Profile

A decade ago the synthesis of glycogen which occurs in the liver after oral glucose feeding was thought to be the result of the ingested glucose triggering insulin release and the insulin in turn causing the liver to take up and store the glucose. It is now clear that this storage response is much more complicated than first thought. We now know that another signal, as yet poorly understood, is involved in activating the liver, and further, that much of the glycogen deposited does not come "directly" from ingested glucose but "indirectly" from 3-carbon precursors which enter liver glycogen via the gluconeogenic pathway. We are currently using a chronically catheterized dog model to study the physiology of this "new" signal and the conditions under which liver glycogen is synthesized via the "direct" or "indirect" routes.

Remarkably, if the body is exposed to an insulin level 30 times normal, the resulting hypoglycemia will be limited to a level compatible with life. The reason for this life saving response is that the stimulatory effect of insulin on glucose utilization and its inhibitory effect on glucose production are limited by a variety of hormonal and neural mechanisms. We are currently investigating the role of each mechanism in limiting insulin induced hypoglycemia using conscious dogs. In addition, we are studying the ability of the brain to sense and respond directly to insulin via vertebral and carotid artery infusion or insulin infusion into the 3rd ventricle. We are also examining the defects which occur in counterregulation in diabetes.

We continue to define the actions of various hormones (insulin, glucagon, epinephrine, cortisol) and neural mediators (norepinephrine, acetylcholine, cGRP, NPY) and drugs on glucose production (glycogenolysis and gluconeogenesis) and utilization by the liver.

Our experiments are carried out in vivo using transgenic mice, the conscious dog and man or in vitro using perfused liver and isolated liver cells. Control over various aspects of the endocrine and/or nervous system is gained using pharmacologic and/or surgical techniques. The rates of glucose production (glycogenolysis; gluconeogenesis) and utilization, as well as ketone body production and clearance are assessed using tracer and arteriovenous differences techniques.
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Publications

The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. Biologic comparison of inhaled insulin formulations: Exubera™ and novel spray-dried engineered particles of dextran-10. Kuehl PJ, Cherrington A, Dobry DE, Edgerton D, Friesen DT, Hobbs C, Leach CL, Murri B, Neal D, Lyon DK, Vodak DT, Reed MD (2014) AAPS PharmSciTech 15(6): 1545-50
    › Primary publication · 25106135 (PubMed) · PMC4245427 (PubMed Central)
  2. Changes in glucose and fat metabolism in response to the administration of a hepato-preferential insulin analog. Edgerton DS, Moore MC, Winnick JJ, Scott M, Farmer B, Naver H, Jeppesen CB, Madsen P, Kjeldsen TB, Nishimura E, Brand CL, Cherrington AD (2014) Diabetes 63(11): 3946-54
    › Primary publication · 24947349 (PubMed) · PMC4392933 (PubMed Central)
  3. Hepatic glucose uptake and disposition during short-term high-fat vs. high-fructose feeding. Coate KC, Kraft G, Moore MC, Smith MS, Ramnanan C, Irimia JM, Roach PJ, Farmer B, Neal DW, Williams P, Cherrington AD (2014) Am J Physiol Endocrinol Metab 307(2): E151-60
    › Primary publication · 24865981 (PubMed) · PMC4101635 (PubMed Central)
  4. Effect of the glucagon-like peptide-1 receptor agonist lixisenatide on postprandial hepatic glucose metabolism in the conscious dog. Moore MC, Werner U, Smith MS, Farmer TD, Cherrington AD (2013) Am J Physiol Endocrinol Metab 305(12): E1473-82
    › Primary publication · 24148347 (PubMed) · PMC3882379 (PubMed Central)
  5. Novel PEGylated basal insulin LY2605541 has a preferential hepatic effect on glucose metabolism. Moore MC, Smith MS, Sinha VP, Beals JM, Michael MD, Jacober SJ, Cherrington AD (2014) Diabetes 63(2): 494-504
    › Primary publication · 24089512 (PubMed) · PMC5361402 (PubMed Central)
  6. Glucagon's yin and yang effects on hepatic glucose production. Edgerton DS, Cherrington AD (2013) Nat Med 19(6): 674-5
    › Primary publication · 23744146 (PubMed) · PMC5407006 (PubMed Central)
  7. Effects of intraportal exenatide on hepatic glucose metabolism in the conscious dog. Edgerton DS, An Z, Johnson KM, Farmer T, Farmer B, Neal D, Cherrington AD (2013) Am J Physiol Endocrinol Metab 305(1): E132-9
    › Primary publication · 23673158 (PubMed) · PMC3725568 (PubMed Central)
  8. Canine body composition quantification using 3 tesla fat-water MRI. Gifford A, Kullberg J, Berglund J, Malmberg F, Coate KC, Williams PE, Cherrington AD, Avison MJ, Welch EB (2014) J Magn Reson Imaging 39(2): 485-91
    › Primary publication · 23596090 (PubMed) · PMC3735857 (PubMed Central)
  9. Dissecting the actions of widely used diabetes drugs. Unger RH, Berglund ED, Habener JF, Cherrington AD (2013) Nat Med 19(3): 272-3
    › Primary publication · 23467236 (PubMed)
  10. Effects of 11β-hydroxysteroid dehydrogenase-1 inhibition on hepatic glycogenolysis and gluconeogenesis. Winnick JJ, Ramnanan CJ, Saraswathi V, Roop J, Scott M, Jacobson P, Jung P, Basu R, Cherrington AD, Edgerton DS (2013) Am J Physiol Endocrinol Metab 304(7): E747-56
    › Primary publication · 23403942 (PubMed) · PMC3625750 (PubMed Central)
  11. Evolution of exenatide as a diabetes therapeutic. Bhavsar S, Mudaliar S, Cherrington A (2013) Curr Diabetes Rev 9(2): 161-93
    › Primary publication · 23256660 (PubMed) · PMC3664512 (PubMed Central)
  12. Portal vein glucose entry triggers a coordinated cellular response that potentiates hepatic glucose uptake and storage in normal but not high-fat/high-fructose-fed dogs. Coate KC, Kraft G, Irimia JM, Smith MS, Farmer B, Neal DW, Roach PJ, Shiota M, Cherrington AD (2013) Diabetes 62(2): 392-400
    › Primary publication · 23028137 (PubMed) · PMC3554368 (PubMed Central)
  13. Interaction between the central and peripheral effects of insulin in controlling hepatic glucose metabolism in the conscious dog. Ramnanan CJ, Kraft G, Smith MS, Farmer B, Neal D, Williams PE, Lautz M, Farmer T, Donahue EP, Cherrington AD, Edgerton DS (2013) Diabetes 62(1): 74-84
    › Primary publication · 23011594 (PubMed) · PMC3526039 (PubMed Central)
  14. Portal glucose delivery stimulates muscle but not liver protein metabolism. Kraft G, Coate KC, Dardevet D, Farmer B, Donahue EP, Williams PE, Cherrington AD, Moore MC (2012) Am J Physiol Endocrinol Metab 303(10): E1202-11
    › Primary publication · 23011060 (PubMed) · PMC3774325 (PubMed Central)
  15. Liver glycogen loading dampens glycogen synthesis seen in response to either hyperinsulinemia or intraportal glucose infusion. Winnick JJ, An Z, Kraft G, Ramnanan CJ, Irimia JM, Smith M, Lautz M, Roach PJ, Cherrington AD (2013) Diabetes 62(1): 96-101
