Sebastian JOYCE
Last active: 10/1/2019


The IMMUNE SYSTEM functions much like a sensor-actuator system akin to the nervous system. Cells of these physiologic systems sense perturbations in homeostasis and generate an appropriate response so as to restore homeostatic state. The immune system most times works quietly, unless o’ course winter turns to spring—for those allergic begin coughing and sneezing and huffing and wheezing! We all recognize the power of the immune system when recovering from a microbial infectious disease or expulsing an intestinal worm or, alternatively, its wrath in those suffering autoimmune diseases. In all of these instances, the initiation of an immune response begins with sensing of an antigenic substance—this sensing is called IMMUNOLOGIC RECOGNITION. 

The focus of our research programme is on immunologic recognition that regulates T lymphocyte function in health and disease. This entails an in-depth understanding of (a) what T cells recognize during development and during an immune response; (b) how T cell antigens are processed and transported to cellular sites of assembly for presentation by MHC and MHC-like molecules; and (c) how antigen presentation leads to the induction of the proper immune response? Our laboratory addresses these questions through three major projects: (a) large-scale pathogen-derived CD8 T cell epitope discovery and mechanisms of action of new generation, microbe-free mucosal vaccines; (b) mechanisms of peptide and lipid antigen processing and presentation; and (c) the molecular basis of NKT cell ontogeny and function. We take a systematic, multi-disciplinary approach—immunologic, cell and molecular biologic, biochemical, proteomics and genomics—to address questions in these areas. 

Knowledge of antigens that are presented to T cells during a natural infection is key to rational vaccine design. This knowledge is lacking for many pathogens that cause life-threatening diseases such as smallpox, tuberculosis and malaria. As the first step toward this goal, we have developed proteomics-based platform for large-scale discovery of T cell epitopes that are presented during a natural infection; for this smallpox vaccine was used as a model. Such epitope discovery has led our group to develop microbe-free, no-replicating vaccines to probe mucosal CD8 T cell-mediated immunity in the lung—a common site for the entry of numerous pathogens. Lessons learnt from this work will be applied to real infectious menaces such are tuberculosis and malaria that currently plague mankind.

Another area of investigation pertains to the regulation of bacterial and viral protein antigen transport from the cytoplasm of infected cells into the endo-lysosomal vesicles for MHC class II-restricted antigen presentation to CD4+ T cells. We have developed several genetically engineered mouse models to elucidate the transport mechanism. Perturbing antigen transport can alter MHC class II-restricted antigen presentation as well as CD4+ T cell development, repertoire selection and function.

The semi-invariant natural killer T (NKT) cells are a unique subset of T lymphocytes that have distinctive characteristics. NKT cells function in bridging the innate with the adaptive arm of the immune system and, play important roles in regulating immune responses to tumors, several pathogens and some autoimmune diseases. NKT cell function is regulated by endogenous and exogenous glycolipid antigens presented to them by the MHC-like CD1d molecules. These properties also make NKT cells a useful target for novel lipid-based vaccine adjuvants. By using a variety of pathogenic bacteria as a model, we are working to elucidate the mechanism(s) underlying the assembly of lipid antigens with CD1d molecules. Because NKT cells attain their unique functional characteristics during development, we are researching into the transcriptional and signaling requirements for the ontogeny and function of this unique subset of T cells as well.

Insights gained from these studies will advance our understanding of immune system functions in health and disease. This knowledge will serve as a foundation for novel vaccine design strategies to augment immunity to prevent or treat infectious diseases and cancers. So also this knowledge will have implications for understanding the initiation of inflammatory diseases such as graft-versus-host disease and autoimmunity.


