Profile

Our group conducts patient-oriented and population-based research focusing on the interaction between cardiovascular disease, obesity, and metabolism.

One of our principal areas of interest is the cardiac hormonal axis, the natriuretic peptide system.  The natriuretic peptides play a key role in blood pressure regulation, sodium homeostasis, and cardiac remodeling.  We have investigated how genetic and environmental factors affect natriuretic peptide activity, which has led to the elucidation of genetic variants that alter natriuretic peptide production via interference with microRNA binding.  We are currently investigating the mechanisms linking obesity, insulin resistance, and reduced natriuretic peptide production.

We also have an active interest in the application of metabolomics to large-scale datasets, such as those derived from population-based cohorts or randomized trials.  We have applied metabolomics to identify biomarkers of diabetes and cardiovascular disease, and to examine the genetic determinants of circulating metabolites in humans.

 

Publications

The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. Head-to-head comparison of serial soluble ST2, growth differentiation factor-15, and highly-sensitive troponin T measurements in patients with chronic heart failure. Gaggin HK, Szymonifka J, Bhardwaj A, Belcher A, De Berardinis B, Motiwala S, Wang TJ, Januzzi JL (2014) JACC Heart Fail 2(1): 65-72
    › Primary publication · 24622120 (PubMed)
  2. Circulating natriuretic peptide concentrations reflect changes in insulin sensitivity over time in the Diabetes Prevention Program. Walford GA, Ma Y, Christophi CA, Goldberg RB, Jarolim P, Horton E, Mather KJ, Barrett-Connor E, Davis J, Florez JC, Wang TJ, Diabetes Prevention Program Research Group (2014) Diabetologia 57(5): 935-9
    › Primary publication · 24554005 (PubMed) · PMC4158711 (PubMed Central)
  3. β-Aminoisobutyric acid induces browning of white fat and hepatic β-oxidation and is inversely correlated with cardiometabolic risk factors. Roberts LD, Boström P, O'Sullivan JF, Schinzel RT, Lewis GD, Dejam A, Lee YK, Palma MJ, Calhoun S, Georgiadi A, Chen MH, Ramachandran VS, Larson MG, Bouchard C, Rankinen T, Souza AL, Clish CB, Wang TJ, Estall JL, Soukas AA, Cowan CA, Spiegelman BM, Gerszten RE (2014) Cell Metab 19(1): 96-108
    › Primary publication · 24411942 (PubMed) · PMC4017355 (PubMed Central)
  4. Relation between soluble ST2, growth differentiation factor-15, and high-sensitivity troponin I and incident atrial fibrillation. Rienstra M, Yin X, Larson MG, Fontes JD, Magnani JW, McManus DD, McCabe EL, Coglianese EE, Amponsah M, Ho JE, Januzzi JL, Wollert KC, Fradley MG, Vasan RS, Ellinor PT, Wang TJ, Benjamin EJ (2014) Am Heart J 167(1): 109-115.e2
    › Primary publication · 24332149 (PubMed) · PMC3884900 (PubMed Central)
  5. Left ventricular hypertrophy patterns and incidence of heart failure with preserved versus reduced ejection fraction. Velagaleti RS, Gona P, Pencina MJ, Aragam J, Wang TJ, Levy D, D'Agostino RB, Lee DS, Kannel WB, Benjamin EJ, Vasan RS (2014) Am J Cardiol 113(1): 117-22
    › Primary publication · 24210333 (PubMed) · PMC3881171 (PubMed Central)
  6. Association of novel biomarkers of cardiovascular stress with left ventricular hypertrophy and dysfunction: implications for screening. Xanthakis V, Larson MG, Wollert KC, Aragam J, Cheng S, Ho J, Coglianese E, Levy D, Colucci WS, Michael Felker G, Benjamin EJ, Januzzi JL, Wang TJ, Vasan RS (2013) J Am Heart Assoc 2(6): e000399
    › Primary publication · 24200688 (PubMed) · PMC3886765 (PubMed Central)
  7. 2-Aminoadipic acid is a biomarker for diabetes risk. Wang TJ, Ngo D, Psychogios N, Dejam A, Larson MG, Vasan RS, Ghorbani A, O'Sullivan J, Cheng S, Rhee EP, Sinha S, McCabe E, Fox CS, O'Donnell CJ, Ho JE, Florez JC, Magnusson M, Pierce KA, Souza AL, Yu Y, Carter C, Light PE, Melander O, Clish CB, Gerszten RE (2013) J Clin Invest 123(10): 4309-17
    › Primary publication · 24091325 (PubMed) · PMC3784523 (PubMed Central)
  8. The Framingham Heart Study and the epidemiology of cardiovascular disease: a historical perspective. Mahmood SS, Levy D, Vasan RS, Wang TJ (2014) Lancet 383(9921): 999-1008
    › Primary publication · 24084292 (PubMed) · PMC4159698 (PubMed Central)
  9. Common genetic variation at the IL1RL1 locus regulates IL-33/ST2 signaling. Ho JE, Chen WY, Chen MH, Larson MG, McCabe EL, Cheng S, Ghorbani A, Coglianese E, Emilsson V, Johnson AD, Walter S, Franceschini N, O'Donnell CJ, CARDIoGRAM Consortium, CHARGE Inflammation Working Group, Dehghan A, Lu C, Levy D, Newton-Cheh C, CHARGE Heart Failure Working Group, Lin H, Felix JF, Schreiter ER, Vasan RS, Januzzi JL, Lee RT, Wang TJ (2013) J Clin Invest 123(10): 4208-18