    › Primary publication · 22923473 (PubMed) · PMC3526057 (PubMed Central)
  16. A cyclic guanosine monophosphate-dependent pathway can regulate net hepatic glucose uptake in vivo. An Z, Winnick JJ, Moore MC, Farmer B, Smith M, Irimia JM, Roach PJ, Cherrington AD (2012) Diabetes 61(10): 2433-41
    › Primary publication · 22688328 (PubMed) · PMC3447895 (PubMed Central)
  17. Regulation of hepatic glucose uptake and storage in vivo. Moore MC, Coate KC, Winnick JJ, An Z, Cherrington AD (2012) Adv Nutr 3(3): 286-94
    › Primary publication · 22585902 (PubMed) · PMC3649460 (PubMed Central)
  18. Evidence against a physiologic role for acute changes in CNS insulin action in the rapid regulation of hepatic glucose production. Ramnanan CJ, Edgerton DS, Cherrington AD (2012) Cell Metab 15(5): 656-64
    › Primary publication · 22560218 (PubMed) · PMC3348512 (PubMed Central)
  19. Glucagonocentric restructuring of diabetes: a pathophysiologic and therapeutic makeover. Unger RH, Cherrington AD (2012) J Clin Invest 122(1): 4-12
    › Primary publication · 22214853 (PubMed) · PMC3248306 (PubMed Central)
  20. Brain insulin action augments hepatic glycogen synthesis without suppressing glucose production or gluconeogenesis in dogs. Ramnanan CJ, Saraswathi V, Smith MS, Donahue EP, Farmer B, Farmer TD, Neal D, Williams PE, Lautz M, Mari A, Cherrington AD, Edgerton DS (2011) J Clin Invest 121(9): 3713-23
    › Primary publication · 21865644 (PubMed) · PMC3163950 (PubMed Central)
  21. Physiologic action of glucagon on liver glucose metabolism. Ramnanan CJ, Edgerton DS, Kraft G, Cherrington AD (2011) Diabetes Obes Metab : 118-25
    › Primary publication · 21824265 (PubMed) · PMC5371022 (PubMed Central)
  22. A high-fat, high-fructose diet accelerates nutrient absorption and impairs net hepatic glucose uptake in response to a mixed meal in partially pancreatectomized dogs. Coate KC, Kraft G, Lautz M, Smith M, Neal DW, Cherrington AD (2011) J Nutr 141(9): 1643-51
    › Primary publication · 21775526 (PubMed) · PMC3159053 (PubMed Central)
  23. Endogenously released GLP-1 is not sufficient to alter postprandial glucose regulation in the dog. Johnson KM, Farmer T, Schurr K, Patrick Donahue E, Farmer B, Neal D, Cherrington AD (2011) Endocrine 39(3): 229-34
    › Primary publication · 21547512 (PubMed) · PMC5371028 (PubMed Central)
  24. Impact of a glycogen phosphorylase inhibitor and metformin on basal and glucagon-stimulated hepatic glucose flux in conscious dogs. Torres TP, Sasaki N, Donahue EP, Lacy B, Printz RL, Cherrington AD, Treadway JL, Shiota M (2011) J Pharmacol Exp Ther 337(3): 610-20
    › Primary publication · 21363927 (PubMed) · PMC3207486 (PubMed Central)
  25. Glucagon as a critical factor in the pathology of diabetes. Edgerton DS, Cherrington AD (2011) Diabetes 60(2): 377-80
    › Primary publication · 21270249 (PubMed) · PMC3028334 (PubMed Central)
  26. Insulin-induced hypoglycemia increases hepatic sensitivity to glucagon in dogs. Rivera N, Ramnanan CJ, An Z, Farmer T, Smith M, Farmer B, Irimia JM, Snead W, Lautz M, Roach PJ, Cherrington AD (2010) J Clin Invest 120(12): 4425-35
    › Primary publication · 21084754 (PubMed) · PMC2993579 (PubMed Central)
  27. Chronic consumption of a high-fat/high-fructose diet renders the liver incapable of net hepatic glucose uptake. Coate KC, Scott M, Farmer B, Moore MC, Smith M, Roop J, Neal DW, Williams P, Cherrington AD (2010) Am J Physiol Endocrinol Metab 299(6): E887-98
    › Primary publication · 20823448 (PubMed) · PMC3006253 (PubMed Central)
  28. A soluble guanylate cyclase-dependent mechanism is involved in the regulation of net hepatic glucose uptake by nitric oxide in vivo. An Z, Winnick JJ, Farmer B, Neal D, Lautz M, Irimia JM, Roach PJ, Cherrington AD (2010) Diabetes 59(12): 2999-3007
    › Primary publication · 20823104 (PubMed) · PMC2992759 (PubMed Central)
  29. Molecular characterization of insulin-mediated suppression of hepatic glucose production in vivo. Ramnanan CJ, Edgerton DS, Rivera N, Irimia-Dominguez J, Farmer B, Neal DW, Lautz M, Donahue EP, Meyer CM, Roach PJ, Cherrington AD (2010) Diabetes 59(6): 1302-11
    › Primary publication · 20185816 (PubMed) · PMC2874690 (PubMed Central)
  30. Effect of 11 beta-hydroxysteroid dehydrogenase-1 inhibition on hepatic glucose metabolism in the conscious dog. Edgerton DS, Basu R, Ramnanan CJ, Farmer TD, Neal D, Scott M, Jacobson P, Rizza RA, Cherrington AD (2010) Am J Physiol Endocrinol Metab 298(5): E1019-26
    › Primary publication · 20159854 (PubMed) · PMC2867371 (PubMed Central)
  31. Effects of insulin on the metabolic control of hepatic gluconeogenesis in vivo. Edgerton DS, Ramnanan CJ, Grueter CA, Johnson KM, Lautz M, Neal DW, Williams PE, Cherrington AD (2009) Diabetes 58(12): 2766-75
    › Primary publication · 19755527 (PubMed) · PMC2780867 (PubMed Central)
  32. A physiological increase in the hepatic glycogen level does not affect the response of net hepatic glucose uptake to insulin. Winnick JJ, An Z, Moore MC, Ramnanan CJ, Farmer B, Shiota M, Cherrington AD (2009) Am J Physiol Endocrinol Metab 297(2): E358-66
    › Primary publication · 19470836 (PubMed) · PMC2724107 (PubMed Central)
  33. Portal infusion of escitalopram enhances hepatic glucose disposal in conscious dogs. An Z, Moore MC, Winnick JJ, Farmer B, Neal DW, Lautz M, Smith M, Rodewald T, Cherrington AD (2009) Eur J Pharmacol 607(1-3): 251-7
    › Primary publication · 19326481 (PubMed) · PMC2775505 (PubMed Central)
  34. Current strategies for the inhibition of hepatic glucose production in type 2 diabetes. Edgerton DS, Johnson KM, Cherrington AD (2009) Front Biosci (Landmark Ed) : 1169-81
    › Primary publication · 19273123 (PubMed)
  35. Inhaled insulin is associated with prolonged enhancement of glucose disposal in muscle and liver in the canine. Edgerton DS, Cherrington AD, Neal DW, Scott M, Lautz M, Brown N, Petro J, Hobbs CH, Leach C, Del Parigi A, Strack TR (2009) J Pharmacol Exp Ther 328(3): 970-5
    › Primary publication · 19098161 (PubMed) · PMC3202424 (PubMed Central)
  36. Regulation of hepatic metabolism by enteral delivery of nutrients. Dardevet D, Moore MC, Remond D, Everett-Grueter CA, Cherrington AD (2006) Nutr Res Rev 19(2): 161-73
    › Primary publication · 19079883 (PubMed)
  37. Portal infusion of amino acids is more efficient than peripheral infusion in stimulating liver protein synthesis at the same hepatic amino acid load in dogs. Dardevet D, Kimball SR, Jefferson LS, Cherrington AD, Rémond D, DiCostanzo CA, Moore MC (2008) Am J Clin Nutr 88(4): 986-96
    › Primary publication · 18842785 (PubMed) · PMC2750082 (PubMed Central)
  38. Inhibition of dipeptidyl peptidase-4 by vildagliptin during glucagon-like Peptide 1 infusion increases liver glucose uptake in the conscious dog. Edgerton DS, Johnson KM, Neal DW, Scott M, Hobbs CH, Zhang X, Duttaroy A, Cherrington AD (2009) Diabetes 58(1): 243-9