The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. Novel HLA-A2-restricted human metapneumovirus epitopes reduce viral titers in mice and are recognized by human T cells. Hastings AK, Gilchuk P, Joyce S, Williams JV (2016) Vaccine 34(24): 2663-70
    › Primary publication · 27105560 (PubMed) · PMC4875773 (PubMed Central)
  2. Viral infection causes a shift in the self peptide repertoire presented by human MHC class I molecules. Spencer CT, Bezbradica JS, Ramos MG, Arico CD, Conant SB, Gilchuk P, Gray JJ, Zheng M, Niu X, Hildebrand W, Link AJ, Joyce S (2015) Proteomics Clin Appl 9(11-12): 1035-52
    › Primary publication · 26768311 (PubMed) · PMC4920078 (PubMed Central)
  3. Acute Viral Respiratory Infection Rapidly Induces a CD8+ T Cell Exhaustion-like Phenotype. Erickson JJ, Lu P, Wen S, Hastings AK, Gilchuk P, Joyce S, Shyr Y, Williams JV (2015) J Immunol 195(9): 4319-30
    › Primary publication · 26401005 (PubMed) · PMC4733528 (PubMed Central)
  4. Histone Deacetylase 3 Is Required for Efficient T Cell Development. Stengel KR, Zhao Y, Klus NJ, Kaiser JF, Gordy LE, Joyce S, Hiebert SW, Summers AR (2015) Mol Cell Biol 35(22): 3854-65
    › Primary publication · 26324326 (PubMed) · PMC4609739 (PubMed Central)
  5. Border Patrol Gone Awry: Lung NKT Cell Activation by Francisella tularensis Exacerbates Tularemia-Like Disease. Hill TM, Gilchuk P, Cicek BB, Osina MA, Boyd KL, Durrant DM, Metzger DW, Khanna KM, Joyce S (2015) PLoS Pathog 11(6): e1004975
    › Primary publication · 26068662 (PubMed) · PMC4465904 (PubMed Central)
  6. Lung CD8+ T Cell Impairment Occurs during Human Metapneumovirus Infection despite Virus-Like Particle Induction of Functional CD8+ T Cells. Wen SC, Schuster JE, Gilchuk P, Boyd KL, Joyce S, Williams JV (2015) J Virol 89(17): 8713-26
    › Primary publication · 26063431 (PubMed) · PMC4524081 (PubMed Central)
  7. A cell-based systems biology assessment of human blood to monitor immune responses after influenza vaccination. Hoek KL, Samir P, Howard LM, Niu X, Prasad N, Galassie A, Liu Q, Allos TM, Floyd KA, Guo Y, Shyr Y, Levy SE, Joyce S, Edwards KM, Link AJ (2015) PLoS One 10(2): e0118528
    › Primary publication · 25706537 (PubMed) · PMC4338067 (PubMed Central)
  8. Discovering protective CD8 T cell epitopes--no single immunologic property predicts it! Gilchuk P, Hill TM, Wilson JT, Joyce S (2015) Curr Opin Immunol : 43-51
    › Primary publication · 25660347 (PubMed) · PMC5023008 (PubMed Central)
  9. Role of type I interferon signaling in human metapneumovirus pathogenesis and control of viral replication. Hastings AK, Erickson JJ, Schuster JE, Boyd KL, Tollefson SJ, Johnson M, Gilchuk P, Joyce S, Williams JV (2015) J Virol 89(8): 4405-20
    › Primary publication · 25653440 (PubMed) · PMC4442394 (PubMed Central)
  10. Myeloid IKKβ promotes antitumor immunity by modulating CCL11 and the innate immune response. Yang J, Hawkins OE, Barham W, Gilchuk P, Boothby M, Ayers GD, Joyce S, Karin M, Yull FE, Richmond A (2014) Cancer Res 74(24): 7274-84
    › Primary publication · 25336190 (PubMed) · PMC4349570 (PubMed Central)
  11. Acute clearance of human metapneumovirus occurs independently of natural killer cells. Wen SC, Tollefson SJ, Johnson M, Gilchuk P, Boyd KL, Shepherd B, Joyce S, Williams JV (2014) J Virol 88(18): 10963-9
    › Primary publication · 24965465 (PubMed) · PMC4178848 (PubMed Central)
  12. Discovering naturally processed antigenic determinants that confer protective T cell immunity. Gilchuk P, Spencer CT, Conant SB, Hill T, Gray JJ, Niu X, Zheng M, Erickson JJ, Boyd KL, McAfee KJ, Oseroff C, Hadrup SR, Bennink JR, Hildebrand W, Edwards KM, Crowe JE, Williams JV, Buus S, Sette A, Schumacher TN, Link AJ, Joyce S (2013) J Clin Invest 123(5): 1976-87
