Profile

The goal of my work is to identify the determinants of bone fragility and understand how aging and disease affect these determinants. Ultimately, we want to lower the number of bone fractures associated with osteoporosis, diabetes, cancer, and aging. There are promising anabolic treatments for osteoporosis, but little is known about the biological mechanisms that regulate the organization of bone tissue. The propensity to fracture does not just depend on bone mass, size, or density but also on the distribution of the bone tissue (structure) and the inherent quality of the bone matrix (bone quality). Therefore, we combine biomechanical and biological techniques to investigate the regulatory mechanisms involved in bone quality and to better understand how to treat diseases of the bone.

Publications

The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. Applying Full Spectrum Analysis to a Raman Spectroscopic Assessment of Fracture Toughness of Human Cortical Bone. Makowski AJ, Granke M, Ayala OD, Uppuganti S, Mahadevan-Jansen A, Nyman JS (2017) Appl Spectrosc : 3702817718149
    › Primary publication · 28708001 (PubMed)
  2. 30-Second bound and pore water concentration mapping of cortical bone using 2D UTE with optimized half-pulses. Manhard MK, Harkins KD, Gochberg DF, Nyman JS, Does MD (2017) Magn Reson Med 77(3): 945-950
    › Primary publication · 28090655 (PubMed)
  3. The impact of SGLT2 inhibitors, compared with insulin, on diabetic bone disease in a mouse model of type 1 diabetes. Thrailkill KM, Nyman JS, Bunn RC, Uppuganti S, Thompson KL, Lumpkin CK, Kalaitzoglou E, Fowlkes JL (2016) Bone
    › Primary publication · 27989651 (PubMed)
  4. Technical note: Recommendations for a standard procedure to assess cortical bone at the tissue-level in vivo using impact microindentation. Diez-Perez A, Bouxsein ML, Eriksen EF, Khosla S, Nyman JS, Papapoulos S, Tang SY (2016) Bone Rep : 181-185
    › Primary publication · 27975078 (PubMed) · PMC5152622 (PubMed Central)
  5. Advances in imaging approaches to fracture risk evaluation. Manhard MK, Nyman JS, Does MD (2016) Transl Res
    › Primary publication · 27816505 (PubMed)
  6. Differences in sensitivity to microstructure between cyclic- and impact-based microindentation of human cortical bone. Uppuganti S, Granke M, Manhard MK, Does MD, Perrien DS, Lee DH, Nyman JS (2016) J Orthop Res
    › Primary publication · 27513922 (PubMed)
  7. Combined treatment with a transforming growth factor beta inhibitor (1D11) and bortezomib improves bone architecture in a mouse model of myeloma-induced bone disease. Nyman JS, Merkel AR, Uppuganti S, Nayak B, Rowland B, Makowski AJ, Oyajobi BO, Sterling JA (2016) Bone : 81-91
    › Primary publication · 27423464 (PubMed) · PMC4996753 (PubMed Central)
  8. Prevalent role of porosity and osteonal area over mineralization heterogeneity in the fracture toughness of human cortical bone. Granke M, Makowski AJ, Uppuganti S, Nyman JS (2016) J Biomech 49(13): 2748-2755
    › Primary publication · 27344202 (PubMed) · PMC5056137 (PubMed Central)
  9. Tissue-Level Mechanical Properties of Bone Contributing to Fracture Risk. Nyman JS, Granke M, Singleton RC, Pharr GM (2016) Curr Osteoporos Rep 14(4): 138-50
    › Primary publication · 27263108 (PubMed) · PMC4927361 (PubMed Central)
  10. Changes in the Fracture Resistance of Bone with the Progression of Type 2 Diabetes in the ZDSD Rat. Creecy A, Uppuganti S, Merkel AR, O'Neal D, Makowski AJ, Granke M, Voziyan P, Nyman JS (2016) Calcif Tissue Int 99(3): 289-301
    › Primary publication · 27209312 (PubMed) · PMC4961536 (PubMed Central)
  11. MRI-derived bound and pore water concentrations as predictors of fracture resistance. Manhard MK, Uppuganti S, Granke M, Gochberg DF, Nyman JS, Does MD (2016) Bone : 1-10
    › Primary publication · 26993059 (PubMed) · PMC4862893 (PubMed Central)
  12. Age-related changes in the fracture resistance of male Fischer F344 rat bone. Uppuganti S, Granke M, Makowski AJ, Does MD, Nyman JS (2016) Bone : 220-32
    › Primary publication · 26610688 (PubMed) · PMC4724327 (PubMed Central)
  13. In Vivo Quantitative MR Imaging of Bound and Pore Water in Cortical Bone. Manhard MK, Horch RA, Gochberg DF, Nyman JS, Does MD (2015) Radiology 277(3): 927