    › Primary publication · 18840785 (PubMed) · PMC2606880 (PubMed Central)
  39. Central versus peripheral glucose sensing and the response to hypoglycemia. Cherrington AD (2008) Diabetes 57(5): 1158-9
    › Primary publication · 18443372 (PubMed)
  40. Intraportal administration of neuropeptide Y and hepatic glucose metabolism. Nishizawa M, Shiota M, Moore MC, Gustavson SM, Neal DW, Cherrington AD (2008) Am J Physiol Regul Integr Comp Physiol 294(4): R1197-204
    › Primary publication · 18234742 (PubMed)
  41. Hepatic portal venous delivery of a nitric oxide synthase inhibitor enhances net hepatic glucose uptake. Moore MC, Dicostanzo CA, Smith MS, Farmer B, Rodewald TD, Neal DW, Williams PE, Cherrington AD (2008) Am J Physiol Endocrinol Metab 294(4): E768-77
    › Primary publication · 18212022 (PubMed)
  42. Intraportally delivered GLP-1, in the presence of hyperglycemia induced via peripheral glucose infusion, does not change whole body glucose utilization. Johnson KM, Edgerton DS, Rodewald T, Scott M, Farmer B, Neal D, Cherrington AD (2008) Am J Physiol Endocrinol Metab 294(2): E380-4
    › Primary publication · 18056788 (PubMed)
  43. Effects of the nitric oxide donor SIN-1 on net hepatic glucose uptake in the conscious dog. An Z, DiCostanzo CA, Moore MC, Edgerton DS, Dardevet DP, Neal DW, Cherrington AD (2008) Am J Physiol Endocrinol Metab 294(2): E300-6
    › Primary publication · 18029444 (PubMed)
  44. Insulin action on the liver in vivo. Cherrington AD, Moore MC, Sindelar DK, Edgerton DS (2007) Biochem Soc Trans 35(Pt 5): 1171-4
    › Primary publication · 17956305 (PubMed)
  45. Do adults who believe in periodic health examinations receive more clinical preventive services? Cherrington A, Corbie-Smith G, Pathman DE (2007) Prev Med 45(4): 282-9
    › Primary publication · 17692368 (PubMed) · PMC3757124 (PubMed Central)
  46. Intraportal GLP-1 infusion increases nonhepatic glucose utilization without changing pancreatic hormone levels. Johnson KM, Edgerton DS, Rodewald T, Scott M, Farmer B, Neal D, Cherrington AD (2007) Am J Physiol Endocrinol Metab 293(4): E1085-91
    › Primary publication · 17684104 (PubMed)
  47. The effect of vagal cooling on canine hepatic glucose metabolism in the presence of hyperglycemia of peripheral origin. DiCostanzo CA, Dardevet DP, Williams PE, Moore MC, Hastings JR, Neal DW, Cherrington AD (2007) Metabolism 56(6): 814-24
    › Primary publication · 17512315 (PubMed)
  48. Triglyceride uptake and lipoprotein lipase-generated fatty acid spillover in the splanchnic bed of dogs. Nelson RH, Edgerton DS, Basu R, Roesner JC, Cherrington AD, Miles JM (2007) Diabetes 56(7): 1850-5
    › Primary publication · 17416801 (PubMed)
  49. A novel glucagon receptor antagonist, NNC 25-0926, blunts hepatic glucose production in the conscious dog. Rivera N, Everett-Grueter CA, Edgerton DS, Rodewald T, Neal DW, Nishimura E, Larsen MO, Jacobsen LO, Kristensen K, Brand CL, Cherrington AD (2007) J Pharmacol Exp Ther 321(2): 743-52
    › Primary publication · 17308040 (PubMed)
  50. Inhalation of human insulin (exubera) augments the efficiency of muscle glucose uptake in vivo. Edgerton DS, Cherrington AD, Williams P, Neal DW, Scott M, Bowen L, Wilson W, Hobbs CH, Leach C, Kuo MC, Strack TR (2006) Diabetes 55(12): 3604-10
    › Primary publication · 17130510 (PubMed)
  51. Splanchnic cortisol production in dogs occurs primarily in the liver: evidence for substantial hepatic specific 11beta hydroxysteroid dehydrogenase type 1 activity. Basu R, Edgerton DS, Singh RJ, Cherrington A, Rizza RA (2006) Diabetes 55(11): 3013-9
    › Primary publication · 17065337 (PubMed)
  52. Inhalation of human insulin is associated with improved insulin action compared with subcutaneous injection and endogenous secretion in dogs. Edgerton DS, Stettler KM, Neal DW, Scott M, Bowen L, Wilson W, Hobbs CH, Leach C, Strack TR, Cherrington AD (2006) J Pharmacol Exp Ther 319(3): 1258-64
    › Primary publication · 16963622 (PubMed)
  53. 2005 Presidential Address: Diabetes: past, present, and future. Cherrington AD (2006) Diabetes Care 29(9): 2158-64
    › Primary publication · 16936170 (PubMed)
  54. Selective antagonism of the hepatic glucocorticoid receptor reduces hepatic glucose production. Edgerton DS, Jacobson PB, Opgenorth TJ, Zinker B, Beno D, von Geldern T, Ohman L, Scott M, Neal D, Cherrington AD (2006) Metabolism 55(9): 1255-62
    › Primary publication · 16919547 (PubMed)
  55. The effect of an acute elevation of NEFA concentrations on glucagon-stimulated hepatic glucose output. Everett-Grueter C, Edgerton DS, Donahue EP, Vaughan S, Chu CA, Sindelar DK, Cherrington AD (2006) Am J Physiol Endocrinol Metab 291(3): E449-59
    › Primary publication · 16608886 (PubMed)
  56. Insulin's direct effects on the liver dominate the control of hepatic glucose production. Edgerton DS, Lautz M, Scott M, Everett CA, Stettler KM, Neal DW, Chu CA, Cherrington AD (2006) J Clin Invest 116(2): 521-7
    › Primary publication · 16453026 (PubMed) · PMC1359060 (PubMed Central)
  57. Islet auto-transplantation into an omental or splenic site results in a normal beta cell but abnormal alpha cell response to mild non-insulin-induced hypoglycemia. Gustavson SM, Rajotte RV, Hunkeler D, Lakey JR, Edgerton DS, Neal DW, Snead WL, Penaloza AR, Cherrington AD (2005) Am J Transplant 5(10): 2368-77
    › Primary publication · 16162184 (PubMed)
  58. Role of the hepatic sympathetic nerves in the regulation of net hepatic glucose uptake and the mediation of the portal glucose signal. Dicostanzo CA, Dardevet DP, Neal DW, Lautz M, Allen E, Snead W, Cherrington AD (2006) Am J Physiol Endocrinol Metab 290(1): E9-E16
    › Primary publication · 16105863 (PubMed)
  59. Insulin secretion-independent effects of GLP-1 on canine liver glucose metabolism do not involve portal vein GLP-1 receptors. Dardevet D, Moore MC, DiCostanzo CA, Farmer B, Neal DW, Snead W, Lautz M, Cherrington AD (2005) Am J Physiol Gastrointest Liver Physiol 289(5): G806-14
    › Primary publication · 16051922 (PubMed) · PMC2435373 (PubMed Central)
  60. The role of hepatic insulin receptors in the regulation of glucose production. Cherrington AD (2005) J Clin Invest 115(5): 1136-9
    › Primary publication · 15864342 (PubMed) · PMC1087191 (PubMed Central)
  61. Inhalation of insulin (Exubera) is associated with augmented disposal of portally infused glucose in dogs. Edgerton DS, Neal DW, Scott M, Bowen L, Wilson W, Hobbs CH, Leach C, Sivakumaran S, Strack TR, Cherrington AD (2005) Diabetes 54(4): 1164-70
    › Primary publication · 15793257 (PubMed)