    › Primary publication · 23543059 (PubMed) · PMC3635741 (PubMed Central)
  13. Sculpting MHC class II-restricted self and non-self peptidome by the class I Ag-processing machinery and its impact on Th-cell responses. Spencer CT, Dragovic SM, Conant SB, Gray JJ, Zheng M, Samir P, Niu X, Moutaftsi M, Van Kaer L, Sette A, Link AJ, Joyce S (2013) Eur J Immunol 43(5): 1162-72
    › Primary publication · 23386199 (PubMed) · PMC3798073 (PubMed Central)
  14. Viral acute lower respiratory infections impair CD8+ T cells through PD-1. Erickson JJ, Gilchuk P, Hastings AK, Tollefson SJ, Johnson M, Downing MB, Boyd KL, Johnson JE, Kim AS, Joyce S, Williams JV (2012) J Clin Invest 122(8): 2967-82
    › Primary publication · 22797302 (PubMed) · PMC3408742 (PubMed Central)
  15. IL-15 regulates homeostasis and terminal maturation of NKT cells. Gordy LE, Bezbradica JS, Flyak AI, Spencer CT, Dunkle A, Sun J, Stanic AK, Boothby MR, He YW, Zhao Z, Van Kaer L, Joyce S (2011) J Immunol 187(12): 6335-45
    › Primary publication · 22084435 (PubMed) · PMC3237743 (PubMed Central)
  16. NKT cell ligand recognition logic: molecular basis for a synaptic duet and transmission of inflammatory effectors. Joyce S, Girardi E, Zajonc DM (2011) J Immunol 187(3): 1081-9
    › Primary publication · 21772035 (PubMed) · PMC3166221 (PubMed Central)
  17. Proteasomes, TAP, and endoplasmic reticulum-associated aminopeptidase associated with antigen processing control CD4+ Th cell responses by regulating indirect presentation of MHC class II-restricted cytoplasmic antigens. Dragovic SM, Hill T, Christianson GJ, Kim S, Elliott T, Scott D, Roopenian DC, Van Kaer L, Joyce S (2011) J Immunol 186(12): 6683-92
    › Primary publication · 21572029 (PubMed) · PMC3537507 (PubMed Central)
  18. Immunology: TRIM5 does double duty. Aiken C, Joyce S (2011) Nature 472(7343): 305-6
    › Primary publication · 21512569 (PubMed)
  19. Rgs2 mediates pro-angiogenic function of myeloid derived suppressor cells in the tumor microenvironment via upregulation of MCP-1. Boelte KC, Gordy LE, Joyce S, Thompson MA, Yang L, Lin PC (2011) PLoS One 6(4): e18534
    › Primary publication · 21494556 (PubMed) · PMC3073977 (PubMed Central)
  20. The hunt for iNKT cell antigens: alpha-galactosidase-deficient mice to the rescue? Van Kaer L, Joyce S (2010) Immunity 33(2): 143-5
    › Primary publication · 20732635 (PubMed)
  21. Follicular B cell trafficking within the spleen actively restricts humoral immune responses. Hoek KL, Gordy LE, Collins PL, Parekh VV, Aune TM, Joyce S, Thomas JW, Van Kaer L, Sebzda E (2010) Immunity 33(2): 254-65
    › Primary publication · 20691614 (PubMed) · PMC2929658 (PubMed Central)
  22. Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways. Lee K, Gudapati P, Dragovic S, Spencer C, Joyce S, Killeen N, Magnuson MA, Boothby M (2010) Immunity 32(6): 743-53
    › Primary publication · 20620941 (PubMed) · PMC2911434 (PubMed Central)
  23. Minor histocompatibility antigens: presentation principles, recognition logic and the potential for a healing hand. Spencer CT, Gilchuk P, Dragovic SM, Joyce S (2010) Curr Opin Organ Transplant 15(4): 512-25
    › Primary publication · 20616723 (PubMed)
  24. Natural killer T cell-a cat o' nine lives! Joyce S, Gordy LE (2010) EMBO J 29(9): 1475-6
    › Primary publication · 20442728 (PubMed) · PMC2876948 (PubMed Central)
