Eddie Siew
Last active: 4/13/2017


Dr. Edward D. Siew is an Associate Professor of Medicine at the Vanderbilt University School of Medicine in Nashville, TN within the Division of Nephrology and Hypertension and a Staff Physician at the Nashville VA.  Dr. Siew received his medical degree at the University of Chicago Pritzker School of Medicine and completed his residency in internal medicine at The University of California, San Francisco.  He also completed fellowships in Critical Care Medicine and the University of Pittsburgh School of Medicine and Nephrology at Vanderbilt University School of Medicine.  Dr. Siew is also a graduate of the Masters of Science in Clinical Investigation at Vanderbilt whose research program is focused on improving the care of patients with acute kidney injury (AKI).  Ongoing projects include using novel biomarkers of injury to refine the diagnosis of AKI and provide better prognostic information, leveraging the electronic health record to better examine healthcare delivery to patients who experience AKI, and improving understanding of the long-term impact of this disease, including identifying mechanisms that contribute to progressive loss of kidney function and cardiovascular disease in this population.  Dr. Siew currently also serves as a co-investigator of the NIH-sponsored Assessment and Serial Evaluation of the Subsequent Sequelae of Acute Kidney Injury (ASSESS-AKI) study, a prospective multi-center study examining the long-term natural history of AKI. 





The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. National Veterans Health Administration inpatient risk stratification models for hospital-acquired acute kidney injury. Cronin RM, VanHouten JP, Siew ED, Eden SK, Fihn SD, Nielson CD, Peterson JF, Baker CR, Ikizler TA, Speroff T, Matheny ME (2015) J Am Med Inform Assoc 22(5): 1054-71
    › Primary publication · 26104740 (PubMed) · PMC5009929 (PubMed Central)
  2. The potential utility of urinary biomarkers for risk prediction in combat casualties: a prospective observational cohort study. Stewart IJ, Glass KR, Howard JT, Morrow BD, Sosnov JA, Siew ED, Wickersham N, Latack W, Kwan HK, Heegard KD, Diaz C, Henderson AT, Saenz KK, Ikizler TA, Chung KK (2015) Crit Care : 252
    › Primary publication · 26077788 (PubMed) · PMC4487799 (PubMed Central)
  3. Membranous glomerulopathy with superimposed pauci-immune necrotizing crescentic glomerulonephritis. Fatima H, Siew ED, Dwyer JP, Paueksakon P (2012) Clin Kidney J 5(6): 587-90
    › Primary publication · 26069808 (PubMed) · PMC4400567 (PubMed Central)
  4. Cigarette Smoke Exposure and the Acute Respiratory Distress Syndrome. Calfee CS, Matthay MA, Kangelaris KN, Siew ED, Janz DR, Bernard GR, May AK, Jacob P, Havel C, Benowitz NL, Ware LB (2015) Crit Care Med 43(9): 1790-7
    › Primary publication · 26010690 (PubMed) · PMC4737582 (PubMed Central)
  5. Early acute kidney injury in military casualties. Heegard KD, Stewart IJ, Cap AP, Sosnov JA, Kwan HK, Glass KR, Morrow BD, Latack W, Henderson AT, Saenz KK, Siew ED, Ikizler TA, Chung KK (2015) J Trauma Acute Care Surg 78(5): 988-93
    › Primary publication · 25909420 (PubMed)
  6. The growth of acute kidney injury: a rising tide or just closer attention to detail? Siew ED, Davenport A (2015) Kidney Int 87(1): 46-61
    › Primary publication · 25229340 (PubMed) · PMC4281297 (PubMed Central)
  7. Urinary L-FABP predicts poor outcomes in critically ill patients with early acute kidney injury. Parr SK, Clark AJ, Bian A, Shintani AK, Wickersham NE, Ware LB, Ikizler TA, Siew ED (2015) Kidney Int 87(3): 640-8
    › Primary publication · 25229339 (PubMed) · PMC4344867 (PubMed Central)