    › Primary publication · 23999434 (PubMed) · PMC3784527 (PubMed Central)
  10. The epidemiology of congestive heart failure: the Framingham Heart Study perspective. Mahmood SS, Wang TJ (2013) Glob Heart 8(1): 77-82
    › Primary publication · 23998000 (PubMed) · PMC3756692 (PubMed Central)
  11. Branched chain and aromatic amino acids change acutely following two medical therapies for type 2 diabetes mellitus. Walford GA, Davis J, Warner AS, Ackerman RJ, Billings LK, Chamarthi B, Fanelli RR, Hernandez AM, Huang C, Khan SQ, Littleton KR, Lo J, McCarthy RM, Rhee EP, Deik A, Stolerman E, Taylor A, Hudson MS, Wang TJ, Altshuler D, Grant RW, Clish CB, Gerszten RE, Florez JC (2013) Metabolism 62(12): 1772-8
    › Primary publication · 23953891 (PubMed) · PMC3833885 (PubMed Central)
  12. Blood pressure and left ventricular hypertrophy during American-style football participation. Weiner RB, Wang F, Isaacs SK, Malhotra R, Berkstresser B, Kim JH, Hutter AM, Picard MH, Wang TJ, Baggish AL (2013) Circulation 128(5): 524-31
    › Primary publication · 23897848 (PubMed)
  13. Biomarkers of cardiovascular stress and incident chronic kidney disease. Ho JE, Hwang SJ, Wollert KC, Larson MG, Cheng S, Kempf T, Vasan RS, Januzzi JL, Wang TJ, Fox CS (2013) Clin Chem 59(11): 1613-20
    › Primary publication · 23873716 (PubMed) · PMC3972213 (PubMed Central)
  14. Atrial natriuretic peptide is negatively regulated by microRNA-425. Arora P, Wu C, Khan AM, Bloch DB, Davis-Dusenbery BN, Ghorbani A, Spagnolli E, Martinez A, Ryan A, Tainsh LT, Kim S, Rong J, Huan T, Freedman JE, Levy D, Miller KK, Hata A, Del Monte F, Vandenwijngaert S, Swinnen M, Janssens S, Holmes TM, Buys ES, Bloch KD, Newton-Cheh C, Wang TJ (2013) J Clin Invest 123(8): 3378-82
    › Primary publication · 23867623 (PubMed) · PMC3726159 (PubMed Central)
  15. A genome-wide association study of the human metabolome in a community-based cohort. Rhee EP, Ho JE, Chen MH, Shen D, Cheng S, Larson MG, Ghorbani A, Shi X, Helenius IT, O'Donnell CJ, Souza AL, Deik A, Pierce KA, Bullock K, Walford GA, Vasan RS, Florez JC, Clish C, Yeh JR, Wang TJ, Gerszten RE (2013) Cell Metab 18(1): 130-43
    › Primary publication · 23823483 (PubMed) · PMC3973158 (PubMed Central)
  16. Circulating CD31+ leukocyte frequency is associated with cardiovascular risk factors. Ge Y, Cheng S, Larson MG, Ghorbani A, Martin RP, Klein RJ, O'Donnell CJ, Vasan RS, Shaw SY, Wang TJ, Cohen KS (2013) Atherosclerosis 229(1): 228-33
    › Primary publication · 23701996 (PubMed) · PMC3984590 (PubMed Central)
  17. A combined epidemiologic and metabolomic approach improves CKD prediction. Rhee EP, Clish CB, Ghorbani A, Larson MG, Elmariah S, McCabe E, Yang Q, Cheng S, Pierce K, Deik A, Souza AL, Farrell L, Domos C, Yeh RW, Palacios I, Rosenfield K, Vasan RS, Florez JC, Wang TJ, Fox CS, Gerszten RE (2013) J Am Soc Nephrol 24(8): 1330-8
    › Primary publication · 23687356 (PubMed) · PMC3736702 (PubMed Central)
  18. Multiple inflammatory biomarkers in relation to cardiovascular events and mortality in the community. Schnabel RB, Yin X, Larson MG, Yamamoto JF, Fontes JD, Kathiresan S, Rong J, Levy D, Keaney JF, Wang TJ, Murabito JM, Vasan RS, Benjamin EJ (2013) Arterioscler Thromb Vasc Biol 33(7): 1728-33
    › Primary publication · 23640499 (PubMed) · PMC3753537 (PubMed Central)
  19. Soluble ST2 predicts elevated SBP in the community. Ho JE, Larson MG, Ghorbani A, Cheng S, Vasan RS, Wang TJ, Januzzi JL (2013) J Hypertens 31(7): 1431-6; discussion 1436
    › Primary publication · 23615326 (PubMed) · PMC3986262 (PubMed Central)
  20. Risk assessment for incident heart failure in individuals with atrial fibrillation. Schnabel RB, Rienstra M, Sullivan LM, Sun JX, Moser CB, Levy D, Pencina MJ, Fontes JD, Magnani JW, McManus DD, Lubitz SA, Tadros TM, Wang TJ, Ellinor PT, Vasan RS, Benjamin EJ (2013) Eur J Heart Fail 15(8): 843-9
    › Primary publication · 23594831 (PubMed) · PMC3858114 (PubMed Central)
  21. Effects of subacute dietary salt intake and acute volume expansion on diastolic function in young normotensive individuals. Mak GS, Sawaya H, Khan AM, Arora P, Martinez A, Ryan A, Ernande L, Newton-Cheh C, Wang TJ, Scherrer-Crosbie M (2013) Eur Heart J Cardiovasc Imaging 14(11): 1092-8
    › Primary publication · 23515219 (PubMed) · PMC3806580 (PubMed Central)