  62. Hepatic glucocorticoid receptor antagonism is sufficient to reduce elevated hepatic glucose output and improve glucose control in animal models of type 2 diabetes. Jacobson PB, von Geldern TW, Ohman L, Osterland M, Wang J, Zinker B, Wilcox D, Nguyen PT, Mika A, Fung S, Fey T, Goos-Nilsson A, Grynfarb M, Barkhem T, Marsh K, Beno DW, Nga-Nguyen B, Kym PR, Link JT, Tu N, Edgerton DS, Cherrington A, Efendic S, Lane BC, Opgenorth TJ (2005) J Pharmacol Exp Ther 314(1): 191-200
    › Primary publication · 15784656 (PubMed)
  63. Impact of continuous and pulsatile insulin delivery on net hepatic glucose uptake. Grubert JM, Lautz M, Lacy DB, Moore MC, Farmer B, Penaloza A, Cherrington AD, McGuinness OP (2005) Am J Physiol Endocrinol Metab 289(2): E232-40
    › Primary publication · 15755768 (PubMed)
  64. Portal 5-hydroxytryptophan infusion enhances glucose disposal in conscious dogs. Moore MC, Kimura K, Shibata H, Honjoh T, Saito M, Everett CA, Smith MS, Cherrington AD (2005) Am J Physiol Endocrinol Metab 289(2): E225-31
    › Primary publication · 15755767 (PubMed) · PMC2430063 (PubMed Central)
  65. Simulated first-phase insulin release using Humulin or insulin analog HIM2 is associated with prolonged improvement in postprandial glycemia. DiCostanzo CA, Moore MC, Lautz M, Scott M, Farmer B, Everett CA, Still JG, Higgins A, Cherrington AD (2005) Am J Physiol Endocrinol Metab 289(1): E46-52
    › Primary publication · 15713685 (PubMed)
  66. Inclusion of low amounts of fructose with an intraportal glucose load increases net hepatic glucose uptake in the presence of relative insulin deficiency in dog. Shiota M, Galassetti P, Igawa K, Neal DW, Cherrington AD (2005) Am J Physiol Endocrinol Metab 288(6): E1160-7
    › Primary publication · 15671083 (PubMed)
  67. Interaction of a selective serotonin reuptake inhibitor with insulin in the control of hepatic glucose uptake in conscious dogs. Moore MC, DiCostanzo CA, Dardevet D, Lautz M, Farmer B, Cherrington AD (2005) Am J Physiol Endocrinol Metab 288(3): E556-63
    › Primary publication · 15522992 (PubMed)
  68. Portal infusion of a selective serotonin reuptake inhibitor enhances hepatic glucose disposal in conscious dogs. Moore MC, DiCostanzo CA, Dardevet D, Lautz M, Farmer B, Neal DW, Cherrington AD (2004) Am J Physiol Endocrinol Metab 287(6): E1057-63
    › Primary publication · 15315909 (PubMed)
  69. Effects of hyperglycemia, glucagon, and epinephrine on renal glucose release in the conscious dog. Gustavson SM, Chu CA, Nishizawa M, Neal D, Farmer B, Yang Y, Donahue EP, Flakoll P, Cherrington AD (2004) Metabolism 53(7): 933-41
    › Primary publication · 15254890 (PubMed)
  70. Inhalation of insulin in dogs: assessment of insulin levels and comparison to subcutaneous injection. Cherrington AD, Neal DW, Edgerton DS, Glass D, Bowen L, Hobbs CH, Leach C, Rosskamp R, Strack TR (2004) Diabetes 53(4): 877-81
    › Primary publication · 15047601 (PubMed)
  71. Insulin-independent effects of GLP-1 on canine liver glucose metabolism: duration of infusion and involvement of hepatoportal region. Dardevet D, Moore MC, Neal D, DiCostanzo CA, Snead W, Cherrington AD (2004) Am J Physiol Endocrinol Metab 287(1): E75-81
    › Primary publication · 15026303 (PubMed)
  72. Selective stimulation of G-6-Pase catalytic subunit but not G-6-P transporter gene expression by glucagon in vivo and cAMP in situ. Hornbuckle LA, Everett CA, Martin CC, Gustavson SS, Svitek CA, Oeser JK, Neal DW, Cherrington AD, O'Brien RM (2004) Am J Physiol Endocrinol Metab 286(5): E795-808
    › Primary publication · 14722027 (PubMed)
  73. Nonesterified fatty acids and hepatic glucose metabolism in the conscious dog. Moore MC, Satake S, Lautz M, Soleimanpour SA, Neal DW, Smith M, Cherrington AD (2004) Diabetes 53(1): 32-40
    › Primary publication · 14693695 (PubMed)
  74. Portal serotonin infusion and glucose disposal in conscious dogs. Moore MC, Geho WB, Lautz M, Farmer B, Neal DW, Cherrington AD (2004) Diabetes 53(1): 14-20
    › Primary publication · 14693692 (PubMed)
  75. Rapid translocation of hepatic glucokinase in response to intraduodenal glucose infusion and changes in plasma glucose and insulin in conscious rats. Chu CA, Fujimoto Y, Igawa K, Grimsby J, Grippo JF, Magnuson MA, Cherrington AD, Shiota M (2004) Am J Physiol Gastrointest Liver Physiol 286(4): G627-34
    › Primary publication · 14656711 (PubMed)
  76. Effects of hyperglycemia on hepatic gluconeogenic flux during glycogen phosphorylase inhibition in the conscious dog. Edgerton DS, Cardin S, Neal D, Farmer B, Lautz M, Pan C, Cherrington AD (2004) Am J Physiol Endocrinol Metab 286(4): E510-22
    › Primary publication · 14644767 (PubMed)
  77. A fall in portal vein insulin does not cause the alpha-cell response to mild, non-insulin-induced hypoglycemia in conscious dogs. Gustavson SM, Nishizawa M, Farmer B, Neal D, Brissova M, Powers AC, Cherrington AD (2003) Metabolism 52(11): 1418-25
    › Primary publication · 14624400 (PubMed)
  78. Unlike mice, dogs exhibit effective glucoregulation during low-dose portal and peripheral glucose infusion. Moore MC, Cardin S, Edgerton DS, Farmer B, Neal DW, Lautz M, Cherrington AD (2004) Am J Physiol Endocrinol Metab 286(2): E226-33
    › Primary publication · 14519598 (PubMed)
  79. Regulation of hepatic and peripheral glucose disposal. Moore MC, Cherrington AD, Wasserman DH (2003) Best Pract Res Clin Endocrinol Metab 17(3): 343-64
    › Primary publication · 12962690 (PubMed)
  80. Chronic hepatic artery ligation does not prevent liver from differentiating portal vs. peripheral glucose delivery. Moore MC, Burish MJ, Farmer B, Neal DW, Pan C, Cherrington AD (2003) Am J Physiol Endocrinol Metab 285(4): E845-53
    › Primary publication · 12773306 (PubMed)
  81. Glucagon's actions are modified by the combination of epinephrine and gluconeogenic precursor infusion. Gustavson SM, Chu CA, Nishizawa M, Farmer B, Neal D, Yang Y, Vaughan S, Donahue EP, Flakoll P, Cherrington AD (2003) Am J Physiol Endocrinol Metab 285(3): E534-44
    › Primary publication · 12736160 (PubMed)
  82. Splanchnic free fatty acid kinetics. Jensen MD, Cardin S, Edgerton D, Cherrington A (2003) Am J Physiol Endocrinol Metab 284(6): E1140-8
    › Primary publication · 12736157 (PubMed)
  83. Interaction of glucagon and epinephrine in the control of hepatic glucose production in the conscious dog. Gustavson SM, Chu CA, Nishizawa M, Farmer B, Neal D, Yang Y, Donahue EP, Flakoll P, Cherrington AD (2003) Am J Physiol Endocrinol Metab 284(4): E695-707
    › Primary publication · 12626324 (PubMed)
  84. The role of neural signalling and hypoglycaemia per se in the counterregulatory response. Cherrington AD, Connolly CC, Chu CA, Moore MC (2002) Diabetes Nutr Metab 15(5): 303-7; discussion 307-8
    › Primary publication · 12625474 (PubMed)
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  188. Compartmental modeling of glucagon kinetics in the conscious dog. Dobbins RL, Davis SN, Neal DW, Cobelli C, Jaspan J, Cherrington AD (1995) Metabolism 44(4): 452-9