  8. Omega-3 fatty acids inhibit the up-regulation of endothelial chemokines in maintenance hemodialysis patients. Hung AM, Booker C, Ellis CD, Siew ED, Graves AJ, Shintani A, Abumrad NN, Himmelfarb J, Ikizler TA (2015) Nephrol Dial Transplant 30(2): 266-74
    › Primary publication · 25204316 (PubMed) · PMC4309191 (PubMed Central)
  9. Laboratory test surveillance following acute kidney injury. Matheny ME, Peterson JF, Eden SK, Hung AM, Speroff T, Abdel-Kader K, Parr SK, Ikizler TA, Siew ED (2014) PLoS One 9(8): e103746
    › Primary publication · 25117447 (PubMed) · PMC4130516 (PubMed Central)
  10. Administration of IL-1ra improves adiponectin levels in chronic hemodialysis patients. Hung AM, Limkunakul C, Placido JS, Siew ED, Ellis CD, Shintani A, Ikizler TA (2014) J Nephrol 27(6): 681-8
    › Primary publication · 24609887 (PubMed)
  11. Acute kidney injury: a not-so-silent disease. Siew ED, Furth SL (2014) Kidney Int 85(3): 494-5
    › Primary publication · 24583979 (PubMed) · PMC4000542 (PubMed Central)
  12. Urine stability studies for novel biomarkers of acute kidney injury. Parikh CR, Butrymowicz I, Yu A, Chinchilli VM, Park M, Hsu CY, Reeves WB, Devarajan P, Kimmel PL, Siew ED, Liu KD, ASSESS-AKI Study Investigators (2014) Am J Kidney Dis 63(4): 567-72
    › Primary publication · 24200462 (PubMed) · PMC3969397 (PubMed Central)
  13. Association of elevated urinary concentration of renin-angiotensin system components and severe AKI. Alge JL, Karakala N, Neely BA, Janech MG, Tumlin JA, Chawla LS, Shaw AD, Arthur JM, SAKInet Investigators (2013) Clin J Am Soc Nephrol 8(12): 2043-52
    › Primary publication · 24009222 (PubMed) · PMC3848399 (PubMed Central)
  14. Evaluation of 32 urine biomarkers to predict the progression of acute kidney injury after cardiac surgery. Arthur JM, Hill EG, Alge JL, Lewis EC, Neely BA, Janech MG, Tumlin JA, Chawla LS, Shaw AD, SAKInet Investigators (2014) Kidney Int 85(2): 431-8
    › Primary publication · 24005224 (PubMed) · PMC3880389 (PubMed Central)
  15. Distinct injury markers for the early detection and prognosis of incident acute kidney injury in critically ill adults with preserved kidney function. Siew ED, Ware LB, Bian A, Shintani A, Eden SK, Wickersham N, Cripps B, Ikizler TA (2013) Kidney Int 84(4): 786-94
    › Primary publication · 23698227 (PubMed) · PMC3788840 (PubMed Central)
  16. Diagnosis of acute kidney injury using functional and injury biomarkers: workgroup statements from the tenth Acute Dialysis Quality Initiative Consensus Conference. McCullough PA, Shaw AD, Haase M, Bouchard J, Waikar SS, Siew ED, Murray PT, Mehta RL, Ronco C (2013) Contrib Nephrol : 13-29
    › Primary publication · 23689653 (PubMed)
  17. Implementation of novel biomarkers in the diagnosis, prognosis, and management of acute kidney injury: executive summary from the tenth consensus conference of the Acute Dialysis Quality Initiative (ADQI). McCullough PA, Bouchard J, Waikar SS, Siew ED, Endre ZH, Goldstein SL, Koyner JL, Macedo E, Doi K, Di Somma S, Lewington A, Thadhani R, Chakravarthi R, Ice C, Okusa MD, Duranteau J, Doran P, Yang L, Jaber BL, Meehan S, Kellum JA, Haase M, Murray PT, Cruz D, Maisel A, Bagshaw SM, Chawla LS, Mehta RL, Shaw AD, Ronco C (2013) Contrib Nephrol : 5-12
    › Primary publication · 23689652 (PubMed) · PMC3856225 (PubMed Central)
  18. Urinary angiotensinogen predicts adverse outcomes among acute kidney injury patients in the intensive care unit. Alge JL, Karakala N, Neely BA, Janech MG, Velez JC, Arthur JM, SAKInet Investigators (2013) Crit Care 17(2): R69
    › Primary publication · 23587112 (PubMed) · PMC3672721 (PubMed Central)
  19. Adverse drug events during AKI and its recovery. Cox ZL, McCoy AB, Matheny ME, Bhave G, Peterson NB, Siew ED, Lewis J, Danciu I, Bian A, Shintani A, Ikizler TA, Neal EB, Peterson JF (2013) Clin J Am Soc Nephrol 8(7): 1070-8
    › Primary publication · 23539228 (PubMed) · PMC3700703 (PubMed Central)