  22. Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts. Vimaleswaran KS, Berry DJ, Lu C, Tikkanen E, Pilz S, Hiraki LT, Cooper JD, Dastani Z, Li R, Houston DK, Wood AR, Michaëlsson K, Vandenput L, Zgaga L, Yerges-Armstrong LM, McCarthy MI, Dupuis J, Kaakinen M, Kleber ME, Jameson K, Arden N, Raitakari O, Viikari J, Lohman KK, Ferrucci L, Melhus H, Ingelsson E, Byberg L, Lind L, Lorentzon M, Salomaa V, Campbell H, Dunlop M, Mitchell BD, Herzig KH, Pouta A, Hartikainen AL, Genetic Investigation of Anthropometric Traits-GIANT Consortium, Streeten EA, Theodoratou E, Jula A, Wareham NJ, Ohlsson C, Frayling TM, Kritchevsky SB, Spector TD, Richards JB, Lehtimäki T, Ouwehand WH, Kraft P, Cooper C, März W, Power C, Loos RJ, Wang TJ, Järvelin MR, Whittaker JC, Hingorani AD, Hyppönen E (2013) PLoS Med 10(2): e1001383
    › Primary publication · 23393431 (PubMed) · PMC3564800 (PubMed Central)
  23. Metabolite profiles during oral glucose challenge. Ho JE, Larson MG, Vasan RS, Ghorbani A, Cheng S, Rhee EP, Florez JC, Clish CB, Gerszten RE, Wang TJ (2013) Diabetes 62(8): 2689-98
    › Primary publication · 23382451 (PubMed) · PMC3717862 (PubMed Central)
  24. Mild renal dysfunction and metabolites tied to low HDL cholesterol are associated with monocytosis and atherosclerosis. Ganda A, Magnusson M, Yvan-Charvet L, Hedblad B, Engström G, Ai D, Wang TJ, Gerszten RE, Melander O, Tall AR (2013) Circulation 127(9): 988-96
    › Primary publication · 23378299 (PubMed) · PMC4074592 (PubMed Central)
  25. Circulating CD34(+) progenitor cell frequency is associated with clinical and genetic factors. Cohen KS, Cheng S, Larson MG, Cupples LA, McCabe EL, Wang YA, Ngwa JS, Martin RP, Klein RJ, Hashmi B, Ge Y, O'Donnell CJ, Vasan RS, Shaw SY, Wang TJ (2013) Blood 121(8): e50-6
    › Primary publication · 23287867 (PubMed) · PMC3578962 (PubMed Central)
  26. A diabetes-predictive amino acid score and future cardiovascular disease. Magnusson M, Lewis GD, Ericson U, Orho-Melander M, Hedblad B, Engström G, Ostling G, Clish C, Wang TJ, Gerszten RE, Melander O (2013) Eur Heart J 34(26): 1982-9
    › Primary publication · 23242195 (PubMed) · PMC3703309 (PubMed Central)
  27. Association of plasma B-type natriuretic peptide concentrations with longitudinal blood pressure tracking in African Americans: findings from the Jackson Heart Study. Fox ER, Musani SK, Singh P, Bidulescu A, Nagarajarao HS, Samdarshi TE, Steffes MW, Wang TJ, Taylor HA, Vasan RS (2013) Hypertension 61(1): 48-54
    › Primary publication · 23184379 (PubMed) · PMC3521855 (PubMed Central)
  28. Low serum magnesium and the development of atrial fibrillation in the community: the Framingham Heart Study. Khan AM, Lubitz SA, Sullivan LM, Sun JX, Levy D, Vasan RS, Magnani JW, Ellinor PT, Benjamin EJ, Wang TJ (2013) Circulation 127(1): 33-8
    › Primary publication · 23172839 (PubMed) · PMC3541701 (PubMed Central)
  29. Calcium intake is not associated with increased coronary artery calcification: the Framingham Study. Samelson EJ, Booth SL, Fox CS, Tucker KL, Wang TJ, Hoffmann U, Cupples LA, O'Donnell CJ, Kiel DP (2012) Am J Clin Nutr 96(6): 1274-80
    › Primary publication · 23134889 (PubMed) · PMC3497924 (PubMed Central)
  30. Distribution and clinical correlates of the interleukin receptor family member soluble ST2 in the Framingham Heart Study. Coglianese EE, Larson MG, Vasan RS, Ho JE, Ghorbani A, McCabe EL, Cheng S, Fradley MG, Kretschman D, Gao W, O'Connor G, Wang TJ, Januzzi JL (2012) Clin Chem 58(12): 1673-81
    › Primary publication · 23065477 (PubMed) · PMC3557515 (PubMed Central)
  31. Clinical and genetic correlates of growth differentiation factor 15 in the community. Ho JE, Mahajan A, Chen MH, Larson MG, McCabe EL, Ghorbani A, Cheng S, Johnson AD, Lindgren CM, Kempf T, Lind L, Ingelsson E, Vasan RS, Januzzi J, Wollert KC, Morris AP, Wang TJ (2012) Clin Chem 58(11): 1582-91
    › Primary publication · 22997280 (PubMed) · PMC4150608 (PubMed Central)
  32. Circulating branched-chain amino acid concentrations are associated with obesity and future insulin resistance in children and adolescents. McCormack SE, Shaham O, McCarthy MA, Deik AA, Wang TJ, Gerszten RE, Clish CB, Mootha VK, Grinspoon SK, Fleischman A (2013) Pediatr Obes 8(1): 52-61
    › Primary publication · 22961720 (PubMed) · PMC3519972 (PubMed Central)
  33. Identifying novel biomarkers for cardiovascular disease risk prediction. Ge Y, Wang TJ (2012) J Intern Med 272(5): 430-9
    › Primary publication · 22950687 (PubMed)
  34. Prognostic utility of novel biomarkers of cardiovascular stress: the Framingham Heart Study. Wang TJ, Wollert KC, Larson MG, Coglianese E, McCabe EL, Cheng S, Ho JE, Fradley MG, Ghorbani A, Xanthakis V, Kempf T, Benjamin EJ, Levy D, Vasan RS, Januzzi JL (2012) Circulation 126(13): 1596-604