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  189. Effect of glucose, independent of changes in insulin and glucagon secretion, on alanine metabolism in the conscious dog. Shulman GI, Lacy WW, Liljenquist JE, Keller U, Williams PE, Cherrington AD (1980) J Clin Invest 65(2): 496-505
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  190. Effect of dichloroacetate on gluconeogenesis in vivo in the presence of a fixed gluconeogenic substrate supply to the liver. Diamond MP, Williams PE, Lacy WW, Cherrington AD (1981) Metabolism 30(9): 880-5
    › Primary publication · 7266378 (PubMed)
  191. Absorption and disposition of a glucose load in the conscious dog. Abumrad NN, Cherrington AD, Williams PE, Lacy WW, Rabin D (1982) Am J Physiol 242(6): E398-406
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  192. Insulin as a mediator of hepatic glucose uptake in the conscious dog. Cherrington AD, Williams PE, Abou-Mourad N, Lacy WW, Steiner KE, Liljenquist JE (1982) Am J Physiol 242(2): E97-101
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  193. Effects of pharmacologic hyperglucagonemia on plasma amino acid concentrations in normal and diabetic man. Liljenquist JE, Lewis SB, Cherrington AD, Sinclair-Smith BC, Lacy WW (1981) Metabolism 30(12): 1195-9
    › Primary publication · 7031418 (PubMed)
  194. Dichloroacetate--its in vivo effects on carbohydrate metabolism in the conscious dog. Diamond MP, Rollings RC, Erlendson L, Williams PE, Lacy WW, Rabin D, Cherrington AD (1980) Diabetes 29(9): 702-9
    › Primary publication · 7002686 (PubMed)
  195. Effects of insulin at two dose levels on gluconeogenesis from alanine in fasting man. Chiasson JL, Atkinson RL, Cherrington AD, Keller U, Sinclair-Smith BC, Lacy WW, Liljenquist JE (1980) Metabolism 29(9): 810-8
    › Primary publication · 6997676 (PubMed)
  196. Evidence for an intrahepatic contribution to the waning effect of glucagon on glucose production in the conscious dog. Cherrington AD, Diamond MP, Green DR, Williams PE (1982) Diabetes 31(10): 917-22
    › Primary publication · 6759225 (PubMed)
  197. The relative importance of first- and second-phase insulin secretion in countering the action of glucagon on glucose turnover in the conscious dog. Steiner KE, Mouton SM, Bowles CR, Williams PE, Cherrington AD (1982) Diabetes 31(11): 964-72
    › Primary publication · 6757015 (PubMed)
  198. The effects of insulin on carbohydrate metabolism in vivo. Cherrington AD, Steiner KE (1982) Clin Endocrinol Metab 11(2): 307-28
    › Primary publication · 6754160 (PubMed)
  199. Lack of effect of somatostatin on the stimulation of hepatic glycogenolysis by epinephrine in isolated canine hepatocytes. Stevenson RW, Steiner KE, Green DR, Cherrington AD (1984) Biochim Biophys Acta 804(4): 414-8
    › Primary publication · 6432062 (PubMed)
  200. Effect of a mixed meal on hepatic lactate and gluconeogenic precursor metabolism in dogs. Davis MA, Williams PE, Cherrington AD (1984) Am J Physiol 247(3 Pt 1): E362-9
    › Primary publication · 6383070 (PubMed)
  201. Effect of epinephrine on glycogenolysis and gluconeogenesis in conscious overnight-fasted dogs. Cherrington AD, Fuchs H, Stevenson RW, Williams PE, Alberti KG, Steiner KE (1984) Am J Physiol 247(2 Pt 1): E137-44
    › Primary publication · 6380303 (PubMed)
  202. Effects of morphine on glucose homeostasis in the conscious dog. Radosevich PM, Williams PE, Lacy DB, McRae JR, Steiner KE, Cherrington AD, Lacy WW, Abumrad NN (1984) J Clin Invest 74(4): 1473-80
    › Primary publication · 6148357 (PubMed) · PMC425317 (PubMed Central)
  203. Failure of somatostatin to modify effect of glucagon on carbohydrate metabolism in the dog. Cherrington AD, Lacy WW, Williams PE, Steiner KE (1983) Am J Physiol 244(6): E596-602
    › Primary publication · 6134474 (PubMed)
  204. Contribution of the liver and extrasplanchnic tissues to the hypoglycemic action of dichloroacetate in the conscious dog. Diamond MP, Suhrer JH, Williams PE, Lacy WW, Cherrington AD (1982) Diabetes 31(4 Pt 1): 326-32
    › Primary publication · 6130020 (PubMed)
  205. Role of insulin in the regulation of leucine kinetics in the conscious dog. Abumrad NN, Jefferson LS, Rannels SR, Williams PE, Cherrington AD, Lacy WW (1982) J Clin Invest 70(5): 1031-41
    › Primary publication · 6127347 (PubMed) · PMC370315 (PubMed Central)
  206. Dichloroacetate: direct inhibitor of lipolysis in the conscious dog. Diamond MP, Suhrer JH, Williams PE, Cherrington AD (1982) Horm Metab Res 14(2): 102-3
    › Primary publication · 6121746 (PubMed)
  207. Retardant effect of hyperglycemia on the rise in plasma fatty acids following insulin withdrawal in man. Liljenquist JE, Mueller GL, Cherrington AD, Perry JM, Rabin D (1981) Horm Metab Res 13(10): 542-5
    › Primary publication · 6117512 (PubMed)
  208. Mechanisms of hormonal regulation of liver metabolism. Exton JH, Blackmore PF, El-Refai MF, Dehaye JP, Strickland WG, Cherrington AD, Chan TM, Assimacopoulos-Jeannet FD, Chrisman TD (1981) Adv Cyclic Nucleotide Res : 491-505
    › Primary publication · 6116389 (PubMed)
  209. Altered ability of the liver to produce glucose following a period of glucagon deficiency. Deri JJ, Williams PE, Steiner KE, Cherrington AD (1981) Diabetes 30(6): 490-5
    › Primary publication · 6112181 (PubMed)
  210. Differential time course of glucagon's effect on glycogenolysis and gluconeogenesis in the conscious dog. Cherrington AD, Williams PE, Shulman GI, Lacy WW (1981) Diabetes 30(3): 180-7
    › Primary publication · 6110598 (PubMed)
  211. Effect of hyperglycemia independent of changes in insulin or glucagon on lipolysis in the conscious dog. Shulman GI, Williams PE, Liljenquist JE, Lacy WW, Keller U, Cherrington AD (1980) Metabolism 29(4): 317-20
    › Primary publication · 6103495 (PubMed)
  212. The effect of somatostatin on the intestinal transport of glucose in vivo and in vitro in the rat. Wilson FA, Antonson DL, Hart BL, Warr TA, Cherrington AD, Liljenquist JE (1980) Endocrinology 106(5): 1562-7
    › Primary publication · 6102512 (PubMed)
  213. Drug-metabolizing activity of the human placenta. Van Petten GR, Hirsch GH, Cherrington AD (1968) Can J Biochem 46(9): 1057-61
    › Primary publication · 5687633 (PubMed)
  214. Role of glucagon and insulin in control of glucose turnover. Cherrington A, Vranic M (1971) Metabolism 20(6): 625-8
    › Primary publication · 5578975 (PubMed)
  215. Effect of interaction between insulin and glucagon on glucose turnover and FFA concentration in normal and depancreatized dogs. Cherrington AD, Vranic M (1974) Metabolism 23(8): 729-44
    › Primary publication · 4851653 (PubMed)
  216. Insulin metabolism in depancreatized dogs during hemorrhagic shock. Lau TS, McMillan N, Cherrington A, Lo S, Drucker WR, Koven IH (1973) Surg Forum : 94-6
    › Primary publication · 4806107 (PubMed)
