Pinelopi Kapitsinou
Last active: 3/17/2014

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Pinelopi Kapitsinou, M.D.

Official Affiliation: Medicine

Profile

I am interested in understanding mechanisms by which the oxygen sensing machinery regulates endothelial cell specific responses under physiologic and pathophysiologic conditions. Our recent studies identified a critical role for endothelial HIF-2 in regulation of post-ischemic kidney injury and inflammation. Current studies focus on exploring further the cytoprotective effects of endothelial PHD2/HIF axis utilizing transgenic mice, molecular biology, biochemical, metabolomic and cell-culture approaches.  

Publications

The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. Myeloid cell-derived hypoxia-inducible factor attenuates inflammation in unilateral ureteral obstruction-induced kidney injury. Kobayashi H, Gilbert V, Liu Q, Kapitsinou PP, Unger TL, Rha J, Rivella S, Schlöndorff D, Haase VH (2012) J Immunol 188(10): 5106-15
    › Primary publication · 22490864 (PubMed) · PMC3345098 (PubMed Central)
  2. Preischemic targeting of HIF prolyl hydroxylation inhibits fibrosis associated with acute kidney injury. Kapitsinou PP, Jaffe J, Michael M, Swan CE, Duffy KJ, Erickson-Miller CL, Haase VH (2012) Am J Physiol Renal Physiol 302(9): F1172-9
    › Primary publication · 22262480 (PubMed) · PMC3362175 (PubMed Central)
  3. HO-1 in control of a self-eating kidney. Kapitsinou PP, Haase VH (2010) J Am Soc Nephrol 21(10): 1600-2
    › Primary publication · 20829407 (PubMed) · PMC4530623 (PubMed Central)
  4. Hepatic HIF-2 regulates erythropoietic responses to hypoxia in renal anemia. Kapitsinou PP, Liu Q, Unger TL, Rha J, Davidoff O, Keith B, Epstein JA, Moores SL, Erickson-Miller CL, Haase VH (2010) Blood 116(16): 3039-48
    › Primary publication · 20628150 (PubMed) · PMC2974609 (PubMed Central)
  5. Human and murine kidneys show gender- and species-specific gene expression differences in response to injury. Si H, Banga RS, Kapitsinou P, Ramaiah M, Lawrence J, Kambhampati G, Gruenwald A, Bottinger E, Glicklich D, Tellis V, Greenstein S, Thomas DB, Pullman J, Fazzari M, Susztak K (2009) PLoS One 4(3): e4802
    › Primary publication · 19277126 (PubMed) · PMC2652077 (PubMed Central)
  6. Kidney transplantation in lupus patients: a case-control study from a single centre. Lionaki S, Kapitsinou PP, Iniotaki A, Kostakis A, Moutsopoulos HM, Boletis JN (2008) Lupus 17(7): 670-5
    › Primary publication · 18625640 (PubMed)
  7. Acute renal failure in an AIDS patient on tenofovir: a case report. Kapitsinou PP, Ansari N (2008) J Med Case Rep : 94
    › Primary publication · 18373879 (PubMed) · PMC2329655 (PubMed Central)
  8. The VHL tumor suppressor and HIF: insights from genetic studies in mice. Kapitsinou PP, Haase VH (2008) Cell Death Differ 15(4): 650-9
    › Primary publication · 18219317 (PubMed) · PMC3799983 (PubMed Central)
  9. Lupus nephritis: treatment with mycophenolate mofetil. Kapitsinou PP, Boletis JN, Skopouli FN, Boki KA, Moutsopoulos HM (2004) Rheumatology (Oxford) 43(3): 377-80
    › Primary publication · 14963204 (PubMed)
  10. Clinicopathologic predictors of death and ESRD in patients with pauci-immune necrotizing glomerulonephritis. Kapitsinou PP, Ioannidis JP, Boletis JN, Sotsiou F, Nakopoulou L, Daphnis E, Moutsopoulos HM (2003) Am J Kidney Dis 41(1): 29-37
    › Primary publication · 12500219 (PubMed)

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    Keywords & MeSH Terms

    MeSH terms are retrieved from PubMed records. Learn more.

    Key: MeSH Term Keyword

    Albuminuria Basic Helix-Loop-Helix Transcription Factors Blood Sedimentation Carcinoma, Renal Cell Case-Control Studies Disease Models, Animal Endothelial Cells Erythropoietin Follow-Up Studies Gene Expression Regulation Gene Expression Regulation, Developmental Gene Expression Regulation, Neoplastic Glomerulosclerosis, Focal Segmental Glucocorticoids Humans Hypoxia Hypoxia-Inducible Factor 1 Hypoxia Inducible Factors Immunosuppressive Agents inflammation Kaplan-Meier Estimate kidney injury Kidney Neoplasms Metabolomics Mice Mycophenolic Acid Neoplasms Primary Cell Culture Procollagen-Proline Dioxygenase RNA, Messenger Sex Characteristics Transcription Factors Vascular Biology von Hippel-Lindau Disease Von Hippel-Lindau Tumor Suppressor Protein Xylazine