Huifang Cheng
Last active: 5/1/2017

Profile

      I received my M.D. from Peking Union Medical University, Msc. from Beijing Medical University, and experienced extensive post-graduate training in Nephrology mentored by Prof. J steward Cameron and molecular biology in the Molecular Biology Department in Manchester University, U.K. Since 1992, I have been a member of the laboratory of Dr. Raymond Harris in the Division of Nephrology and promoted to Research Instructor in 1995, to Research Assistant Professor in 1999 and to Research Associate Professor in 2002. I published more than fifty original scientific manuscripts in high quality journals, including Journal of Clinical Investigation, Journal of Biologic Chemistry, American Journal of Physiology, Journal of the American Society of Nephrology and Kidney International, which have been widely cited. Our work involves in the role of renin- angiotensin-system, cyclooxygenase-2 and Nitric oxide during renal injury and our goal is to investigate the crosslink with pro-inflammation factors in glomerular cells (such as podocyte and endothelial cells etc.) and their molecular mechanisms during the development of renal diseases, such as diabetic nephropathy, especially in aged population.

Publications

The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. Low nitric oxide bioavailability upregulates renal heparin binding EGF-like growth factor expression. Miyazawa T, Zeng F, Wang S, Fan X, Cheng H, Yang H, Bian A, Fogo AB, Harris RC (2013) Kidney Int 84(6): 1176-88
    › Citation · 23760291 (PubMed) · PMC3796048 (PubMed Central)
  2. Improvement of endothelial nitric oxide synthase activity retards the progression of diabetic nephropathy in db/db mice. Cheng H, Wang H, Fan X, Paueksakon P, Harris RC (2012) Kidney Int 82(11): 1176-83
    › Citation · 22785174 (PubMed) · PMC3473143 (PubMed Central)
  3. Integrin α1/Akita double-knockout mice on a Balb/c background develop advanced features of human diabetic nephropathy. Yu L, Su Y, Paueksakon P, Cheng H, Chen X, Wang H, Harris RC, Zent R, Pozzi A (2012) Kidney Int 81(11): 1086-97
    › Citation · 22297672 (PubMed) · PMC3345314 (PubMed Central)
  4. Podocyte COX-2 exacerbates diabetic nephropathy by increasing podocyte (pro)renin receptor expression. Cheng H, Fan X, Moeckel GW, Harris RC (2011) J Am Soc Nephrol 22(7): 1240-51
    › Citation · 21737546 (PubMed) · PMC3137572 (PubMed Central)
  5. The glomerulus--a view from the outside--the podocyte. Cheng H, Harris RC (2010) Int J Biochem Cell Biol 42(9): 1380-7
    › Citation · 20542138 (PubMed) · PMC2910191 (PubMed Central)
  6. Distinct roles for basal and induced COX-2 in podocyte injury. Cheng H, Fan X, Guan Y, Moeckel GW, Zent R, Harris RC (2009) J Am Soc Nephrol 20(9): 1953-62
    › Citation · 19643929 (PubMed) · PMC2736764 (PubMed Central)
  7. Puromycin induces reversible proteinuric injury in transgenic mice expressing cyclooxygenase-2 in podocytes. Jo YI, Cheng H, Wang S, Moeckel GW, Harris RC (2007) Nephron Exp Nephrol 107(3): e87-94
    › Citation · 17890881 (PubMed)
  8. Overexpression of cyclooxygenase-2 predisposes to podocyte injury. Cheng H, Wang S, Jo YI, Hao CM, Zhang M, Fan X, Kennedy C, Breyer MD, Moeckel GW, Harris RC (2007) J Am Soc Nephrol 18(2): 551-9
    › Citation · 17202413 (PubMed)
  9. Renal cortical cyclooxygenase 2 expression is differentially regulated by angiotensin II AT(1) and AT(2) receptors. Zhang MZ, Yao B, Cheng HF, Wang SW, Inagami T, Harris RC (2006) Proc Natl Acad Sci U S A 103(43): 16045-50
    › Citation · 17043228 (PubMed) · PMC1635124 (PubMed Central)
