Gautam Bhave
Faculty Member
Last active: 8/12/2015

Profile

Dr. Bhave is interested in the assembly and function of basement membranes and extracellular matrix particularly in renal disease. By studying matrix biochemistry at a fundamental level, I hope to gain insight into renal glomerular and tubulointerstitial fibrosis which represents the common final pathway to injury in nearly all kidney diseases. My group utilizes cell culture systems, molecular biology, biochemistry, mass spectrometry, and mouse genetics to answer questions of interest.

 

Publications

The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. The Ancient Immunoglobulin Domains of Peroxidasin Are Required to Form Sulfilimine Cross-links in Collagen IV. Ero-Tolliver IA, Hudson BG, Bhave G (2015) J Biol Chem 290(35): 21741-8
    › Primary publication · 26178375 (PubMed) · PMC4571896 (PubMed Central)
  2. Bromine is an essential trace element for assembly of collagen IV scaffolds in tissue development and architecture. McCall AS, Cummings CF, Bhave G, Vanacore R, Page-McCaw A, Hudson BG (2014) Cell 157(6): 1380-92
    › Primary publication · 24906154 (PubMed) · PMC4144415 (PubMed Central)
  3. A unique covalent bond in basement membrane is a primordial innovation for tissue evolution. Fidler AL, Vanacore RM, Chetyrkin SV, Pedchenko VK, Bhave G, Yin VP, Stothers CL, Rose KL, McDonald WH, Clark TA, Borza DB, Steele RE, Ivy MT, Aspirnauts, Hudson JK, Hudson BG (2014) Proc Natl Acad Sci U S A 111(1): 331-6
    › Primary publication · 24344311 (PubMed) · PMC3890831 (PubMed Central)
  4. Adverse drug events during AKI and its recovery. Cox ZL, McCoy AB, Matheny ME, Bhave G, Peterson NB, Siew ED, Lewis J, Danciu I, Bian A, Shintani A, Ikizler TA, Neal EB, Peterson JF (2013) Clin J Am Soc Nephrol 8(7): 1070-8
    › Primary publication · 23539228 (PubMed) · PMC3700703 (PubMed Central)
  5. Peroxidasin forms sulfilimine chemical bonds using hypohalous acids in tissue genesis. Bhave G, Cummings CF, Vanacore RM, Kumagai-Cresse C, Ero-Tolliver IA, Rafi M, Kang JS, Pedchenko V, Fessler LI, Fessler JH, Hudson BG (2012) Nat Chem Biol 8(9): 784-90
    › Primary publication · 22842973 (PubMed) · PMC4128002 (PubMed Central)
  6. Real-time pharmacy surveillance and clinical decision support to reduce adverse drug events in acute kidney injury: a randomized, controlled trial. McCoy AB, Cox ZL, Neal EB, Waitman LR, Peterson NB, Bhave G, Siew ED, Danciu I, Lewis JB, Peterson JF (2012) Appl Clin Inform 3(2): 221-238
    › Primary publication · 22719796 (PubMed) · PMC3377180 (PubMed Central)
  7. Body fluid dynamics: back to the future. Bhave G, Neilson EG (2011) J Am Soc Nephrol 22(12): 2166-81
    › Primary publication · 22034644 (PubMed) · PMC4096826 (PubMed Central)
  8. Volume depletion versus dehydration: how understanding the difference can guide therapy. Bhave G, Neilson EG (2011) Am J Kidney Dis 58(2): 302-9
    › Primary publication · 21705120 (PubMed) · PMC4096820 (PubMed Central)
  9. Sulphilimine cross-links in Goodpasture's disease. Vanacore R, Pedchenko V, Bhave G, Hudson BG (2011) Clin Exp Immunol : 4-6
    › Primary publication · 21447121 (PubMed) · PMC3095855 (PubMed Central)