  25. Neurons preferentially respond to self-MHC class I allele products regardless of peptide presented. Escande-Beillard N, Washburn L, Zekzer D, Wu ZP, Eitan S, Ivkovic S, Lu Y, Dang H, Middleton B, Bilousova TV, Yoshimura Y, Evans CJ, Joyce S, Tian J, Kaufman DL (2010) J Immunol 184(2): 816-23
    › Primary publication · 20018625 (PubMed) · PMC2997386 (PubMed Central)
  26. Adaptability of the semi-invariant natural killer T-cell receptor towards structurally diverse CD1d-restricted ligands. Florence WC, Xia C, Gordy LE, Chen W, Zhang Y, Scott-Browne J, Kinjo Y, Yu KO, Keshipeddy S, Pellicci DG, Patel O, Kjer-Nielsen L, McCluskey J, Godfrey DI, Rossjohn J, Richardson SK, Porcelli SA, Howell AR, Hayakawa K, Gapin L, Zajonc DM, Wang PG, Joyce S (2009) EMBO J 28(23): 3781
    › Primary publication · 19953109 (PubMed) · PMC2790496 (PubMed Central)
  27. Adaptability of the semi-invariant natural killer T-cell receptor towards structurally diverse CD1d-restricted ligands. Florence WC, Xia C, Gordy LE, Chen W, Zhang Y, Scott-Browne J, Kinjo Y, Yu KO, Keshipeddy S, Pellicci DG, Patel O, Kjer-Nielsen L, McCluskey J, Godfrey DI, Rossjohn J, Richardson SK, Porcelli SA, Howell AR, Hayakawa K, Gapin L, Zajonc DM, Wang PG, Joyce S (2009) EMBO J 28(22): 3579-90
    › Primary publication · 19816402 (PubMed) · PMC2782097 (PubMed Central)
  28. CD1d-restricted glycolipid antigens: presentation principles, recognition logic and functional consequences. Florence WC, Bhat RK, Joyce S (2008) Expert Rev Mol Med : e20
    › Primary publication · 18601810 (PubMed)
  29. Cutting edge: K63-linked polyubiquitination of NEMO modulates TLR signaling and inflammation in vivo. Ni CY, Wu ZH, Florence WC, Parekh VV, Arrate MP, Pierce S, Schweitzer B, Van Kaer L, Joyce S, Miyamoto S, Ballard DW, Oltz EM (2008) J Immunol 180(11): 7107-11
    › Primary publication · 18490708 (PubMed) · PMC2601684 (PubMed Central)
  30. Invariant natural killer T cells trigger adaptive lymphocytes to churn up bile. Joyce S, Van Kaer L (2008) Cell Host Microbe 3(5): 275-7
    › Primary publication · 18474352 (PubMed)
  31. Characterization and functional analysis of mouse invariant natural T (iNKT) cells. Bezbradica JS, Stanic AK, Joyce S (2006) Curr Protoc Immunol : Unit 14.13
    › Primary publication · 18432968 (PubMed)
  32. A Staphylococcus aureus regulatory system that responds to host heme and modulates virulence. Torres VJ, Stauff DL, Pishchany G, Bezbradica JS, Gordy LE, Iturregui J, Anderson KL, Dunman PM, Joyce S, Skaar EP (2007) Cell Host Microbe 1(2): 109-19
    › Primary publication · 18005689 (PubMed) · PMC2083280 (PubMed Central)
  33. Aging is associated with a rapid decline in frequency, alterations in subset composition, and enhanced Th2 response in CD1d-restricted NKT cells from human peripheral blood. Jing Y, Gravenstein S, Chaganty NR, Chen N, Lyerly KH, Joyce S, Deng Y (2007) Exp Gerontol 42(8): 719-32
    › Primary publication · 17368996 (PubMed)
  34. Granulocyte-macrophage colony-stimulating factor regulates effector differentiation of invariant natural killer T cells during thymic ontogeny. Bezbradica JS, Gordy LE, Stanic AK, Dragovic S, Hill T, Hawiger J, Unutmaz D, Van Kaer L, Joyce S (2006) Immunity 25(3): 487-97
    › Primary publication · 16949316 (PubMed)
  35. The role of invariant natural killer T cells in lupus and atherogenesis. Major AS, Singh RR, Joyce S, Van Kaer L (2006) Immunol Res 34(1): 49-66
    › Primary publication · 16720898 (PubMed) · PMC2291524 (PubMed Central)
  36. Lipid metabolism, atherogenesis and CD1-restricted antigen presentation. Major AS, Joyce S, Van Kaer L (2006) Trends Mol Med 12(6): 270-8
    › Primary publication · 16651026 (PubMed)