    › Primary publication · 22907935 (PubMed) · PMC3656719 (PubMed Central)
  35. The impact of isometric handgrip testing on left ventricular twist mechanics. Weiner RB, Weyman AE, Kim JH, Wang TJ, Picard MH, Baggish AL (2012) J Physiol 590(20): 5141-50
    › Primary publication · 22890704 (PubMed) · PMC3497568 (PubMed Central)
  36. Measurement of multiple biomarkers in advanced stage heart failure patients treated with pulmonary artery catheter guided therapy. Zilinski JL, Shah RV, Gaggin HK, Gantzer ML, Wang TJ, Januzzi JL (2012) Crit Care 16(4): R135
    › Primary publication · 22830581 (PubMed) · PMC3580720 (PubMed Central)
  37. The natriuretic peptides and fat metabolism. Wang TJ (2012) N Engl J Med 367(4): 377-8
    › Primary publication · 22830469 (PubMed)
  38. Circulating, imaging, and genetic biomarkers in cardiovascular risk prediction. Ge Y, Wang TJ (2011) Trends Cardiovasc Med 21(4): 105-12
    › Primary publication · 22681965 (PubMed) · PMC3376748 (PubMed Central)
  39. Regression of "gray zone" exercise-induced concentric left ventricular hypertrophy during prescribed detraining. Weiner RB, Wang F, Berkstresser B, Kim J, Wang TJ, Lewis GD, Hutter AM, Picard MH, Baggish AL (2012) J Am Coll Cardiol 59(22): 1992-4
    › Primary publication · 22624842 (PubMed)
  40. Orthostatic hypotension and novel blood pressure-associated gene variants: Genetics of Postural Hemodynamics (GPH) Consortium. Fedorowski A, Franceschini N, Brody J, Liu C, Verwoert GC, Boerwinkle E, Couper D, Rice KM, Rotter JI, Mattace-Raso F, Uitterlinden A, Hofman A, Almgren P, Sjögren M, Hedblad B, Larson MG, Newton-Cheh C, Wang TJ, Rose KM, Psaty BM, Levy D, Witteman J, Melander O (2012) Eur Heart J 33(18): 2331-41
    › Primary publication · 22504314 (PubMed) · PMC3442958 (PubMed Central)
  41. Metabolite profiling identifies pathways associated with metabolic risk in humans. Cheng S, Rhee EP, Larson MG, Lewis GD, McCabe EL, Shen D, Palma MJ, Roberts LD, Dejam A, Souza AL, Deik AA, Magnusson M, Fox CS, O'Donnell CJ, Vasan RS, Melander O, Clish CB, Gerszten RE, Wang TJ (2012) Circulation 125(18): 2222-31
    › Primary publication · 22496159 (PubMed) · PMC3376658 (PubMed Central)
  42. Correlation of renin angiotensin and aldosterone system activity with subcutaneous and visceral adiposity: the framingham heart study. O'Seaghdha CM, Hwang SJ, Vasan RS, Larson MG, Hoffmann U, Wang TJ, Fox CS (2012) BMC Endocr Disord : 3
    › Primary publication · 22475205 (PubMed) · PMC3352034 (PubMed Central)
  43. Vitamin D and cardiovascular risk. Motiwala SR, Wang TJ (2012) Curr Hypertens Rep 14(3): 209-18
    › Primary publication · 22457243 (PubMed)
  44. Multiple biomarkers and risk of clinical and subclinical vascular brain injury: the Framingham Offspring Study. Pikula A, Beiser AS, DeCarli C, Himali JJ, Debette S, Au R, Selhub J, Toffler GH, Wang TJ, Meigs JB, Kelly-Hayes M, Kase CS, Wolf PA, Vasan RS, Seshadri S (2012) Circulation 125(17): 2100-7
    › Primary publication · 22456473 (PubMed) · PMC3427730 (PubMed Central)
  45. Cardiac arrest during long-distance running races. Kim JH, Malhotra R, Chiampas G, d'Hemecourt P, Troyanos C, Cianca J, Smith RN, Wang TJ, Roberts WO, Thompson PD, Baggish AL, Race Associated Cardiac Arrest Event Registry (RACER) Study Group (2012) N Engl J Med 366(2): 130-40
    › Primary publication · 22236223 (PubMed)
  46. Biomarkers and cardiovascular risk assessment for primary prevention: an update. Gilstrap LG, Wang TJ (2012) Clin Chem 58(1): 72-82
    › Primary publication · 22125305 (PubMed) · PMC4105324 (PubMed Central)
  47. Circulating angiogenic cell populations, vascular function, and arterial stiffness. Cheng S, Wang N, Larson MG, Palmisano JN, Mitchell GF, Benjamin EJ, Vasan RS, Levy D, McCabe EL, Vita JA, Wang TJ, Shaw SY, Cohen KS, Hamburg NM (2012) Atherosclerosis 220(1): 145-50
    › Primary publication · 22093724 (PubMed) · PMC3277804 (PubMed Central)
  48. Use of amino-terminal pro-B-type natriuretic peptide to guide outpatient therapy of patients with chronic left ventricular systolic dysfunction. Januzzi JL, Rehman SU, Mohammed AA, Bhardwaj A, Barajas L, Barajas J, Kim HN, Baggish AL, Weiner RB, Chen-Tournoux A, Marshall JE, Moore SA, Carlson WD, Lewis GD, Shin J, Sullivan D, Parks K, Wang TJ, Gregory SA, Uthamalingam S, Semigran MJ (2011) J Am Coll Cardiol 58(18): 1881-9
    › Primary publication · 22018299 (PubMed)
  49. Usefulness of the blood hematocrit level to predict development of heart failure in a community. Coglianese EE, Qureshi MM, Vasan RS, Wang TJ, Moore LL (2012) Am J Cardiol 109(2): 241-5