  10. Endothelial nitric oxide synthase deficiency produces accelerated nephropathy in diabetic mice. Zhao HJ, Wang S, Cheng H, Zhang MZ, Takahashi T, Fogo AB, Breyer MD, Harris RC (2006) J Am Soc Nephrol 17(10): 2664-9
    › Citation · 16971655 (PubMed) · PMC4618687 (PubMed Central)
  11. Potential side effects of renin inhibitors--mechanisms based on comparison with other renin-angiotensin blockers. Cheng H, Harris RC (2006) Expert Opin Drug Saf 5(5): 631-41
    › Citation · 16907653 (PubMed)
  12. Expression of mediators of renal injury in the remnant kidney of ROP mice is attenuated by cyclooxygenase-2 inhibition. Cheng H, Zhang M, Moeckel GW, Zhao Y, Wang S, Qi Z, Breyer MD, Harris RC (2005) Nephron Exp Nephrol 101(3): e75-85
    › Citation · 15995341 (PubMed)
  13. Renal effects of non-steroidal anti-inflammatory drugs and selective cyclooxygenase-2 inhibitors. Cheng HF, Harris RC (2005) Curr Pharm Des 11(14): 1795-804
    › Citation · 15892676 (PubMed)
  14. Cyclooxygenase-2 and the renal renin-angiotensin system. Harris RC, Zhang MZ, Cheng HF (2004) Acta Physiol Scand 181(4): 543-7
    › Citation · 15283769 (PubMed)
  15. Cyclooxygenases, the kidney, and hypertension. Cheng HF, Harris RC (2004) Hypertension 43(3): 525-30
    › Citation · 14732722 (PubMed)
  16. Regulation of renal cortical cyclooxygenase-2 in young rats. Zhang MZ, Wang SW, Cheng H, Zhang Y, McKanna JA, Harris RC (2003) Am J Physiol Renal Physiol 285(5): F881-8
    › Citation · 12851252 (PubMed)
  17. Does cyclooxygenase-2 affect blood pressure? Cheng HF, Harris RC (2003) Curr Hypertens Rep 5(1): 87-92
    › Citation · 12530941 (PubMed)
  18. Cyclooxygenase-2 expression in cultured cortical thick ascending limb of Henle increases in response to decreased extracellular ionic content by both transcriptional and post-transcriptional mechanisms. Role of p38-mediated pathways. Cheng HF, Harris RC (2002) J Biol Chem 277(47): 45638-43
    › Citation · 12237297 (PubMed)
  19. Prostaglandins that increase renin production in response to ACE inhibition are not derived from cyclooxygenase-1. Cheng HF, Wang SW, Zhang MZ, McKanna JA, Breyer R, Harris RC (2002) Am J Physiol Regul Integr Comp Physiol 283(3): R638-46
    › Citation · 12184998 (PubMed)
  20. Cyclooxygenase-2 inhibitor blocks expression of mediators of renal injury in a model of diabetes and hypertension. Cheng HF, Wang CJ, Moeckel GW, Zhang MZ, McKanna JA, Harris RC (2002) Kidney Int 62(3): 929-39
    › Citation · 12164875 (PubMed)
  21. Genetic deletion of COX-2 prevents increased renin expression in response to ACE inhibition. Cheng HF, Wang JL, Zhang MZ, Wang SW, McKanna JA, Harris RC (2001) Am J Physiol Renal Physiol 280(3): F449-56
    › Citation · 11181406 (PubMed)
  22. Role of p38 in the regulation of renal cortical cyclooxygenase-2 expression by extracellular chloride. Cheng HF, Wang JL, Zhang MZ, McKanna JA, Harris RC (2000) J Clin Invest 106(5): 681-8
    › Citation · 10974021 (PubMed) · PMC381289 (PubMed Central)
  23. Nitric oxide regulates renal cortical cyclooxygenase-2 expression. Cheng HF, Wang JL, Zhang MZ, McKanna JA, Harris RC (2000) Am J Physiol Renal Physiol 279(1): F122-9
    › Citation · 10894794 (PubMed)
  24. A selective cyclooxygenase-2 inhibitor decreases proteinuria and retards progressive renal injury in rats. Wang JL, Cheng HF, Shappell S, Harris RC (2000) Kidney Int 57(6): 2334-42
    › Citation · 10844603 (PubMed)
  25. Interactions of the renin-angiotensin system and neuronal nitric oxide synthase in regulation of cyclooxygenase-2 in the macula densa. Harris RC, Cheng H, Wang J, Zhang M, McKanna JA (2000) Acta Physiol Scand 168(1): 47-51