  37. In vivo role of ER-associated peptidase activity in tailoring peptides for presentation by MHC class Ia and class Ib molecules. Yan J, Parekh VV, Mendez-Fernandez Y, Olivares-Villagómez D, Dragovic S, Hill T, Roopenian DC, Joyce S, Van Kaer L (2006) J Exp Med 203(3): 647-59
    › Primary publication · 16505142 (PubMed) · PMC2118255 (PubMed Central)
  38. Glycolipid antigen induces long-term natural killer T cell anergy in mice. Parekh VV, Wilson MT, Olivares-Villagómez D, Singh AK, Wu L, Wang CR, Joyce S, Van Kaer L (2005) J Clin Invest 115(9): 2572-83
    › Primary publication · 16138194 (PubMed) · PMC1193878 (PubMed Central)
  39. Innate immunity: NKT cells in the spotlight. Van Kaer L, Joyce S (2005) Curr Biol 15(11): R429-31
    › Primary publication · 15936267 (PubMed)
  40. Distinct roles of dendritic cells and B cells in Va14Ja18 natural T cell activation in vivo. Bezbradica JS, Stanic AK, Matsuki N, Bour-Jordan H, Bluestone JA, Thomas JW, Unutmaz D, Van Kaer L, Joyce S (2005) J Immunol 174(8): 4696-705
    › Primary publication · 15814694 (PubMed)
  41. Commitment toward the natural T (iNKT) cell lineage occurs at the CD4+8+ stage of thymic ontogeny. Bezbradica JS, Hill T, Stanic AK, Van Kaer L, Joyce S (2005) Proc Natl Acad Sci U S A 102(14): 5114-9
    › Primary publication · 15792999 (PubMed) · PMC555981 (PubMed Central)
  42. The natural killer T cell ligand alpha-galactosylceramide prevents or promotes pristane-induced lupus in mice. Singh AK, Yang JQ, Parekh VV, Wei J, Wang CR, Joyce S, Singh RR, Van Kaer L (2005) Eur J Immunol 35(4): 1143-54
    › Primary publication · 15761849 (PubMed) · PMC2291523 (PubMed Central)
  43. Quantitative and qualitative differences in proatherogenic NKT cells in apolipoprotein E-deficient mice. Major AS, Wilson MT, McCaleb JL, Ru Su Y, Stanic AK, Joyce S, Van Kaer L, Fazio S, Linton MF (2004) Arterioscler Thromb Vasc Biol 24(12): 2351-7
    › Primary publication · 15472130 (PubMed)
  44. Quantitative and qualitative differences in the in vivo response of NKT cells to distinct alpha- and beta-anomeric glycolipids. Parekh VV, Singh AK, Wilson MT, Olivares-Villagómez D, Bezbradica JS, Inazawa H, Ehara H, Sakai T, Serizawa I, Wu L, Wang CR, Joyce S, Van Kaer L (2004) J Immunol 173(6): 3693-706
    › Primary publication · 15356115 (PubMed)
  45. Duration of alloantigen presentation and avidity of T cell antigen recognition correlate with immunodominance of CTL response to minor histocompatibility antigens. Yoshimura Y, Yadav R, Christianson GJ, Ajayi WU, Roopenian DC, Joyce S (2004) J Immunol 172(11): 6666-74
    › Primary publication · 15153482 (PubMed)
  46. Cutting edge: the ontogeny and function of Va14Ja18 natural T lymphocytes require signal processing by protein kinase C theta and NF-kappa B. Stanic AK, Bezbradica JS, Park JJ, Van Kaer L, Boothby MR, Joyce S (2004) J Immunol 172(8): 4667-71
    › Primary publication · 15067039 (PubMed)
  47. NF-kappa B controls cell fate specification, survival, and molecular differentiation of immunoregulatory natural T lymphocytes. Stanic AK, Bezbradica JS, Park JJ, Matsuki N, Mora AL, Van Kaer L, Boothby MR, Joyce S (2004) J Immunol 172(4): 2265-73
    › Primary publication · 14764695 (PubMed)
  48. Lipid-protein interactions: biosynthetic assembly of CD1 with lipids in the endoplasmic reticulum is evolutionarily conserved. Park JJ, Kang SJ, De Silva AD, Stanic AK, Casorati G, Hachey DL, Cresswell P, Joyce S (2004) Proc Natl Acad Sci U S A 101(4): 1022-6
    › Primary publication · 14722359 (PubMed) · PMC327144 (PubMed Central)
