Melinda Aldrich
Faculty Member
Last active: 3/18/2014


Dr. Aldrich is an Assistant Professor in the Department of Thoracic Surgery and holds a joint appointment in the Division of Epidemiology.  Dr. Aldrich is Principal Investigator on a Lung Cancer Early Investigator Department of Defense grant and a NIH/NCI K07 grant recipient.  Dr. Aldrich co-leads the TREAT Lung Cancer Program within the Thoracic Surgery Department. 


Our lab is focused on identifying genetic and environmental risk factors for lung cancer and its related phenotypes, such as COPD and nicotine addiction, in racially diverse populations. We are applying genomic, epidemiologic, and statistical approaches to identify determinants of lung cancer risk and survival.  Much of our research is conducted within the longitudinal Southern Community Cohort Study (SCCS), a large population-based study of low-income and medically underserved African Americans and whites living in the Southeastern U.S. Using a multidisciplinary approach, we collaborate with statisticians, bioinformaticians, and clinical colleagues to identify factors contributing to poor lung cancer prognosis. Another active area of our research leverages large electronic health record systems and DNA biobanks to investigate genetic variants contributing to disease.  Ultimately the goal is to understand racial differences in disease and translate biomedical findings to all populations. 



The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. Accuracy of fluorodeoxyglucose-positron emission tomography within the clinical practice of the American College of Surgeons Oncology Group Z4031 trial to diagnose clinical stage I non-small cell lung cancer. Grogan EL, Deppen SA, Ballman KV, Andrade GM, Verdial FC, Aldrich MC, Chen CL, Decker PA, Harpole DH, Cerfolio RJ, Keenan RJ, Jones DR, D'Amico TA, Shrager JB, Meyers BF, Putnam JB (2014) Ann Thorac Surg 97(4): 1142-8
    › Primary publication · 24576597 (PubMed) · PMC4008142 (PubMed Central)
  2. Stage-adjusted lung cancer survival does not differ between low-income Blacks and Whites. Aldrich MC, Grogan EL, Munro HM, Signorello LB, Blot WJ (2013) J Thorac Oncol 8(10): 1248-54
    › Primary publication · 24457235 (PubMed) · PMC3901948 (PubMed Central)
  3. Socioeconomic status and lung cancer: unraveling the contribution of genetic admixture. Aldrich MC, Selvin S, Wrensch MR, Sison JD, Hansen HM, Quesenberry CP, Seldin MF, Barcellos LF, Buffler PA, Wiencke JK (2013) Am J Public Health 103(10): e73-80
    › Primary publication · 23948011 (PubMed) · PMC3780736 (PubMed Central)
  4. Genetic ancestry-smoking interactions and lung function in African Americans: a cohort study. Aldrich MC, Kumar R, Colangelo LA, Williams LK, Sen S, Kritchevsky SB, Meibohm B, Galanter J, Hu D, Gignoux CR, Liu Y, Harris TB, Ziv E, Zmuda J, Garcia M, Leak TS, Foreman MG, Smith LJ, Fornage M, Liu K, Burchard EG, Health ABC and CARDIA Studies Groups (2012) PLoS One 7(6): e39541
    › Primary publication · 22737244 (PubMed) · PMC3380861 (PubMed Central)
  5. Lung cancer risk among smokers of menthol cigarettes. Blot WJ, Cohen SS, Aldrich M, McLaughlin JK, Hargreaves MK, Signorello LB (2011) J Natl Cancer Inst 103(10): 810-6
    › Primary publication · 21436064 (PubMed) · PMC3096798 (PubMed Central)
  6. Genetic ancestry in lung-function predictions. Kumar R, Seibold MA, Aldrich MC, Williams LK, Reiner AP, Colangelo L, Galanter J, Gignoux C, Hu D, Sen S, Choudhry S, Peterson EL, Rodriguez-Santana J, Rodriguez-Cintron W, Nalls MA, Leak TS, O'Meara E, Meibohm B, Kritchevsky SB, Li R, Harris TB, Nickerson DA, Fornage M, Enright P, Ziv E, Smith LJ, Liu K, Burchard EG (2010) N Engl J Med 363(4): 321-30
    › Primary publication · 20647190 (PubMed) · PMC2922981 (PubMed Central)