Frank Harrell
Last active: 4/25/2016


Chair, Department of Biostatistics, Vanderbilt University School of Medicine

Professor of Biostatistics

Head, Cardiovascular Biostatistics



The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. Do optimal prognostic thresholds in continuous physiological variables really exist? Analysis of origin of apparent thresholds, with systematic review for peak oxygen consumption, ejection fraction and BNP. Giannoni A, Baruah R, Leong T, Rehman MB, Pastormerlo LE, Harrell FE, Coats AJ, Francis DP (2014) PLoS One 9(1): e81699
    › Primary publication · 24475020 (PubMed) · PMC3903471 (PubMed Central)
  2. Strategies for developing biostatistics resources in an academic health center. Welty LJ, Carter RE, Finkelstein DM, Harrell FE, Lindsell CJ, Macaluso M, Mazumdar M, Nietert PJ, Oster RA, Pollock BH, Roberson PK, Ware JH, Biostatistics, Epidemiology, and Research Design Key Function Committee of the Clinical and Translational Science Award Consortium (2013) Acad Med 88(4): 454-60
    › Primary publication · 23425984 (PubMed) · PMC3610776 (PubMed Central)
  3. Is cardiac catheterization necessary before initial management of patients with stable ischemic heart disease? Results from a Web-based survey of cardiologists. Maron DJ, Stone GW, Berman DS, Mancini GB, Scott TA, Byrne DW, Harrell FE, Shaw LJ, Hachamovitch R, Boden WE, Weintraub WS, Spertus JA (2011) Am Heart J 162(6): 1034-1043.e13
    › Primary publication · 22137077 (PubMed)
  4. Logistic regression modeling and the number of events per variable: selection bias dominates. Steyerberg EW, Schemper M, Harrell FE (2011) J Clin Epidemiol 64(12): 1464-5; author reply 1463-4
    › Primary publication · 22032755 (PubMed)
  5. Constrictive bronchiolitis in soldiers returning from Iraq and Afghanistan. King MS, Eisenberg R, Newman JH, Tolle JJ, Harrell FE, Nian H, Ninan M, Lambright ES, Sheller JR, Johnson JE, Miller RF (2011) N Engl J Med 365(3): 222-30
    › Primary publication · 21774710 (PubMed) · PMC3296566 (PubMed Central)
  6. Quantitative estimates of the variability of in vivo sonographic measurements of the mouse aorta for studies of abdominal aortic aneurysms and related arterial diseases. Sampson UK, Perati PR, Prins PA, Pham W, Liu Z, Harrell FE, Linton MF, Gore JC, Kon V, Fazio S (2011) J Ultrasound Med 30(6): 773-84
    › Primary publication · 21632991 (PubMed) · PMC3810347 (PubMed Central)
  7. The prognosis and predictors of sports function and activity at minimum 6 years after anterior cruciate ligament reconstruction: a population cohort study. Spindler KP, Huston LJ, Wright RW, Kaeding CC, Marx RG, Amendola A, Parker RD, Andrish JT, Reinke EK, Harrell FE, MOON Group, Dunn WR (2011) Am J Sports Med 39(2): 348-59
    › Primary publication · 21084660 (PubMed) · PMC3692351 (PubMed Central)
  8. A clinical prediction model to estimate risk for 30-day adverse events in emergency department patients with symptomatic atrial fibrillation. Barrett TW, Martin AR, Storrow AB, Jenkins CA, Harrell FE, Russ S, Roden DM, Darbar D (2011) Ann Emerg Med 57(1): 1-12
    › Primary publication · 20728962 (PubMed) · PMC3008754 (PubMed Central)
  9. Which preoperative factors, including bone bruise, are associated with knee pain/symptoms at index anterior cruciate ligament reconstruction (ACLR)? A Multicenter Orthopaedic Outcomes Network (MOON) ACLR Cohort Study. Dunn WR, Spindler KP, Amendola A, Andrish JT, Kaeding CC, Marx RG, McCarty EC, Parker RD, Harrell FE, An AQ, Wright RW, Brophy RH, Matava MJ, Flanigan DC, Huston LJ, Jones MH, Wolcott ML, Vidal AF, Wolf BR, MOON ACL Investigation (2010) Am J Sports Med 38(9): 1778-87
    › Primary publication · 20595556 (PubMed) · PMC3692374 (PubMed Central)