  20. The inexorable rise of AKI: can we bend the growth curve? Siew ED, Himmelfarb J (2013) J Am Soc Nephrol 24(1): 3-5
    › Primary publication · 23243210 (PubMed) · PMC3537222 (PubMed Central)
  21. Insulin resistance and protein metabolism in chronic hemodialysis patients. Deger SM, Sundell MB, Siew ED, Egbert P, Ellis CD, Sha F, Ikizler TA, Hung AM (2013) J Ren Nutr 23(3): e59-66
    › Primary publication · 23194840 (PubMed) · PMC3852904 (PubMed Central)
  22. Use of multiple imputation method to improve estimation of missing baseline serum creatinine in acute kidney injury research. Siew ED, Peterson JF, Eden SK, Moons KG, Ikizler TA, Matheny ME (2013) Clin J Am Soc Nephrol 8(1): 10-8
    › Primary publication · 23037980 (PubMed) · PMC3531649 (PubMed Central)
  23. A pilot study of active vitamin D administration and insulin resistance in African American patients undergoing chronic hemodialysis. Hung AM, Sundell MB, Plotnikova NE, Bian A, Shintani A, Ellis CD, Siew ED, Ikizler TA (2013) J Ren Nutr 23(3): 185-93
    › Primary publication · 22959781 (PubMed) · PMC3519966 (PubMed Central)
  24. Real-time pharmacy surveillance and clinical decision support to reduce adverse drug events in acute kidney injury: a randomized, controlled trial. McCoy AB, Cox ZL, Neal EB, Waitman LR, Peterson NB, Bhave G, Siew ED, Danciu I, Lewis JB, Peterson JF (2012) Appl Clin Inform 3(2): 221-238
    › Primary publication · 22719796 (PubMed) · PMC3377180 (PubMed Central)
  25. Recent advances in acute kidney injury epidemiology. Siew ED, Deger SM (2012) Curr Opin Nephrol Hypertens 21(3): 309-17
    › Primary publication · 22449946 (PubMed) · PMC3357067 (PubMed Central)
  26. Estimating baseline kidney function in hospitalized patients with impaired kidney function. Siew ED, Ikizler TA, Matheny ME, Shi Y, Schildcrout JS, Danciu I, Dwyer JP, Srichai M, Hung AM, Smith JP, Peterson JF (2012) Clin J Am Soc Nephrol 7(5): 712-9
    › Primary publication · 22422536 (PubMed) · PMC3338282 (PubMed Central)
  27. Outpatient nephrology referral rates after acute kidney injury. Siew ED, Peterson JF, Eden SK, Hung AM, Speroff T, Ikizler TA, Matheny ME (2012) J Am Soc Nephrol 23(2): 305-12
    › Primary publication · 22158435 (PubMed) · PMC3269178 (PubMed Central)
  28. Blind men and elephants and the biological markers of AKI. Siew ED (2011) J Am Soc Nephrol 22(9): 1578-80
    › Primary publication · 21836142 (PubMed)
  29. CRP polymorphisms and chronic kidney disease in the third national health and nutrition examination survey. Hung AM, Ikizler TA, Griffin MR, Glenn K, Greevy RA, Grijalva CG, Siew ED, Crawford DC (2011) BMC Med Genet : 65
    › Primary publication · 21569369 (PubMed) · PMC3119179 (PubMed Central)
  30. The outcome of neutrophil gelatinase-associated lipocalin-positive subclinical acute kidney injury: a multicenter pooled analysis of prospective studies. Haase M, Devarajan P, Haase-Fielitz A, Bellomo R, Cruz DN, Wagener G, Krawczeski CD, Koyner JL, Murray P, Zappitelli M, Goldstein SL, Makris K, Ronco C, Martensson J, Martling CR, Venge P, Siew E, Ware LB, Ikizler TA, Mertens PR (2011) J Am Coll Cardiol 57(17): 1752-61
    › Primary publication · 21511111 (PubMed) · PMC4866647 (PubMed Central)
  31. Biological markers of acute kidney injury. Siew ED, Ware LB, Ikizler TA (2011) J Am Soc Nephrol 22(5): 810-20
    › Primary publication · 21493774 (PubMed)
  32. A comparison of novel and commonly-used indices of insulin sensitivity in African American chronic hemodialysis patients. Hung AM, Sundell MB, Egbert P, Siew ED, Shintani A, Ellis CD, Bian A, Ikizler TA (2011) Clin J Am Soc Nephrol 6(4): 767-74
    › Primary publication · 21441124 (PubMed) · PMC3069368 (PubMed Central)
