Jennifer Gaddy
Research Instructor
Last active: 4/26/2017

Profile

Jennifer A. Gaddy received her undergraduate degrees in Chemistry and Biology from Indiana University (East) and her Ph.D. from Miami University in Oxford, Ohio.  Her doctoral work in the laboratory of Dr. Luis A. Actis focused on how the emerging opportunistic pathogen Acinetobacter baumannii forms biofilms and how iron-acquisition systems such as siderophore biosynthesis pathways help facilitate a pathogenic lifestyle for this organism.  Dr. Gaddy came to Vanderbilt University in 2010 for a post-doctoral fellowship in the laboratory of Dr. Timothy L. Cover.  Dr. Gaddy’s post-doctoral research focused on the gastric pathogen Helicobacter pylori and how it elaborates toxin secretion in response to varying conditions of micronutrient ions.    Dr. Gaddy was promoted to junior faculty in 2013 and is currently funded through the Dept. of Veterans Affairs to study how dietary micronutrient intake affects bacterial infection, toxin secretion and disease progression.  She is particularly interested in how host antimicrobial strategies, including those involved in nutritional immunity, affect bacterial pathogenesis and subsequently alter the inflammatory response.

Publications

The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. Group B Streptococcus Induces Neutrophil Recruitment to Gestational Tissues and Elaboration of Extracellular Traps and Nutritional Immunity. Kothary V, Doster RS, Rogers LM, Kirk LA, Boyd KL, Romano-Keeler J, Haley KP, Manning SD, Aronoff DM, Gaddy JA (2017) Front Cell Infect Microbiol : 19
    › Primary publication · 28217556 (PubMed) · PMC5289994 (PubMed Central)
  2. Current concepts in maternal-fetal immunology: Recognition and response to microbial pathogens by decidual stromal cells. Anders AP, Gaddy JA, Doster RS, Aronoff DM (2017) Am J Reprod Immunol 77(3)
    › Primary publication · 28044385 (PubMed) · PMC5321847 (PubMed Central)
  3. The PAS Domain-Containing Protein HeuR Regulates Heme Uptake in Campylobacter jejuni. Johnson JG, Gaddy JA, DiRita VJ (2016) MBio 7(6)
    › Primary publication · 27935836 (PubMed) · PMC5111405 (PubMed Central)
  4. Nutrition and Helicobacter pylori: Host Diet and Nutritional Immunity Influence Bacterial Virulence and Disease Outcome. Haley KP, Gaddy JA (2016) Gastroenterol Res Pract : 3019362
    › Primary publication · 27688750 (PubMed) · PMC5027306 (PubMed Central)
  5. Clinical investigation of biofilm in non-healing wounds by high resolution microscopy techniques. Hurlow J, Blanz E, Gaddy JA (2016) J Wound Care : S11-22
    › Primary publication · 27608736 (PubMed) · PMC5058422 (PubMed Central)
  6. Staphylococcus aureus Infection of Human Gestational Membranes Induces Bacterial Biofilm Formation and Host Production of Cytokines. Doster RS, Kirk LA, Tetz LM, Rogers LM, Aronoff DM, Gaddy JA (2017) J Infect Dis 215(4): 653-657
    › Primary publication · 27436434 (PubMed)
  7. Characterization of Key Helicobacter pylori Regulators Identifies a Role for ArsRS in Biofilm Formation. Servetas SL, Carpenter BM, Haley KP, Gilbreath JJ, Gaddy JA, Merrell DS (2016) J Bacteriol 198(18): 2536-48
    › Primary publication · 27432830 (PubMed) · PMC4999924 (PubMed Central)
  8. The innate immune protein calprotectin promotes Pseudomonas aeruginosa and Staphylococcus aureus interaction. Wakeman CA, Moore JL, Noto MJ, Zhang Y, Singleton MD, Prentice BM, Gilston BA, Doster RS, Gaddy JA, Chazin WJ, Caprioli RM, Skaar EP (2016) Nat Commun : 11951
    › Primary publication · 27301800 (PubMed) · PMC4912628 (PubMed Central)