    › Primary publication · 21996141 (PubMed) · PMC3663594 (PubMed Central)
  50. Insulin resistance and atrial fibrillation (from the Framingham Heart Study). Fontes JD, Lyass A, Massaro JM, Rienstra M, Dallmeier D, Schnabel RB, Wang TJ, Vasan RS, Lubitz SA, Magnani JW, Levy D, Ellinor PT, Fox CS, Benjamin EJ (2012) Am J Cardiol 109(1): 87-90
    › Primary publication · 21996140 (PubMed) · PMC3242834 (PubMed Central)
  51. Vitamin D status is not related to development of atrial fibrillation in the community. Rienstra M, Cheng S, Larson MG, McCabe EL, Booth SL, Jacques PF, Lubitz SA, Yin X, Levy D, Magnani JW, Ellinor PT, Benjamin EJ, Wang TJ (2011) Am Heart J 162(3): 538-41
    › Primary publication · 21884873 (PubMed) · PMC3170821 (PubMed Central)
  52. Reference limits for N-terminal-pro-B-type natriuretic peptide in healthy individuals (from the Framingham Heart Study). Fradley MG, Larson MG, Cheng S, McCabe E, Coglianese E, Shah RV, Levy D, Vasan RS, Wang TJ (2011) Am J Cardiol 108(9): 1341-5
    › Primary publication · 21864812 (PubMed) · PMC3209520 (PubMed Central)
  53. Cardiac natriuretic peptides, obesity, and insulin resistance: evidence from two community-based studies. Khan AM, Cheng S, Magnusson M, Larson MG, Newton-Cheh C, McCabe EL, Coviello AD, Florez JC, Fox CS, Levy D, Robins SJ, Arora P, Bhasin S, Lam CS, Vasan RS, Melander O, Wang TJ (2011) J Clin Endocrinol Metab 96(10): 3242-9
    › Primary publication · 21849523 (PubMed) · PMC3200240 (PubMed Central)
  54. Relation of visceral adiposity to circulating natriuretic peptides in ambulatory individuals. Cheng S, Fox CS, Larson MG, Massaro JM, McCabe EL, Khan AM, Levy D, Hoffmann U, O'Donnell CJ, Miller KK, Newton-Cheh C, Coviello AD, Bhasin S, Vasan RS, Wang TJ (2011) Am J Cardiol 108(7): 979-84
    › Primary publication · 21813106 (PubMed) · PMC3175269 (PubMed Central)
  55. Influence of sex and hormone status on circulating natriuretic peptides. Lam CS, Cheng S, Choong K, Larson MG, Murabito JM, Newton-Cheh C, Bhasin S, McCabe EL, Miller KK, Redfield MM, Vasan RS, Coviello AD, Wang TJ (2011) J Am Coll Cardiol 58(6): 618-26
    › Primary publication · 21798425 (PubMed) · PMC3170816 (PubMed Central)
  56. Dynamic regulation of circulating microRNA during acute exhaustive exercise and sustained aerobic exercise training. Baggish AL, Hale A, Weiner RB, Lewis GD, Systrom D, Wang F, Wang TJ, Chan SY (2011) J Physiol 589(Pt 16): 3983-94
    › Primary publication · 21690193 (PubMed) · PMC3179997 (PubMed Central)
  57. Performance of the 2010 European Society of Cardiology criteria for ECG interpretation in athletes. Weiner RB, Hutter AM, Wang F, Kim JH, Wood MJ, Wang TJ, Picard MH, Baggish AL (2011) Heart 97(19): 1573-7
    › Primary publication · 21602522 (PubMed)
  58. Early repolarization pattern in competitive athletes: clinical correlates and the effects of exercise training. Noseworthy PA, Weiner R, Kim J, Keelara V, Wang F, Berkstresser B, Wood MJ, Wang TJ, Picard MH, Hutter AM, Newton-Cheh C, Baggish AL (2011) Circ Arrhythm Electrophysiol 4(4): 432-40
    › Primary publication · 21543642 (PubMed) · PMC3700366 (PubMed Central)
  59. Vitamin D and cardiovascular disease. Motiwala SR, Wang TJ (2011) Curr Opin Nephrol Hypertens 20(4): 345-53
    › Primary publication · 21519252 (PubMed)
  60. Genetic and clinical correlates of early-outgrowth colony-forming units. Shaw SY, Cheng S, Cupples LA, Larson MG, McCabe EL, Ngwa JS, Wang YA, Martin RP, Klein RJ, Hashmi B, Ajijola OA, Lau E, O'Donnell CJ, Vasan RS, Cohen KS, Wang TJ (2011) Circ Cardiovasc Genet 4(3): 296-304
    › Primary publication · 21493818 (PubMed) · PMC3339257 (PubMed Central)
  61. Higher aldosterone and lower N-terminal proatrial natriuretic peptide as biomarkers of salt sensitivity in the community. Lieb W, Pencina MJ, Jacques PF, Wang TJ, Larson MG, Levy D, Kannel WB, Vasan RS (2011) Eur J Cardiovasc Prev Rehabil 18(4): 664-73
    › Primary publication · 21450637 (PubMed) · PMC3179529 (PubMed Central)
  62. Metabolite profiles and the risk of developing diabetes. Wang TJ, Larson MG, Vasan RS, Cheng S, Rhee EP, McCabe E, Lewis GD, Fox CS, Jacques PF, Fernandez C, O'Donnell CJ, Carr SA, Mootha VK, Florez JC, Souza A, Melander O, Clish CB, Gerszten RE (2011) Nat Med 17(4): 448-53
    › Primary publication · 21423183 (PubMed) · PMC3126616 (PubMed Central)
  63. Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans. Rhee EP, Cheng S, Larson MG, Walford GA, Lewis GD, McCabe E, Yang E, Farrell L, Fox CS, O'Donnell CJ, Carr SA, Vasan RS, Florez JC, Clish CB, Wang TJ, Gerszten RE (2011) J Clin Invest 121(4): 1402-11
    › Primary publication · 21403394 (PubMed) · PMC3069773 (PubMed Central)