  10. Missing covariate data in medical research: to impute is better than to ignore. Janssen KJ, Donders AR, Harrell FE, Vergouwe Y, Chen Q, Grobbee DE, Moons KG (2010) J Clin Epidemiol 63(7): 721-7
    › Primary publication · 20338724 (PubMed)
  11. Prediction rules must be developed according to methodological guidelines. Janssen KJ, Moons KG, Harrell FE (2010) Ann Intern Med 152(4): 263; author reply 263-4
    › Primary publication · 20157143 (PubMed)
  12. Visualizing covariates in proportional hazards model. Karvanen J, Harrell FE (2009) Stat Med 28(14): 1957-66
    › Primary publication · 19378282 (PubMed)
  13. Criteria for evaluation of novel markers of cardiovascular risk: a scientific statement from the American Heart Association. Hlatky MA, Greenland P, Arnett DK, Ballantyne CM, Criqui MH, Elkind MS, Go AS, Harrell FE, Hong Y, Howard BV, Howard VJ, Hsue PY, Kramer CM, McConnell JP, Normand SL, O'Donnell CJ, Smith SC, Wilson PW, American Heart Association Expert Panel on Subclinical Atherosclerotic Diseases and Emerging Risk Factors and the Stroke Council (2009) Circulation 119(17): 2408-16
    › Primary publication · 19364974 (PubMed) · PMC2956982 (PubMed Central)
  14. Dealing with missing predictor values when applying clinical prediction models. Janssen KJ, Vergouwe Y, Donders AR, Harrell FE, Chen Q, Grobbee DE, Moons KG (2009) Clin Chem 55(5): 994-1001
    › Primary publication · 19282357 (PubMed)
  15. Analysis of longitudinal laboratory data in the presence of common selection mechanisms: a view toward greater emphasis on pre-marketing pharmaceutical safety. Schildcrout JS, Jenkins CA, Ostroff JH, Gillen DL, Harrell FE, Trost DC (2008) Stat Med 27(12): 2248-66
    › Primary publication · 17929332 (PubMed)
  16. Case complexity scores in congenital heart surgery: a comparative study of the Aristotle Basic Complexity score and the Risk Adjustment in Congenital Heart Surgery (RACHS-1) system. Al-Radi OO, Harrell FE, Caldarone CA, McCrindle BW, Jacobs JP, Williams MG, Van Arsdell GS, Williams WG (2007) J Thorac Cardiovasc Surg 133(4): 865-75
    › Primary publication · 17382616 (PubMed)
  17. Present-at-admission diagnoses improved mortality risk adjustment among acute myocardial infarction patients. Stukenborg GJ, Wagner DP, Harrell FE, Oliver MN, Heim SW, Price AL, Han CK, Wolf AM, Connors AF (2007) J Clin Epidemiol 60(2): 142-54
    › Primary publication · 17208120 (PubMed)
  18. Using the outcome for imputation of missing predictor values was preferred. Moons KG, Donders RA, Stijnen T, Harrell FE (2006) J Clin Epidemiol 59(10): 1092-101
    › Primary publication · 16980150 (PubMed)
  19. Heart rate characteristics: novel physiomarkers to predict neonatal infection and death. Griffin MP, Lake DE, Bissonette EA, Harrell FE, O'Shea TM, Moorman JR (2005) Pediatrics 116(5): 1070-4
    › Primary publication · 16263991 (PubMed)
  20. Present-at-admission diagnoses improve mortality risk adjustment and allow more accurate assessment of the relationship between volume of lung cancer operations and mortality risk. Stukenborg GJ, Kilbridge KL, Wagner DP, Harrell FE, Oliver MN, Lyman JA, Einbinder JS, Connors AF (2005) Surgery 138(3): 498-507
    › Primary publication · 16213904 (PubMed)
  21. Penalized maximum likelihood estimation to directly adjust diagnostic and prognostic prediction models for overoptimism: a clinical example. Moons KG, Donders AR, Steyerberg EW, Harrell FE (2004) J Clin Epidemiol 57(12): 1262-70
    › Primary publication · 15617952 (PubMed)
  22. Selection of thrombolytic therapy for individual patients: development of a clinical model. GUSTO-I Investigators. Califf RM, Woodlief LH, Harrell FE, Lee KL, White HD, Guerci A, Barbash GI, Simes RJ, Weaver WD, Simoons ML, Topol EJ (1997) Am Heart J 133(6): 630-9
    › Primary publication · 9200390 (PubMed)