  33. Prehospital statin and aspirin use and the prevalence of severe sepsis and acute lung injury/acute respiratory distress syndrome. O'Neal HR, Koyama T, Koehler EA, Siew E, Curtis BR, Fremont RD, May AK, Bernard GR, Ware LB (2011) Crit Care Med 39(6): 1343-50
    › Primary publication · 21336116 (PubMed) · PMC3102130 (PubMed Central)
  34. MCP-1 gene activation marks acute kidney injury. Munshi R, Johnson A, Siew ED, Ikizler TA, Ware LB, Wurfel MM, Himmelfarb J, Zager RA (2011) J Am Soc Nephrol 22(1): 165-75
    › Primary publication · 21071523 (PubMed) · PMC3014045 (PubMed Central)
  35. The assessment, serial evaluation, and subsequent sequelae of acute kidney injury (ASSESS-AKI) study: design and methods. Go AS, Parikh CR, Ikizler TA, Coca S, Siew ED, Chinchilli VM, Hsu CY, Garg AX, Zappitelli M, Liu KD, Reeves WB, Ghahramani N, Devarajan P, Faulkner GB, Tan TC, Kimmel PL, Eggers P, Stokes JB, Assessment Serial Evaluation, and Subsequent Sequelae of Acute Kidney Injury Study Investigators (2010) BMC Nephrol : 22
    › Primary publication · 20799966 (PubMed) · PMC2944247 (PubMed Central)
  36. Insulin resistance and protein energy metabolism in patients with advanced chronic kidney disease. Siew ED, Ikizler TA (2010) Semin Dial 23(4): 378-82
    › Primary publication · 20701717 (PubMed)
  37. Early postoperative statin therapy is associated with a lower incidence of acute kidney injury after cardiac surgery. Billings FT, Pretorius M, Siew ED, Yu C, Brown NJ (2010) J Cardiothorac Vasc Anesth 24(6): 913-20
    › Primary publication · 20599398 (PubMed) · PMC2992577 (PubMed Central)
  38. Elevated urinary IL-18 levels at the time of ICU admission predict adverse clinical outcomes. Siew ED, Ikizler TA, Gebretsadik T, Shintani A, Wickersham N, Bossert F, Peterson JF, Parikh CR, May AK, Ware LB (2010) Clin J Am Soc Nephrol 5(8): 1497-505
    › Primary publication · 20558561 (PubMed) · PMC2924408 (PubMed Central)
  39. Commonly used surrogates for baseline renal function affect the classification and prognosis of acute kidney injury. Siew ED, Matheny ME, Ikizler TA, Lewis JB, Miller RA, Waitman LR, Go AS, Parikh CR, Peterson JF (2010) Kidney Int 77(6): 536-42
    › Primary publication · 20042998 (PubMed) · PMC2929703 (PubMed Central)
  40. CRP polymorphisms and progression of chronic kidney disease in African Americans. Hung AM, Crawford DC, Griffin MR, Brown-Gentry K, Lipkowitz MS, Siew ED, Cavanaugh K, Lewis JB, Ikizler TA, AASK Study Group (2010) Clin J Am Soc Nephrol 5(1): 24-33
    › Primary publication · 19965533 (PubMed) · PMC2801650 (PubMed Central)
  41. Urine neutrophil gelatinase-associated lipocalin moderately predicts acute kidney injury in critically ill adults. Siew ED, Ware LB, Gebretsadik T, Shintani A, Moons KG, Wickersham N, Bossert F, Ikizler TA (2009) J Am Soc Nephrol 20(8): 1823-32
    › Primary publication · 19628673 (PubMed) · PMC2723988 (PubMed Central)
  42. Determinants of insulin resistance and its effects on protein metabolism in patients with advanced chronic kidney disease. Siew ED, Ikizler TA (2008) Contrib Nephrol : 138-144
    › Primary publication · 18451670 (PubMed)
  43. Determinants of C-reactive protein in chronic hemodialysis patients: relevance of dialysis catheter utilization. Hung A, Pupim L, Yu C, Shintani A, Siew E, Ayus C, Hakim RM, Ikizler TA (2008) Hemodial Int 12(2): 236-43
    › Primary publication · 18394058 (PubMed)
  44. Insulin resistance is associated with skeletal muscle protein breakdown in non-diabetic chronic hemodialysis patients. Siew ED, Pupim LB, Majchrzak KM, Shintani A, Flakoll PJ, Ikizler TA (2007) Kidney Int 71(2): 146-52
    › Primary publication · 17063174 (PubMed)
  45. Color mixing in dental porcelain. Wozniak WT, Siew ED, Lim J, McGill SL, Sabri Z, Moser JB (1993) Dent Mater 9(4): 229-33
    › Primary publication · 7988753 (PubMed)