Mathilde Granke
Post-doctoral Fellow
Last active: 8/10/2016


Mathilde holds a PhD in Biomedical Engineering (2012) from Paris Diderot University and a Masters of Engineering (2007) from Centrale Nantes (France). Her PhD thesis explored the relationships between the structure and elastic properties of human cortical bone tissue assessed via quantitative ultrasonic methods and was carried out using a wide network of collaborating international laboratories (Charite - University Medicine Berlin, Germany; University of Manchester, UK; European Synchrotron Radiation Facility, France; Doshisha University, Kyoto, Japan).

She joined the Nyman lab and the VCBB in 2013 as a post-doctoral fellow. Her research seeks to better understand the mechanisms that lead to bone fractures and explores new methods that could improve the prediction of fracture risk. Currently, she is investigating the role of bound water in the age- and diabetes- related decrease in bone’s fracture resistance.

Because bone is a biocomposite (made of collagen, mineral and water) with a hierarchical structure, Mathilde’s methods are multimodal (ultrasounds, microCT, nuclear magnetic resonance, scanning electron microscopy, biomechanical testing) and multiscale (spanning from the collagen fibers to the whole bone).


The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. Prevalent role of porosity and osteonal area over mineralization heterogeneity in the fracture toughness of human cortical bone. Granke M, Makowski AJ, Uppuganti S, Nyman JS (2016) J Biomech 49(13): 2748-2755
    › Primary publication · 27344202 (PubMed) · PMC5056137 (PubMed Central)
  2. Tissue-Level Mechanical Properties of Bone Contributing to Fracture Risk. Nyman JS, Granke M, Singleton RC, Pharr GM (2016) Curr Osteoporos Rep 14(4): 138-50
    › Primary publication · 27263108 (PubMed) · PMC4927361 (PubMed Central)
  3. Changes in the Fracture Resistance of Bone with the Progression of Type 2 Diabetes in the ZDSD Rat. Creecy A, Uppuganti S, Merkel AR, O'Neal D, Makowski AJ, Granke M, Voziyan P, Nyman JS (2016) Calcif Tissue Int 99(3): 289-301
    › Primary publication · 27209312 (PubMed) · PMC4961536 (PubMed Central)
  4. MRI-derived bound and pore water concentrations as predictors of fracture resistance. Manhard MK, Uppuganti S, Granke M, Gochberg DF, Nyman JS, Does MD (2016) Bone : 1-10
    › Primary publication · 26993059 (PubMed) · PMC4862893 (PubMed Central)
  5. Age-related changes in the fracture resistance of male Fischer F344 rat bone. Uppuganti S, Granke M, Makowski AJ, Does MD, Nyman JS (2016) Bone : 220-232
    › Primary publication · 26610688 (PubMed) · PMC4724327 (PubMed Central)
  6. Raloxifene improves skeletal properties in an animal model of cystic chronic kidney disease. Newman CL, Creecy A, Granke M, Nyman JS, Tian N, Hammond MA, Wallace JM, Brown DM, Chen N, Moe SM, Allen MR (2016) Kidney Int 89(1): 95-104
    › Primary publication · 26489025 (PubMed) · PMC4840093 (PubMed Central)
  7. Compressive fatigue and fracture toughness behavior of injectable, settable bone cements. Harmata AJ, Uppuganti S, Granke M, Guelcher SA, Nyman JS (2015) J Mech Behav Biomed Mater : 345-55
    › Primary publication · 26282077 (PubMed) · PMC4581977 (PubMed Central)
  8. The Role of Water Compartments in the Material Properties of Cortical Bone. Granke M, Does MD, Nyman JS (2015) Calcif Tissue Int 97(3): 292-307
    › Primary publication · 25783011 (PubMed) · PMC4526331 (PubMed Central)
  9. Identifying Novel Clinical Surrogates to Assess Human Bone Fracture Toughness. Granke M, Makowski AJ, Uppuganti S, Does MD, Nyman JS (2015) J Bone Miner Res 30(7): 1290-300
    › Primary publication · 25639628 (PubMed) · PMC4478129 (PubMed Central)
  10. Changes in skeletal collagen cross-links and matrix hydration in high- and low-turnover chronic kidney disease. Allen MR, Newman CL, Chen N, Granke M, Nyman JS, Moe SM (2015) Osteoporos Int 26(3): 977-85
    › Primary publication · 25466530 (PubMed) · PMC4512757 (PubMed Central)
  11. To what extent can cortical bone millimeter-scale elasticity be predicted by a two-phase composite model with variable porosity? Granke M, Grimal Q, Parnell WJ, Raum K, Gerisch A, Peyrin F, Saïed A, Laugier P (2015) Acta Biomater : 207-215
    › Primary publication · 25462527 (PubMed)
  12. Insights into reference point indentation involving human cortical bone: sensitivity to tissue anisotropy and mechanical behavior. Granke M, Coulmier A, Uppuganti S, Gaddy JA, Does MD, Nyman JS (2014) J Mech Behav Biomed Mater : 174-85
    › Primary publication · 24929851 (PubMed) · PMC4112765 (PubMed Central)
  13. The loss of activating transcription factor 4 (ATF4) reduces bone toughness and fracture toughness. Makowski AJ, Uppuganti S, Wadeer SA, Whitehead JM, Rowland BJ, Granke M, Mahadevan-Jansen A, Yang X, Nyman JS (2014) Bone : 1-9
    › Primary publication · 24509412 (PubMed) · PMC3992706 (PubMed Central)
  14. Microfibril orientation dominates the microelastic properties of human bone tissue at the lamellar length scale. Granke M, Gourrier A, Rupin F, Raum K, Peyrin F, Burghammer M, Saïed A, Laugier P (2013) PLoS One 8(3): e58043
    › Primary publication · 23472132 (PubMed) · PMC3589472 (PubMed Central)
  15. Comparative investigation of elastic properties in a trabecula using micro-Brillouin scattering and scanning acoustic microscopy. Kawabe M, Fukui K, Matsukawa M, Granke M, Saïed A, Grimal Q, Laugier P (2012) J Acoust Soc Am 132(1): EL54-60
    › Primary publication · 22779573 (PubMed)
  16. Change in porosity is the major determinant of the variation of cortical bone elasticity at the millimeter scale in aged women. Granke M, Grimal Q, Saïed A, Nauleau P, Peyrin F, Laugier P (2011) Bone 49(5): 1020-6
    › Primary publication · 21855669 (PubMed)
  17. Experimental and simulation results on the effect of cortical bone mineralization in ultrasound axial transmission measurements: a model for fracture healing ultrasound monitoring. Machado CB, Pereira WC, Granke M, Talmant M, Padilla F, Laugier P (2011) Bone 48(5): 1202-9
    › Primary publication · 21376151 (PubMed)