  64. Assessing the role of circulating, genetic, and imaging biomarkers in cardiovascular risk prediction. Wang TJ (2011) Circulation 123(5): 551-65
    › Primary publication · 21300963 (PubMed) · PMC3059807 (PubMed Central)
  65. Validation of an atrial fibrillation risk algorithm in whites and African Americans. Schnabel RB, Aspelund T, Li G, Sullivan LM, Suchy-Dicey A, Harris TB, Pencina MJ, D'Agostino RB, Levy D, Kannel WB, Wang TJ, Kronmal RA, Wolf PA, Burke GL, Launer LJ, Vasan RS, Psaty BM, Benjamin EJ, Gudnason V, Heckbert SR (2010) Arch Intern Med 170(21): 1909-17
    › Primary publication · 21098350 (PubMed) · PMC3021784 (PubMed Central)
  66. Effect of weight loss after weight loss surgery on plasma N-terminal pro-B-type natriuretic peptide levels. Chen-Tournoux A, Khan AM, Baggish AL, Castro VM, Semigran MJ, McCabe EL, Moukarbel G, Reingold J, Durrani S, Lewis GD, Newton-Cheh C, Scherrer-Crosbie M, Kaplan LM, Wang TJ (2010) Am J Cardiol 106(10): 1450-5
    › Primary publication · 21059435 (PubMed) · PMC3170817 (PubMed Central)
  67. A multi-marker approach to predict incident CKD and microalbuminuria. Fox CS, Gona P, Larson MG, Selhub J, Tofler G, Hwang SJ, Meigs JB, Levy D, Wang TJ, Jacques PF, Benjamin EJ, Vasan RS (2010) J Am Soc Nephrol 21(12): 2143-9
    › Primary publication · 20966127 (PubMed) · PMC3014027 (PubMed Central)
  68. Multimarker approach for the prediction of heart failure incidence in the community. Velagaleti RS, Gona P, Larson MG, Wang TJ, Levy D, Benjamin EJ, Selhub J, Jacques PF, Meigs JB, Tofler GH, Vasan RS (2010) Circulation 122(17): 1700-6
    › Primary publication · 20937976 (PubMed) · PMC2993157 (PubMed Central)
  69. Lack of association between serum magnesium and the risks of hypertension and cardiovascular disease. Khan AM, Sullivan L, McCabe E, Levy D, Vasan RS, Wang TJ (2010) Am Heart J 160(4): 715-20
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  135. Association of plasma natriuretic peptide levels with metabolic risk factors in ambulatory individuals. Wang TJ, Larson MG, Keyes MJ, Levy D, Benjamin EJ, Vasan RS (2007) Circulation 115(11): 1345-53
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  136. Pulse pressure and risk of new-onset atrial fibrillation. Mitchell GF, Vasan RS, Keyes MJ, Parise H, Wang TJ, Larson MG, D'Agostino RB, Kannel WB, Levy D, Benjamin EJ (2007) JAMA 297(7): 709-15
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  137. Clinical and genetic correlates of aldosterone-to-renin ratio and relations to blood pressure in a community sample. Newton-Cheh C, Guo CY, Gona P, Larson MG, Benjamin EJ, Wang TJ, Kathiresan S, O'Donnell CJ, Musone SL, Camargo AL, Drake JA, Levy D, Hirschhorn JN, Vasan RS (2007) Hypertension 49(4): 846-56
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  138. Clinical correlates of circulating visfatin levels in a community-based sample. Ingelsson E, Larson MG, Fox CS, Yin X, Wang TJ, Lipinska I, Pou KM, Hoffmann U, Benjamin EJ, Keaney JF, Vasan RS (2007) Diabetes Care 30(5): 1278-80
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  139. Multiple biomarkers and the risk of incident hypertension. Wang TJ, Gona P, Larson MG, Levy D, Benjamin EJ, Tofler GH, Jacques PF, Meigs JB, Rifai N, Selhub J, Robins SJ, Newton-Cheh C, Vasan RS (2007) Hypertension 49(3): 432-8
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  140. Multiple biomarkers for the prediction of first major cardiovascular events and death. Wang TJ, Gona P, Larson MG, Tofler GH, Levy D, Newton-Cheh C, Jacques PF, Rifai N, Selhub J, Robins SJ, Benjamin EJ, D'Agostino RB, Vasan RS (2006) N Engl J Med 355(25): 2631-9
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  141. Gamma glutamyl transferase and metabolic syndrome, cardiovascular disease, and mortality risk: the Framingham Heart Study. Lee DS, Evans JC, Robins SJ, Wilson PW, Albano I, Fox CS, Wang TJ, Benjamin EJ, D'Agostino RB, Vasan RS (2007) Arterioscler Thromb Vasc Biol 27(1): 127-33
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  142. Obstructive sleep apnea and plasma natriuretic peptide levels in a community-based sample. Patwardhan AA, Larson MG, Levy D, Benjamin EJ, Leip EP, Keyes MJ, Wang TJ, Gottlieb DJ, Vasan RS (2006) Sleep 29(10): 1301-6
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  143. Clinical and echocardiographic correlates of plasma osteopontin in the community: the Framingham Heart Study. Arnlöv J, Evans JC, Benjamin EJ, Larson MG, Levy D, Sutherland P, Siwik DA, Wang TJ, Colucci WS, Vasan RS (2006) Heart 92(10): 1514-5