  9. Idiopathic subglottic stenosis is associated with activation of the inflammatory IL-17A/IL-23 axis. Gelbard A, Katsantonis NG, Mizuta M, Newcomb D, Rotsinger J, Rousseau B, Daniero JJ, Edell ES, Ekbom DC, Kasperbauer JL, Hillel AT, Yang L, Garrett CG, Netterville JL, Wootten CT, Francis DO, Stratton C, Jenkins K, McGregor TL, Gaddy JA, Blackwell TS, Drake WP (2016) Laryngoscope 126(11): E356-E361
    › Primary publication · 27296163 (PubMed) · PMC5077677 (PubMed Central)
  10. Molecular analysis of idiopathic subglottic stenosis for Mycobacterium species. Gelbard A, Katsantonis NG, Mizuta M, Newcomb D, Rotsinger J, Rousseau B, Daniero JJ, Edell ES, Ekbom DC, Kasperbauer JL, Hillel AT, Yang L, Garrett CG, Netterville JL, Wootten CT, Francis DO, Stratton C, Jenkins K, McGregor TL, Gaddy JA, Blackwell TS, Drake WP (2017) Laryngoscope 127(1): 179-185
    › Primary publication · 27295947 (PubMed) · PMC5156582 (PubMed Central)
  11. Association between genotypic diversity and biofilm production in group B Streptococcus. Parker RE, Laut C, Gaddy JA, Zadoks RN, Davies HD, Manning SD (2016) BMC Microbiol : 86
    › Primary publication · 27206613 (PubMed) · PMC4875601 (PubMed Central)
  12. Peptidomimetic Small Molecules Disrupt Type IV Secretion System Activity in Diverse Bacterial Pathogens. Shaffer CL, Good JA, Kumar S, Krishnan KS, Gaddy JA, Loh JT, Chappell J, Almqvist F, Cover TL, Hadjifrangiskou M (2016) MBio 7(2): e00221-16
    › Primary publication · 27118587 (PubMed) · PMC4850256 (PubMed Central)
  13. Helicobacter pylori Resists the Antimicrobial Activity of Calprotectin via Lipid A Modification and Associated Biofilm Formation. Gaddy JA, Radin JN, Cullen TW, Chazin WJ, Skaar EP, Trent MS, Algood HM (2015) MBio 6(6): e01349-15
    › Primary publication · 26646009 (PubMed) · PMC4669380 (PubMed Central)
  14. Highly differentiated human airway epithelial cells: a model to study host cell-parasite interactions in pertussis. Guevara C, Zhang C, Gaddy JA, Iqbal J, Guerra J, Greenberg DP, Decker MD, Carbonetti N, Starner TD, McCray PB, Mooi FR, Gómez-Duarte OG (2016) Infect Dis (Lond) 48(3): 177-88
    › Primary publication · 26492208 (PubMed) · PMC5278880 (PubMed Central)
  15. Helicobacter pylori adaptation in vivo in response to a high-salt diet. Loh JT, Gaddy JA, Algood HM, Gaudieri S, Mallal S, Cover TL (2015) Infect Immun 83(12): 4871-83
    › Primary publication · 26438795 (PubMed) · PMC4645402 (PubMed Central)
  16. Metalloregulation of Helicobacter pylori physiology and pathogenesis. Haley KP, Gaddy JA (2015) Front Microbiol : 911
    › Primary publication · 26388855 (PubMed) · PMC4557348 (PubMed Central)
  17. The Human Antimicrobial Protein Calgranulin C Participates in Control of Helicobacter pylori Growth and Regulation of Virulence. Haley KP, Delgado AG, Piazuelo MB, Mortensen BL, Correa P, Damo SM, Chazin WJ, Skaar EP, Gaddy JA (2015) Infect Immun 83(7): 2944-56
    › Primary publication · 25964473 (PubMed) · PMC4468547 (PubMed Central)
  18. Helicobacter pylori: Genomic Insight into the Host-Pathogen Interaction. Haley KP, Gaddy JA (2015) Int J Genomics : 386905
    › Primary publication · 25722969 (PubMed) · PMC4334614 (PubMed Central)
  19. Regulation of Helicobacter pylori Virulence Within the Context of Iron Deficiency. Noto JM, Lee JY, Gaddy JA, Cover TL, Amieva MR, Peek RM (2015) J Infect Dis 211(11): 1790-4
    › Primary publication · 25505301 (PubMed) · PMC4447831 (PubMed Central)
  20. High resolution electron microscopy of the Helicobacter pylori Cag type IV secretion system pili produced in varying conditions of iron availability. Haley KP, Blanz EJ, Gaddy JA (2014) J Vis Exp (93): e52122