  49. A murine locus on chromosome 18 controls NKT cell homeostasis and Th cell differentiation. Zhang F, Liang Z, Matsuki N, Van Kaer L, Joyce S, Wakeland EK, Aune TM (2003) J Immunol 171(9): 4613-20
    › Primary publication · 14568935 (PubMed)
  50. Another view of T cell antigen recognition: cooperative engagement of glycolipid antigens by Va14Ja18 natural T(iNKT) cell receptor [corrected]. Stanic AK, Shashidharamurthy R, Bezbradica JS, Matsuki N, Yoshimura Y, Miyake S, Choi EY, Schell TD, Van Kaer L, Tevethia SS, Roopenian DC, Yamamura T, Joyce S (2003) J Immunol 171(9): 4539-51
    › Primary publication · 14568927 (PubMed)
  51. The response of natural killer T cells to glycolipid antigens is characterized by surface receptor down-modulation and expansion. Wilson MT, Johansson C, Olivares-Villagómez D, Singh AK, Stanic AK, Wang CR, Joyce S, Wick MJ, Van Kaer L (2003) Proc Natl Acad Sci U S A 100(19): 10913-8
    › Primary publication · 12960397 (PubMed) · PMC196902 (PubMed Central)
  52. Antiapoptotic function of NF-kappaB in T lymphocytes is influenced by their differentiation status: roles of Fas, c-FLIP, and Bcl-xL. Mora AL, Corn RA, Stanic AK, Goenka S, Aronica M, Stanley S, Ballard DW, Joyce S, Boothby M (2003) Cell Death Differ 10(9): 1032-44
    › Primary publication · 12934078 (PubMed)
  53. Chronic rejection of murine cardiac allografts discordant at the H13 minor histocompatibility antigen correlates with the generation of the H13-specific CD8+ cytotoxic T cells. Yang J, Jaramillo A, Liu W, Olack B, Yoshimura Y, Joyce S, Kaleem Z, Mohanakumar T (2003) Transplantation 76(1): 84-91
    › Primary publication · 12865791 (PubMed)
  54. Identification and simian immunodeficiency virus infection of CD1d-restricted macaque natural killer T cells. Motsinger A, Azimzadeh A, Stanic AK, Johnson RP, Van Kaer L, Joyce S, Unutmaz D (2003) J Virol 77(14): 8153-8
    › Primary publication · 12829854 (PubMed) · PMC161937 (PubMed Central)
  55. Genetic dissection of V alpha 14J alpha 18 natural T cell number and function in autoimmune-prone mice. Matsuki N, Stanic AK, Embers ME, Van Kaer L, Morel L, Joyce S (2003) J Immunol 170(11): 5429-37
    › Primary publication · 12759418 (PubMed)
  56. Innate self recognition by an invariant, rearranged T-cell receptor and its immune consequences. Stanic AK, Park JJ, Joyce S (2003) Immunology 109(2): 171-84
    › Primary publication · 12757612 (PubMed) · PMC1782955 (PubMed Central)
  57. The H4b minor histocompatibility antigen is caused by a combination of genetically determined and posttranslational modifications. Yadav R, Yoshimura Y, Boesteanu A, Christianson GJ, Ajayi WU, Shashidharamurthy R, Stanic AK, Roopenian DC, Joyce S (2003) J Immunol 170(10): 5133-42
    › Primary publication · 12734360 (PubMed)
  58. Cancer-associated immunodeficiency and dendritic cell abnormalities mediated by the prostaglandin EP2 receptor. Yang L, Yamagata N, Yadav R, Brandon S, Courtney RL, Morrow JD, Shyr Y, Boothby M, Joyce S, Carbone DP, Breyer RM (2003) J Clin Invest 111(5): 727-35
    › Primary publication · 12618527 (PubMed) · PMC151895 (PubMed Central)
  59. Defective presentation of the CD1d1-restricted natural Va14Ja18 NKT lymphocyte antigen caused by beta-D-glucosylceramide synthase deficiency. Stanic AK, De Silva AD, Park JJ, Sriram V, Ichikawa S, Hirabyashi Y, Hayakawa K, Van Kaer L, Brutkiewicz RR, Joyce S (2003) Proc Natl Acad Sci U S A 100(4): 1849-54
    › Primary publication · 12576547 (PubMed) · PMC149922 (PubMed Central)
  60. CD1-restricted antigen presentation: an oily matter. Joyce S, Van Kaer L (2003) Curr Opin Immunol 15(1): 95-104
    › Primary publication · 12495740 (PubMed)
