Clarence Creech
Last active: 2/3/2014


Dr. Creech and his colleagues seek to understand the clinical and molecular epidemiology of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA). The work of the group focuses on describing the changing dynamics of nasal colonization with CA-MRSA and on how these isolates differ from those that cause invasive staphylococcal disease. In addition, the laboratory studies the adaptive response to infection, focusing on the serum antibody response to critical staphylococcal antigens. Work in the Vanderbilt Vaccine Research Program, where Dr. Creech serves as Associate Director, is directed towards clinical trials of vaccines and therapeutics, including monoclonal antibodies targeting S. aureus, influenza vaccine trials, and malaria vaccines. Clinical investigations in the group are led by Gayle Johnson, RN, Shanda Phillips, RN and others within the Vanderbilt Vaccine Research Program. The laboratory is directed by Ms. Nicki Soper, who has extensive experience in microbiology, molecular epidemiology, and human immunology. Dr. Creech graduated cum laude from Vanderbilt University before attending the University of Tennessee College of Medicine. After graduating with high honors, he joined the pediatric housestaff at Vanderbilt Children's Hospital and was Chief Resident in Pediatrics in 2002. During his pediatric infectious diseases fellowship at Vanderbilt Children's Hospital, Dr. Creech completed the Masters in Public Health degree and became part of the Vanderbilt Clinical Research Scholars (VCRS) Program, a competitive NIH K12 award given to young investigators at VUMC. He joined the faculty in July 2006 as Assistant Professor of Pediatric Infectious Diseases and now serves as Associate Director of the Vaccine Research Program and Co-Director of the Pediatric Infectious Diseases Fellowship. The group can be contacted by email ( or by phone: 615-343-0332 (VVRP). 


The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. Evaluation of the feasibility of a state-based vaccine safety advice network. Williams SE, Vellozzi C, Edwards KM, Moore KL, Sharma D, Creech CB (2014) Vaccine 32(8): 901-3
    › Primary publication · 24412301 (PubMed)
  2. Children with invasive Staphylococcus aureus disease exhibit a potently neutralizing antibody response to the cytotoxin LukAB. Thomsen IP, Dumont AL, James DB, Yoong P, Saville BR, Soper N, Torres VJ, Creech CB (2014) Infect Immun 82(3): 1234-42
    › Primary publication · 24379282 (PubMed) · PMC3957992 (PubMed Central)
  3. Frequency of disinfectant resistance genes in pediatric strains of methicillin-resistant Staphylococcus aureus. Johnson JG, Saye EJ, Jimenez-Truque N, Soper N, Thomsen I, Talbot TR, Creech CB (2013) Infect Control Hosp Epidemiol 34(12): 1326-7
    › Primary publication · 24225622 (PubMed) · PMC3965576 (PubMed Central)
  4. Randomized, placebo-controlled trial to assess the safety and immunogenicity of an adenovirus type 35-based circumsporozoite malaria vaccine in healthy adults. Creech CB, Dekker CL, Ho D, Phillips S, Mackey S, Murray-Krezan C, Grazia Pau M, Hendriks J, Brown V, Dally LG, Versteege I, Edwards KM (2013) Hum Vaccin Immunother 9(12): 2548-57
    › Primary publication · 23955431 (PubMed) · PMC4162066 (PubMed Central)
  5. Relationship between maternal and neonatal Staphylococcus aureus colonization. Jimenez-Truque N, Tedeschi S, Saye EJ, McKenna BD, Langdon W, Wright JP, Alsentzer A, Arnold S, Saville BR, Wang W, Thomsen I, Creech CB (2012) Pediatrics 129(5): e1252-9
    › Primary publication · 22473373 (PubMed) · PMC3340589 (PubMed Central)
  6. Chronic granulomatous disease masquerading as Beh├žet disease: a case report and review of the literature. Thomsen I, Dulek DE, Creech CB, Graham TB, Williams JV (2012) Pediatr Infect Dis J 31(5): 529-31
    › Primary publication · 22228233 (PubMed)
  7. Frequency of peripherally inserted central catheter complications in children. Barrier A, Williams DJ, Connelly M, Creech CB (2012) Pediatr Infect Dis J 31(5): 519-21
    › Primary publication · 22189533 (PubMed) · PMC3329567 (PubMed Central)
  8. Comparative effectiveness of antibiotic treatment strategies for pediatric skin and soft-tissue infections. Williams DJ, Cooper WO, Kaltenbach LA, Dudley JA, Kirschke DL, Jones TF, Arbogast PG, Griffin MR, Creech CB (2011) Pediatrics 128(3): e479-87
    › Primary publication · 21844058 (PubMed) · PMC3387880 (PubMed Central)