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  144. Endogenous sex hormones and cardiovascular disease incidence in men. Arnlöv J, Pencina MJ, Amin S, Nam BH, Benjamin EJ, Murabito JM, Wang TJ, Knapp PE, D'Agostino RB, Bhasin S, Vasan RS (2006) Ann Intern Med 145(3): 176-84
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  145. Association of parental heart failure with risk of heart failure in offspring. Lee DS, Pencina MJ, Benjamin EJ, Wang TJ, Levy D, O'Donnell CJ, Nam BH, Larson MG, D'Agostino RB, Vasan RS (2006) N Engl J Med 355(2): 138-47
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  146. Screening for ventricular remodeling. Lee DS, Wang TJ, Vasan RS (2006) Curr Heart Fail Rep 3(1): 5-13
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  147. Electrocardiographic QRS duration and the risk of congestive heart failure: the Framingham Heart Study. Dhingra R, Pencina MJ, Wang TJ, Nam BH, Benjamin EJ, Levy D, Larson MG, Kannel WB, D'Agostino RB, Vasan RS (2006) Hypertension 47(5): 861-7
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  148. Cross-sectional relations of multiple biomarkers from distinct biological pathways to brachial artery endothelial function. Kathiresan S, Gona P, Larson MG, Vita JA, Mitchell GF, Tofler GH, Levy D, Newton-Cheh C, Wang TJ, Benjamin EJ, Vasan RS (2006) Circulation 113(7): 938-45
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  149. Sibling cardiovascular disease as a risk factor for cardiovascular disease in middle-aged adults. Murabito JM, Pencina MJ, Nam BH, D'Agostino RB, Wang TJ, Lloyd-Jones D, Wilson PW, O'Donnell CJ (2005) JAMA 294(24): 3117-23
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  150. Epidemiology of uncontrolled hypertension in the United States. Wang TJ, Vasan RS (2005) Circulation 112(11): 1651-62
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  151. Low-grade albuminuria and incidence of cardiovascular disease events in nonhypertensive and nondiabetic individuals: the Framingham Heart Study. Arnlöv J, Evans JC, Meigs JB, Wang TJ, Fox CS, Levy D, Benjamin EJ, D'Agostino RB, Vasan RS (2005) Circulation 112(7): 969-75
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  152. Low-grade albuminuria and the risks of hypertension and blood pressure progression. Wang TJ, Evans JC, Meigs JB, Rifai N, Fox CS, D'Agostino RB, Levy D, Vasan RS (2005) Circulation 111(11): 1370-6
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  153. Cross-sectional relations of electrocardiographic QRS duration to left ventricular dimensions: the Framingham Heart Study. Dhingra R, Ho Nam B, Benjamin EJ, Wang TJ, Larson MG, D'Agostino RB, Levy D, Vasan RS (2005) J Am Coll Cardiol 45(5): 685-9
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  154. Obesity and the risk of new-onset atrial fibrillation. Wang TJ, Parise H, Levy D, D'Agostino RB, Wolf PA, Vasan RS, Benjamin EJ (2004) JAMA 292(20): 2471-7
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  155. Lifetime risk for development of atrial fibrillation: the Framingham Heart Study. Lloyd-Jones DM, Wang TJ, Leip EP, Larson MG, Levy D, Vasan RS, D'Agostino RB, Massaro JM, Beiser A, Wolf PA, Benjamin EJ (2004) Circulation 110(9): 1042-6
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  156. Parental atrial fibrillation as a risk factor for atrial fibrillation in offspring. Fox CS, Parise H, D'Agostino RB, Lloyd-Jones DM, Vasan RS, Wang TJ, Levy D, Wolf PA, Benjamin EJ (2004) JAMA 291(23): 2851-5
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  157. Parental cardiovascular disease as a risk factor for cardiovascular disease in middle-aged adults: a prospective study of parents and offspring. Lloyd-Jones DM, Nam BH, D'Agostino RB, Levy D, Murabito JM, Wang TJ, Wilson PW, O'Donnell CJ (2004) JAMA 291(18): 2204-11
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  158. Plasma natriuretic peptide levels and the risk of cardiovascular events and death. Wang TJ, Larson MG, Levy D, Benjamin EJ, Leip EP, Omland T, Wolf PA, Vasan RS (2004) N Engl J Med 350(7): 655-63
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  159. Impact of obesity on plasma natriuretic peptide levels. Wang TJ, Larson MG, Levy D, Benjamin EJ, Leip EP, Wilson PW, Vasan RS (2004) Circulation 109(5): 594-600
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  160. A risk score for predicting stroke or death in individuals with new-onset atrial fibrillation in the community: the Framingham Heart Study. Wang TJ, Massaro JM, Levy D, Vasan RS, Wolf PA, D'Agostino RB, Larson MG, Kannel WB, Benjamin EJ (2003) JAMA 290(8): 1049-56
