David Robertson
Last active: 5/16/2015

Profile

Our laboratory is interested in identifying the mechanisms of neural regulation of heart rate and blood pressure in normal individuals, as well as in patients with cardiovascular, psychiatric or neurological disorders. Using a bench-to-bedside approach that merges our clinical research and our basic research, we have successfully identified the previously unrecognized disorders of dopamine -hydroxylase deficiency, baroreflex failure, and norepinephrine transporter deficiency. New therapeutic advances have been a natural follow-up to these discoveries.

Investigative strengths of our laboratory include genetic linkage studies and identification of polymorphisms in candidate genes relevant to autonomic neuroscience. The laboratory focuses on transgenic mice as models of human disease, examining whole animal physiology and using radio telemetry, power spectral analysis, bioengineering, and pharmacologic testing in phenotyping relevant knock-out mice.

Publications

The following timeline graph is generated from all co-authored publications.

  1. Acute hemodynamic effects of a selective serotonin reuptake inhibitor in postural tachycardia syndrome: a randomized, crossover trial. Mar PL, Raj V, Black BK, Biaggioni I, Shibao CA, Paranjape SY, Dupont WD, Robertson D, Raj SR (2014) J Psychopharmacol 28(2): 155-61
    › Primary publication · 24227635 (PubMed) · PMC3956655 (PubMed Central)
  2. SHC2 gene copy number in multiple system atrophy (MSA). Ferguson MC, Garland EM, Hedges L, Womack-Nunley B, Hamid R, Phillips JA, Shibao CA, Raj SR, Biaggioni I, Robertson D (2014) Clin Auton Res 24(1): 25-30
    › Primary publication · 24170347 (PubMed) · PMC3946192 (PubMed Central)
  3. Effects of norepinephrine reuptake inhibition on postural tachycardia syndrome. Green EA, Raj V, Shibao CA, Biaggioni I, Black BK, Dupont WD, Robertson D, Raj SR (2013) J Am Heart Assoc 2(5): e000395
    › Primary publication · 24002370 (PubMed) · PMC3835251 (PubMed Central)
  4. Pediatric ptosis as a sign of treatable autonomic dysfunction. Phillips L, Robertson D, Melson MR, Garland EM, Joos KM (2013) Am J Ophthalmol 156(2): 370-374.e2
    › Primary publication · 23622564 (PubMed) · PMC3720787 (PubMed Central)
  5. Neurogenic orthostatic hypotension: pathophysiology, evaluation, and management. Metzler M, Duerr S, Granata R, Krismer F, Robertson D, Wenning GK (2013) J Neurol 260(9): 2212-9
    › Primary publication · 23180176 (PubMed) · PMC3764319 (PubMed Central)
  6. Long-term treatment with rituximab of autoimmune autonomic ganglionopathy in a patient with lymphoma. Hollenbeck R, Black BK, Peltier AC, Biaggioni I, Robertson D, Winton EF, Raj SR (2011) Arch Neurol 68(3): 372-5
    › Primary publication · 21059985 (PubMed) · PMC3725638 (PubMed Central)
  7. Comparative efficacy of yohimbine against pyridostigmine for the treatment of orthostatic hypotension in autonomic failure. Shibao C, Okamoto LE, Gamboa A, Yu C, Diedrich A, Raj SR, Robertson D, Biaggioni I (2010) Hypertension 56(5): 847-51
    › Primary publication · 20837887 (PubMed) · PMC2959129 (PubMed Central)
  8. The effect of donepezil treatment on cardiovascular mortality. Sato K, Urbano R, Yu C, Yamasaki F, Sato T, Jordan J, Robertson D, Diedrich A (2010) Clin Pharmacol Ther 88(3): 335-8
    › Primary publication · 20664535 (PubMed) · PMC3120840 (PubMed Central)
  9. Tachycardia, reduced vagal capacity, and age-dependent ventricular dysfunction arising from diminished expression of the presynaptic choline transporter. English BA, Appalsamy M, Diedrich A, Ruggiero AM, Lund D, Wright J, Keller NR, Louderback KM, Robertson D, Blakely RD (2010) Am J Physiol Heart Circ Physiol 299(3): H799-810
    › Primary publication · 20601463 (PubMed) · PMC2944482 (PubMed Central)
  10. Identifying unpredicted drug benefit through query of patient experiential knowledge: a proof of concept web-based system. Pulley J, Hassan NN, Bernard GR, Jirjis JN, Schildcrout J, Robertson D, Masys DR, Harris P (2010) Clin Transl Sci 3(3): 98-103
    › Primary publication · 20590678 (PubMed) · PMC2910903 (PubMed Central)