  61. The assembly of functional beta(2)-microglobulin-free MHC class I molecules that interact with peptides and CD8(+) T lymphocytes. Schell TD, Mylin LM, Tevethia SS, Joyce S (2002) Int Immunol 14(7): 775-82
    › Primary publication · 12096037 (PubMed)
  62. CD1d-restricted human natural killer T cells are highly susceptible to human immunodeficiency virus 1 infection. Motsinger A, Haas DW, Stanic AK, Van Kaer L, Joyce S, Unutmaz D (2002) J Exp Med 195(7): 869-79
    › Primary publication · 11927631 (PubMed) · PMC2193731 (PubMed Central)
  63. Lipid protein interactions: the assembly of CD1d1 with cellular phospholipids occurs in the endoplasmic reticulum. De Silva AD, Park JJ, Matsuki N, Stanic AK, Brutkiewicz RR, Medof ME, Joyce S (2002) J Immunol 168(2): 723-33
    › Primary publication · 11777966 (PubMed)
  64. Natural killer T cell activation protects mice against experimental autoimmune encephalomyelitis. Singh AK, Wilson MT, Hong S, Olivares-Villagómez D, Du C, Stanic AK, Joyce S, Sriram S, Koezuka Y, Van Kaer L (2001) J Exp Med 194(12): 1801-11
    › Primary publication · 11748281 (PubMed) · PMC2193577 (PubMed Central)
  65. Immune recognition, response, and regulation: how T lymphocytes do it. Joyce S (2001) Immunol Res 23(2-3): 215-28
    › Primary publication · 11444386 (PubMed)
  66. CD1d and natural T cells: how their properties jump-start the immune system. Joyce S (2001) Cell Mol Life Sci 58(3): 442-69
    › Primary publication · 11315191 (PubMed)
  67. Quantitation of CD8(+) T-lymphocyte responses to multiple epitopes from simian virus 40 (SV40) large T antigen in C57BL/6 mice immunized with SV40, SV40 T-antigen-transformed cells, or vaccinia virus recombinants expressing full-length T antigen or epitope minigenes. Mylin LM, Schell TD, Roberts D, Epler M, Boesteanu A, Collins EJ, Frelinger JA, Joyce S, Tevethia SS (2000) J Virol 74(15): 6922-34
    › Primary publication · 10888631 (PubMed) · PMC112209 (PubMed Central)
  68. Natural T cells: cranking up the immune system by prompt cytokine secretion. Joyce S (2000) Proc Natl Acad Sci U S A 97(13): 6933-5
    › Primary publication · 10860950 (PubMed) · PMC34363 (PubMed Central)
  69. Thermolabile H-2Kb molecules expressed by transporter associated with antigen processing-deficient RMA-S cells are occupied by low-affinity peptides. De Silva AD, Boesteanu A, Song R, Nagy N, Harhaj E, Harding CV, Joyce S (1999) J Immunol 163(8): 4413-20
    › Primary publication · 10510382 (PubMed)
  70. Point mutations in the beta chain CDR3 can alter the T cell receptor recognition pattern on an MHC class I/peptide complex over a broad interface area. Goyarts EC, Vegh Z, Kalergis AM, Hörig H, Papadopoulos NJ, Young AC, Thomson CT, Chang HC, Joyce S, Nathenson SG (1998) Mol Immunol 35(10): 593-607
    › Primary publication · 9823758 (PubMed)
  71. A molecular basis for how a single TCR interfaces multiple ligands. Boesteanu A, Brehm M, Mylin LM, Christianson GJ, Tevethia SS, Roopenian DC, Joyce S (1998) J Immunol 161(9): 4719-27
    › Primary publication · 9794402 (PubMed)
  72. Natural ligand of mouse CD1d1: cellular glycosylphosphatidylinositol. Joyce S, Woods AS, Yewdell JW, Bennink JR, De Silva AD, Boesteanu A, Balk SP, Cotter RJ, Brutkiewicz RR (1998) Science 279(5356): 1541-4
    › Primary publication · 9488653 (PubMed)
  73. Distinct roles for signals relayed through the common cytokine receptor gamma chain and interleukin 7 receptor alpha chain in natural T cell development. Boesteanu A, Silva AD, Nakajima H, Leonard WJ, Peschon JJ, Joyce S (1997) J Exp Med 186(2): 331-6
    › Primary publication · 9221763 (PubMed) · PMC2198975 (PubMed Central)