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  161. Natural history of asymptomatic left ventricular systolic dysfunction in the community. Wang TJ, Evans JC, Benjamin EJ, Levy D, LeRoy EC, Vasan RS (2003) Circulation 108(8): 977-82
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  162. Carotid intima-media thickness is associated with premature parental coronary heart disease: the Framingham Heart Study. Wang TJ, Nam BH, D'Agostino RB, Wolf PA, Lloyd-Jones DM, MacRae CA, Wilson PW, Polak JF, O'Donnell CJ (2003) Circulation 108(5): 572-6
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  163. Heritability and genetic linkage of plasma natriuretic peptide levels. Wang TJ, Larson MG, Levy D, Benjamin EJ, Corey D, Leip EP, Vasan RS (2003) Circulation 108(1): 13-6
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  164. The epidemiology of "asymptomatic" left ventricular systolic dysfunction: implications for screening. Wang TJ, Levy D, Benjamin EJ, Vasan RS (2003) Ann Intern Med 138(11): 907-16
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  165. Temporal relations of atrial fibrillation and congestive heart failure and their joint influence on mortality: the Framingham Heart Study. Wang TJ, Larson MG, Levy D, Vasan RS, Leip EP, Wolf PA, D'Agostino RB, Murabito JM, Kannel WB, Benjamin EJ (2003) Circulation 107(23): 2920-5
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  166. Plasma brain natriuretic peptide levels and blood pressure tracking in the Framingham Heart Study. Freitag MH, Larson MG, Levy D, Benjamin EJ, Wang TJ, Leip EP, Wilson PW, Vasan RS, Framingham Heart Study (2003) Hypertension 41(4): 978-83
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  167. Association of C-reactive protein with carotid atherosclerosis in men and women: the Framingham Heart Study. Wang TJ, Nam BH, Wilson PW, Wolf PA, Levy D, Polak JF, D'Agostino RB, O'Donnell CJ (2002) Arterioscler Thromb Vasc Biol 22(10): 1662-7
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  168. Plasma natriuretic peptides for community screening for left ventricular hypertrophy and systolic dysfunction: the Framingham heart study. Vasan RS, Benjamin EJ, Larson MG, Leip EP, Wang TJ, Wilson PW, Levy D (2002) JAMA 288(10): 1252-9
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  169. C-reactive protein is associated with subclinical epicardial coronary calcification in men and women: the Framingham Heart Study. Wang TJ, Larson MG, Levy D, Benjamin EJ, Kupka MJ, Manning WJ, Clouse ME, D'Agostino RB, Wilson PW, O'Donnell CJ (2002) Circulation 106(10): 1189-91
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  170. A utilization management intervention to reduce unnecessary testing in the coronary care unit. Wang TJ, Mort EA, Nordberg P, Chang Y, Cadigan ME, Mylott L, Ananian LV, Thompson BT, Fessler M, Warren W, Wheeler A, Jordan M, Fifer MA (2002) Arch Intern Med 162(16): 1885-90
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  171. Impact of age and sex on plasma natriuretic peptide levels in healthy adults. Wang TJ, Larson MG, Levy D, Leip EP, Benjamin EJ, Wilson PW, Sutherland P, Omland T, Vasan RS (2002) Am J Cardiol 90(3): 254-8
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  172. Randomized clinical trials and recent patterns in the use of statins. Wang TJ, Stafford RS, Ausiello JC, Chaisson CE (2001) Am Heart J 141(6): 957-63
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  173. Coexposure to Borrelia burgdorferi and Babesia microti does not worsen the long-term outcome of lyme disease. Wang TJ, Liang MH, Sangha O, Phillips CB, Lew RA, Wright EA, Berardi V, Fossel AH, Shadick NA (2000) Clin Infect Dis 31(5): 1149-54
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  174. Trends in antihypertensive drug advertising, 1985-1996. Wang TJ, Ausiello JC, Stafford RS (1999) Circulation 99(15): 2055-7
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  175. Outcomes of children treated for Lyme disease. Wang TJ, Sangha O, Phillips CB, Wright EA, Lew RA, Fossel AH, Fossel K, Shadick NA, Liang MH, Sundel RP (1998) J Rheumatol 25(11): 2249-53
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  176. National patterns and predictors of beta-blocker use in patients with coronary artery disease. Wang TJ, Stafford RS (1998) Arch Intern Med 158(17): 1901-6
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  177. Lack of cardiac manifestations among patients with previously treated Lyme disease. Sangha O, Phillips CB, Fleischmann KE, Wang TJ, Fossel AH, Lew R, Liang MH, Shadick NA (1998) Ann Intern Med 128(5): 346-53
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