  217. Effect of glucagon on glucose turnover and plasma free fatty acids in depancreatized dogs maintained on matched insulin infusions. Cherrington A, Vranic M, Fono P, Kovacevic N (1972) Can J Physiol Pharmacol 50(10): 946-54
    › Primary publication · 4637182 (PubMed)
  218. Effect of arginine on glucose turnover and plasma free fatty acids in normal dogs. Cherrington AD, Vranic M (1973) Diabetes 22(7): 537-43
    › Primary publication · 4578218 (PubMed)
  219. Arginine infusion in dogs. Model for the roles of insulin and glucagon in regulating glucose turnover and free fatty acid levels. Cherrington AD, Kawamori R, Pek S, Vranic M (1974) Diabetes 23(10): 805-15
    › Primary publication · 4422477 (PubMed)
  220. Mechanism of epinephrine's glycogenolytic effect in isolated canine hepatocytes. Steiner KE, Stevenson RW, Green DR, Cherrington AD (1985) Metabolism 34(11): 1020-3
    › Primary publication · 4058306 (PubMed)
  221. The relationship between plasma concentration and disappearance rate of immunoreactive insulin in the conscious dog. Stevenson RW, Cherrington AD, Steiner KE (1985) Horm Metab Res 17(11): 551-3
    › Primary publication · 3908265 (PubMed)
  222. Regulation of ketogenesis by epinephrine and norepinephrine in the overnight-fasted, conscious dog. Steiner KE, Fuchs H, Williams PE, Stevenson RW, Cherrington AD, Alberti KG (1985) Diabetes 34(5): 425-32
    › Primary publication · 3886459 (PubMed)
  223. Lactate as substrate for glycogen resynthesis after exercise. Stevenson RW, Mitchell DR, Hendrick GK, Rainey R, Cherrington AD, Frizzell RT (1987) J Appl Physiol (1985) 62(6): 2237-40
    › Primary publication · 3610920 (PubMed)
  224. Insulin, glucagon, and glucose as regulators of hepatic glucose uptake and production in vivo. Cherrington AD, Stevenson RW, Steiner KE, Davis MA, Myers SR, Adkins BA, Abumrad NN, Williams PE (1987) Diabetes Metab Rev 3(1): 307-32
    › Primary publication · 3552525 (PubMed)
  225. The synthetic 32-46 fragment of human growth hormone increases insulin and glucagon levels in the conscious dog. Stevenson RW, Stebbing N, Rudman CG, Williams PE, Cherrington AD (1987) Metabolism 36(4): 400-4
    › Primary publication · 3550377 (PubMed)
  226. The effect of biosynthetic human proinsulin on the hepatic response to glucagon in insulin-deficient diabetes. Cohen RM, Licinio J, Polonsky KS, Galloway JA, Frank BH, Cherrington AD, Rubenstein AH (1987) J Clin Endocrinol Metab 64(3): 476-81
    › Primary publication · 3546347 (PubMed)
  227. Relative importance of first- and second-phase insulin secretion in glucose homeostasis in conscious dog. II. Effects on gluconeogenesis. Steiner KE, Mouton SM, Williams PE, Lacy WW, Cherrington AD (1986) Diabetes 35(7): 776-84
    › Primary publication · 3522319 (PubMed)
  228. Glucagon as a regulator of hepatic glucose production in vivo. Cherrington AD, Stevenson RW, Steiner KE (1987) Biochem Soc Trans 15(6): 1023-7
    › Primary publication · 3446548 (PubMed)
  229. Dynamics of hepatic lactate and glucose balances during prolonged exercise and recovery in the dog. Wasserman DH, Lacy DB, Green DR, Williams PE, Cherrington AD (1987) J Appl Physiol (1985) 63(6): 2411-7
    › Primary publication · 3325489 (PubMed)
  230. Role of glucagon suppression on gluconeogenesis during insulin treatment of the conscious diabetic dog. Stevenson RW, Williams PE, Cherrington AD (1987) Diabetologia 30(10): 782-90
    › Primary publication · 3322904 (PubMed)
  231. Net hepatic lactate balance following mixed meal feeding in the four-day fasted conscious dog. Davis MA, Williams PE, Cherrington AD (1987) Metabolism 36(9): 856-62
    › Primary publication · 3306279 (PubMed)
  232. The synthetic human growth hormone fragment (32-38) increases glucose uptake in the conscious dog. Stevenson RW, Stebbing N, Jones T, Carr K, Jones PM, Hii C, Cherrington AD (1988) Acta Endocrinol (Copenh) 117(4): 457-62
    › Primary publication · 3291525 (PubMed)
  233. Role of gluconeogenesis in sustaining glucose production during hypoglycemia caused by continuous insulin infusion in conscious dogs. Frizzell RT, Hendrick GK, Biggers DW, Lacy DB, Donahue DP, Green DR, Carr RK, Williams PE, Stevenson RW, Cherrington AD (1988) Diabetes 37(6): 749-59
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  234. Importance of intrahepatic mechanisms to gluconeogenesis from alanine during exercise and recovery. Wasserman DH, Williams PE, Lacy DB, Green DR, Cherrington AD (1988) Am J Physiol 254(4 Pt 1): E518-25
    › Primary publication · 3281473 (PubMed)
  235. Gluconeogenesis and hypoglycemia. Frizzell RT, Campbell PJ, Cherrington AD (1988) Diabetes Metab Rev 4(1): 51-70
    › Primary publication · 3278874 (PubMed)
  236. Effect of alanine concentration independent of changes in insulin and glucagon on alanine and glucose homeostasis in the conscious dog. Diamond MP, Rollings RC, Steiner KE, Williams PE, Lacy WW, Cherrington AD (1988) Metabolism 37(1): 28-33
    › Primary publication · 3275858 (PubMed)
  237. Glyburide sensitizes perfused rat liver to insulin-induced suppression of glucose output. McGuinness OP, Green DR, Cherrington AD (1987) Diabetes 36(4): 472-6
    › Primary publication · 3102299 (PubMed)
  238. Stimulation of glucose production through hormone secretion and other mechanisms during insulin-induced hypoglycemia. Frizzell RT, Hendrick GK, Brown LL, Lacy DB, Donahue EP, Carr RK, Williams PE, Parlow AF, Stevenson RW, Cherrington AD (1988) Diabetes 37(11): 1531-41
    › Primary publication · 3053302 (PubMed)
  239. Metabolic role of the exercise-induced increment in epinephrine in the dog. Moates JM, Lacy DB, Goldstein RE, Cherrington AD, Wasserman DH (1988) Am J Physiol 255(4 Pt 1): E428-36
    › Primary publication · 3052103 (PubMed)
  240. Alterations in carbohydrate metabolism as they apply to reproductive endocrinology. Diamond MP, Wentz AC, Cherrington AD (1988) Fertil Steril 50(3): 387-97
    › Primary publication · 3044841 (PubMed)
  241. Effect of somatostatin on nonesterified fatty acid levels modifies glucose homeostasis during fasting. Hendrick GK, Frizzell RT, Cherrington AD (1987) Am J Physiol 253(4 Pt 1): E443-52
    › Primary publication · 2889364 (PubMed)
  242. Effect of somatostatin on glucose homeostasis in conscious long-fasted dogs. Stevenson RW, Steiner KE, Hendrick GK, Cherrington AD (1987) Am J Physiol 253(4 Pt 1): E435-42
    › Primary publication · 2889363 (PubMed)
  243. Lack of effect of somatostatin on epinephrine-stimulated glucose production in the dog. Stevenson RW, Steiner KE, Williams PE, Cherrington AD (1987) Metabolism 36(5): 451-7
    › Primary publication · 2883556 (PubMed)
  244. Importance of the route of intravenous glucose delivery to hepatic glucose balance in the conscious dog. Adkins BA, Myers SR, Hendrick GK, Stevenson RW, Williams PE, Cherrington AD (1987) J Clin Invest 79(2): 557-65
    › Primary publication · 2879854 (PubMed) · PMC424126 (PubMed Central)