    › Citation · 10691779 (PubMed)
  26. Cyclooxygenase-2-selective inhibitors impair glomerulogenesis and renal cortical development. Kömhoff M, Wang JL, Cheng HF, Langenbach R, McKanna JA, Harris RC, Breyer MD (2000) Kidney Int 57(2): 414-22
    › Citation · 10652018 (PubMed)
  27. Cyclooxygenase-2 inhibition decreases renin content and lowers blood pressure in a model of renovascular hypertension. Wang JL, Cheng HF, Harris RC (1999) Hypertension 34(1): 96-101
    › Citation · 10406830 (PubMed)
  28. Selective increase of cyclooxygenase-2 expression in a model of renal ablation. Wang JL, Cheng HF, Zhang MZ, McKanna JA, Harris RC (1998) Am J Physiol 275(4): F613-22
    › Citation · 9755133 (PubMed)
  29. Prostaglandins in macula densa function. Harris RC, Wang JL, Cheng HF, Zhang MZ, McKanna JA (1998) Kidney Int Suppl : S49-52
    › Citation · 9736253 (PubMed)
  30. Constitutive expression of cyclooxygenase-2 in rat vas deferens. McKanna JA, Zhang MZ, Wang JL, Cheng H, Harris RC (1998) Am J Physiol 275(1): R227-33
    › Citation · 9688983 (PubMed)
  31. Young SHR express increased type 1 angiotensin II receptors in renal proximal tubule. Cheng HF, Wang JL, Vinson GP, Harris RC (1998) Am J Physiol 274(1): F10-7
    › Citation · 9458818 (PubMed)
  32. Cyclooxygenase-2 in rat nephron development. Zhang MZ, Wang JL, Cheng HF, Harris RC, McKanna JA (1997) Am J Physiol 273(6): F994-1002
    › Citation · 9435689 (PubMed)
  33. Apical ANG II-stimulated PLA2 activity and Na+ flux: a potential role for Ca2+-independent PLA2. Becker BN, Cheng HF, Harris RC (1997) Am J Physiol 273(4): F554-62
    › Citation · 9362333 (PubMed)
  34. Effect of glucose, pyruvate, and insulin on type 1 angiotensin II receptor expression in SV40-immortalized rabbit proximal tubule epithelial cells. Becker BN, Kondo S, Cheng HF, Harris RC (1997) Kidney Int 52(1): 87-92
    › Citation · 9211350 (PubMed)
  35. Acute and chronic mechanisms for regulating proximal tubule angiotensin II receptor expression. Harris RC, Becker BN, Cheng HF (1997) J Am Soc Nephrol 8(2): 306-13
    › Citation · 9048351 (PubMed)
  36. The intrarenal renin-angiotensin system: a paracrine system for the local control of renal function separate from the systemic axis. Harris RC, Cheng HF (1996) Exp Nephrol : 2-7
    › Citation · 9001891 (PubMed)
  37. Dopamine decreases expression of type-1 angiotensin II receptors in renal proximal tubule. Cheng HF, Becker BN, Harris RC (1996) J Clin Invest 97(12): 2745-52
    › Citation · 8675685 (PubMed) · PMC507367 (PubMed Central)
  38. Angiotensin II upregulates type-1 angiotensin II receptors in renal proximal tubule. Cheng HF, Becker BN, Burns KD, Harris RC (1995) J Clin Invest 95(5): 2012-9
    › Citation · 7738168 (PubMed) · PMC295780 (PubMed Central)
  39. Reduced proximal tubule angiotensin II receptor expression in streptozotocin-induced diabetes mellitus. Cheng HF, Burns KD, Harris RC (1994) Kidney Int 46(6): 1603-10
    › Citation · 7700017 (PubMed)
  40. Induction of heparin-binding epidermal growth factor-like growth factor mRNA in rat kidney after acute injury. Homma T, Sakai M, Cheng HF, Yasuda T, Coffey RJ, Harris RC (1995) J Clin Invest 96(2): 1018-25
    › Citation · 7635938 (PubMed) · PMC185290 (PubMed Central)
  41. Polarized rabbit type 1 angiotensin II receptors manifest differential rates of endocytosis and recycling. Becker BN, Cheng HF, Burns KD, Harris RC (1995) Am J Physiol 269(4 Pt 1): C1048-56
    › Citation · 7485445 (PubMed)