Harris FT, Rahman SM, Hassanein M, Qian J, Hoeksema MD, Chen H, Eisenberg R, Chaurand P, Caprioli RM, Shiota M, Massion PP (2014) Cancer Prev Res (Phila) 7(7): 748-57
    › Primary publication · 24819876 (PubMed) · PMC4090029 (PubMed Central)
  59. High resolution MALDI imaging mass spectrometry of retinal tissue lipids. Anderson DM, Ablonczy Z, Koutalos Y, Spraggins J, Crouch RK, Caprioli RM, Schey KL (2014) J Am Soc Mass Spectrom 25(8): 1394-403
    › Primary publication · 24819461 (PubMed) · PMC4180438 (PubMed Central)
  60. Matrix pre-coated targets for high throughput MALDI imaging of proteins. Yang J, Caprioli RM (2014) J Mass Spectrom 49(5): 417-22
    › Primary publication · 24809903 (PubMed) · PMC4028164 (PubMed Central)
  61. Hippocampal immunostaining of CCK-GAD1 transgenic mice. Schmidt MJ, Horvath S, Ebert P, Norris JL, Seeley EH, Brown J, Gellert L, Everheart M, Garbett KA, Grice TW, Caprioli RM, Mirnics K (2014) Mol Psychiatry 19(5): 529
    › Primary publication · 24755516 (PubMed)
  62. Implementation of a Gaussian beam laser and aspheric optics for high spatial resolution MALDI imaging MS. Zavalin A, Yang J, Haase A, Holle A, Caprioli R (2014) J Am Soc Mass Spectrom 25(6): 1079-82
    › Primary publication · 24692046 (PubMed) · PMC4035219 (PubMed Central)
  63. MALDI imaging mass spectrometry: spatial molecular analysis to enable a new age of discovery. Gessel MM, Norris JL, Caprioli RM (2014) J Proteomics : 71-82
    › Primary publication · 24686089 (PubMed) · PMC4104210 (PubMed Central)
  64. Race disparities in peptide profiles of North American and Kenyan Wilms tumor specimens. Libes JM, Seeley EH, Li M, Axt JR, Pierce J, Correa H, Newton M, Hansen E, Judd A, McDonald H, Caprioli RM, Naranjo A, Huff V, O'Neill JA, Lovvorn HN, Kenyan Wilms Tumor Consortium (2014) J Am Coll Surg 218(4): 707-20
    › Primary publication · 24655859 (PubMed) · PMC3964369 (PubMed Central)
  65. Imaging mass spectrometry: molecular microscopy for enabling a new age of discovery. Caprioli RM (2014) Proteomics 14(7-8): 807-9
    › Primary publication · 24497141 (PubMed) · PMC4882602 (PubMed Central)
  66. Co-registration of multi-modality imaging allows for comprehensive analysis of tumor-induced bone disease. Seeley EH, Wilson KJ, Yankeelov TE, Johnson RW, Gore JC, Caprioli RM, Matrisian LM, Sterling JA (2014) Bone : 208-16
    › Primary publication · 24487126 (PubMed) · PMC4005328 (PubMed Central)
  67. Modulation of behavioral networks by selective interneuronal inactivation. Schmidt MJ, Horvath S, Ebert P, Norris JL, Seeley EH, Brown J, Gellert L, Everheart M, Garbett KA, Grice TW, Caprioli RM, Mirnics K (2014) Mol Psychiatry 19(5): 580-7
    › Primary publication · 24322205 (PubMed) · PMC4179403 (PubMed Central)
  68. Identification of promethazine as an amyloid-binding molecule using a fluorescence high-throughput assay and MALDI imaging mass spectrometry. McClure RA, Chumbley CW, Reyzer ML, Wilson K, Caprioli RM, Gore JC, Pham W (2013) Neuroimage Clin : 620-9
    › Primary publication · 24179813 (PubMed) · PMC3778261 (PubMed Central)
  69. Imaging mass spectrometry: a new tool for pathology in a molecular age. Norris JL, Caprioli RM (2013) Proteomics Clin Appl 7(11-12): 733-8
    › Primary publication · 24178781 (PubMed) · PMC3919023 (PubMed Central)
  70. An LC-MS assay for the screening of cardiovascular medications in human samples. Dias E, Hachey B, McNaughton C, Nian H, Yu C, Straka B, Brown NJ, Caprioli RM (2013) J Chromatogr B Analyt Technol Biomed Life Sci : 44-53
    › Primary publication · 24013190 (PubMed) · PMC3800555 (PubMed Central)
  71. MALDI imaging and in situ identification of integral membrane proteins from rat brain tissue sections. Nicklay JJ, Harris GA, Schey KL, Caprioli RM (2013) Anal Chem 85(15): 7191-6
    › Primary publication · 23829295 (PubMed) · PMC3782084 (PubMed Central)
  72. MntABC and MntH contribute to systemic Staphylococcus aureus infection by competing with calprotectin for nutrient manganese. Kehl-Fie TE, Zhang Y, Moore JL, Farrand AJ, Hood MI, Rathi S, Chazin WJ, Caprioli RM, Skaar EP (2013) Infect Immun 81(9): 3395-405
    › Primary publication · 23817615 (PubMed) · PMC3754211 (PubMed Central)
  73. Laser beam filtration for high spatial resolution MALDI imaging mass spectrometry. Zavalin A, Yang J, Caprioli R (2013) J Am Soc Mass Spectrom 24(7): 1153-6
    › Primary publication · 23661425 (PubMed) · PMC3690593 (PubMed Central)
  74. Activation of heme biosynthesis by a small molecule that is toxic to fermenting Staphylococcus aureus. Mike LA, Dutter BF, Stauff DL, Moore JL, Vitko NP, Aranmolate O, Kehl-Fie TE, Sullivan S, Reid PR, DuBois JL, Richardson AR, Caprioli RM, Sulikowski GA, Skaar EP (2013) Proc Natl Acad Sci U S A 110(20): 8206-11
    › Primary publication · 23630262 (PubMed) · PMC3657828 (PubMed Central)
  75. Self-limiting outbreak of crayfish plague in an Austropotamobius pallipes population of a river basin in the Abruzzi region (central Italy). Caprioli R, Cargini D, Marcacci M, Cammà C, Giansante C, Ferri N (2013) Dis Aquat Organ 103(2): 149-56
    › Primary publication · 23548365 (PubMed)
  76. Differential intrahepatic phospholipid zonation in simple steatosis and nonalcoholic steatohepatitis. Wattacheril J, Seeley EH, Angel P, Chen H, Bowen BP, Lanciault C, Caprioli RM, Abumrad N, Flynn CR (2013) PLoS One 8(2): e57165
    › Primary publication · 23451176 (PubMed) · PMC3581520 (PubMed Central)
  77. Cell-autonomous and non-cell-autonomous roles for IRF6 during development of the tongue. Goudy S, Angel P, Jacobs B, Hill C, Mainini V, Smith AL, Kousa YA, Caprioli R, Prince LS, Baldwin S, Schutte BC (2013) PLoS One 8(2): e56270
    › Primary publication · 23451037 (PubMed) · PMC3579850 (PubMed Central)
  78. Direct imaging of single cells and tissue at sub-cellular spatial resolution using transmission geometry MALDI MS. Zavalin A, Todd EM, Rawhouser PD, Yang J, Norris JL, Caprioli RM (2012) J Mass Spectrom 47(11): i
    › Primary publication · 23147833 (PubMed) · PMC3507384 (PubMed Central)