  10. Development of a selective small-molecule inhibitor of Kir1.1, the renal outer medullary potassium channel. Bhave G, Chauder BA, Liu W, Dawson ES, Kadakia R, Nguyen TT, Lewis LM, Meiler J, Weaver CD, Satlin LM, Lindsley CW, Denton JS (2011) Mol Pharmacol 79(1): 42-50
    › Primary publication · 20926757 (PubMed) · PMC3014278 (PubMed Central)
  11. Small-molecule modulators of inward rectifier K+ channels: recent advances and future possibilities. Bhave G, Lonergan D, Chauder BA, Denton JS (2010) Future Med Chem 2(5): 757-74
    › Primary publication · 20543968 (PubMed) · PMC2883187 (PubMed Central)
  12. High-throughput screening reveals a small-molecule inhibitor of the renal outer medullary potassium channel and Kir7.1. Lewis LM, Bhave G, Chauder BA, Banerjee S, Lornsen KA, Redha R, Fallen K, Lindsley CW, Weaver CD, Denton JS (2009) Mol Pharmacol 76(5): 1094-103
    › Primary publication · 19706730 (PubMed) · PMC2774996 (PubMed Central)
  13. Association of gadolinium based magnetic resonance imaging contrast agents and nephrogenic systemic fibrosis. Bhave G, Lewis JB, Chang SS (2008) J Urol 180(3): 830-5; discussion 835
    › Primary publication · 18635232 (PubMed) · PMC4128001 (PubMed Central)
  14. Posttranslational mechanisms of peripheral sensitization. Bhave G, Gereau RW (2004) J Neurobiol 61(1): 88-106
    › Primary publication · 15362155 (PubMed)
  15. Protein kinase C phosphorylation sensitizes but does not activate the capsaicin receptor transient receptor potential vanilloid 1 (TRPV1). Bhave G, Hu HJ, Glauner KS, Zhu W, Wang H, Brasier DJ, Oxford GS, Gereau RW (2003) Proc Natl Acad Sci U S A 100(21): 12480-5
    › Primary publication · 14523239 (PubMed) · PMC218783 (PubMed Central)
  16. Growing pains: the cytoskeleton as a critical regulator of pain plasticity. Bhave G, Gereau RW (2003) Neuron 39(4): 577-9
    › Primary publication · 12925270 (PubMed)
  17. Membrane topology of a metabotropic glutamate receptor. Bhave G, Nadin BM, Brasier DJ, Glauner KS, Shah RD, Heinemann SF, Karim F, Gereau RW (2003) J Biol Chem 278(32): 30294-301
    › Primary publication · 12764131 (PubMed)
  18. Synaptic plasticity in the amygdala in a model of arthritic pain: differential roles of metabotropic glutamate receptors 1 and 5. Neugebauer V, Li W, Bird GC, Bhave G, Gereau RW (2003) J Neurosci 23(1): 52-63
    › Primary publication · 12514201 (PubMed)
  19. Prostaglandin and protein kinase A-dependent modulation of vanilloid receptor function by metabotropic glutamate receptor 5: potential mechanism for thermal hyperalgesia. Hu HJ, Bhave G, Gereau RW (2002) J Neurosci 22(17): 7444-52
    › Primary publication · 12196566 (PubMed)
  20. cAMP-dependent protein kinase regulates desensitization of the capsaicin receptor (VR1) by direct phosphorylation. Bhave G, Zhu W, Wang H, Brasier DJ, Oxford GS, Gereau RW (2002) Neuron 35(4): 721-31
    › Primary publication · 12194871 (PubMed)
  21. Metabotropic glutamate receptors on peripheral sensory neuron terminals as targets for the development of novel analgesics. Karim F, Bhave G, Gereau RW (2001) Mol Psychiatry 6(6): 615-7
    › Primary publication · 11673787 (PubMed)
  22. Peripheral group I metabotropic glutamate receptors modulate nociception in mice. Bhave G, Karim F, Carlton SM, Gereau RW (2001) Nat Neurosci 4(4): 417-23
    › Primary publication · 11276233 (PubMed)