    › Primary publication · 26599934 (PubMed)
  14. Fibrinolysis is essential for fracture repair and prevention of heterotopic ossification. Yuasa M, Mignemi NA, Nyman JS, Duvall CL, Schwartz HS, Okawa A, Yoshii T, Bhattacharjee G, Zhao C, Bible JE, Obremskey WT, Flick MJ, Degen JL, Barnett JV, Cates JM, Schoenecker JG (2015) J Clin Invest 125(9): 3723
    › Primary publication · 26325037 (PubMed) · PMC4588290 (PubMed Central)
  15. Compressive fatigue and fracture toughness behavior of injectable, settable bone cements. Harmata AJ, Uppuganti S, Granke M, Guelcher SA, Nyman JS (2015) J Mech Behav Biomed Mater : 345-55
    › Primary publication · 26282077 (PubMed) · PMC4581977 (PubMed Central)
  16. SGLT2 inhibitor therapy improves blood glucose but does not prevent diabetic bone disease in diabetic DBA/2J male mice. Thrailkill KM, Clay Bunn R, Nyman JS, Rettiganti MR, Cockrell GE, Wahl EC, Uppuganti S, Lumpkin CK, Fowlkes JL (2016) Bone : 101-7
    › Primary publication · 26211996 (PubMed) · PMC4679447 (PubMed Central)
  17. In Vivo Quantitative MR Imaging of Bound and Pore Water in Cortical Bone. Manhard MK, Horch RA, Gochberg DF, Nyman JS, Does MD (2015) Radiology 277(1): 221-9
    › Primary publication · 26020434 (PubMed) · PMC4613881 (PubMed Central)
  18. Predicting mouse vertebra strength with micro-computed tomography-derived finite element analysis. Nyman JS, Uppuganti S, Makowski AJ, Rowland BJ, Merkel AR, Sterling JA, Bredbenner TL, Perrien DS (2015) Bonekey Rep : 664
    › Primary publication · 25908967 (PubMed) · PMC4407510 (PubMed Central)
  19. The Role of Water Compartments in the Material Properties of Cortical Bone. Granke M, Does MD, Nyman JS (2015) Calcif Tissue Int 97(3): 292-307
    › Primary publication · 25783011 (PubMed) · PMC4526331 (PubMed Central)
  20. Effects of long-term doxycycline on bone quality and strength in diabetic male DBA/2J mice. Fowlkes JL, Nyman JS, Bunn RC, Cockrell GE, Wahl EC, Rettiganti MR, Lumpkin CK, Thrailkill KM (2015) Bone Rep : 16-19
    › Primary publication · 25685827 (PubMed) · PMC4324548 (PubMed Central)
  21. Identifying Novel Clinical Surrogates to Assess Human Bone Fracture Toughness. Granke M, Makowski AJ, Uppuganti S, Does MD, Nyman JS (2015) J Bone Miner Res 30(7): 1290-300
    › Primary publication · 25639628 (PubMed) · PMC4478129 (PubMed Central)
  22. Polarization in Raman spectroscopy helps explain bone brittleness in genetic mouse models. Makowski AJ, Pence IJ, Uppuganti S, Zein-Sabatto A, Huszagh MC, Mahadevan-Jansen A, Nyman JS (2014) J Biomed Opt 19(11): 117008
    › Primary publication · 25402627 (PubMed) · PMC4240742 (PubMed Central)
  23. Combined MEK inhibition and BMP2 treatment promotes osteoblast differentiation and bone healing in Nf1Osx -/- mice. de la Croix Ndong J, Stevens DM, Vignaux G, Uppuganti S, Perrien DS, Yang X, Nyman JS, Harth E, Elefteriou F (2015) J Bone Miner Res 30(1): 55-63
    › Primary publication · 25043591 (PubMed) · PMC4280331 (PubMed Central)
  24. Asfotase-α improves bone growth, mineralization and strength in mouse models of neurofibromatosis type-1. de la Croix Ndong J, Makowski AJ, Uppuganti S, Vignaux G, Ono K, Perrien DS, Joubert S, Baglio SR, Granchi D, Stevenson DA, Rios JJ, Nyman JS, Elefteriou F (2014) Nat Med 20(8): 904-10
    › Primary publication · 24997609 (PubMed) · PMC4126855 (PubMed Central)
  25. Insights into reference point indentation involving human cortical bone: sensitivity to tissue anisotropy and mechanical behavior. Granke M, Coulmier A, Uppuganti S, Gaddy JA, Does MD, Nyman JS (2014) J Mech Behav Biomed Mater : 174-85
    › Primary publication · 24929851 (PubMed) · PMC4112765 (PubMed Central)
  26. The loss of activating transcription factor 4 (ATF4) reduces bone toughness and fracture toughness. Makowski AJ, Uppuganti S, Wadeer SA, Whitehead JM, Rowland BJ, Granke M, Mahadevan-Jansen A, Yang X, Nyman JS (2014) Bone : 1-9
    › Primary publication · 24509412 (PubMed) · PMC3992706 (PubMed Central)
  27. Osteo-promoting effects of insulin-like growth factor I (IGF-I) in a mouse model of type 1 diabetes. Fowlkes JL, Nyman JS, Bunn RC, Jo C, Wahl EC, Liu L, Cockrell GE, Morris LM, Lumpkin CK, Thrailkill KM (2013) Bone 57(1): 36-40