  245. Similar dose responsiveness of hepatic glycogenolysis and gluconeogenesis to glucagon in vivo. Stevenson RW, Steiner KE, Davis MA, Hendrick GK, Williams PE, Lacy WW, Brown L, Donahue P, Lacy DB, Cherrington AD (1987) Diabetes 36(3): 382-9
    › Primary publication · 2879758 (PubMed)
  246. Effect of glucagon on hepatic lactate metabolism in the conscious dog. Davis MA, Williams PE, Cherrington AD (1985) Am J Physiol 248(4 Pt 1): E463-70
    › Primary publication · 2858980 (PubMed)
  247. Hypoglycemia in IDDM. Cryer PE, Binder C, Bolli GB, Cherrington AD, Gale EA, Gerich JE, Sherwin RS (1989) Diabetes 38(9): 1193-9
    › Primary publication · 2767340 (PubMed)
  248. Glucagon is a primary controller of hepatic glycogenolysis and gluconeogenesis during muscular work. Wasserman DH, Spalding JA, Lacy DB, Colburn CA, Goldstein RE, Cherrington AD (1989) Am J Physiol 257(1 Pt 1): E108-17
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  249. Exercise-induced fall in insulin and hepatic carbohydrate metabolism during muscular work. Wasserman DH, Williams PE, Lacy DB, Goldstein RE, Cherrington AD (1989) Am J Physiol 256(4 Pt 1): E500-9
    › Primary publication · 2650562 (PubMed)
  250. Exercise-induced fall in insulin and increase in fat metabolism during prolonged muscular work. Wasserman DH, Lacy DB, Goldstein RE, Williams PE, Cherrington AD (1989) Diabetes 38(4): 484-90
    › Primary publication · 2647555 (PubMed)
  251. Role of brain in counterregulation of insulin-induced hypoglycemia in dogs. Biggers DW, Myers SR, Neal D, Stinson R, Cooper NB, Jaspan JB, Williams PE, Cherrington AD, Frizzell RT (1989) Diabetes 38(1): 7-16
    › Primary publication · 2642436 (PubMed)
  252. Exercise-induced rise in glucagon and ketogenesis during prolonged muscular work. Wasserman DH, Spalding JA, Bracy D, Lacy DB, Cherrington AD (1989) Diabetes 38(6): 799-807
    › Primary publication · 2566546 (PubMed)
  253. Intraportal hyperinsulinemia decreases insulin-stimulated glucose uptake in the dog. McGuinness OP, Friedman A, Cherrington AD (1990) Metabolism 39(2): 127-32
    › Primary publication · 2405232 (PubMed)
  254. Effects of insulin on glucagon-stimulated glucose production in the conscious dog. Steiner KE, Williams PE, Lacy WW, Cherrington AD (1990) Metabolism 39(12): 1325-33
    › Primary publication · 2246975 (PubMed)
  255. Interaction between insulin and glucose-delivery route in regulation of net hepatic glucose uptake in conscious dogs. Adkins-Marshall BA, Myers SR, Hendrick GK, Williams PE, Triebwasser K, Floyd B, Cherrington AD (1990) Diabetes 39(1): 87-95
    › Primary publication · 2210065 (PubMed)
  256. Chronic hyperinsulinemia decreases insulin action but not insulin sensitivity. McGuinness OP, Myers SR, Neal D, Cherrington AD (1990) Metabolism 39(9): 931-7
    › Primary publication · 2202884 (PubMed)
  257. Hepatic nerves are not essential to the increase in hepatic glucose production during muscular work. Wasserman DH, Williams PE, Lacy DB, Bracy D, Cherrington AD (1990) Am J Physiol 259(2 Pt 1): E195-203
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  258. Effect of hyperglucagonemia on hepatic glycogenolysis and gluconeogenesis after a prolonged fast. Hendrick GK, Frizzell RT, Williams PE, Cherrington AD (1990) Am J Physiol 258(5 Pt 1): E841-9
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  259. Hepatic fuel metabolism during muscular work: role and regulation. Wasserman DH, Cherrington AD (1991) Am J Physiol 260(6 Pt 1): E811-24
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  260. Intraportal glucose delivery enhances the effects of hepatic glucose load on net hepatic glucose uptake in vivo. Myers SR, Biggers DW, Neal DW, Cherrington AD (1991) J Clin Invest 88(1): 158-67
    › Primary publication · 2056115 (PubMed) · PMC296016 (PubMed Central)
  261. Dose-related effects of epinephrine on glucose production in conscious dogs. Stevenson RW, Steiner KE, Connolly CC, Fuchs H, Alberti KG, Williams PE, Cherrington AD (1991) Am J Physiol 260(3 Pt 1): E363-70
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  262. Intraportal glucose delivery alters the relationship between net hepatic glucose uptake and the insulin concentration. Myers SR, McGuinness OP, Neal DW, Cherrington AD (1991) J Clin Invest 87(3): 930-9
    › Primary publication · 1999501 (PubMed) · PMC329884 (PubMed Central)
  263. The effects of etomidate on cerebral metabolism and blood flow in a canine model for hypoperfusion. Frizzell RT, Meyer YJ, Borchers DJ, Weprin BE, Allen EC, Pogue WR, Reisch JS, Cherrington AD, Batjer HH (1991) J Neurosurg 74(2): 263-9
    › Primary publication · 1988597 (PubMed)
  264. Effects of small changes in glucagon on glucose production during a euglycemic, hyperinsulinemic clamp. Myers SR, Diamond MP, Adkins-Marshall BA, Williams PE, Stinsen R, Cherrington AD (1991) Metabolism 40(1): 66-71
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  265. Efficiency of compensation for absence of fall in insulin during exercise. Wasserman DH, Lacy DB, Colburn CA, Bracy D, Cherrington AD (1991) Am J Physiol 261(5 Pt 1): E587-97
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  266. The effects of epinephrine on ketogenesis in the dog after a prolonged fast. Steiner KE, Stevenson RW, Adkins-Marshall BA, Cherrington AD (1991) Metabolism 40(10): 1057-62
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  267. Regulation of lipolysis and ketogenesis by norepinephrine in conscious dogs. Connolly CC, Steiner KE, Stevenson RW, Neal DW, Williams PE, Alberti KG, Cherrington AD (1991) Am J Physiol 261(4 Pt 1): E466-72
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  268. Hypoglycemia, gluconeogenesis and the brain. Cherrington AD, Frizzell RT, Biggers DW, Connolly CC (1991) Adv Exp Med Biol : 197-211
    › Primary publication · 1927682 (PubMed)
  269. Factors which regulate net hepatic glucose uptake in vivo. Cherrington AD, Pagliassotti MJ, Myers SR, Adkins-Marshall B, McGuinness OP (1991) JPEN J Parenter Enteral Nutr 15(3): 71S-73S
    › Primary publication · 1865561 (PubMed)
  270. Sources of carbon for hepatic glycogen synthesis in the conscious dog. Moore MC, Cherrington AD, Cline G, Pagliassotti MJ, Jones EM, Neal DW, Badet C, Shulman GI (1991) J Clin Invest 88(2): 578-87
    › Primary publication · 1864968 (PubMed) · PMC295390 (PubMed Central)
  271. Hepatic denervation alters the disposition of an enteral glucose load in conscious dogs. Pagliassotti MJ, Tarumi C, Neal DW, Cherrington AD (1991) J Nutr 121(8): 1255-61
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  272. Role of glucagon in countering hypoglycemia induced by insulin infusion in dogs. Dobbins RL, Connolly CC, Neal DW, Palladino LJ, Parlow AF, Cherrington AD (1991) Am J Physiol 261(6 Pt 1): E773-81