    › Primary publication · 25489938 (PubMed) · PMC4354248 (PubMed Central)
  21. The host protein calprotectin modulates the Helicobacter pylori cag type IV secretion system via zinc sequestration. Gaddy JA, Radin JN, Loh JT, Piazuelo MB, Kehl-Fie TE, Delgado AG, Ilca FT, Peek RM, Cover TL, Chazin WJ, Skaar EP, Scott Algood HM (2014) PLoS Pathog 10(10): e1004450
    › Primary publication · 25330071 (PubMed) · PMC4199781 (PubMed Central)
  22. Genes required for assembly of pili associated with the Helicobacter pylori cag type IV secretion system. Johnson EM, Gaddy JA, Voss BJ, Hennig EE, Cover TL (2014) Infect Immun 82(8): 3457-70
    › Primary publication · 24891108 (PubMed) · PMC4136203 (PubMed Central)
  23. Analysis of surface-exposed outer membrane proteins in Helicobacter pylori. Voss BJ, Gaddy JA, McDonald WH, Cover TL (2014) J Bacteriol 196(13): 2455-71
    › Primary publication · 24769695 (PubMed) · PMC4054173 (PubMed Central)
  24. Role of connexin 43 in Helicobacter pylori VacA-induced cell death. Radin JN, González-Rivera C, Frick-Cheng AE, Sheng J, Gaddy JA, Rubin DH, Algood HM, McClain MS, Cover TL (2014) Infect Immun 82(1): 423-32
    › Primary publication · 24191302 (PubMed) · PMC3911829 (PubMed Central)
  25. Control of gene expression in Helicobacter pylori using the Tet repressor. McClain MS, Duncan SS, Gaddy JA, Cover TL (2013) J Microbiol Methods 95(3): 336-41
    › Primary publication · 24113399 (PubMed) · PMC3856897 (PubMed Central)
  26. Flagellar localization of a Helicobacter pylori autotransporter protein. Radin JN, Gaddy JA, González-Rivera C, Loh JT, Algood HM, Cover TL (2013) MBio 4(2): e00613-12
    › Primary publication · 23572556 (PubMed) · PMC3622936 (PubMed Central)
  27. High dietary salt intake exacerbates Helicobacter pylori-induced gastric carcinogenesis. Gaddy JA, Radin JN, Loh JT, Zhang F, Washington MK, Peek RM, Algood HM, Cover TL (2013) Infect Immun 81(6): 2258-67
    › Primary publication · 23569116 (PubMed) · PMC3676043 (PubMed Central)
  28. Functional plasticity in the type IV secretion system of Helicobacter pylori. Barrozo RM, Cooke CL, Hansen LM, Lam AM, Gaddy JA, Johnson EM, Cariaga TA, Suarez G, Peek RM, Cover TL, Solnick JV (2013) PLoS Pathog 9(2): e1003189
    › Primary publication · 23468628 (PubMed) · PMC3585145 (PubMed Central)
  29. Iron deficiency accelerates Helicobacter pylori-induced carcinogenesis in rodents and humans. Noto JM, Gaddy JA, Lee JY, Piazuelo MB, Friedman DB, Colvin DC, Romero-Gallo J, Suarez G, Loh J, Slaughter JC, Tan S, Morgan DR, Wilson KT, Bravo LE, Correa P, Cover TL, Amieva MR, Peek RM (2013) J Clin Invest 123(1): 479-92
    › Primary publication · 23257361 (PubMed) · PMC3533289 (PubMed Central)
  30. Alterations in Helicobacter pylori triggered by contact with gastric epithelial cells. Johnson EM, Gaddy JA, Cover TL (2012) Front Cell Infect Microbiol : 17
    › Primary publication · 22919609 (PubMed) · PMC3417513 (PubMed Central)
  31. Helicobacter pylori exploits a unique repertoire of type IV secretion system components for pilus assembly at the bacteria-host cell interface. Shaffer CL, Gaddy JA, Loh JT, Johnson EM, Hill S, Hennig EE, McClain MS, McDonald WH, Cover TL (2011) PLoS Pathog 7(9): e1002237
    › Primary publication · 21909278 (PubMed) · PMC3164655 (PubMed Central)
  32. CsuA/BABCDE-dependent pili are not involved in the adherence of Acinetobacter baumannii ATCC19606(T) to human airway epithelial cells and their inflammatory response. de Breij A, Gaddy J, van der Meer J, Koning R, Koster A, van den Broek P, Actis L, Nibbering P, Dijkshoorn L (2009) Res Microbiol 160(3): 213-8
    › Primary publication · 19530313 (PubMed)