  74. CD1d1 mutant mice are deficient in natural T cells that promptly produce IL-4. Mendiratta SK, Martin WD, Hong S, Boesteanu A, Joyce S, Van Kaer L (1997) Immunity 6(4): 469-77
    › Primary publication · 9133426 (PubMed)
  75. Traffic control of completely assembled MHC class I molecules beyond the endoplasmic reticulum. Joyce S (1997) J Mol Biol 266(5): 993-1001
    › Primary publication · 9086276 (PubMed)
  76. Alloreactivity, antigen recognition and T-cell selection: three diverse T-cell recognition problems with a common solution. Joyce S, Nathenson SG (1996) Immunol Rev : 59-103
    › Primary publication · 9034864 (PubMed)
  77. Expansion of natural (NK1+) T cells that express alpha beta T cell receptors in transporters associated with antigen presentation-1 null and thymus leukemia antigen positive mice. Joyce S, Negishi I, Boesteanu A, DeSilva AD, Sharma P, Chorney MJ, Loh DY, Van Kaer L (1996) J Exp Med 184(4): 1579-84
    › Primary publication · 8879233 (PubMed) · PMC2192848 (PubMed Central)
  78. Thymus-leukemia antigen interacts with T cells and self-peptides. Sharma P, Joyce S, Chorney KA, Griffith JW, Bonneau RH, Wilson FD, Johnson CA, Flavell RA, Chorney MJ (1996) J Immunol 156(3): 987-96
    › Primary publication · 8558026 (PubMed)
  79. A nonpolymorphic major histocompatibility complex class Ib molecule binds a large array of diverse self-peptides. Joyce S, Tabaczewski P, Angeletti RH, Nathenson SG, Stroynowski I (1994) J Exp Med 179(2): 579-88
    › Primary publication · 8294869 (PubMed) · PMC2191392 (PubMed Central)
  80. Characterization of an incompletely assembled major histocompatibility class I molecule (H-2Kb) associated with unusually long peptides: implications for antigen processing and presentation. Joyce S, Kuzushima K, Kepecs G, Angeletti RH, Nathenson SG (1994) Proc Natl Acad Sci U S A 91(10): 4145-9
    › Primary publication · 8183884 (PubMed) · PMC43741 (PubMed Central)
  81. Characterization of kidney cell-specific, non-major histocompatibility complex alloantigen using antibodies eluted from rejected human renal allografts. Joyce S, Flye MW, Mohanakumar T (1988) Transplantation 46(3): 362-9
    › Primary publication · 3047925 (PubMed)
  82. Human kidney specific non-MHC antigen: isolation and characterization using eluates from rejected renal allografts. Joyce S, Flye MW, Mohanakumar T (1989) Transplant Proc 21(1 Pt 1): 628-9
    › Primary publication · 2650207 (PubMed)
  83. Evidence that antibodies eluted from rejected kidneys of HLA-identical transplants define a non-MHC alloantigen expressed on human kidneys. Mathew JM, Joyce S, Lawrence W, Mohanakumar T (1991) Transplantation 52(3): 559-62
    › Primary publication · 1897033 (PubMed)
  84. Mapping the orientation of an antigenic peptide bound in the antigen binding groove of H-2Kb using a monoclonal antibody. Joyce S, Sun R, Nathenson SG (1992) Biochem Biophys Res Commun 186(3): 1449-54
    › Primary publication · 1380802 (PubMed)
  85. A polymorphic human kidney-specific non-MHC alloantigen. Its possible role in tissue-specific allograft immunity. Joyce S, Mathew JM, Flye MW, Mohanakumar T (1992) Transplantation 53(5): 1119-27
    › Primary publication · 1374945 (PubMed)
  86. Vesicular stomatitis virus antigenic octapeptide N52-59 is anchored into the groove of the H-2Kb molecule by the side chains of three amino acids and the main-chain atoms of the amino terminus. Shibata K, Imarai M, van Bleek GM, Joyce S, Nathenson SG (1992) Proc Natl Acad Sci U S A 89(7): 3135-9
    › Primary publication · 1313583 (PubMed) · PMC48819 (PubMed Central)