    › Primary publication · 23886838 (PubMed) · PMC3789626 (PubMed Central)
  28. Validation of quantitative bound- and pore-water imaging in cortical bone. Manhard MK, Horch RA, Harkins KD, Gochberg DF, Nyman JS, Does MD (2014) Magn Reson Med 71(6): 2166-71
    › Primary publication · 23878027 (PubMed) · PMC3899101 (PubMed Central)
  29. Prostate cancer metastases alter bone mineral and matrix composition independent of effects on bone architecture in mice--a quantitative study using microCT and Raman spectroscopy. Bi X, Sterling JA, Merkel AR, Perrien DS, Nyman JS, Mahadevan-Jansen A (2013) Bone 56(2): 454-60
    › Primary publication · 23867219 (PubMed) · PMC3799839 (PubMed Central)
  30. Bmp2 in osteoblasts of periosteum and trabecular bone links bone formation to vascularization and mesenchymal stem cells. Yang W, Guo D, Harris MA, Cui Y, Gluhak-Heinrich J, Wu J, Chen XD, Skinner C, Nyman JS, Edwards JR, Mundy GR, Lichtler A, Kream BE, Rowe DW, Kalajzic I, David V, Quarles DL, Villareal D, Scott G, Ray M, Liu S, Martin JF, Mishina Y, Harris SE (2013) J Cell Sci 126(Pt 18): 4085-98
    › Primary publication · 23843612 (PubMed) · PMC3772385 (PubMed Central)
  31. Polarization control of Raman spectroscopy optimizes the assessment of bone tissue. Makowski AJ, Patil CA, Mahadevan-Jansen A, Nyman JS (2013) J Biomed Opt 18(5): 55005
    › Primary publication · 23708192 (PubMed) · PMC3662990 (PubMed Central)
  32. Partial removal of pore and loosely bound water by low-energy drying decreases cortical bone toughness in young and old donors. Nyman JS, Gorochow LE, Adam Horch R, Uppuganti S, Zein-Sabatto A, Manhard MK, Does MD (2013) J Mech Behav Biomed Mater : 136-45
    › Primary publication · 23631897 (PubMed) · PMC3655090 (PubMed Central)
  33. Differential development of the distal and proximal femoral epiphysis and physis in mice. Cole HA, Yuasa M, Hawley G, Cates JM, Nyman JS, Schoenecker JG (2013) Bone 52(1): 337-46
    › Primary publication · 23079139 (PubMed)
  34. The contribution of the extracellular matrix to the fracture resistance of bone. Nyman JS, Makowski AJ (2012) Curr Osteoporos Rep 10(2): 169-77
    › Primary publication · 22527725 (PubMed)
  35. Differential effects between the loss of MMP-2 and MMP-9 on structural and tissue-level properties of bone. Nyman JS, Lynch CC, Perrien DS, Thiolloy S, O'Quinn EC, Patil CA, Bi X, Pharr GM, Mahadevan-Jansen A, Mundy GR (2011) J Bone Miner Res 26(6): 1252-60
    › Primary publication · 21611966 (PubMed) · PMC3312757 (PubMed Central)
  36. Measuring differences in compositional properties of bone tissue by confocal Raman spectroscopy. Nyman JS, Makowski AJ, Patil CA, Masui TP, O'Quinn EC, Bi X, Guelcher SA, Nicollela DP, Mahadevan-Jansen A (2011) Calcif Tissue Int 89(2): 111-22
    › Primary publication · 21597909 (PubMed) · PMC4471954 (PubMed Central)
  37. Non-invasive predictors of human cortical bone mechanical properties: T(2)-discriminated H NMR compared with high resolution X-ray. Horch RA, Gochberg DF, Nyman JS, Does MD (2011) PLoS One 6(1): e16359
    › Primary publication · 21283693 (PubMed) · PMC3025007 (PubMed Central)
  38. Increasing duration of type 1 diabetes perturbs the strength-structure relationship and increases brittleness of bone. Nyman JS, Even JL, Jo CH, Herbert EG, Murry MR, Cockrell GE, Wahl EC, Bunn RC, Lumpkin CK, Fowlkes JL, Thrailkill KM (2011) Bone 48(4): 733-40
    › Primary publication · 21185416 (PubMed) · PMC3062641 (PubMed Central)
  39. Raman and mechanical properties correlate at whole bone- and tissue-levels in a genetic mouse model. Bi X, Patil CA, Lynch CC, Pharr GM, Mahadevan-Jansen A, Nyman JS (2011) J Biomech 44(2): 297-303
    › Primary publication · 21035119 (PubMed) · PMC3019269 (PubMed Central)
  40. Inhibition of TGF-β signaling by 1D11 antibody treatment increases bone mass and quality in vivo. Edwards JR, Nyman JS, Lwin ST, Moore MM, Esparza J, O'Quinn EC, Hart AJ, Biswas S, Patil CA, Lonning S, Mahadevan-Jansen A, Mundy GR (2010) J Bone Miner Res 25(11): 2419-26
    › Primary publication · 20499365 (PubMed)