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  273. Regulation of glucose metabolism by norepinephrine in conscious dogs. Connolly CC, Steiner KE, Stevenson RW, Neal DW, Williams PE, Alberti KG, Cherrington AD (1991) Am J Physiol 261(6 Pt 1): E764-72
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  274. Magnitude of negative arterial-portal glucose gradient alters net hepatic glucose balance in conscious dogs. Pagliassotti MJ, Myers SR, Moore MC, Neal DW, Cherrington AD (1991) Diabetes 40(12): 1659-68
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  275. Role of hepatic nerves in response of liver to intraportal glucose delivery in dogs. Adkins-Marshall B, Pagliassotti MJ, Asher JR, Connolly CC, Neal DW, Williams PE, Myers SR, Hendrick GK, Adkins RB, Cherrington AD (1992) Am J Physiol 262(5 Pt 1): E679-86
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  276. Regulation of net hepatic glucose uptake in vivo. Pagliassotti MJ, Cherrington AD (1992) Annu Rev Physiol : 847-60
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  277. The effects of acute elevations in plasma cortisol levels on alanine metabolism in the conscious dog. Goldstein RE, Reed GW, Wasserman DH, Williams PE, Lacy DB, Buckspan R, Abumrad NN, Cherrington AD (1992) Metabolism 41(12): 1295-303
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  278. Effects of differing insulin levels on response to equivalent hypoglycemia in conscious dogs. Davis SN, Dobbins R, Tarumi C, Colburn C, Neal D, Cherrington AD (1992) Am J Physiol 263(4 Pt 1): E688-95
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  279. Importance of basal glucagon in maintaining hepatic glucose production during a prolonged fast in conscious dogs. Hendrick GK, Wasserman DH, Frizzell RT, Williams PE, Lacy DB, Jaspan JB, Cherrington AD (1992) Am J Physiol 263(3 Pt 1): E541-9
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  280. Relationship between decrements in glucose level and metabolic response to hypoglycemia in absence of counterregulatory hormones in the conscious dog. Connolly CC, Adkins-Marshall BA, Neal DW, Pugh W, Jaspan JB, Cherrington AD (1992) Diabetes 41(10): 1308-19
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  281. Insulin is required for the liver to respond to intraportal glucose delivery in the conscious dog. Pagliassotti MJ, Moore MC, Neal DW, Cherrington AD (1992) Diabetes 41(10): 1247-56
    › Primary publication · 1397697 (PubMed)
  282. Insulin metabolism in depancreatized dogs during hemorrhagic shock. Lau TS, McMillan N, Cherrington A, Lo S, Drucker WR, Koven IH (1976) J Surg Oncol 8(1): 49-52
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  283. The role of insulin and glucagon in the regulation of basal glucose production in the postabsorptive dog. Cherrington AD, Chiasson JL, Liljenquist JE, Jennings AS, Keller U, Lacy WW (1976) J Clin Invest 58(6): 1407-18
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  284. An important role for glucagon in the regulation of glucose production in vivo. Liljenquist JE, Chiassan JL, Cherrington AD, Keller U, Jennings AS, Bomboy JD, Lacy WW (1976) Metabolism 25(11 Suppl 1): 1371-3
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  285. The roles of insulin, glucagon, and free fatty acids in the regulation of ketogenesis in dogs. Keller U, Chiasson JL, Liljenquist JE, Cherrington AD, Jennings AS, Crofford OS (1977) Diabetes 26(11): 1040-51
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  286. The roles of insulin and glucagon in the regulation of gluconeogenesis in the postabsorptive dog. Jennings AS, Cherrington AD, Liljenquist JE, Keller U, Lacy WW, Chiasson JL (1977) Diabetes 26(9): 847-56
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  287. Evidence for an important role of glucagon in the regulation of hepatic glucose production in normal man. Liljenquist JE, Mueller GL, Cherrington AD, Keller U, Chiasson J-L , Perry JM, Lacy WW, Rabinowitz D (1977) J Clin Invest 59(2): 369-74
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  288. Effects of fasting on gluconeogenesis from alanine in nondiabetic man. Chiasson JL, Atkinson RL, Cherrington AD, Keller U, Sinclair-Smith BC, Lacy WW, Liljenquist JE (1979) Diabetes 28(1): 56-60
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  289. Effect of glucagon on glucose production during insulin deficiency in the dog. Cherrington AD, Lacy WW, Chiasson JL (1978) J Clin Invest 62(3): 664-77
    › Primary publication · 690190 (PubMed) · PMC371813 (PubMed Central)
  290. Ketone body turnover and net hepatic ketone production in fasted and diabetic dogs. Keller U, Cherrington AD, Liljenquist JE (1978) Am J Physiol 235(2): E238-47
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  291. Glucose disposal during insulinopenia in somatostatin-treated dogs. The roles of glucose and glucagon. Shulman GI, Liljenquist JE, Williams PE, Lacy WW, Cherrington AD (1978) J Clin Invest 62(2): 487-91
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  292. Relationship between the plasma glucose level and glucose uptake in the conscious dog. Cherrington AD, Williams PE, Harris MS (1978) Metabolism 27(7): 787-91
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  293. Possible mechanism by which somatostatin-induced glucagon suppression improves glucose tolerance during insulinopaenia in man. Liljenquist JE, Bloomgarden ZT, Cherrington AD, Perry JM, Rabin D (1979) Diabetologia 17(3): 139-43
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  294. Importance of hypoglycemia-induced glucose production during isolated glucagon deficiency. Cherrington AD, Liljenquist JE, Shulman GI, Williams PE, Lacy WW (1979) Am J Physiol 236(3): E263-71
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  295. Hyperglycemia per se (insulin and glucagon withdrawn) can inhibit hepatic glucose production in man. Liljenquist JE, Mueller GL, Cherrington AD, Perry JM, Rabinowitz D (1979) J Clin Endocrinol Metab 48(1): 171-5
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  296. Control of hepatic glucose output by glucagon and insulin in the intact dog. Cherrington AD, Chiasson JL, Liljenquist JE, Lacy WW, Park CR (1978) Biochem Soc Symp (43): 31-45
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  297. Gluconeogenesis: methodological approaches in vivo. Chiasson JL, Liljenquist JE, Lacy WW, Jennings AS, Cherrington AD (1977) Fed Proc 36(2): 229-35
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  298. Mechanisms of catecholamine actions on liver carbohydrate metabolism. Exton JH, Assimacopoulos-Jeannet FD, Blackmore PF, Cherrington AD, Chan TM (1978) Adv Cyclic Nucleotide Res : 441-52
    › Primary publication · 208389 (PubMed)
  299. Studies of the role of beta-adrenergic receptors in the activation of phosphorylase in rat hepatocytes by catecholamines. Cherrington AD, Hundley RF, Dolgin S, Exton JH (1977) J Cyclic Nucleotide Res 3(4): 263-73
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