Our research focuses on the use of functional genomic and epigenetic approaches to understand gene regulation. Our interests range from detailed mechanistic studies of the interferon-gamma gene, a key cytokine produced by cells of the innate and adaptive immune system, a critical cytokine required to induce cell-mediated inflammation to the use of these approaches to gain new insights into human disease, including diseases of the endocrine system. These include recent studies evaluating relationships among gene expression signatures in atherosclerosis, type 2 diabetes and metabolic syndrome and study of copy number polymorphisms in type 1 diabetes, type 2 diabetes, and multiple sclerosis.
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Key: MeSH Term KeywordAutoantigens Autoimmunity Binding Sites Bone Marrow Transplantation Cell Line, Tumor Chromosomes, Human, Pair 7 Chromosomes, Human, Pair 13 Cyclin-Dependent Kinase Inhibitor p21 Diabetes Mellitus, Type 2 DNA epigenetics Erythroid-Specific DNA-Binding Factors gene regulation Genetic Linkage Genetic Markers Genetic Predisposition to Disease Histone Deacetylase Inhibitors human autoimmune disease Immune Sera Immune Tolerance Immunology In Situ Hybridization Jurkat Cells Lithium Compounds MAP Kinase Kinase 4 Metabolic Syndrome X Mice, Knockout NF-KappaB Inhibitor alpha Polymorphism, Single Nucleotide Serine T-Lymphocytes, Cytotoxic T-Lymphocyte Subsets Th1 Cells Th17 Cells